{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:14:43Z","timestamp":1786122883298,"version":"build-2736575974"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013238","name":"Mahidol University Faculty of Medicine Siriraj Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cbi.2026.112228","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:50:21Z","timestamp":1782975021000},"page":"112228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Epigallocatechin-3-gallate, l-theanine and theophylline abolish high-glucose-induced renal cell senescence and subsequent epithelial-mesenchymal transition and fibroblast activation via SIRT1\/PGC-1\u03b1 axis: Implications for diabetic kidney disease"],"prefix":"10.1016","volume":"437","author":[{"given":"Rattiyaporn","family":"Kanlaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunisa","family":"Yoodee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanokwan","family":"Nonthawong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonicha","family":"Subkod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supanan","family":"Nanthawuttiphan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7865-0765","authenticated-orcid":false,"given":"Visith","family":"Thongboonkerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2026.112228_bib1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13098-025-01726-4","article-title":"Decoding diabetic kidney disease: a comprehensive review of interconnected pathways, molecular mediators, and therapeutic insights","volume":"17","author":"Efiong","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.cbi.2026.112228_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41581-024-00907-0","article-title":"Crosstalk between glomeruli and tubules","volume":"21","author":"Fogo","year":"2025","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cbi.2026.112228_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1185317","article-title":"Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols","volume":"14","author":"Jin","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbi.2026.112228_bib4","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.7150\/ijbs.112737","article-title":"Macrophages in focus: key drivers and therapeutic opportunities in diabetic kidney disease","volume":"21","author":"Zhao","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cbi.2026.112228_bib5","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.2147\/JIR.S334996","article-title":"The multiple roles of fibroblast growth factor in diabetic nephropathy","volume":"14","author":"Deng","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.cbi.2026.112228_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111784","article-title":"Oxidative stress and inflammation in renal fibrosis: novel molecular mechanisms and therapeutic targets","volume":"421","author":"Liu","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112228_bib7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2023.07.014","article-title":"Oxidative stress and inflammation are mediated via aryl hydrocarbon receptor signalling in idiopathic membranous nephropathy","volume":"207","author":"Wang","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2026.112228_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41401-023-01148-w","article-title":"Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1\/beta-catenin pathway","volume":"45","author":"Miao","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cbi.2026.112228_bib9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.kint.2022.05.012","article-title":"Molecular mechanisms and therapeutic targets for diabetic kidney disease","volume":"102","author":"Tuttle","year":"2022","journal-title":"Kidney Int."},{"key":"10.1016\/j.cbi.2026.112228_bib10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41581-025-00934-5","article-title":"Advances and challenges in kidney fibrosis therapeutics","volume":"21","author":"Abbad","year":"2025","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cbi.2026.112228_bib11","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/IMNA-D-24-00027","article-title":"Kidney fibrosis: fundamental questions, challenges, and perspectives","volume":"11","author":"Liu","year":"2024","journal-title":"Integrative Medicine in Nephrology and Andrology"},{"key":"10.1016\/j.cbi.2026.112228_bib12","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.kint.2025.10.019","article-title":"Targeting cellular senescence in diabetic kidney disease: potential of regenerative, cell-based therapies and other senotherapeutic approaches","volume":"109","author":"Patel","year":"2026","journal-title":"Kidney Int."},{"key":"10.1016\/j.cbi.2026.112228_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11892-020-01314-y","article-title":"Role of senescent renal cells in pathophysiology of diabetic kidney disease","volume":"20","author":"Wiley","year":"2020","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.cbi.2026.112228_bib14","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1097\/CM9.0000000000003746","article-title":"Cellular senescence in kidney diseases","volume":"138","author":"Wang","year":"2025","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.cbi.2026.112228_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/acel.70024","article-title":"Targeting ATF6alpha attenuates UVB-induced senescence and improves skin homeostasis by regulating IL8 expression","volume":"24","author":"Giroud","year":"2025","journal-title":"Aging Cell"},{"key":"10.1016\/j.cbi.2026.112228_bib16","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202503532R","article-title":"Cellular senescence in kidney diseases: from bench to clinic","volume":"39","author":"Shu","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2026.112228_bib17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1210\/endrev\/bnae010","article-title":"Targeting cell senescence and senolytics: novel interventions for age-related endocrine dysfunction","volume":"45","author":"Suda","year":"2024","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cbi.2026.112228_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1330942","article-title":"The functional role of cellular senescence during vascular calcification in chronic kidney disease","volume":"15","author":"Fang","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.cbi.2026.112228_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-3-031-21410-3_7","article-title":"Cellular senescence and ageing","volume":"102","author":"Reed","year":"2023","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.cbi.2026.112228_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13020-025-01150-w","article-title":"Traditional Chinese medicine in diabetic kidney disease: multifaceted therapeutic mechanisms and research progress","volume":"20","author":"Cai","year":"2025","journal-title":"Chin. Med."},{"key":"10.1016\/j.cbi.2026.112228_bib21","article-title":"Traditional Chinese medicine for the treatment of diabetic kidney disease: a study-level pooled analysis of 44 randomized controlled trials","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112228_bib22","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.2147\/DDDT.S521265","article-title":"Anthraquinones from Rheum officinale ameliorate renal fibrosis in acute kidney injury and chronic kidney disease","volume":"19","author":"Feng","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.cbi.2026.112228_bib23","doi-asserted-by":"crossref","first-page":"9457","DOI":"10.2147\/DDDT.S557114","article-title":"Rhubarb: traditional uses, phytochemistry, multiomics-based novel pharmacological and toxicological mechanisms","volume":"19","author":"Miao","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.cbi.2026.112228_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112794","article-title":"A new strategy for Astragaloside IV in the treatment of diabetic kidney disease: analyzing the regulation of ferroptosis and mitochondrial function of renal tubular epithelial cells","volume":"141","author":"Liu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cbi.2026.112228_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctmp.2025.200245","article-title":"Total Panax notoginseng saponins treats diabetic kidney disease in mice by regulating the TXNIP\/NLRP3 signaling pathway","volume":"6","author":"Gao","year":"2025","journal-title":"Clinical Traditional Medicine and Pharmacology"},{"key":"10.1016\/j.cbi.2026.112228_bib26","doi-asserted-by":"crossref","DOI":"10.1097\/IMNA-D-25-00019","article-title":"Hypoxia-induced metabolic reprogramming in the renal tubules of patients with diabetic kidney disease and the associated traditional Chinese medicine intervention strategies","volume":"12","author":"Jiang","year":"2025","journal-title":"Integrative Medicine in Nephrology and Andrology"},{"key":"10.1016\/j.cbi.2026.112228_bib27","doi-asserted-by":"crossref","DOI":"10.1097\/IMNA-D-25-00021","article-title":"Macrophages: novel molecular mechanism and therapeutic strategy in diabetic kidney disease","volume":"12","author":"Ai","year":"2025","journal-title":"Integrative Medicine in Nephrology and Andrology"},{"key":"10.1016\/j.cbi.2026.112228_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cbi.2026.112228_bib29","first-page":"65","article-title":"Potential bioactive components and health promotional benefits of tea (Camellia sinensis)","volume":"41","author":"Samanta","year":"2022","journal-title":"J. Am. Nutr. Assoc."},{"key":"10.1016\/j.cbi.2026.112228_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116179","article-title":"Anti-senescence effects of Rhodiola crenulate extracts on LO(2) cells and bioactive compounds","volume":"306","author":"Liang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2026.112228_bib31","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1038\/s41598-025-34828-0","article-title":"In vitro release kinetics and in vivo plasma exposure of green tea polyphenols and caffeine from iron oxide chitosan nanoparticles","volume":"16","author":"Al Awawdeh","year":"2026","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbi.2026.112228_bib32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nutres.2024.12.008","article-title":"l-theanine: from tea leaf to trending supplement - does the science match the hype for brain health and relaxation?","volume":"134","author":"Dashwood","year":"2025","journal-title":"Nutr. Res."},{"key":"10.1016\/j.cbi.2026.112228_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/00368504241285122","article-title":"Current status and usefulness of therapeutic drug monitoring implementation of theophylline in elderly patients based on a nationwide database study and modeling approach","volume":"107","author":"Okada","year":"2024","journal-title":"Sci. Prog."},{"key":"10.1016\/j.cbi.2026.112228_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111250","article-title":"EGCG inhibits migration, invasion and epithelial-mesenchymal transition of renal cell carcinoma by activating TFEB-mediated autophagy","volume":"403","author":"Liu","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112228_bib35","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/jsfa.13096","article-title":"l-Theanine delays d-galactose-induced senescence by regulating the cell cycle and inhibiting apoptosis in rat intestinal cells","volume":"104","author":"Xu","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.cbi.2026.112228_bib36","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1113\/JP276796","article-title":"NHA2 promotes cyst development in an in vitro model of polycystic kidney disease","volume":"597","author":"Prasad","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbi.2026.112228_bib37","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1017\/S0007114512004370","article-title":"Comparison of catechin profiles in human plasma and urine after single dosing and regular intake of green tea (Camellia sinensis)","volume":"109","author":"Fung","year":"2013","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.cbi.2026.112228_bib38","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.3945\/jn.112.166371","article-title":"Kinetics of L-theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theanine via capsules and green tea","volume":"142","author":"Scheid","year":"2012","journal-title":"J. Nutr."},{"key":"10.1016\/j.cbi.2026.112228_bib39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0378-5173(01)00942-5","article-title":"Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers","volume":"233","author":"Haruta","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.cbi.2026.112228_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1253275","article-title":"The effect of green tea (Camellia sinensis) on lipid profiles and renal function in people with type 2 diabetes and nephropathy: a randomized controlled clinical trial","volume":"10","author":"Yazdanpanah","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.cbi.2026.112228_bib41","article-title":"Causal association between tea consumption and kidney function: a mendelian randomization study","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.cbi.2026.112228_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/jnme\/2301278","article-title":"Effects of green tea-intake timing on glucose and lipid metabolism in older adults: an 8-Week randomized controlled trial","volume":"2026","author":"Fuke","year":"2026","journal-title":"J. Nutr. Metab."},{"key":"10.1016\/j.cbi.2026.112228_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70787","article-title":"The association between tea consumption timing and kidney function: insights from a national survey","volume":"13","author":"Tang","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.cbi.2026.112228_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1234059","article-title":"Accelerated kidney aging in diabetes mellitus","volume":"2020","author":"Guo","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cbi.2026.112228_bib45","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.2147\/DMSO.S543814","article-title":"The role of renal cell senescence in diabetic kidney disease: mechanisms and therapeutic advances","volume":"18","author":"Yan","year":"2025","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.cbi.2026.112228_bib46","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2741\/s541","article-title":"Beneficial effects of green tea on age related diseases","volume":"12","author":"Chen","year":"2020","journal-title":"Front Biosci (Schol Ed)"},{"key":"10.1016\/j.cbi.2026.112228_bib47","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/advances\/nmy077","article-title":"Protective effects of Epigallocatechin-3-Gallate from green tea in various kidney diseases","volume":"10","author":"Kanlaya","year":"2019","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.cbi.2026.112228_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6092715","article-title":"EGCG attenuates renal damage via reversing Klotho hypermethylation in diabetic db\/db mice and HK-2 cells","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cbi.2026.112228_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4793125","article-title":"Epigallocatechin gallate effectively affects senescence and Anti-SASP via SIRT3 in 3T3-L1 preadipocytes in comparison with other bioactive substances","volume":"2020","author":"Lilja","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cbi.2026.112228_bib50","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10522-018-9785-1","article-title":"Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K\/Akt\/mTOR pathway and induces senescent cell death by regulation of Bax\/Bcl-2 pathway","volume":"20","author":"Kumar","year":"2019","journal-title":"Biogerontology"},{"key":"10.1016\/j.cbi.2026.112228_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0253066","article-title":"An imaging approach for determining the mechanism of enhancement of intestinal absorption of an L-theanine supplement","volume":"16","author":"Sato","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2026.112228_bib52","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1007\/s00213-023-06458-9","article-title":"L-Theanine adjunct to risperidone in the treatment of chronic schizophrenia inpatients: a randomized, double-blind, placebo-controlled clinical trial","volume":"240","author":"Shamabadi","year":"2023","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.cbi.2026.112228_bib53","doi-asserted-by":"crossref","DOI":"10.1080\/15502783.2023.2267536","article-title":"Effect of single or combined caffeine and L-Theanine supplementation on shooting and cognitive performance in elite curling athletes: a double-blind, placebo-controlled study","volume":"20","author":"Yilmaz","year":"2023","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"10.1016\/j.cbi.2026.112228_bib54","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jad.2023.04.029","article-title":"l-theanine adjunct to sertraline for major depressive disorder: a randomized, double-blind, placebo-controlled clinical trial","volume":"333","author":"Shamabadi","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.cbi.2026.112228_bib55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/foods14020221","article-title":"L-Theanine extends the lifespan of Caenorhabditis elegans by reducing the end products of advanced glycosylation","volume":"14","author":"Huang","year":"2025","journal-title":"Foods"},{"key":"10.1016\/j.cbi.2026.112228_bib56","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.3390\/molecules24101862","article-title":"The association between green and black tea consumption on successful aging: a combined analysis of the ATTICA and MEDiterranean ISlands (MEDIS) epidemiological studies","volume":"24","author":"Naumovski","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2026.112228_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2019.110823","article-title":"l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation","volume":"131","author":"Zeng","year":"2020","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.cbi.2026.112228_bib58","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/phar.2843","article-title":"Theophylline for the management of respiratory disorders in adults in the 21st century: a scoping review from the American college of clinical pharmacy pulmonary practice and research network","volume":"43","author":"Boylan","year":"2023","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.cbi.2026.112228_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2019.100005","article-title":"Pro-oxidant and lifespan extension effects of caffeine and related methylxanthines in Caenorhabditis elegans","volume":"1","author":"Li","year":"2019","journal-title":"Food Chem. X"},{"key":"10.1016\/j.cbi.2026.112228_bib60","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/ics.12589","article-title":"Theophylline exerts complex anti-ageing and anti-cytotoxicity effects in human skin ex vivo","volume":"42","author":"Bertolini","year":"2020","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.cbi.2026.112228_bib61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s13577-024-01156-w","article-title":"High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux","volume":"38","author":"Zhang","year":"2025","journal-title":"Hum. Cell"},{"key":"10.1016\/j.cbi.2026.112228_bib62","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41420-025-02650-2","article-title":"P16-positive senescent cells promote DKD by the dysregulation of glycolysis and mitochondrial metabolism","volume":"11","author":"Lu","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cbi.2026.112228_bib63","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1002\/ptr.7142","article-title":"The p53\/p21\/p16 and PI3K\/Akt signaling pathways are involved in the ameliorative effects of maltol on D-galactose-induced liver and kidney aging and injury","volume":"35","author":"Sha","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.cbi.2026.112228_bib64","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1038\/s41467-022-32477-9","article-title":"Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression","volume":"13","author":"Al-Dabet","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2026.112228_bib65","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00018-025-05836-0","article-title":"The role of the SIRT1 and mTOR pathways in exercise-induced beta-cell senescence reduction in type 2 diabetes mellitus","volume":"82","author":"Hoseini","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbi.2026.112228_bib66","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s11658-026-00917-9","article-title":"DYRK2 drives renal fibrosis through CDK1-dependent G2\/M phase dysregulation in tubular epithelial cells","volume":"31","author":"Bai","year":"2026","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.cbi.2026.112228_bib67","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.2174\/0113892010276372231129105022","article-title":"Icariin attenuates human renal tubular epithelial cell senescence by targeting PAK2 via miR-23b-3p","volume":"25","author":"Zhang","year":"2024","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.cbi.2026.112228_bib68","article-title":"The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.cbi.2026.112228_bib69","article-title":"FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112228_bib70","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.3390\/molecules26227002","article-title":"Protective effects of L-Theanine on IPEC-J2 cells growth inhibition induced by dextran sulfate sodium via p53 signaling pathway","volume":"26","author":"Zhang","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.cbi.2026.112228_bib71","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.biopha.2018.09.171","article-title":"Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats","volume":"108","author":"Altinkaynak","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2026.112228_bib72","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1007\/s12035-016-9822-5","article-title":"L-theanine, a component of green tea prevents 3-Nitropropionic acid (3-NP)-Induced striatal toxicity by modulating nitric oxide pathway","volume":"54","author":"Jamwal","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.cbi.2026.112228_bib73","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.3892\/etm.2017.4420","article-title":"Resveratrol ameliorates diabetic nephropathy in rats through negative regulation of the p38 MAPK\/TGF-beta1 pathway","volume":"13","author":"Qiao","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.cbi.2026.112228_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.127913","article-title":"Effect of resveratrol on the repair of kidney and brain injuries and its regulation on klotho gene in d-galactose-induced aging mice","volume":"40","author":"Chu","year":"2021","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.cbi.2026.112228_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1491315","article-title":"JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1\/PGC-1alpha\/mitophagy axis in hypertensive nephropathy","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112228_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116144","article-title":"The protective effect of caffeine against oxalate-induced epithelial-mesenchymal transition in renal tubular cells via mitochondrial preservation","volume":"171","author":"Kanlaya","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbi.2026.112228_bib77","doi-asserted-by":"crossref","first-page":"83","DOI":"10.18632\/aging.101361","article-title":"Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury","volume":"10","author":"Kim","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.cbi.2026.112228_bib78","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12904","article-title":"Sirt1-hypoxia-inducible factor-1alpha interaction is a key mediator of tubulointerstitial damage in the aged kidney","volume":"18","author":"Ryu","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.cbi.2026.112228_bib79","doi-asserted-by":"crossref","first-page":"12599","DOI":"10.1096\/fj.202000949R","article-title":"Aristolochic acid induces renal fibrosis by arresting proximal tubular cells in G2\/M phase mediated by HIF-1alpha","volume":"34","author":"Zhao","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.cbi.2026.112228_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.05.016","article-title":"Inhibition of 4E-BP1 phosphorylation promotes tubular cell escaping from G2\/M arrest and ameliorates kidney fibrosis","volume":"62","author":"Sun","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cbi.2026.112228_bib81","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1089\/jmf.2020.0212","article-title":"Green tea extract increases soluble RAGE and improves renal function in patients with diabetic nephropathy","volume":"24","author":"Barocio-Pantoja","year":"2021","journal-title":"J. Med. Food"},{"key":"10.1016\/j.cbi.2026.112228_bib82","article-title":"Association of tea consumption with all-cause\/cardiovascular disease mortality in the chronic kidney disease population: an assessment of participation in the national cohort","volume":"47","author":"Li","year":"2025","journal-title":"Ren. Fail."},{"key":"10.1016\/j.cbi.2026.112228_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114032","article-title":"Green tea infusion prevents diabetic nephropathy aggravation in recent-onset type 1 diabetes regardless of glycemic control","volume":"274","author":"Ladeira","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbi.2026.112228_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.116502","article-title":"Tea drinking effectively improves symptoms of diabetes and prevents hepatorenal damage in mice","volume":"211","author":"Zhao","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.cbi.2026.112228_bib85","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12967-024-04950-0","article-title":"High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad?","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cbi.2026.112228_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116899","article-title":"FABP4 inhibition protects renal tubular cells and ameliorates renal inflammation in diabetic kidney disease","volume":"236","author":"Wu","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112228_bib87","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41467-024-44886-z","article-title":"WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease","volume":"15","author":"Cohen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbi.2026.112228_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1454586","article-title":"Focus on podocytes: diabetic kidney disease and renal fibrosis - a global bibliometric analysis (2000-2024)","volume":"15","author":"An","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112228_bib89","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1038\/s41467-024-49854-1","article-title":"Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726003364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726003364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T12:58:59Z","timestamp":1786107539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726003364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":89,"alternative-id":["S0009279726003364"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112228","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigallocatechin-3-gallate, l-theanine and theophylline abolish high-glucose-induced renal cell senescence and subsequent epithelial-mesenchymal transition and fibroblast activation via SIRT1\/PGC-1\u03b1 axis: Implications for diabetic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112228"}}