{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:20:09Z","timestamp":1783603209889,"version":"3.55.0"},"reference-count":145,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["67985823"],"award-info":[{"award-number":["67985823"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cbi.2026.112189","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:19:58Z","timestamp":1780417198000},"page":"112189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Selective mitochondrial dysfunction and redox collapse induced by an indole chalcone in breast cancer cells"],"prefix":"10.1016","volume":"436","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4594-3363","authenticated-orcid":false,"given":"Annam\u00e1ria","family":"Bardel\u010d\u00edkov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katar\u00edna","family":"Smolkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"\u0160pa\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Gotvaldov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-907X","authenticated-orcid":false,"given":"Roman","family":"Gardl\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Ga\u00e1l Koval\u010d\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Kudli\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2454-5799","authenticated-orcid":false,"given":"Martin","family":"Kello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-4525","authenticated-orcid":false,"given":"J\u00e1n","family":"Moj\u017ei\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2026.112189_bib1","article-title":"Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence","volume":"11","author":"Salehi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112189_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s42250-019-00043-4","article-title":"Synthesis, characterization and antibacterial activities of new fluorinated chalcones","volume":"2","author":"Amole","year":"2019","journal-title":"Chem. Afr."},{"key":"10.1016\/j.cbi.2026.112189_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173628","article-title":"Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity","volume":"12","author":"Okuda-Tanino","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2026.112189_bib4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.phrs.2017.11.022","article-title":"Chalcones as putative hepatoprotective agents: preclinical evidence and molecular mechanisms","volume":"129","author":"Karimi-Sales","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbi.2026.112189_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22081210","article-title":"Chalcone derivatives: promising starting points for drug design","volume":"22","author":"Gomes","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2026.112189_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111306","article-title":"Anticancer activity of natural and synthetic chalcones","volume":"22","author":"Constantinescu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112189_bib7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/1521-1878(200103)23:3<295::AID-BIES1040>3.0.CO;2-M","article-title":"Causes and consequences of hypoxia and acidity in tumour microenvironments","volume":"23","author":"Griffiths","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/j.cbi.2026.112189_bib8","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1158\/0008-5472.CAN-03-1101","article-title":"Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells","volume":"64","author":"Rossignol","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2026.112189_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50141-z","article-title":"Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells","volume":"9","author":"Reda","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2026.112189_bib10","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1742-4658.2007.05686.x","article-title":"Energy metabolism in tumor cells","volume":"274","author":"Moreno-S\u00e1nchez","year":"2007","journal-title":"FEBS J."},{"key":"10.1016\/j.cbi.2026.112189_bib11","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.cbi.2026.112189_bib12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/BJ20120294","article-title":"Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition","volume":"444","author":"Diers","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbi.2026.112189_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/biom12030379","article-title":"Characterization of mitochondrial proteome and function in luminal A and basal-like breast cancer subtypes reveals alteration in mitochondrial dynamics and bioenergetics relevant to their diagnosis","volume":"12","author":"Ortega-Lozano","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.cbi.2026.112189_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/BJ20131608","article-title":"Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by oestradiol and tamoxifen","volume":"465","author":"Radde","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbi.2026.112189_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010198","article-title":"Coenzyme Q depletion reshapes MCF-7 cells metabolism","volume":"22","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112189_bib16","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3389\/fonc.2020.01703","article-title":"Total cellular ATP production changes with primary substrate in MCF7 breast cancer cells","volume":"10","author":"Louie","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cbi.2026.112189_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-37677-x","article-title":"Viability of HepG2 and MCF-7 cells is not correlated with mitochondrial bioenergetics","volume":"13","author":"Doczi","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2026.112189_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020543","article-title":"Metabolomics profiling reveals the role of PEDF in triple-negative breast cancer cell MDA-MB-231 under glycaemic loading","volume":"15","author":"Abooshahab","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cbi.2026.112189_bib19","article-title":"Role of lactate in the regulation of transcriptional activity of breast cancer-related genes and epithelial-to-mesenchymal transition proteins: a compassion of MCF7 and MDA-MB-231 cancer cell lines. Preprint","author":"San-Millan","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.cbi.2026.112189_bib20","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3389\/fonc.2020.01053","article-title":"Metabolic and OXPHOS activities quantified by temporal ex vivo analysis display patient-specific metabolic vulnerabilities in human breast cancers","volume":"10","author":"Koit","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cbi.2026.112189_bib21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/msb.2011.56","article-title":"Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth","volume":"7","author":"Gaglio","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.cbi.2026.112189_bib22","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1158\/1078-0432.CCR-14-1200","article-title":"Targeting glutamine metabolism in breast cancer with aminooxyacetate","volume":"21","author":"Korangath","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cbi.2026.112189_bib23","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1073\/pnas.1816391116","article-title":"Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways","volume":"116","author":"Jia","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2026.112189_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2023.100949","article-title":"Mitochondrial adaptation decreases drug sensitivity of persistent triple negative breast cancer cells surviving combinatory and sequential chemotherapy","volume":"46","author":"Winter","year":"2023","journal-title":"Neoplasia"},{"key":"10.1016\/j.cbi.2026.112189_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.cellbio.22.010305.104638","article-title":"Mitochondrial fusion and fission in mammals","volume":"22","author":"Chan","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cbi.2026.112189_bib26","first-page":"1278","article-title":"The role of mitochondrial dynamics in human cancers","volume":"10","author":"Ma","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cbi.2026.112189_bib27","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1074\/jbc.C200677200","article-title":"Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis","volume":"278","author":"Olichon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib28","doi-asserted-by":"crossref","first-page":"21583","DOI":"10.1074\/jbc.C700083200","article-title":"Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology","volume":"282","author":"Chang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib29","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1083\/jcb.201007152","article-title":"Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells","volume":"191","author":"Otera","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cbi.2026.112189_bib30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nature21408","article-title":"LACTB is a tumour suppressor that modulates lipid metabolism and cell state","volume":"543","author":"Keckesova","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2026.112189_bib31","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1089\/ars.2011.4085","article-title":"Mitochondrial regulation of cell cycle and proliferation","volume":"16","author":"Antico Arciuch","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.cbi.2026.112189_bib32","article-title":"Cancer cells change their glucose metabolism to overcome increased ROS: one step from cancer cell to cancer stem cell?","volume":"112","author":"Movahed","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2026.112189_bib33","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bcp.2014.07.017","article-title":"Targeting antioxidants for cancer therapy","volume":"92","author":"Glasauer","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112189_bib34","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrc3803","article-title":"Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?","volume":"14","author":"Sabharwal","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cbi.2026.112189_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14030503","article-title":"Programmed cell death alterations mediated by synthetic indole chalcone resulted in cell cycle arrest, DNA damage, apoptosis and signaling pathway modulations in breast cancer model","volume":"14","author":"Michalkova","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cbi.2026.112189_bib36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10637-006-9027-2","article-title":"Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors","volume":"25","author":"Kuppens","year":"2007","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.cbi.2026.112189_bib37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1248\/cpb.c19-00217","article-title":"Synthesis, anticancer activity and molecular modeling studies of novel chalcone derivatives containing indole and naphthalene moieties as tubulin polymerization inhibitors","volume":"67","author":"Wang","year":"2019","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.cbi.2026.112189_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28186583","article-title":"Design, synthesis, and evaluation of novel indole hybrid chalcones and their antiproliferative and antioxidant activity","volume":"28","author":"Kudlickova","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2026.112189_bib39","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/1871520615666150518093144","article-title":"A review on mechanisms of anti tumor activity of chalcones","volume":"16","author":"Sharma","year":"2015","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib40","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1074\/mcp.M700076-MCP200","article-title":"High resolution clear native electrophoresis for in-gel functional assays and fluorescence studies of membrane protein complexes","volume":"6","author":"Wittig","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cbi.2026.112189_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10863-009-9267-x","article-title":"Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia","volume":"42","author":"Smolkova","year":"2010","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.cbi.2026.112189_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-61779-382-0_3","article-title":"High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle","volume":"810","author":"Pesta","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cbi.2026.112189_bib43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1155\/2005\/693437","article-title":"Salivary thiobarbituric acid reacting substances and malondialdehyde--their relationship to reported smoking and to parodontal status described by the papillary bleeding index","volume":"21","author":"Celec","year":"2005","journal-title":"Dis. Markers"},{"key":"10.1016\/j.cbi.2026.112189_bib44","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/jop.12008","article-title":"Salivary markers of oxidative stress are related to age and oral health in adult non-smokers","volume":"42","author":"Celecova","year":"2013","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.cbi.2026.112189_bib45","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11325-011-0510-4","article-title":"Oxidative and carbonyl stress in patients with obstructive sleep apnea treated with continuous positive airway pressure","volume":"16","author":"Celec","year":"2012","journal-title":"Sleep Breath."},{"key":"10.1016\/j.cbi.2026.112189_bib46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1155\/2013\/341302","article-title":"Salivary markers of oxidative stress and antioxidant status: influence of external factors","volume":"34","author":"Kamodyova","year":"2013","journal-title":"Dis. Markers"},{"key":"10.1016\/j.cbi.2026.112189_bib47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.fct.2013.08.073","article-title":"No harmful effect of different Coca-cola beverages after 6 months of intake on rat testes","volume":"62","author":"Tothova","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2026.112189_bib48","first-page":"72","article-title":"Mitochondrial dynamics regulates migration and invasion of breast cancer cells","author":"Tu","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2026.112189_bib49","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/s43018-023-00563-6","article-title":"Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases","volume":"4","author":"Parida","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cbi.2026.112189_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158010","article-title":"Biomarkers and mechanisms of oxidative stress-last 20 years of research with an emphasis on kidney damage and renal transplantation","volume":"22","author":"Tejchman","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112189_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39379-w","article-title":"Association between enhanced carbonyl stress and decreased apparent axonal density in schizophrenia by multimodal white matter imaging","volume":"13","author":"Son","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2026.112189_bib52","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2026.112189_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/736837","article-title":"Glutathione homeostasis and functions: potential targets for medical interventions","volume":"2012","author":"Lushchak","year":"2012","journal-title":"J. Amino Acids"},{"key":"10.1016\/j.cbi.2026.112189_bib54","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bbrc.2016.11.088","article-title":"The role of mitochondria in metabolism and cell death","volume":"482","author":"Vakifahmetoglu-Norberg","year":"2017","journal-title":"Biochem Bioph Res Co"},{"key":"10.1016\/j.cbi.2026.112189_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1520072","article-title":"The role of mitochondria in aging, cell death, and tumor immunity","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbi.2026.112189_bib56","first-page":"10","article-title":"Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation","author":"Schiliro","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cbi.2026.112189_bib57","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-024-02119-3","article-title":"Altered metabolism in cancer: insights into energy pathways and therapeutic targets","volume":"23","author":"Tufail","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cbi.2026.112189_bib58","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s10495-022-01735-y","article-title":"Programmed cell death detection methods: a systematic review and a categorical comparison","volume":"27","author":"Kari","year":"2022","journal-title":"Apoptosis"},{"key":"10.1016\/j.cbi.2026.112189_bib59","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/A:1022945107762","article-title":"The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update","volume":"8","author":"Ly","year":"2003","journal-title":"Apoptosis"},{"key":"10.1016\/j.cbi.2026.112189_bib60","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1021\/acs.jmedchem.6b00021","article-title":"Synthesis, evaluation, and mechanism Study of novel indole-chalcone derivatives exerting effective antitumor activity through microtubule destabilization in vitro and in vivo","volume":"59","author":"Yan","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117058","article-title":"Synthesis, biological evaluation and mechanism study of a novel indole-pyridine chalcone derivative as antiproliferative agent against tumor cells through dual targeting tubulin and HK2","volume":"282","author":"Zheng","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib62","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nm.4055","article-title":"Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer","volume":"22","author":"Camarda","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cbi.2026.112189_bib63","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1158\/2767-9764.CRC-22-0394","article-title":"Mitochondrial metabolism drives low-density lipoprotein-induced breast cancer cell migration","volume":"3","author":"Nobrega-Pereira","year":"2023","journal-title":"Cancer Res. Commun."},{"key":"10.1016\/j.cbi.2026.112189_bib64","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.celrep.2016.02.004","article-title":"Fatty acid oxidation-driven src links mitochondrial energy reprogramming and oncogenic properties in triple-negative breast cancer","volume":"14","author":"Park","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cbi.2026.112189_bib65","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1021\/acschembio.5b00734","article-title":"Deciphering the nongenomic, mitochondrial toxicity of tamoxifens as determined by cell metabolism and redox activity","volume":"11","author":"Theodossiou","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.cbi.2026.112189_bib66","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.drudis.2021.11.006","article-title":"Targeting protein interaction networks in mitochondrial dynamics for cancer therapy","volume":"27","author":"Yin","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.cbi.2026.112189_bib67","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100067R","article-title":"Mitochondrial fusion and fission: the fine-tune balance for cellular homeostasis","volume":"35","author":"Adebayo","year":"2021","journal-title":"Faseb J"},{"key":"10.1016\/j.cbi.2026.112189_bib68","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Tar"},{"key":"10.1016\/j.cbi.2026.112189_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115247","article-title":"The role of dynamin-related protein 1 in cerebral ischemia\/hypoxia injury","volume":"165","author":"Huan","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2026.112189_bib70","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12935-018-0665-1","article-title":"Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2\/Omi pathways","volume":"18","author":"Wan","year":"2018","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cbi.2026.112189_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.559","article-title":"Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2026.112189_bib72","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.freeradbiomed.2012.09.035","article-title":"Mitochondrial morphology-emerging role in bioenergetics","volume":"53","author":"Galloway","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2026.112189_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107594","article-title":"New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology","volume":"213","author":"Rosdah","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbi.2026.112189_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1570385","article-title":"Pharmacological potential of natural chalcones: a recent studies and future perspective","volume":"16","author":"Adhikari","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112189_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065964","article-title":"Chalcones and gastrointestinal cancers: experimental evidence","volume":"24","author":"Michalkova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112189_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179623","article-title":"Medicinally privileged natural chalcones: Abundance, mechanisms of action, and clinical trials","volume":"25","author":"Villa","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112189_bib77","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/01913123.2017.1419328","article-title":"Mitochondrial autophagosomes as a mechanism of drug resistance in breast carcinoma","volume":"42","author":"Abunimer","year":"2018","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.cbi.2026.112189_bib78","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.7150\/thno.8502","article-title":"Quantitative proteomics analysis identifies mitochondria as therapeutic targets of multidrug-resistance in ovarian cancer","volume":"4","author":"Chen","year":"2014","journal-title":"Theranostics"},{"key":"10.1016\/j.cbi.2026.112189_bib79","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3892\/ijo.2014.2781","article-title":"Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells","volume":"46","author":"Han","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.cbi.2026.112189_bib80","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s12957-022-02799-5","article-title":"Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review","volume":"20","author":"Xing","year":"2022","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.cbi.2026.112189_bib81","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1074\/jbc.RA118.006673","article-title":"Myoglobin induces mitochondrial fusion, thereby inhibiting breast cancer cell proliferation","volume":"294","author":"Braganza","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib82","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-020-01301-x","article-title":"Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer","volume":"22","author":"Humphries","year":"2020","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cbi.2026.112189_bib83","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1007\/s11912-022-01333-w","article-title":"Mitochondrial dynamin-related protein Drp1: a new player in cardio-oncology","volume":"24","author":"Deng","year":"2022","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.cbi.2026.112189_bib84","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10565-021-09662-5","article-title":"Mitochondrial dynamics regulators: implications for therapeutic intervention in cancer","volume":"38","author":"Kumar","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.cbi.2026.112189_bib85","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/s41419-018-1083-y","article-title":"Positive feedback loop between mitochondrial fission and notch signaling promotes survivin-mediated survival of TNBC cells","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2026.112189_bib86","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1038\/onc.2012.494","article-title":"Mitochondrial dynamics regulates migration and invasion of breast cancer cells","volume":"32","author":"Zhao","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.cbi.2026.112189_bib87","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1111\/cas.13830","article-title":"Mitochondrial network structure homeostasis and cell death","volume":"109","author":"Xie","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.cbi.2026.112189_bib88","first-page":"2434","article-title":"Mitofusin 2 inhibits bladder cancer cell proliferation and invasion via the Wnt\/beta-catenin pathway","volume":"18","author":"Pang","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.cbi.2026.112189_bib89","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ncb2220","article-title":"During autophagy mitochondria elongate, are spared from degradation and sustain cell viability","volume":"13","author":"Gomes","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbi.2026.112189_bib90","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tem.2015.12.001","article-title":"Mitochondrial dynamics and metabolic regulation","volume":"27","author":"Wai","year":"2016","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.cbi.2026.112189_bib91","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/348699a0","article-title":"A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas","volume":"348","author":"Basset","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2026.112189_bib92","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0169-5002(99)00088-4","article-title":"Prognostic impact of cathepsin B and matrix metalloproteinase-9 in pulmonary adenocarcinomas by immunohistochemical study","volume":"27","author":"Fujise","year":"2000","journal-title":"Lung Cancer"},{"key":"10.1016\/j.cbi.2026.112189_bib93","doi-asserted-by":"crossref","first-page":"35592","DOI":"10.18632\/oncotarget.16022","article-title":"Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells","volume":"8","author":"Limoge","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cbi.2026.112189_bib94","doi-asserted-by":"crossref","DOI":"10.3390\/s18103249","article-title":"Matrix Metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: recent advances","volume":"18","author":"Huang","year":"2018","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.cbi.2026.112189_bib95","article-title":"Applications of matrix Metalloproteinase-9-Related nanomedicines in tumors and vascular diseases","volume":"17","author":"Li","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cbi.2026.112189_bib96","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1006762425323","article-title":"Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells","volume":"18","author":"Balduyck","year":"2000","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.cbi.2026.112189_bib97","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.18632\/oncotarget.1932","article-title":"Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer","volume":"5","author":"Mehner","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.cbi.2026.112189_bib98","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s43440-025-00721-w","article-title":"Chalcone-9: a novel inhibitor of the JAK-STAT pathway with potent anti-cancer effects in triple-negative breast cancer cells","volume":"77","author":"Lee","year":"2025","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.cbi.2026.112189_bib99","first-page":"16","article-title":"Targeting STAT3 and NF-kappaB signaling pathways in cancer prevention and treatment: the role of chalcones","author":"Krajka-Kuzniak","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cbi.2026.112189_bib100","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1055\/s-2005-837779","article-title":"Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells","volume":"71","author":"Hsu","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.cbi.2026.112189_bib101","doi-asserted-by":"crossref","first-page":"17340","DOI":"10.1074\/jbc.M700890200","article-title":"Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue","volume":"282","author":"Pandey","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib102","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1021\/jf205053r","article-title":"The chalcone flavokawain B induces G2\/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt\/p38 MAPK signaling pathway","volume":"60","author":"Hseu","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib103","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biocel.2012.05.016","article-title":"Complex I impairment in mitochondrial diseases and cancer: parallel roads leading to different outcomes","volume":"45","author":"Iommarini","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cbi.2026.112189_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102926","article-title":"Mitochondrial complex I ROS production and redox signaling in hypoxia","volume":"67","author":"Okoye","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbi.2026.112189_bib105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fonc.2017.00118","article-title":"The mitochondrial Complex(I)ty of cancer","volume":"7","author":"Urra","year":"2017","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cbi.2026.112189_bib106","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s12967-023-04341-x","article-title":"Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration","volume":"21","author":"Bastin","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cbi.2026.112189_bib107","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1172\/JCI64264","article-title":"Mitochondrial complex I activity and NAD+\/NADH balance regulate breast cancer progression","volume":"123","author":"Santidrian","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.cbi.2026.112189_bib108","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1590\/s0100-83582016340300022","article-title":"Biological activities and novel applications of chalcones","volume":"34","author":"D\u00edaz-Tielas","year":"2016","journal-title":"Planta Daninha"},{"key":"10.1016\/j.cbi.2026.112189_bib109","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12935-015-0172-6","article-title":"Adenovirus-mediated co-expression of the TRAIL and HN genes inhibits growth and induces apoptosis in Marek's disease tumor cell line MSB-1","volume":"15","author":"Dong","year":"2015","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cbi.2026.112189_bib110","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/630760","article-title":"Inhibition of tumor growth and immunomodulatory effects of flavonoids and scutebarbatines of Scutellaria barbata D. Don in lewis-bearing C57BL\/6 mice","volume":"2015","author":"Gong","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.cbi.2026.112189_bib111","doi-asserted-by":"crossref","first-page":"15996","DOI":"10.18632\/oncotarget.13723","article-title":"Inhibition of cancer antioxidant defense by natural compounds","volume":"8","author":"Sznarkowska","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cbi.2026.112189_bib112","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2174\/1568026615666150209123100","article-title":"Selected attributes of polyphenols in targeting oxidative stress in cancer","volume":"15","author":"Stepanic","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib113","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.78","article-title":"Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs","volume":"6","author":"Mei","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2026.112189_bib114","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/10715760701236741","article-title":"The plasma concentration of advanced oxidation protein products and arterial stiffness in apparently healthy adults","volume":"41","author":"Wykretowicz","year":"2007","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.cbi.2026.112189_bib115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1054\/mehy.1998.0821","article-title":"Theory of malignant cell transformation by superoxide fate coupled with cytoskeletal electron-transport and electron-transfer","volume":"54","author":"Cavelier","year":"2000","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.cbi.2026.112189_bib116","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2174\/1389203715666140530091910","article-title":"Thioredoxin reductase and its inhibitors","volume":"15","author":"Saccoccia","year":"2014","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.cbi.2026.112189_bib117","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1158\/0008-5472.CAN-05-3310","article-title":"Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity","volume":"66","author":"Lu","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.cbi.2026.112189_bib118","first-page":"235","article-title":"The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1 alpha and vascular endothelial growth factor formation","volume":"2","author":"Welsh","year":"2003","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.cbi.2026.112189_bib119","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1016\/j.febslet.2011.09.023","article-title":"Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9\/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells","volume":"585","author":"Farina","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbi.2026.112189_bib120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.abb.2003.08.009","article-title":"Novel inhibitors of advanced glycation endproducts","volume":"419","author":"Rahbar","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbi.2026.112189_bib121","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1196\/annals.1333.084","article-title":"Advanced glycation end products in human cancer tissues: detection of Nepsilon-(carboxymethyl)lysine and argpyrimidine","volume":"1043","author":"van Heijst","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cbi.2026.112189_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2020.100933","article-title":"Prognosis of metastasis based on age and serum analytes after follow-up of non-metastatic lung cancer patients","volume":"14","author":"Balla","year":"2021","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.cbi.2026.112189_bib123","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tem.2019.10.003","article-title":"Methylglyoxal metabolism and aging-related disease: moving from correlation toward causation","volume":"31","author":"Kold-Christensen","year":"2020","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.cbi.2026.112189_bib124","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1517\/13543784.11.9.1205","article-title":"Advanced glycation end products and diabetic complications","volume":"11","author":"Stitt","year":"2002","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.cbi.2026.112189_bib125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103613","article-title":"Role and mechanisms of RAGE-Ligand complexes and RAGE-Inhibitors in cancer progression","volume":"21","author":"El-Far","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112189_bib126","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1389200219666180912104342","article-title":"Advanced glycation end products (AGEs), glutathione and breast cancer: factors, mechanism and therapeutic interventions","volume":"20","author":"Sharma","year":"2019","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.cbi.2026.112189_bib127","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10549-018-4992-7","article-title":"Advanced glycation end products are elevated in estrogen receptor-positive breast cancer patients, alter response to therapy, and can be targeted by lifestyle intervention","volume":"173","author":"Walter","year":"2019","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.cbi.2026.112189_bib128","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1080\/15384047.2016.1210736","article-title":"Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression","volume":"17","author":"He","year":"2016","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.cbi.2026.112189_bib129","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13046-020-01665-0","article-title":"Diabetes promotes invasive pancreatic cancer by increasing systemic and tumour carbonyl stress in Kras(G12D\/+) mice","volume":"39","author":"Menini","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cbi.2026.112189_bib130","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.2174\/1381612825666190130145549","article-title":"Role of advanced glycation end products in carcinogenesis and their therapeutic implications","volume":"24","author":"Schroter","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cbi.2026.112189_bib131","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1021\/jf048550u","article-title":"Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts","volume":"53","author":"Wu","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbi.2026.112189_bib132","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21060739","article-title":"Inhibition of advanced glycation end-product Formation and antioxidant activity by extracts and polyphenols from Scutellaria alpina L. and S. altissima L","volume":"21","author":"Grzegorczyk-Karolak","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2026.112189_bib133","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9101006","article-title":"Protection of polyphenols against Glyco-Oxidative stress: involvement of glyoxalase pathway","volume":"9","author":"Cianfruglia","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbi.2026.112189_bib134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20121743","article-title":"The glyoxalase pathway: the first hundred years \u2026 and beyond","volume":"453","author":"Silva","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbi.2026.112189_bib135","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3748\/wjg.15.513","article-title":"Dysregulation of apoptosis in hepatocellular carcinoma cells","volume":"15","author":"Fabregat","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbi.2026.112189_bib136","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2174\/1381612826666200115095937","article-title":"Exploring dysregulated signaling pathways in cancer","volume":"26","author":"Nisar","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cbi.2026.112189_bib137","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1073\/pnas.92.12.5258","article-title":"The causes and prevention of cancer","volume":"92","author":"Ames","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2026.112189_bib138","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3390\/cancers2020274","article-title":"Oxidative and nitrosative stress in the metastatic microenvironment","volume":"2","author":"Ortega","year":"2010","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cbi.2026.112189_bib139","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1158\/1078-0432.CCR-06-2642","article-title":"Bcl-2 and glutathione depletion sensitizes B16 melanoma to combination therapy and eliminates metastatic disease","volume":"13","author":"Mena","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cbi.2026.112189_bib140","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0891-5849(01)00622-0","article-title":"Glutamine potentiates TNF-alpha-induced tumor cytotoxicity","volume":"31","author":"Obrador","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2026.112189_bib141","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3390\/cancers3011285","article-title":"Glutathione in cancer cell death","volume":"3","author":"Ortega","year":"2011","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cbi.2026.112189_bib142","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/10715760802317663","article-title":"Glutathione and apoptosis","volume":"42","author":"Circu","year":"2008","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.cbi.2026.112189_bib143","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1124\/jpet.110.171983","article-title":"Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line","volume":"336","author":"Guha","year":"2011","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.cbi.2026.112189_bib144","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41419-021-04490-1","article-title":"Double-edge sword roles of iron in driving energy production versus instigating ferroptosis","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2026.112189_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121110","article-title":"Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy","volume":"277","author":"Niu","year":"2021","journal-title":"Biomaterials"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726002978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726002978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:00:05Z","timestamp":1783602005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726002978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":145,"alternative-id":["S0009279726002978"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112189","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective mitochondrial dysfunction and redox collapse induced by an indole chalcone in breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112189","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112189"}}