{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:19:27Z","timestamp":1783041567992,"version":"3.54.6"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472850"],"award-info":[{"award-number":["32472850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002213"],"award-info":[{"award-number":["32002213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFE0124400"],"award-info":[{"award-number":["2023YFE0124400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515030141"],"award-info":[{"award-number":["2024A1515030141"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cbi.2026.112182","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T15:21:12Z","timestamp":1780154472000},"page":"112182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Punicalagin alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal injury via Kr\u00fcppel-like factor 4"],"prefix":"10.1016","volume":"435","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1374-1444","authenticated-orcid":false,"given":"Xiang-Guang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2178-5435","authenticated-orcid":false,"given":"Peizhi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jibin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuqiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12 Suppl 2","key":"10.1016\/j.cbi.2026.112182_bib1","doi-asserted-by":"crossref","first-page":"S813","DOI":"10.1093\/infdis\/jiab359","article-title":"Emerging themes in the molecular pathogenesis of enterotoxigenic Escherichia coli","volume":"224","author":"Fleckenstein","year":"2021","journal-title":"J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.cbi.2026.112182_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cells12040567","article-title":"Heat-Stable enterotoxin secretions assessed via ICP-MS reveal iron-mediated regulation of virulence in CFA\/I- and CS6-Expressing ETEC isolates","volume":"12","author":"Hollifield","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib3","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2055943","article-title":"Enterotoxigenic Escherichia coli: intestinal pathogenesis mechanisms and colonization resistance by gut microbiota","volume":"14","author":"Zhang","year":"2022","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41522-022-00344-6","article-title":"Role of mucus-bacteria interactions in Enterotoxigenic Escherichia coli (ETEC) H10407 virulence and interplay with human microbiome","volume":"8","author":"Sauvaitre","year":"2022","journal-title":"npj Biofilms Microbiomes"},{"issue":"6","key":"10.1016\/j.cbi.2026.112182_bib5","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s12015-021-10205-y","article-title":"Intestinal models for personalized medicine: from conventional models to microfluidic primary Intestine-on-a-chip","volume":"18","author":"Li","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.cbi.2026.112182_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/20417314221149882","article-title":"Gut-on-a-chip for disease models","volume":"14","author":"Xian","year":"2023","journal-title":"J. Tissue Eng."},{"issue":"4","key":"10.1016\/j.cbi.2026.112182_bib7","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/stem.3324","article-title":"Heat-stable enterotoxin inhibits intestinal stem cell expansion to disrupt the intestinal integrity by downregulating the Wnt\/\u03b2-catenin pathway","volume":"39","author":"Zhou","year":"2021","journal-title":"Stem Cell."},{"issue":"11","key":"10.1016\/j.cbi.2026.112182_bib8","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1242\/dev.129.11.2619","article-title":"The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon","volume":"129","author":"Katz","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.cbi.2026.112182_bib9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.aninu.2025.03.004","article-title":"The role of glycosylated mucins in maintaining intestinal homeostasis and gut health","volume":"21","author":"Cheng","year":"2025","journal-title":"Anim. Nutr."},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41467-023-37666-8","article-title":"The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins","volume":"14","author":"Gallego","year":"2023","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cbi.2026.112182_bib11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.15283\/ijsc20048","article-title":"KLF4 regulates goblet cell differentiation in BMI1(+) reserve intestinal stem cell lineage during homeostasis","volume":"13","author":"Katano","year":"2020","journal-title":"Int. J. Stem Cells"},{"issue":"6","key":"10.1016\/j.cbi.2026.112182_bib12","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41401-024-01238-3","article-title":"Intestinal epithelial kr\u00fcppel-like factor 4 alleviates endotoxemia and atherosclerosis through improving NF-\u03baB\/miR-34a-mediated intestinal permeability","volume":"45","author":"Nie","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cbi.2026.112182_bib13","article-title":"Ghrelin alleviates intestinal dysfunction in sepsis through the KLF4\/MMP2 regulatory axis by activating SIRT1","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40104-022-00816-x","article-title":"Protocatechuic acid and quercetin attenuate ETEC-caused IPEC-1 cell inflammation and injury associated with inhibition of necroptosis and pyroptosis signaling pathways","volume":"14","author":"Xiao","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"13","key":"10.1016\/j.cbi.2026.112182_bib15","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1021\/acs.jafc.4c00185","article-title":"Ovomucin hydrolysates reduce bacterial adhesion and inflammation in enterotoxigenic Escherichia coli (ETEC) K88-challenged intestinal epithelial cells","volume":"72","author":"Bao","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.cbi.2026.112182_bib16","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1039\/D4FO01047G","article-title":"Bacillus halotolerans attenuates inflammation induced by enterotoxigenic Escherichia coli infection in vivo and in vitro based on its metabolite soyasaponin I regulating the p105-Tpl2-ERK pathway","volume":"15","author":"Li","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.cbi.2026.112182_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131635","article-title":"Pomegranate peel-derived punicalagin: Ultrasonic-assisted extraction, purification, and its \u03b1-glucosidase inhibitory mechanism","volume":"374","author":"Liu","year":"2022","journal-title":"Food Chem."},{"issue":"19","key":"10.1016\/j.cbi.2026.112182_bib18","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1016\/j.tjnut.2025.08.002","article-title":"The potential and underlying mechanisms of punicalagin in mitigating enterotoxigenic escherichia coli-induced diarrhea","volume":"155","author":"Li","year":"2025","journal-title":"J. Nutr."},{"issue":"7","key":"10.1016\/j.cbi.2026.112182_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/nu13072150","article-title":"Physiological and immune functions of punicalagin","volume":"13","author":"Venusova","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib20","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20212196","article-title":"Lung-protective effect of Punicalagin on LPS-induced acute lung injury in mice","volume":"42","author":"Zeng","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.cbi.2026.112182_bib21","doi-asserted-by":"crossref","DOI":"10.29219\/fnr.v65.5689","article-title":"A new way for punicalagin to alleviate insulin resistance: regulating gut microbiota and autophagy","volume":"65","author":"Cao","year":"2021","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.cbi.2026.112182_bib22","article-title":"Parabacteroides distasonis alleviates enterotoxigenic Escherichia coli-induced diarrhea in mice by mediating gut microbiota","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cbi.2026.112182_bib23","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1126\/science.1060677","article-title":"Molecular cloning","volume":"292","author":"Chong","year":"2001","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.cbi.2026.112182_bib24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"issue":"5259","key":"10.1016\/j.cbi.2026.112182_bib26","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.cbi.2026.112182_bib27","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7","key":"10.1016\/j.cbi.2026.112182_bib28","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2542385","article-title":"Using MUC2 mucin producing tumorigenic human goblet-like cells to uncover functional properties of the mucus barrier","volume":"17","author":"Gorman","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.cbi.2026.112182_bib30","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2147\/JIR.S318327","article-title":"Role of goblet cells in intestinal barrier and mucosal immunity","volume":"14","author":"Yang","year":"2021","journal-title":"J. Inflamm. Res."},{"issue":"14","key":"10.1016\/j.cbi.2026.112182_bib31","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.7150\/ijbs.28576","article-title":"SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression","volume":"14","author":"Chen","year":"2018","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.cbi.2026.112182_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11020132","article-title":"Modulation of Mucin (MUC2, MUC5AC and MUC5B) mRNA expression and protein production and secretion in Caco-2\/HT29-MTX Co-Cultures following exposure to individual and combined Aflatoxin M1 and Ochratoxin A","volume":"11","author":"Huang","year":"2019","journal-title":"Toxins"},{"issue":"9","key":"10.1016\/j.cbi.2026.112182_bib33","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1002\/jcp.30325","article-title":"DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation","volume":"236","author":"Qin","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.cbi.2026.112182_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/nu15081830","article-title":"Age-Related mucus barrier dysfunction in mice is related to the changes in Muc2 mucin in the Colon","volume":"15","author":"Sang","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78141-4","article-title":"Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium","volume":"10","author":"Borisova","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2026.112182_bib36","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.ijbiomac.2020.07.191","article-title":"The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression","volume":"164","author":"Liu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib37","first-page":"363","article-title":"Resveratrol enhances MUC2 synthesis via the ANRIL-miR-34a axis to mitigate IBD","volume":"15","author":"Zhou","year":"2023","journal-title":"Am. J. Transl. Res."},{"issue":"2","key":"10.1016\/j.cbi.2026.112182_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032492","article-title":"Kr\u00fcppel-like factor 4 regulates intestinal epithelial cell morphology and polarity","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib39","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2389320","article-title":"Deciphering internal and external factors influencing intestinal junctional complexes","volume":"16","author":"Markovich","year":"2024","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib40","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1038\/s41467-025-62107-z","article-title":"PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.cbi.2026.112182_bib41","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.tcb.2022.08.007","article-title":"Adherens junction: the ensemble of specialized cadherin clusters","volume":"33","author":"Troyanovsky","year":"2023","journal-title":"Trends Cell Biol."},{"issue":"7","key":"10.1016\/j.cbi.2026.112182_bib42","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1083\/jcb.201008173","article-title":"Structural and functional diversity of cadherin at the adherens junction","volume":"193","author":"Oda","year":"2011","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.cbi.2026.112182_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2024.104398","article-title":"E-Cadherin and its signaling pathways: a novel target of dietary components in modulating cell migration and proliferation","volume":"146","author":"Ashkar","year":"2024","journal-title":"Trends Food Sci. Technol."},{"issue":"26","key":"10.1016\/j.cbi.2026.112182_bib44","doi-asserted-by":"crossref","first-page":"14653","DOI":"10.1021\/acs.jafc.4c00239","article-title":"Glycyrol relieves ulcerative colitis by promoting the fusion of ZO-1 with the cell membrane through the enteric glial cells GDNF\/RET pathway","volume":"72","author":"Lu","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"16","key":"10.1016\/j.cbi.2026.112182_bib45","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1039\/D4FO01794C","article-title":"Miao sour soup alleviates DSS-induced colitis in mice: modulation of gut microbiota and intestinal barrier function","volume":"15","author":"Li","year":"2024","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.cbi.2026.112182_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/nu15010054","article-title":"Zinc laurate protects against intestinal barrier dysfunction and inflammation induced by ETEC in a mice model","volume":"15","author":"Chen","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.cbi.2026.112182_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1181519","article-title":"Effects of zinc oxide and condensed tannins on the growth performance and intestinal health of weaned piglets in ETEC-challenged environment","volume":"14","author":"Yi","year":"2023","journal-title":"Front. Microbiol."},{"issue":"7","key":"10.1016\/j.cbi.2026.112182_bib48","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1021\/acsomega.1c06565","article-title":"Analysis of the molecular mechanism of punicalagin in the treatment of alzheimer's disease by computer-aided drug research technology","volume":"7","author":"Xu","year":"2022","journal-title":"ACS Omega"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726002905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726002905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:05:29Z","timestamp":1783040729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726002905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":48,"alternative-id":["S0009279726002905"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112182","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Punicalagin alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal injury via Kr\u00fcppel-like factor 4","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112182"}}