{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:30:49Z","timestamp":1786487449923,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007959","name":"Chulabhorn Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007959","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016176","name":"Science and Technology Postgraduate Education and Research Development Office, Office of the Higher Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cbi.2026.112225","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:51:47Z","timestamp":1782802307000},"page":"112225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects from combined exposure to arsenic and dichloromethane: in vitro expression of genotoxicity, transformation and metastatic potential for cholangiocarcinogenesis"],"prefix":"10.1016","volume":"437","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-0471","authenticated-orcid":false,"given":"Angkhameen","family":"Buranarom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8463-7011","authenticated-orcid":false,"given":"Panida","family":"Navasumrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varabhorn","family":"Parnlob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-2442","authenticated-orcid":false,"given":"Mathuros","family":"Ruchirawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2026.112225_bib1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.32074\/1591-951X-252","article-title":"Cholangiocarcinoma","volume":"113","author":"Sarcognato","year":"2021","journal-title":"Pathologica"},{"key":"10.1016\/j.cbi.2026.112225_bib2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000453013","article-title":"Epidemiology and risk factors of cholangiocarcinoma","volume":"32","author":"Kirstein","year":"2016","journal-title":"Visc. Med."},{"key":"10.1016\/j.cbi.2026.112225_bib3","article-title":"Updated cholangiocarcinoma incidence trends and projections in Thailand by region based on data from four population-based cancer registries","volume":"35","author":"Sahat","year":"2025","journal-title":"Lancet Reg. Health - Southeast Asia"},{"key":"10.1016\/j.cbi.2026.112225_bib4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12885-016-2390-2","article-title":"Ultrasound screening for cholangiocarcinoma could detect premalignant lesions and early-stage diseases with survival benefits: a population-based prospective study of 4,225 subjects in an endemic area","volume":"16","author":"Sungkasubun","year":"2016","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.cbi.2026.112225_bib5","first-page":"34","article-title":"Herbicide exposure to maize farmers in Northern Thailand: knowledge, attitude, and practices","volume":"3","author":"Wongwichit","year":"2012","journal-title":"J. Med. Med. Sci."},{"key":"10.1016\/j.cbi.2026.112225_bib6","first-page":"1493","article-title":"Occupational exposure to pesticides and bile tract carcinoma in men: results from a European multicenter case-control study","volume":"21","author":"Schmeisser","year":"2010","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.cbi.2026.112225_bib7","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1080\/10807039.2020.1808777","article-title":"Pesticide use in Thailand: current situation, health risks, and gaps in research and policy","volume":"27","author":"Laohaudomchok","year":"2021","journal-title":"Hum. Ecol. Risk Assess."},{"key":"10.1016\/j.cbi.2026.112225_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/24734306.2019.1685222","article-title":"Acute and delayed toxicity from co-ingestion of methylene chloride and methanol","volume":"3","author":"Jaffe","year":"2019","journal-title":"Toxicol. Commun."},{"key":"10.1016\/j.cbi.2026.112225_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109580","article-title":"Dichloromethane increases mutagenic DNA damage and transformation ability in cholangiocytes and enhances metastatic potential in cholangiocarcinoma cell lines","volume":"346","author":"Buranarom","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112225_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3961\/jpmph.14.036","article-title":"Environmental source of arsenic exposure","volume":"47","author":"Chung","year":"2014","journal-title":"J. Prev. Med. Publ. Health"},{"key":"10.1016\/j.cbi.2026.112225_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2019.104539","article-title":"Arsenic exposure: a public health problem leading to several cancers","volume":"110","author":"Palma-Lara","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112225_bib12","doi-asserted-by":"crossref","DOI":"10.1097\/CEJ.0000000000000740","article-title":"Arsenic-contaminated drinking water and cholangiocarcinoma","volume":"32","author":"Reyes","year":"2023","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.cbi.2026.112225_bib13","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/01.TP.0000110292.73873.25","article-title":"Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT","volume":"77","author":"Maruyama","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.cbi.2026.112225_bib14","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.325","article-title":"In vitro tumorsphere formation assays","volume":"3","author":"Johnson","year":"2013","journal-title":"Bio-protocol"},{"key":"10.1016\/j.cbi.2026.112225_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102331","article-title":"Protocol for the generation and automated confocal imaging of whole multi-cellular tumor spheroids","volume":"4","author":"Genenger","year":"2023","journal-title":"STAR Protoc."},{"key":"10.1016\/j.cbi.2026.112225_bib16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4049\/jimmunol.1004117","article-title":"TNF mediates the sustained activation of Nrf2 in human monocytes","volume":"187","author":"Rushworth","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.cbi.2026.112225_bib17","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.3748\/wjg.v9.i12.2801","article-title":"Impact of endoscopically minimal involvement on IL-8 mRNA expression in esophageal mucosa of patients with non-erosive reflux disease","volume":"9","author":"Kanazawa","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbi.2026.112225_bib18","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/oby.2008.276","article-title":"LMNA mRNA expression is altered in human obesity and type 2 diabetes","volume":"16","author":"Miranda","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.cbi.2026.112225_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2024.1377685","article-title":"A review of common statistical methods for dealing with multiple pollutant mixtures and multiple exposures","volume":"12","author":"Zhu","year":"2024","journal-title":"Front. Public Health"},{"key":"10.1016\/j.cbi.2026.112225_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020240","article-title":"The role of reactive oxygen species in arsenic toxicity","volume":"10","author":"Hu","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.cbi.2026.112225_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11010-005-8227-y","article-title":"Inorganic arsenic compounds cause oxidative damage to DNA and protein by inducing ROS and RNS generation in human keratinocytes","volume":"279","author":"Ding","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbi.2026.112225_bib22","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.niox.2012.04.141","article-title":"Arsenic-induced nitrative DNA damage in human HaCaT keratinocytes","volume":"27","author":"Ma","year":"2012","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.cbi.2026.112225_bib23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s44337-025-00303-y","article-title":"Oxidative stress and free radicals in disease pathogenesis: a review","volume":"2","author":"Pooja","year":"2025","journal-title":"Discov. Med."},{"key":"10.1016\/j.cbi.2026.112225_bib24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.taap.2013.10.002","article-title":"Oxidative DNA damage and repair in children exposed to low levels of arsenic in utero and during early childhood: application of salivary and urinary biomarkers","volume":"273","author":"Hinhumpatch","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112225_bib25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.taap.2016.12.015","article-title":"Hypomethylation of inflammatory genes (COX2, EGR1, and SOCS3) and increased urinary 8-nitroguanine in arsenic-exposed newborns and children","volume":"316","author":"Phookphan","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112225_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12940-019-0481-7","article-title":"Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study","volume":"18","author":"Navasumrit","year":"2019","journal-title":"Environ. Health"},{"key":"10.1016\/j.cbi.2026.112225_bib27","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00204-015-1605-7","article-title":"Oxidative DNA damage enhances the carcinogenic potential of in vitro chronic arsenic exposures","volume":"90","author":"Bach","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2026.112225_bib28","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s40726-023-00278-3","article-title":"Arsenic and human health: new molecular mechanisms for arsenic-induced cancers","volume":"9","author":"Nail","year":"2023","journal-title":"Curr. Pollut. Rep."},{"key":"10.1016\/j.cbi.2026.112225_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11122345","article-title":"Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease","volume":"11","author":"Ngo","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbi.2026.112225_bib30","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bbrc.2014.12.010","article-title":"Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells","volume":"456","author":"Zhang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbi.2026.112225_bib31","doi-asserted-by":"crossref","DOI":"10.1289\/EHP6471","article-title":"Effects of inorganic arsenic on human prostate stem-progenitor cell transformation, autophagic flux blockade, and NRF2 pathway activation","volume":"128","author":"Xie","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbi.2026.112225_bib32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3892\/ijo.2015.3234","article-title":"IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways","volume":"48","author":"Long","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.cbi.2026.112225_bib33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3892\/ijo.2015.3226","article-title":"IL-8 suppresses E-cadherin expression in nasopharyngeal carcinoma cells by enhancing E-cadherin promoter DNA methylation","volume":"48","author":"Zhang","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.cbi.2026.112225_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2867-3-17","article-title":"Tumor suppressor gene E-cadherin and its role in normal and malignant cells","volume":"3","author":"Pe\u0107ina-\u0160laus","year":"2003","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cbi.2026.112225_bib35","article-title":"Dual role of E-cadherin in cancer cells","author":"Rubtsova","year":"2021","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.cbi.2026.112225_bib36","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1091\/mbc.E16-01-0058","article-title":"Roles for E-cadherin cell surface regulation in cancer","volume":"27","author":"Petrova","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cbi.2026.112225_bib37","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s00204-014-1445-x","article-title":"TG-interacting factor mediates arsenic-induced malignant transformation of keratinocytes via c-Src\/EGFR\/AKT\/FOXO3A and redox signalings","volume":"89","author":"Liu","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbi.2026.112225_bib38","doi-asserted-by":"crossref","first-page":"10602","DOI":"10.1073\/pnas.0404100101","article-title":"Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C","volume":"101","author":"Dechow","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbi.2026.112225_bib39","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.3390\/ijms19103028","article-title":"Role of extracellular matrix in development and cancer progression","volume":"19","author":"Walker","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112225_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2019.01370","article-title":"Role of matrix metalloproteinases in angiogenesis and cancer","volume":"9","author":"Quintero-Fabi\u00e1n","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cbi.2026.112225_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005535","article-title":"Post-transcriptional regulation across human tissues","volume":"13","author":"Franks","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.cbi.2026.112225_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152440","article-title":"Role of aromatase activation on sodium arsenite-induced proliferation, migration, and invasion of MDA-MB-231 and MDA-MB-453 breast cancer cell lines","volume":"437","author":"Reyes-V\u00e1zquez","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2026.112225_bib43","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4014\/jmb.1911.11068","article-title":"Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK\/STAT3 pathway in MCF-7 breast cancer cells","volume":"30","author":"Jae-Hwan","year":"2020","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.cbi.2026.112225_bib44","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1186\/s12885-021-09025-7","article-title":"pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells","volume":"21","author":"Pu","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cbi.2026.112225_bib45","first-page":"28","article-title":"The significance of genetics for cholangiocarcinoma development","volume":"1","author":"Maroni","year":"2013","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.cbi.2026.112225_bib46","first-page":"384","article-title":"Arsenic and smokeless tobacco exposure induces DNA damage and oxidative stress in reproductive organs of female Swiss albino mice","volume":"38","author":"Nath Barbhuiya","year":"2020","journal-title":"J. Environ. Sci. Health C"},{"key":"10.1016\/j.cbi.2026.112225_bib47","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semcancer.2021.05.009","article-title":"Arsenic co-carcinogenesis: inhibition of DNA repair and interaction with zinc finger proteins","volume":"76","author":"Zhou","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.cbi.2026.112225_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105560","article-title":"Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression","volume":"137","author":"Wang","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2026.112225_bib49","first-page":"771","article-title":"Cell death response to DNA damage","volume":"92","author":"Wang","year":"2019","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.cbi.2026.112225_bib50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/cr.2007.110","article-title":"DNA damage-induced cell death: lessons from the central nervous system","volume":"18","author":"Borges","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.cbi.2026.112225_bib51","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3390\/cancers14071847","article-title":"MMP9: a tough target for targeted therapy for cancer","volume":"14","author":"Augoff","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cbi.2026.112225_bib52","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/cancers17020203","article-title":"A landscape of cancer initiation and cancer stem cells","volume":"17","author":"Seno","year":"2025","journal-title":"Cancers"},{"key":"10.1016\/j.cbi.2026.112225_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417398","article-title":"Can CD133 be regarded as a prognostic biomarker in oncology: pros and cons","volume":"24","author":"Gisina","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112225_bib54","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12967-018-1423-9","article-title":"CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma","volume":"16","author":"Cai","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cbi.2026.112225_bib55","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12935-021-01817-y","article-title":"Identification and characterization of a subpopulation of CD133+ cancer stem\u2010like cells derived from SK-UT-1 cells","volume":"21","author":"Gao","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cbi.2026.112225_bib56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ccell.2017.05.009","article-title":"Common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma","volume":"32","author":"Chaisaingmongkol","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cbi.2026.112225_bib57","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1002\/jcb.29648","article-title":"Upregulated microRNA-194 impairs stemness of cholangiocarcinoma cells through the rho pathway via inhibition of ECT2","volume":"121","author":"Gao","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cbi.2026.112225_bib58","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.3390\/ijms20174154","article-title":"Role of cancer stem cells in cholangiocarcinoma and therapeutic implications","volume":"20","author":"Wu","year":"2019","journal-title":"Int. J. Mol. Sci."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726003339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726003339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:04:50Z","timestamp":1786485890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726003339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":58,"alternative-id":["S0009279726003339"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112225","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects from combined exposure to arsenic and dichloromethane: in vitro expression of genotoxicity, transformation and metastatic potential for cholangiocarcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112225","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112225"}}