{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:17:42Z","timestamp":1783109862640,"version":"3.54.6"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSC109-2320-B-077-004-MY3"],"award-info":[{"award-number":["NSC109-2320-B-077-004-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW-NRICM-M-3-2-5-1-2-2-008"],"award-info":[{"award-number":["MOHW-NRICM-M-3-2-5-1-2-2-008"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW114-NRICM-D-325-000101"],"award-info":[{"award-number":["MOHW114-NRICM-D-325-000101"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cbi.2026.112150","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:10:49Z","timestamp":1779203449000},"page":"112150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["High susceptibility of mouse hepatic Cyp2a to the inactivation by oral imperatorin: isoform sensitivity and tissue specificity"],"prefix":"10.1016","volume":"435","author":[{"given":"Jia-Shan","family":"Chih","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5642-4679","authenticated-orcid":false,"given":"Chia-Ching","family":"Liaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6046-8356","authenticated-orcid":false,"given":"Yune-Fang","family":"Ueng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2026.112150_bib1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.38212\/2224-6614.3421","article-title":"Metabolism-involved drug interactions with traditional Chinese medicines in cardiovascular diseases","volume":"30","author":"Liang","year":"2022","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.cbi.2026.112150_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2165\/11597910-000000000-00000","article-title":"Drug interactions with herbal medicines","volume":"51","author":"Shi","year":"2012","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.cbi.2026.112150_bib3","first-page":"1","article-title":"The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci","volume":"8","author":"Nebert","year":"1989","journal-title":"DNA (N. Y.)"},{"key":"10.1016\/j.cbi.2026.112150_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0009-9236(03)00118-8","article-title":"Time course of recovery of cytochrome P450 3A function after single doses of grapefruit juice","volume":"74","author":"Greenblatt","year":"2003","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2026.112150_bib5","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1124\/pharmrev.124.001173","article-title":"Roles of individual human cytochrome P450 enzymes in drug metabolism","volume":"76","author":"Guengerich","year":"2024","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cbi.2026.112150_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1021\/tx500444e","article-title":"Survey of human oxidoreductases and cytochrome P450 enzymes involved in the metabolism of xenobiotic and natural chemicals","volume":"28","author":"Rendic","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbi.2026.112150_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109574","article-title":"Interactions of the antioxidant enzymes NAD(P)H: quinone oxidoreductase 1 (NQO1) and NRH: quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemical and environmental contaminants","volume":"345","author":"Rashid","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112150_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0378-4347(96)00234-4","article-title":"Simultaneous determination of coumarin, 7-hydroxycoumarin and 7-hydroxycoumarin glucuronide in human serum and plasma by high-performance liquid chromatography","volume":"686","author":"Bogan","year":"1996","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.cbi.2026.112150_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5702","article-title":"Detection and identification of imperatorin metabolites in rat, dog, monkey, and human liver microsomes by ultra-high-performance liquid chromatography combined with high-resolution mass spectrometry and compound discoverer software","volume":"37","author":"He","year":"2023","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.cbi.2026.112150_bib10","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1002\/jssc.201500840","article-title":"Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats","volume":"38","author":"Chen","year":"2015","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.cbi.2026.112150_bib11","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1055\/s-2003-45188","article-title":"Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines","volume":"69","author":"Yang","year":"2003","journal-title":"Planta Med."},{"key":"10.1016\/j.cbi.2026.112150_bib12","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jcma.2017.12.008","article-title":"Population-based comparison of traditional medicine use in adult patients with allergic rhinitis between South Korea and Taiwan","volume":"81","author":"Huang","year":"2018","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.cbi.2026.112150_bib13","article-title":"Identifying the Chinese herbal medicine network and core formula for allergic rhinitis on a real-world database, Evid.-Based Complement. Alternat","volume":"2020","author":"Lu","year":"2020","journal-title":"Med."},{"key":"10.1016\/j.cbi.2026.112150_bib14","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/jpp\/rgad054","article-title":"Identification of the perpetrator imperatorin in xin-yi-san-theophylline interaction: observed and predicted herb-drug interaction in rats","volume":"75","author":"Wang","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112150_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.cbi.2026.112150_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109401","article-title":"Effects of imperatorin in the cardiovascular system and cancer","volume":"120","author":"Nasser","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2026.112150_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.toxlet.2011.11.030","article-title":"Furanocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice","volume":"209","author":"Wang","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbi.2026.112150_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/carcin\/22.1.73","article-title":"Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice","volume":"22","author":"Kleiner","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbi.2026.112150_bib19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.taap.2008.07.004","article-title":"Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice","volume":"232","author":"Kleiner","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112150_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155760","article-title":"Xin-yi-san contains potent human CYP1A2 inhibitors and its combined use with theophylline in treatment increases adverse risks in patients","volume":"130","author":"Kao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbi.2026.112150_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117155","article-title":"Time-dependent inactivation of human cytochrome P450 2A6 variants and 2A13 by imperatorin: natural coumarins and imperatorin oxidation","volume":"241","author":"Ueng","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112150_bib22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1124\/dmd.114.060558","article-title":"Imperatorin is a mechanism-based inactivator of CYP2B6","volume":"43","author":"Zheng","year":"2015","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2026.112150_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1517\/17425255.3.1.51","article-title":"Time-dependent CYP inhibition","volume":"3","author":"Riley","year":"2007","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.cbi.2026.112150_bib24","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nsmb971","article-title":"Structures of human microsomal P450 2A6 complexed with coumarin and methoxsalen","volume":"12","author":"Yano","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cbi.2026.112150_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0278-6915(99)00010-1","article-title":"Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment","volume":"37","author":"Lake","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2026.112150_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/138920013804545223","article-title":"Function and regulation of the Cyp2a5\/CYP2A6 genes in response to toxic insults in the liver","volume":"14","author":"Abu-Bakar","year":"2013","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.cbi.2026.112150_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149813","article-title":"Circadian rhythms in CYP2A5 expression underlie the time-dependent effect of tegafur on breast cancer","volume":"708","author":"Yoshida","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2026.112150_bib28","first-page":"822","article-title":"Differential xenobiotic induction of CYP2A5 in mouse liver, kidney, lung, and olfactory mucosa","volume":"26","author":"Su","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2026.112150_bib29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/bcpt.12329","article-title":"Effects of cucurbitacin E, a tetracyclic triterpene compound from Cucurbitaceae, on the pharmacokinetics and pharmacodynamics of warfarin in rats","volume":"116","author":"Ding","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbi.2026.112150_bib30","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/clpt.2008.34","article-title":"The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo","volume":"84","author":"Tornio","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2026.112150_bib31","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1211\/0022357001774750","article-title":"Interaction of drugs and Chinese herbs: pharmacokinetic changes of tolbutamide and diazepam caused by extract of Angelica dahurica","volume":"52","author":"Ishihara","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112150_bib32","first-page":"413","article-title":"Estrogenic activity of osthole and imperatorin in MCF-7 cells and their osteoblastic effects in Saos-2 cells","volume":"14","author":"Jia","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.cbi.2026.112150_bib33","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1124\/dmd.107.016568","article-title":"Human CYP2A6 is induced by estrogen via estrogen receptor","volume":"35","author":"Higashi","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2026.112150_bib34","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jep.2009.09.018","article-title":"Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL\/5JNarl mice","volume":"126","author":"Ueng","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2026.112150_bib35","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s00204-020-02781-8","article-title":"Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse","volume":"94","author":"Wang","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2026.112150_bib36","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/abbi.1999.1388","article-title":"Expression of cytochrome P450 2A6 in Escherichia coli: purification, spectral and catalytic characterization, and preparation of polyclonal antibodies","volume":"370","author":"Sou\u010dek","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbi.2026.112150_bib37","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s00204-012-0902-7","article-title":"A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation","volume":"86","author":"Lo","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2026.112150_bib38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0009-2797(98)00044-1","article-title":"Effects of \u03b2-ionone on the expression of cytochrome P450s and NADPH-cytochrome P450 reductase in Sprague Dawley rats","volume":"114","author":"Jeong","year":"1998","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112150_bib39","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jfda.2017.01.004","article-title":"The time-dependent effects of St John's wort on cytochrome P450, uridine diphosphate-glucuronosyltransferase, glutathione S-transferase, and NAD(P)H-quinone oxidoreductase in mice","volume":"26","author":"Yang","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.cbi.2026.112150_bib40","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.lfs.2004.11.037","article-title":"Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes","volume":"77","author":"Chou","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.cbi.2026.112150_bib41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1099-081X(199704)18:3<213::AID-BDD15>3.0.CO;2-0","article-title":"Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species, Biopharm","volume":"18","author":"Court","year":"1997","journal-title":"Drug Dispos."},{"key":"10.1016\/j.cbi.2026.112150_bib42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0278-6915(97)00171-3","article-title":"Inhibition of mouse and human CYP1A-and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol","volume":"36","author":"Helsby","year":"1998","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2026.112150_bib43","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0022-3565(24)35332-7","article-title":"Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms","volume":"292","author":"Perloff","year":"2000","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.cbi.2026.112150_bib44","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1124\/dmd.30.3.349","article-title":"The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes","volume":"30","author":"Ueng","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.cbi.2026.112150_bib45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/jpm7040018","article-title":"Variation in CYP2A6 activity and personalized medicine","volume":"7","author":"Tanner","year":"2017","journal-title":"J. Personalized Med."},{"key":"10.1016\/j.cbi.2026.112150_bib46","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1128\/AAC.02532-14","article-title":"Isoniazid mediates the CYP2B6\u22176 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6","volume":"58","author":"Court","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cbi.2026.112150_bib47","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2133\/dmpk.21.277","article-title":"Characterization of humanized liver from chimeric mice using coumarin as a human CYP2A6 and mouse CYP2A5 probe","volume":"21","author":"Aoki","year":"2006","journal-title":"Drug Metabol. Pharmacokinet."},{"key":"10.1016\/j.cbi.2026.112150_bib48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0304-3835(89)90201-2","article-title":"Comparison of the effects of acute and subacute treatment of phenobarbital in different strains of mice","volume":"48","author":"Lin","year":"1989","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cbi.2026.112150_bib49","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0006-2952(94)90363-8","article-title":"Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver","volume":"48","author":"Burke","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112150_bib50","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0006-2952(98)00241-X","article-title":"Methoxyresorufin: an inappropriate substrate for CYP1A2 in the mouse","volume":"56","author":"Hamm","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112150_bib51","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0006-2952(93)90504-P","article-title":"Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochrome P4501A2 and 2B, respectively, in the rat and mouse","volume":"46","author":"Nerurkar","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112150_bib52","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1080\/00498254.2018.1488011","article-title":"Time-dependent inhibition (TDI) of CYP1A2 by a CYP3A4-mediated reactive metabolite: proposal for a novel mechanism of irreversible TDI by a non-suicide substrate","volume":"49","author":"Nishimuta","year":"2019","journal-title":"Xenobiotica"},{"key":"10.1016\/j.cbi.2026.112150_bib53","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jep.2017.10.014","article-title":"High hepatic exposure of furanocoumarins in Radix Angelica dahuricae is associated with transporter mediated active uptake","volume":"212","author":"Chen","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2026.112150_bib54","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2116\/analsci.25.869","article-title":"Development and validation of a gas chromatography-mass spectrometry method for the determination of imperatorin in rat plasma and tissue: application to study its pharmacokinetics","volume":"25","author":"Wang","year":"2009","journal-title":"Anal. Sci."},{"key":"10.1016\/j.cbi.2026.112150_bib55","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0278-6915(94)90078-7","article-title":"Sex and strain differences in mouse hepatic microsomal coumarin 7-hydroxylase activity","volume":"32","author":"van Iersel","year":"1994","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2026.112150_bib56","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00008571-200204000-00009","article-title":"Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females","volume":"12","author":"Ujjin","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.cbi.2026.112150_bib57","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00199885","article-title":"Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers","volume":"46","author":"Merkel","year":"1994","journal-title":"Eur. J. Clin. Pharmacol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726002589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726002589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:32:46Z","timestamp":1783107166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726002589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":57,"alternative-id":["S0009279726002589"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112150","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High susceptibility of mouse hepatic Cyp2a to the inactivation by oral imperatorin: isoform sensitivity and tissue specificity","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112150","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112150"}}