{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:15:53Z","timestamp":1786122953935,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015063","name":"National Institute of Technology Calicut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Education, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cbi.2026.112231","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:49:47Z","timestamp":1782974987000},"page":"112231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Diazepam induces mitotic defects and cytotoxicity through modulation of tubulin and Eg5"],"prefix":"10.1016","volume":"437","author":[{"given":"Mukharjee","family":"Ayswarya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kavya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9685-135X","authenticated-orcid":false,"given":"Krishnan","family":"Rathinasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cbi.2026.112231_bib1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.cbi.2026.112231_bib2","first-page":"71","article-title":"Cancer Statistics, 2008","volume":"58","author":"Jemal","year":"2008","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"10.1016\/j.cbi.2026.112231_bib3","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00280-015-2903-8","article-title":"Antimitotic drugs in the treatment of cancer","volume":"76","author":"van Vuuren","year":"2015","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"2","key":"10.1016\/j.cbi.2026.112231_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1158\/1535-7163.MCT-13-0791","article-title":"Targeting microtubules by natural agents for cancer therapy","volume":"13","author":"Mukhtar","year":"2014","journal-title":"Mol. Cancer Therapeut."},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0092-8674(00)80961-7","article-title":"High-Resolution model of the microtubule","volume":"96","author":"Nogales","year":"1999","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.cbi.2026.112231_bib6","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.biocel.2011.11.009","article-title":"Interplay between microtubule dynamics and intracellular organization","volume":"44","author":"de Forges","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.cbi.2026.112231_bib7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib8","first-page":"1","article-title":"Mechanism of action of Antitumor drugs that interact with microtubules and tubulin","volume":"2","author":"Jordan","year":"2002","journal-title":"Curr. Med. Chem. Anti Cancer Agents"},{"issue":"11","key":"10.1016\/j.cbi.2026.112231_bib9","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2174\/1389450124666230731094837","article-title":"Microtubules and cell division: potential pharmacological targets in cancer therapy","volume":"24","author":"Sebastian","year":"2023","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.cbi.2026.112231_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110973","article-title":"Development of novel derivatives of stilbene and macrocyclic compounds as potent of anti-microtubule factors","volume":"133","author":"Borys","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.cbi.2026.112231_bib11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/cmdc.200500045","article-title":"Inhibitors of mitotic kinesins: Next-Generation antimitotics","volume":"1","author":"Sarli","year":"2006","journal-title":"ChemMedChem"},{"issue":"4","key":"10.1016\/j.cbi.2026.112231_bib12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.drup.2007.06.003","article-title":"Mitotic drug targets and the development of novel anti-mitotic anticancer drugs","volume":"10","author":"Schmidt","year":"2007","journal-title":"Drug Resist. Updates"},{"issue":"4","key":"10.1016\/j.cbi.2026.112231_bib13","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00412-016-0607-4","article-title":"Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation","volume":"126","author":"van Heesbeen","year":"2017","journal-title":"Chromosoma"},{"issue":"15","key":"10.1016\/j.cbi.2026.112231_bib14","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1073\/pnas.0601425103","article-title":"Aurora A, mitotic entry, and spindle bipolarity","volume":"103","author":"Liu","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1650","key":"10.1016\/j.cbi.2026.112231_bib15","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0461","article-title":"Separate to operate: control of centrosome positioning and separation","volume":"369","author":"Agircan","year":"2014","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41420-022-01281-1","article-title":"Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development","volume":"8","author":"Yu","year":"2022","journal-title":"Cell Death Discov."},{"issue":"2","key":"10.1016\/j.cbi.2026.112231_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2165\/00023210-199912020-00005","article-title":"Affective and anxiety disorders in patients with cancer","volume":"12","author":"Ronson","year":"1999","journal-title":"CNS Drugs"},{"issue":"4","key":"10.1016\/j.cbi.2026.112231_bib18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/11250009209386699","article-title":"Effects of diazepam on cellularization and nuclear migration in the early drosophila embryo","volume":"59","author":"Callaini","year":"1992","journal-title":"Bolletino di Zool"},{"issue":"3","key":"10.1016\/j.cbi.2026.112231_bib19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1768-322X.1989.tb00877.x","article-title":"Diazepam induces abnormal mitosis in the early Drosophila embryo","volume":"67","author":"Callaini","year":"1989","journal-title":"Biol. Cell"},{"issue":"2","key":"10.1016\/j.cbi.2026.112231_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12558","article-title":"Zerumbone, a cyclic sesquiterpene, exerts antimitotic activity in HeLa cells through tubulin binding and exhibits synergistic activity with vinblastine and paclitaxel","volume":"52","author":"Ashraf","year":"2019","journal-title":"Cell Prolif."},{"issue":"13","key":"10.1016\/j.cbi.2026.112231_bib21","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer-drug screening","volume":"82","author":"Skehan","year":"1990","journal-title":"JNCI J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.cbi.2026.112231_bib22","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","article-title":"Sulforhodamine B colorimetric assay for cytotoxicity screening","volume":"1","author":"Vichai","year":"2006","journal-title":"Nat. Protoc."},{"issue":"17","key":"10.1016\/j.cbi.2026.112231_bib23","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1111\/j.1742-4658.2006.05413.x","article-title":"Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells","volume":"273","author":"Rathinasamy","year":"2006","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13568-020-01060-0","article-title":"Garcinone-E exhibits anticancer effects in HeLa human cervical carcinoma cells mediated via programmed cell death, cell cycle arrest and suppression of cell migration and invasion","volume":"10","author":"Yang","year":"2020","journal-title":"AMB Express"},{"issue":"3","key":"10.1016\/j.cbi.2026.112231_bib25","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s11030-022-10482-w","article-title":"MD simulation-based screening approach identified tolvaptan as a potential inhibitor of Eg5","volume":"27","author":"Sebastian","year":"2023","journal-title":"Mol. Divers."},{"issue":"28","key":"10.1016\/j.cbi.2026.112231_bib26","doi-asserted-by":"crossref","first-page":"9878","DOI":"10.1073\/pnas.0501821102","article-title":"Kinetic suppression of microtubule dynamic instability by griseofulvin: implications for its possible use in the treatment of cancer","volume":"102","author":"Panda","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"43","key":"10.1016\/j.cbi.2026.112231_bib27","doi-asserted-by":"crossref","first-page":"13029","DOI":"10.1021\/bi025952r","article-title":"Perturbation of microtubule polymerization by Quercetin through Tubulin binding: a novel mechanism of its antiproliferative activity","volume":"41","author":"Gupta","year":"2002","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.toxlet.2013.11.030","article-title":"Indicine N-oxide binds to tubulin at a distinct site and inhibits the assembly of microtubules: a mechanism for its cytotoxic activity","volume":"225","author":"Appadurai","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0003-9861(81)90253-8","article-title":"Glutamate-induced polymerization of tubulin: characteristics of the reaction and application to the large-scale purification of tubulin","volume":"209","author":"Hamel","year":"1981","journal-title":"Arch. Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.cbi.2026.112231_bib30","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s00210-021-02059-5","article-title":"Sertaconazole induced toxicity in HeLa cells through mitotic arrest and inhibition of microtubule assembly","volume":"394","author":"Sebastian","year":"2021","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"13","key":"10.1016\/j.cbi.2026.112231_bib31","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014A visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"16","key":"10.1016\/j.cbi.2026.112231_bib32","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"16","key":"10.1016\/j.cbi.2026.112231_bib33","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"issue":"9","key":"10.1016\/j.cbi.2026.112231_bib34","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1021\/ct300400x","article-title":"Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone \u03d5, \u03c8 and side-chain \u03c71 and \u03c72 dihedral angles","volume":"8","author":"Best","year":"2012","journal-title":"J. Chem. Theor. Comput."},{"issue":"12","key":"10.1016\/j.cbi.2026.112231_bib35","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1021\/ci300363c","article-title":"Automation of the CHARMM general force Field (CGenFF) I: bond perception and atom typing","volume":"52","author":"Vanommeslaeghe","year":"2012","journal-title":"J. Chem. Inf. Model."},{"issue":"2","key":"10.1016\/j.cbi.2026.112231_bib36","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"issue":"7","key":"10.1016\/j.cbi.2026.112231_bib37","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1073\/pnas.71.7.2627","article-title":"Promotion of fluorescence upon binding of colchicine to tubulin","volume":"71","author":"Bhattacharyya","year":"1974","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.cbi.2026.112231_bib38","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00775-021-01872-w","article-title":"Vanadocene dichloride induces apoptosis in HeLa cells through depolymerization of microtubules and inhibition of Eg5","volume":"26","author":"Mahanty","year":"2021","journal-title":"JBIC, J. Biol. Inorg. Chem."},{"issue":"37","key":"10.1016\/j.cbi.2026.112231_bib39","doi-asserted-by":"crossref","first-page":"38861","DOI":"10.1074\/jbc.M404203200","article-title":"Mechanistic analysis of the mitotic Kinesin Eg5","volume":"279","author":"Cochran","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2026.112231_bib40","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.ijbiomac.2017.11.115","article-title":"Biochemical and biophysical characterization of curcumin binding to human mitotic kinesin Eg5: insights into the inhibitory mechanism of curcumin on Eg5","volume":"109","author":"Raghav","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"13","key":"10.1016\/j.cbi.2026.112231_bib41","doi-asserted-by":"crossref","first-page":"12658","DOI":"10.1074\/jbc.M413140200","article-title":"Monastrol inhibition of the mitotic Kinesin Eg5","volume":"280","author":"Cochran","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0003-2697(79)90115-5","article-title":"An improved assay for nanomole amounts of inorganic phosphate","volume":"100","author":"Lanzetta","year":"1979","journal-title":"Anal. Biochem."},{"issue":"50","key":"10.1016\/j.cbi.2026.112231_bib43","doi-asserted-by":"crossref","first-page":"16633","DOI":"10.1021\/bi051724w","article-title":"ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol","volume":"44","author":"Cochran","year":"2005","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.cbi.2026.112231_bib44","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF02628826","article-title":"Rapid assessment of islet viability with acridine orange and propidium iodide","volume":"24","author":"Bank","year":"1988","journal-title":"Vitro Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.cbi.2026.112231_bib45","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1073\/pnas.77.2.990","article-title":"Localization of mitochondria in living cells with rhodamine 123","volume":"77","author":"V Johnson","year":"1980","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"23","key":"10.1016\/j.cbi.2026.112231_bib46","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1080\/14786419.2017.1380022","article-title":"Antibacterial and anticancer activity of the purified cashew nut shell liquid: implications in cancer chemotherapy and wound healing","volume":"32","author":"Ashraf","year":"2018","journal-title":"Nat. Prod. Res."},{"issue":"C","key":"10.1016\/j.cbi.2026.112231_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enzym. Regul."},{"issue":"49","key":"10.1016\/j.cbi.2026.112231_bib48","doi-asserted-by":"crossref","first-page":"13016","DOI":"10.1021\/bi801136q","article-title":"Benomyl and colchicine synergistically inhibit cell proliferation and mitosis: evidence of distinct binding sites for these agents in tubulin","volume":"47","author":"Cl\u00e9ment","year":"2008","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ph13010008","article-title":"Colchicine-Binding site inhibitors from chemistry to Clinic: a review","volume":"13","author":"McLoughlin","year":"2020","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib50","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13008-020-00063-4","article-title":"Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes","volume":"15","author":"She","year":"2020","journal-title":"Cell Div."},{"issue":"12","key":"10.1016\/j.cbi.2026.112231_bib51","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.2337\/diab.46.12.1939","article-title":"Tumor necrosis Factor-\u03b1 induces apoptosis of human adipose cells","volume":"46","author":"Prins","year":"1997","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.cbi.2026.112231_bib52","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1083\/jcb.71.1.172","article-title":"Flow cytofluorometric analysis of cell cycle distributions using propidium iodide. Properties of the method and mathematical analysis of the data","volume":"71","author":"Fried","year":"1976","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.cbi.2026.112231_bib53","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1242\/jcs.107.9.2643","article-title":"The effects of diazepam on mitosis and the microtubule cytoskeleton I. Observations on the diatoms Hantzschia amphioxys and Surirella robusta","volume":"107","author":"Spurck","year":"1994","journal-title":"J. Cell Sci."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972600339X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000927972600339X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T12:59:15Z","timestamp":1786107555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000927972600339X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":53,"alternative-id":["S000927972600339X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112231","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diazepam induces mitotic defects and cytotoxicity through modulation of tubulin and Eg5","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112231","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112231"}}