{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:17:19Z","timestamp":1783192639822,"version":"3.54.6"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["24KJB330010"],"award-info":[{"award-number":["24KJB330010"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013088","name":"Qinglan Project of Jiangsu Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cbi.2026.112111","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:51:26Z","timestamp":1777359086000},"page":"112111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Acetyltransferase p300 promotes NNK-induced colorectal cancer progression by mediating ANKHD1 expression via H3K27ac modification"],"prefix":"10.1016","volume":"434","author":[{"given":"Min","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cbi.2026.112111_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024"},{"issue":"1","key":"10.1016\/j.cbi.2026.112111_bib2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12916-025-03867-9","article-title":"Global, regional, and national burden of early-onset colorectal cancer from 1990 to 2021: a systematic analysis based on the global burden of disease study 2021","volume":"23","author":"Meng","year":"2025","journal-title":"BMC Med."},{"key":"10.1016\/j.cbi.2026.112111_bib3","first-page":"55","volume":"vol. 15","author":"Liu","year":"2023"},{"issue":"7","key":"10.1016\/j.cbi.2026.112111_bib4","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S2468-1253(22)00044-9","article-title":"Global, regional, and national burden of colorectal cancer and its risk factors, 1990-2019: a systematic analysis for the Global burden of disease study 2019","volume":"7","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbi.2026.112111_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133692","article-title":"Nicotine-derived NNK promotes CRC progression through activating TMUB1\/AKT pathway in METTL14\/YTHDF2-mediated m6A manner","volume":"467","author":"Jiang","year":"2024","journal-title":"J Hazard Mater"},{"issue":"23","key":"10.1016\/j.cbi.2026.112111_bib6","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1093\/jnci\/92.23.1888","article-title":"Cigarette smoking and colorectal cancer mortality in the cancer prevention study II","volume":"92","author":"Chao","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.cbi.2026.112111_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106992","article-title":"Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter","volume":"158","author":"Aquilina","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2026.112111_bib8","first-page":"1","volume":"89","year":"2007","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"issue":"22","key":"10.1016\/j.cbi.2026.112111_bib9","article-title":"CBP\/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos","volume":"41","author":"Wang","year":"2022"},{"key":"10.1016\/j.cbi.2026.112111_bib10","series-title":"Dexmedetomidine Inhibits Ferroptosis to Alleviate Hypoxia\/Reoxygenation-Induced Cardiomyocyte Injury by Regulating the HDAC2\/FPN Pathway","author":"Fu","year":"2025"},{"issue":"4","key":"10.1016\/j.cbi.2026.112111_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/17501911.2025.2460900","article-title":"A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer","volume":"17","author":"Zhu","year":"2025","journal-title":"Epigenomics"},{"key":"10.1016\/j.cbi.2026.112111_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: an update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"issue":"W1","key":"10.1016\/j.cbi.2026.112111_bib13","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.cbi.2026.112111_bib14","article-title":"TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues","volume":"22","author":"Bartha Gy\u0151rffy","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cbi.2026.112111_bib15","first-page":"1829","article-title":"The HDOCK server for integrated protein-protein docking","volume":"15","author":"Yan","year":"2020"},{"issue":"12","key":"10.1016\/j.cbi.2026.112111_bib16","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1111\/bph.15331","article-title":"RNA-binding motif protein 39 (RBM39): an emerging cancer target","volume":"179","author":"Xu","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbi.2026.112111_bib17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41420-021-00598-7","article-title":"RNA-binding protein 39: a promising therapeutic target for cancer","volume":"7","author":"Xu","year":"2021","journal-title":"Cell Death Discov."},{"issue":"9","key":"10.1016\/j.cbi.2026.112111_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23095109","article-title":"Metabolism and DNA adduct Formation of tobacco-specific N-Nitrosamines","volume":"23","author":"Li","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.cbi.2026.112111_bib19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11684-023-1038-2","article-title":"Epigenetics and environmental health","volume":"18","author":"Zhang","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.cbi.2026.112111_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109055","article-title":"RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming","volume":"192","author":"Zhang","year":"2024","journal-title":"Environ. Int."},{"issue":"8","key":"10.1016\/j.cbi.2026.112111_bib21","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/acer.12772","article-title":"Identification of ethanol and 4-Nitroquinoline-1-Oxide induced epigenetic and oxidative stress markers during oral cavity carcinogenesis","volume":"39","author":"Urvalek","year":"2015","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.cbi.2026.112111_bib22","first-page":"138","article-title":"The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes","volume":"13","author":"Beacon","year":"2021"},{"issue":"4","key":"10.1016\/j.cbi.2026.112111_bib23","article-title":"Genetic dysregulation of EP300 in cancers in light of cancer epigenome control - targeting of p300-proficient and -deficient cancers","volume":"32","author":"Gronkowska","year":"2024","journal-title":"Mol. Ther. Oncol."},{"issue":"3","key":"10.1016\/j.cbi.2026.112111_bib24","first-page":"730","article-title":"EP300 selectively controls the enhancer landscape of MYCN-Amplified neuroblastoma","volume":"12","author":"Durbin","year":"2022"},{"issue":"16","key":"10.1016\/j.cbi.2026.112111_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612834","article-title":"Evaluating the molecular properties and function of ANKHD1, and its role in cancer","volume":"24","author":"Mullenger","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.cbi.2026.112111_bib26","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.bbagrm.2016.06.007","article-title":"Global regulation of alternative RNA splicing by the SR-rich protein RBM39","volume":"1859","author":"Mai","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.cbi.2026.112111_bib27","first-page":"510","article-title":"Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers","volume":"33","author":"Hilton","year":"2015"},{"issue":"1","key":"10.1016\/j.cbi.2026.112111_bib28","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12951-022-01477-8","article-title":"Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists","volume":"20","author":"Joudeh Nlinke","year":"2022","journal-title":"J. Nanobiotechnol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972600219X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972600219X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:02:41Z","timestamp":1783191761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927972600219X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":28,"alternative-id":["S000927972600219X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112111","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acetyltransferase p300 promotes NNK-induced colorectal cancer progression by mediating ANKHD1 expression via H3K27ac modification","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112111"}}