{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:16:05Z","timestamp":1786122965388,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cbi.2026.112257","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:00:29Z","timestamp":1783983629000},"page":"112257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PDE4B-associated regulation of placental HSD11B2 in fetal growth restriction in a prenatal caffeine exposure model"],"prefix":"10.1016","volume":"437","author":[{"given":"Xinrui","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-8661","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cbi.2026.112257_bib1","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2020.05.010","article-title":"Society for maternal-fetal medicine consult series #52: diagnosis and management of fetal growth restriction: replaces clinical guideline number 3, April 2012","volume":"223","author":"Martins","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cbi.2026.112257_bib2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1196\/annals.1365.012","article-title":"Causes of intrauterine growth restriction and the postnatal development of the metabolic syndrome","volume":"1092","author":"Valsamakis","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.cbi.2026.112257_bib3","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1093\/schbul\/sbs148","article-title":"Fetal growth and schizophrenia: a nested case-control and case-sibling study","volume":"39","author":"Nielsen","year":"2013","journal-title":"Schizophr. Bull."},{"issue":"5","key":"10.1016\/j.cbi.2026.112257_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.comppsych.2007.04.005","article-title":"Low birth weight and risk of affective disorders and selected medical illness in offspring at high and low risk for depression","volume":"48","author":"Nomura","year":"2007","journal-title":"Compr. Psychiatry"},{"issue":"5","key":"10.1016\/j.cbi.2026.112257_bib5","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/1471-0528.12136","article-title":"Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine","volume":"120","author":"Veenendaal","year":"2013","journal-title":"BJOG"},{"issue":"2","key":"10.1016\/j.cbi.2026.112257_bib6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.apsb.2022.05.029","article-title":"Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy","volume":"13","author":"Lu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.cbi.2026.112257_bib7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ncpendmet0515","article-title":"Mechanisms of disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology","volume":"3","author":"Seckl","year":"2007","journal-title":"Nat. Clin. Pract. Endocrinol. Metabol."},{"issue":"7","key":"10.1016\/j.cbi.2026.112257_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrendo.2014.73","article-title":"Glucocorticoids and fetal programming part 1: outcomes","volume":"10","author":"Moisiadis","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.cbi.2026.112257_bib9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/molehr\/7.4.357","article-title":"Expression of 11 beta-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies","volume":"7","author":"Driver","year":"2001","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.cbi.2026.112257_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12989-019-0289-1","article-title":"In utero exposure to ultrafine particles promotes placental stress-induced programming of renin-angiotensin system-related elements in the offspring results in altered blood pressure in adult mice","volume":"16","author":"Morales-Rubio","year":"2019","journal-title":"Part. Fibre Toxicol."},{"issue":"Pt B","key":"10.1016\/j.cbi.2026.112257_bib11","article-title":"Associations between in utero exposure to polybrominated diphenyl ethers, pathophysiological state of fetal growth and placental DNA methylation changes","volume":"133","author":"Zhao","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbi.2026.112257_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106313","article-title":"Prenatal fine particulate matter exposure, placental DNA methylation changes, and fetal growth","volume":"147","author":"Zhao","year":"2021","journal-title":"Environ. Int."},{"issue":"12","key":"10.1016\/j.cbi.2026.112257_bib13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.placenta.2009.10.005","article-title":"Role of human chorionic gonadotropin in maintaining 11beta-hydroxysteroid dehydrogenase type 2 expression in human placental syncytiotrophoblasts","volume":"30","author":"Ni","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.cbi.2026.112257_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.115866","article-title":"Corrigendum to \"cAMP\/PKA\/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11\u03b2-HSD2 expression\" [Published in toxicology and applied pharmacology 352 (2018) 77-86, DOI: 10.1016\/j.taap.2018.05.029]","volume":"436","author":"Yu","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.cbi.2026.112257_bib15","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1128\/MCB.26.5.1770-1785.2006","article-title":"Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription","volume":"26","author":"Hung","year":"2006","journal-title":"Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.cbi.2026.112257_bib16","doi-asserted-by":"crossref","first-page":"E899","DOI":"10.1210\/jc.2010-2852","article-title":"The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts","volume":"96","author":"Li","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.cbi.2026.112257_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.etap.2011.08.013","article-title":"Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco\/alcohol exposure","volume":"32","author":"Li","year":"2011","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"7","key":"10.1016\/j.cbi.2026.112257_bib18","doi-asserted-by":"crossref","first-page":"E1189","DOI":"10.1210\/jc.2012-4291","article-title":"Critical role of histone acetylation by p300 in human placental 11\u03b2-HSD2 expression","volume":"98","author":"Li","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11\u201312","key":"10.1016\/j.cbi.2026.112257_bib19","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.lfs.2008.07.005","article-title":"Differential regulation of 11beta-hydroxysteroid dehydrogenase type-1 and -2 gene transcription by proinflammatory cytokines in vascular smooth muscle cells","volume":"83","author":"Tsugita","year":"2008","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.cbi.2026.112257_bib20","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1002\/hep.25813","article-title":"Elevated coffee consumption and reduced risk of insulin resistance in HIV-HCV coinfected patients (HEPAVIH ANRS CO-13)","volume":"56","author":"Carrieri","year":"2012","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.cbi.2026.112257_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/nu12082463","article-title":"Coffee consumption among adults in the United States by demographic variables and purchase location: analyses of NHANES 2011-2016 data","volume":"12","author":"Rehm","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.cbi.2026.112257_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109031","article-title":"Occurrence and potential risks of pharmaceutical contamination in global estuaries: a critical review and analysis","volume":"192","author":"Adedipe","year":"2024","journal-title":"Environ. Int."},{"issue":"8","key":"10.1016\/j.cbi.2026.112257_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113947119","article-title":"Pharmaceutical pollution of the world's rivers","volume":"119","author":"Wilkinson","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.cbi.2026.112257_bib24","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/21622515.2025.2512483","article-title":"Caffeine removal in wastewater: a comprehensive review of current treatment plants and small-scale innovations","volume":"14","author":"Yang","year":"2025","journal-title":"Environ. Tech. Rev."},{"issue":"22","key":"10.1016\/j.cbi.2026.112257_bib25","doi-asserted-by":"crossref","first-page":"11275","DOI":"10.1021\/acs.est.5c05363","article-title":"High-throughput monitoring of 323 pharmaceuticals and personal care products (PPCPs) and pesticides in surface water for environmental risk assessment","volume":"59","author":"Du","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2026.112257_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.wasman.2025.114955","article-title":"The effect of non-antibiotic pharmaceuticals and personal care products on antibiotic resistance genes in landfill refuse should not be underestimated","volume":"204","author":"Sun","year":"2025","journal-title":"Waste Manag."},{"key":"10.1016\/j.cbi.2026.112257_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124851","article-title":"Occurrence, distribution, and potential health risks of psychoactive substances in Chinese surface waters","volume":"407","author":"Yao","year":"2021","journal-title":"J. Hazard Mater."},{"issue":"3","key":"10.1016\/j.cbi.2026.112257_bib28","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.3238","article-title":"Association between maternal caffeine consumption and metabolism and neonatal anthropometry: a secondary analysis of the NICHD fetal growth studies-singletons","volume":"4","author":"Gleason","year":"2021","journal-title":"JAMA Netw. Open"},{"issue":"5","key":"10.1016\/j.cbi.2026.112257_bib29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/jama.1993.03500050071028","article-title":"Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation","volume":"269","author":"Mills","year":"1993","journal-title":"Jama"},{"key":"10.1016\/j.cbi.2026.112257_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1741-7015-11-42","article-title":"Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study","volume":"11","author":"Sengpiel","year":"2013","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.cbi.2026.112257_bib31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12916-021-02173-4","article-title":"P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss","volume":"19","author":"Ge","year":"2021","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.cbi.2026.112257_bib32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.taap.2015.05.007","article-title":"Low functional programming of renal AT2R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure","volume":"287","author":"Ao","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112257_bib33","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.reprotox.2017.06.045","article-title":"Prenatal caffeine exposure induced high susceptibility to metabolic syndrome in adult female offspring rats and its underlying mechanisms","volume":"71","author":"Pei","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.cbi.2026.112257_bib34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.toxlet.2018.06.1221","article-title":"Prenatal caffeine exprosure increases adult female offspring rat's susceptibility to osteoarthritis via low-functional programming of cartilage IGF-1 with histone acetylation","volume":"295","author":"Tan","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.cbi.2026.112257_bib35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.toxlet.2013.11.006","article-title":"Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring","volume":"224","author":"Wang","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.cbi.2026.112257_bib36","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.taap.2012.08.016","article-title":"A hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion","volume":"264","author":"Xu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.cbi.2026.112257_bib37","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2024-004704","article-title":"Rationale for phosphodiesterase-4 inhibition as a treatment strategy for interstitial lung diseases associated with rheumatic diseases","volume":"10","author":"Aringer","year":"2024","journal-title":"RMD Open"},{"issue":"6","key":"10.1016\/j.cbi.2026.112257_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cells13060476","article-title":"Phosphodiesterases 4B and 4D differentially regulate cAMP signaling in calcium handling microdomains of mouse hearts","volume":"13","author":"Kraft","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.cbi.2026.112257_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2022.12.020","article-title":"Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis","volume":"109","author":"Schepers","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"11","key":"10.1016\/j.cbi.2026.112257_bib40","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.3390\/ijms19113511","article-title":"Dexamethasone inhibits synergistic induction of PDE4B expression by roflumilast and bacterium NTHi","volume":"19","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.cbi.2026.112257_bib41","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1056\/NEJMoa2201737","article-title":"Trial of a preferential phosphodiesterase 4B inhibitor for idiopathic pulmonary fibrosis","volume":"386","author":"Richeldi","year":"2022","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.cbi.2026.112257_bib42","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s12276-022-00743-x","article-title":"The miR-98-3p\/JAG1\/Notch1 axis mediates the multigenerational inheritance of osteopenia caused by maternal dexamethasone exposure in female rat offspring","volume":"54","author":"Han","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.cbi.2026.112257_bib43","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41380-024-02715-1","article-title":"MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress","volume":"30","author":"Rodrigues","year":"2025","journal-title":"Mol. Psychiatr."},{"issue":"8","key":"10.1016\/j.cbi.2026.112257_bib44","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ddr.21461","article-title":"Dose translation between laboratory animals and human in preclinical and clinical phases of drug development","volume":"79","author":"Nair","year":"2018","journal-title":"Drug Dev. Res."},{"issue":"3","key":"10.1016\/j.cbi.2026.112257_bib45","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.cbi.2026.112257_bib46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/resp.13914","article-title":"Effects of roflumilast on arterial stiffness in COPD (ELASTIC): a randomized trial","volume":"26","author":"Urban","year":"2021","journal-title":"Respirology"},{"issue":"2","key":"10.1016\/j.cbi.2026.112257_bib47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.taap.2014.01.007","article-title":"Maternal glucocorticoid elevation and associated blood metabonome changes might be involved in metabolic programming of intrauterine growth retardation in rats exposed to caffeine prenatally","volume":"275","author":"Kou","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.cbi.2026.112257_bib48","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/10408444.2021.1977237","article-title":"Sexual dimorphism in placental development and its contribution to health and diseases","volume":"51","author":"Yu","year":"2021","journal-title":"Crit. Rev. Toxicol."},{"issue":"3","key":"10.1016\/j.cbi.2026.112257_bib49","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1530\/EJE-09-0308","article-title":"Differences in expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender","volume":"161","author":"Mericq","year":"2009","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"10.1016\/j.cbi.2026.112257_bib50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.taap.2015.09.007","article-title":"Prenatal caffeine exposure induced a lower level of fetal blood leptin mainly via placental mechanism","volume":"289","author":"Wu","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.cbi.2026.112257_bib51","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.toxlet.2012.09.007","article-title":"Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation","volume":"214","author":"Tan","year":"2012","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.cbi.2026.112257_bib52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00018-018-2918-5","article-title":"Mechanisms for establishment of the placental glucocorticoid barrier, a guard for life","volume":"76","author":"Zhu","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"20","key":"10.1016\/j.cbi.2026.112257_bib53","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1111\/bph.15225","article-title":"The low-expression programming of 11\u03b2-HSD2 mediates osteoporosis susceptibility induced by prenatal caffeine exposure in male offspring rats","volume":"177","author":"Xiao","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.cbi.2026.112257_bib54","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tig.2021.03.002","article-title":"The PDE-Opathies: Diverse phenotypes produced by a functionally related multigene family","volume":"37","author":"Bolger","year":"2021","journal-title":"Trends Genet."},{"key":"10.1016\/j.cbi.2026.112257_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/751694","article-title":"Glucocorticoids and preterm hypoxic-ischemic brain injury: the good and the bad","volume":"2012","author":"Bennet","year":"2012","journal-title":"J. Pregnancy"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726003650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726003650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T13:02:24Z","timestamp":1786107744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726003650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":55,"alternative-id":["S0009279726003650"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112257","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PDE4B-associated regulation of placental HSD11B2 in fetal growth restriction in a prenatal caffeine exposure model","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112257","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112257"}}