{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:46:58Z","timestamp":1782488818776,"version":"3.54.5"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Provincial Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["YDZJ202401148ZYTS"],"award-info":[{"award-number":["YDZJ202401148ZYTS"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Jilin Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["D18012"],"award-info":[{"award-number":["D18012"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cbi.2026.112149","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:57:56Z","timestamp":1779807476000},"page":"112149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Structure-dependent inhibition of human carboxylesterase 1 by organophosphate esters: integrated in vitro profiling and 3D-QSAR interpretation"],"prefix":"10.1016","volume":"435","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1192-0924","authenticated-orcid":false,"given":"Zhuohua","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6152-7286","authenticated-orcid":false,"given":"Siyu","family":"Men","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingying","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhua","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-0791","authenticated-orcid":false,"given":"Hanyong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2026.112149_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1584\/jpestics.R10-07","article-title":"Carboxylesterases: dual roles in lipid and pesticide metabolism","author":"Ross","year":"2010","journal-title":"J. Pestic. Sci."},{"key":"10.1016\/j.cbi.2026.112149_bib2","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1021\/bi500934j","article-title":"The catalytic mechanism of carboxylesterases: a computational study","author":"Aranda","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2026.112149_bib3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/molecules13020412","article-title":"Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs","author":"Hosokawa","year":"2008","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2026.112149_bib4","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1021\/tx500221a","article-title":"Effects of toxicologically relevant xenobiotics and the lipid-derived electrophile 4-hydroxynonenal on macrophage cholesterol efflux: silencing carboxylesterase 1 has paradoxical effects on cholesterol uptake and efflux","author":"Ross","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2026.112149_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1389200219666180821094502","article-title":"The impact of carboxylesterases in drug metabolism and pharmacokinetics","author":"Di","year":"2019","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.cbi.2026.112149_bib6","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/hep.25961","article-title":"Deficiency of carboxylesterase 1\/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia","author":"Quiroga","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2026.112149_bib7","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/hep.26714","article-title":"Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis","author":"Xu","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2026.112149_bib8","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.apsb.2022.10.017","article-title":"Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism","author":"Gan","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cbi.2026.112149_bib9","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/hep4.1487","article-title":"Hepatocyte-specific expression of human carboxylesterase 1 attenuates diet-induced steatohepatitis and hyperlipidemia in mice","author":"Xu","year":"2020","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.cbi.2026.112149_bib10","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/andr.12789","article-title":"Effects of brominated and organophosphate ester flame retardants on male reproduction","author":"Hales","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.cbi.2026.112149_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2022.116601","article-title":"A review on organophosphate esters: physiochemical properties, applications, and toxicities as well as occurrence and human exposure in dust environment","author":"Dou","year":"2023","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.cbi.2026.112149_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132095","article-title":"Established and emerging organophosphate esters (OPEs) and the expansion of an environmental contamination issue: a review and future directions","author":"Ye","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.cbi.2026.112149_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105178","article-title":"Organophosphate esters in indoor dust from 12 countries: concentrations, composition profiles, and human exposure","author":"Li","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2026.112149_bib14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.scitotenv.2016.02.171","article-title":"Organophosphate ester flame retardants and plasticizers in human placenta in Eastern China","author":"Ding","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2026.112149_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/kfj124","article-title":"Each lipase has a unique sensitivity profile for organophosphorus inhibitors","author":"Quistad","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbi.2026.112149_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.taap.2011.10.017","article-title":"Inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon","author":"Crow","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112149_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109148","article-title":"Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes","author":"Tsugoshi","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112149_bib18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.apsb.2018.05.005","article-title":"Human carboxylesterases: a comprehensive review","author":"Wang","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cbi.2026.112149_bib19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/toxsci\/kfz149","article-title":"Inhibition of human liver carboxylesterase (hCE1) by organophosphate ester flame retardants and plasticizers: implications for pharmacotherapy","author":"Phillips","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbi.2026.112149_bib20","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1021\/cb500014r","article-title":"Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia","author":"Morris","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.cbi.2026.112149_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116785","article-title":"Inhibitory effects of phthalate esters (PAEs) and phthalate monoesters towards human carboxylesterases (CESs)","author":"Gong","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112149_bib22","article-title":"Per- and polyfluoroalkyl substances exert strong inhibition towards human carboxylesterases","author":"Liu","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2026.112149_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00204-012-0934-z","article-title":"Quantitative structure-activity relationships for organophosphates binding to acetylcholinesterase","author":"Ruark","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2026.112149_bib24","doi-asserted-by":"crossref","first-page":"14525","DOI":"10.1021\/acs.est.0c04376","article-title":"Structure-oriented research on the antiestrogenic effect of organophosphate esters and the potential mechanism","author":"Li","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2026.112149_bib25","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1124\/mol.105.021683","article-title":"Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds","author":"Wadkins","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112149_bib26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bmc.2008.11.008","article-title":"Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis","author":"Harada","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.cbi.2026.112149_bib27","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1142\/S2737416525501224","article-title":"In-Silico DFT, ADMET prediction, toxicological assessment and molecular modeling studies of hydrazone-derived thiazolidinone derivatives: insight into In-vitro urease activity, and kinetic mechanism investigations","author":"Sardar","year":"2026","journal-title":"J. Comput. Biophys. Chem."},{"key":"10.1016\/j.cbi.2026.112149_bib28","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1142\/S2737416526500018","article-title":"Investigation of In-silico DFT, ADMET prediction and molecular docking insight: synthesis and in-vitro \u03b1-Amylase activity of novel benzoxazole and benzothiazole scaffolds","author":"Sardar","year":"2026","journal-title":"J. Comput. Biophys. Chem."},{"key":"10.1016\/j.cbi.2026.112149_bib29","doi-asserted-by":"crossref","unstructured":"H.M. Alharbi, N. Al-Hoshani, H. Sarfraz, A.S. Bello, T.A. Chohan, A.U. Khan, A. Sardar, M.S. Alwethaynani, H.A. Sagini, H.A. Alwabsi, F.A. Al-Joufi, R. Hussain, Optimization of 1-(Difluoromethyl)-6-(1H2 Imidazole-5-yl) Imidazo[1,5-a] Pyrazin-8(7H)-One frameworks as promising cholinesterase inhibitors for treating Alzheimer's disease, J. Comput. Biophys. Chem., pp. 1-20 http:\/\/doi.org\/10.1142\/s2737416526500663.","DOI":"10.1142\/S2737416526500663"},{"key":"10.1016\/j.cbi.2026.112149_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2021.100165","article-title":"Identification and characterization of cholesterol esterase and lipase inhibitory peptides from amaranth protein hydrolysates","author":"Fisayo Ajayi","year":"2021","journal-title":"Food Chem. X"},{"key":"10.1016\/j.cbi.2026.112149_bib31","doi-asserted-by":"crossref","unstructured":"Y. Khan, M.U. Naeem, S.F. Naqvi, S. Aslam, R. Adnan, M. Naseem, S.B. Fatima, Azmatullah, U. Gulshan, S. Aminullah, Identification of bis-thiazole linked oxazine Schiff bases: synthesis, in-vitro biological evaluation and computational insights toward potent urease and thymidine phosphorylase inhibitors, Pure Appl. Chem., http:\/\/doi.org\/doi:10.1515\/pac-2025-0649.","DOI":"10.1515\/pac-2025-0649"},{"key":"10.1016\/j.cbi.2026.112149_bib32","doi-asserted-by":"crossref","first-page":"8883","DOI":"10.1007\/s00210-025-04879-1","article-title":"Design, synthesis and biological profiling of bis-thiazole linked Schiff bases as effective enzyme inhibitors for targeting urease and thymidine phosphorylase proteins","author":"Khan","year":"2026","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.cbi.2026.112149_bib33","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1515\/pac-2025-0459","article-title":"Novel hybrid indazole-based 2,4-dihydro-3H-1,2,4-triazole-3-thione derivatives: design, synthesis, spectroscopic characterization, SAR, molecular docking, pharmacokinetics and toxicological activities","author":"Arshad","year":"2025","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.cbi.2026.112149_bib34","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbi.2026.112149_bib35","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1021\/bi700246n","article-title":"Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun","author":"Fleming","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbi.2026.112149_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2025.108786","article-title":"Synthesis and computational studies on novel thiazine-thiazole hybrid analogues as dual \u03b1-amylase and \u03b1-glucosidase inhibitors for combating diabetes mellitus","author":"Rehman","year":"2026","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.cbi.2026.112149_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2025.108741","article-title":"New thiazine derivatives with dual potential for lipoxygenase inhibition and hemolytic activity: synthesis, characterization and molecular docking studies","author":"Khan","year":"2026","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.cbi.2026.112149_bib38","series-title":"Gaussian 16, Revision C.01","author":"Frisch","year":"2016"},{"key":"10.1016\/j.cbi.2026.112149_bib39","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density","author":"Lee","year":"1988","journal-title":"Phys. Rev. B"},{"key":"10.1016\/j.cbi.2026.112149_bib40","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","article-title":"Density-functional thermochemistry. III. The role of exact exchange","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.cbi.2026.112149_bib41","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1063\/1.438955","article-title":"Self-consistent molecular orbital methods. XX. A basis set for correlated wave functions","author":"Krishnan","year":"1980","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.cbi.2026.112149_bib42","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1063\/1.449486","article-title":"Natural population analysis","author":"Reed","year":"1985","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.cbi.2026.112149_bib43","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.pharmtox.38.1.257","article-title":"The mammalian carboxylesterases: from molecules to functions","author":"Satoh","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2026.112149_bib44","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fphar.2017.00435","article-title":"Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1","author":"Zou","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112149_bib45","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cbi.2005.10.036","article-title":"Serine hydrolase targets of organophosphorus toxicants","author":"Casida","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112149_bib46","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tox.2016.06.006","article-title":"New insights on molecular interactions of organophosphorus pesticides with esterases","author":"Mangas","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2026.112149_bib47","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cbi.2010.03.002","article-title":"Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine","author":"Lockridge","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112149_bib48","first-page":"63","article-title":"[Aging of cholinesterase after inhibition by organophosphates]","author":"Curtil","year":"1993","journal-title":"Ann. Pharm. Fr."},{"key":"10.1016\/j.cbi.2026.112149_bib49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.envint.2017.10.001","article-title":"Exposure to organophosphate flame retardant chemicals in the U.S. general population: data from the 2013-2014 National Health and Nutrition Examination Survey","author":"Ospina","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2026.112149_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105698","article-title":"Organophosphate esters and their metabolites in paired human whole blood, serum, and urine as biomarkers of exposure","author":"Hou","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2026.112149_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12060437","article-title":"Integrated approach for testing and assessment for developmental neurotoxicity (DNT) to prioritize aromatic organophosphorus flame retardants","author":"Kreutz","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.cbi.2026.112149_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph182312469","article-title":"Liver-based probabilistic risk assessment of exposure to organophosphate esters via dust ingestion using a physiologically based toxicokinetic (PBTK) model","author":"Ding","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.cbi.2026.112149_bib53","series-title":"CompTox Chemicals Dashboard, Version 2.8","year":"2025"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726002577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726002577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:56:16Z","timestamp":1782485776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726002577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":53,"alternative-id":["S0009279726002577"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112149","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-dependent inhibition of human carboxylesterase 1 by organophosphate esters: integrated in vitro profiling and 3D-QSAR interpretation","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112149"}}