{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:15:24Z","timestamp":1788498924558,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260806"],"award-info":[{"award-number":["82260806"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cbi.2026.112305","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:59:40Z","timestamp":1786633180000},"page":"112305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Honokiol targets cyclophilin D and blocks mitochondrial DNA release to inhibit microglial NLRP3 inflammasome activation and alleviate neurodegeneration in Parkinson's disease models"],"prefix":"10.1016","volume":"438","author":[{"given":"Qinglin","family":"Gan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingtong","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cbi.2026.112305_bib1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1474-4422(25)00033-X","article-title":"Advances in diagnosis, classification, and management of pain in Parkinson's disease","volume":"24","author":"Tinazzi","year":"2025","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cbi.2026.112305_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1429977","article-title":"Neuroinflammation in Parkinson's disease: focus on the relationship between miRNAs and microglia","volume":"18","author":"Xu","year":"2024","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib3","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-025-03517-0","article-title":"Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson's disease","volume":"22","author":"Han","year":"2025","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.cbi.2026.112305_bib4","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3390\/cells12071012","article-title":"Microglia mediated neuroinflammation in Parkinson's disease","volume":"12","author":"Isik","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.cbi.2026.112305_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102872","article-title":"Understanding the influence of TLR-mediated immune system on necroptosis-induced neurodegeneration in Parkinson's disease","volume":"112","author":"Jadhav","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"21","key":"10.1016\/j.cbi.2026.112305_bib6","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1021\/acschemneuro.5c00159","article-title":"Shifting microglial phenotypes: targeting disease-associated microglia in neurodegeneration","volume":"16","author":"Sasidharan","year":"2025","journal-title":"ACS Chem. Neurosci."},{"issue":"11","key":"10.1016\/j.cbi.2026.112305_bib7","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.freeradbiomed.2010.08.028","article-title":"Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model","volume":"49","author":"Ghosh","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2026.112305_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115619","article-title":"Role of microglial metabolic reprogramming in Parkinson's disease","volume":"213","author":"Huang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbi.2026.112305_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175091","article-title":"Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome","volume":"928","author":"Li","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12974-025-03396-5","article-title":"Protective role of mitophagy on microglia-mediated neuroinflammatory injury through mtDNA-STING signaling in manganese-induced parkinsonism","volume":"22","author":"Lu","year":"2025","journal-title":"J. Neuroinflammation"},{"issue":"8","key":"10.1016\/j.cbi.2026.112305_bib11","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.32604\/biocell.2025.066320","article-title":"Rotenone-induced mitochondrial dysfunction, neuroinflammation, oxidative stress, and glial activation in Parkinson's and Alzheimer's diseases","volume":"49","author":"Rubio","year":"2025","journal-title":"Biocell"},{"issue":"15","key":"10.1016\/j.cbi.2026.112305_bib12","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.3390\/cells11152364","article-title":"Mitochondrial damage-associated molecular patterns content in extracellular vesicles promotes early inflammation in neurodegenerative disorders","volume":"11","author":"Deus","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/mds.27874","article-title":"Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease","volume":"35","author":"Haque","year":"2020","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib14","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-025-05389-0","article-title":"Nrf2-Keap1 pathway and NLRP3 inflammasome in Parkinson's disease: mechanistic crosstalk and therapeutic implications","volume":"63","author":"Jain","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"15","key":"10.1016\/j.cbi.2026.112305_bib15","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.neuron.2022.05.009","article-title":"Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease","volume":"110","author":"Panicker","year":"2022","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.cbi.2026.112305_bib16","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1080\/15548627.2020.1719723","article-title":"Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice","volume":"16","author":"Cheng","year":"2020","journal-title":"Autophagy"},{"issue":"465","key":"10.1016\/j.cbi.2026.112305_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah4066","article-title":"Inflammasome inhibition prevents \u03b1-synuclein pathology and dopaminergic neurodegeneration in mice","volume":"10","author":"Gordon","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12974-023-02759-0","article-title":"Inflammasome inhibition protects dopaminergic neurons from alpha-synuclein pathology in a model of progressive Parkinson's disease","volume":"20","author":"Grotemeyer","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12974-022-02613-9","article-title":"Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer's disease","volume":"19","author":"Li","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cbi.2026.112305_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.immuni.2024.10.012","article-title":"Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation","volume":"58","author":"Saller","year":"2025","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-023-00462-9","article-title":"The NLRP3 inflammasome: contributions to inflammation-related diseases","volume":"28","author":"Chen","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"11","key":"10.1016\/j.cbi.2026.112305_bib23","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s41423-022-00922-w","article-title":"How location and cellular signaling combine to activate the NLRP3 inflammasome","volume":"19","author":"Akbal","year":"2022","journal-title":"Cell. Mol. Immunol."},{"issue":"8","key":"10.1016\/j.cbi.2026.112305_bib24","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.immuni.2022.06.007","article-title":"Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling","volume":"55","author":"Xian","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.cbi.2026.112305_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.arres.2022.100037","article-title":"Pharmacological significance of MitoQ in ameliorating mitochondria-related diseases","volume":"5","author":"Sulaimon","year":"2022","journal-title":"Advances in Redox Research."},{"key":"10.1016\/j.cbi.2026.112305_bib26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2023.11.014","article-title":"Ribosome-targeting antibiotic control NLRP3-mediated inflammation by inhibiting mitochondrial DNA synthesis","volume":"210","author":"Liu","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbi.2026.112305_bib27","article-title":"Cyclophilin D (PPIF) and MPTP in hepatic ischemia-reperfusion injury: insights into mechanisms","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.cbi.2026.112305_bib28","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.3390\/antiox10121917","article-title":"ROS-induced mtDNA release: the emerging messenger for communication between neurons and innate immune cells during neurodegenerative disorder progression","volume":"10","author":"Zhao","year":"2021","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.cbi.2026.112305_bib29","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/cells13070648","article-title":"Mitochondrial permeability transition, cell death and neurodegeneration","volume":"13","author":"Baev","year":"2024","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.cbi.2026.112305_bib30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4103\/aian.aian_614_24","article-title":"Neurotoxicity of calcineurin inhibitors","volume":"28","author":"Bajon","year":"2025","journal-title":"Ann. Indian Acad. Neurol."},{"issue":"5","key":"10.1016\/j.cbi.2026.112305_bib31","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/med.21892","article-title":"Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases","volume":"42","author":"Haleckova","year":"2022","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.cbi.2026.112305_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2025.114627","article-title":"Delivery of Magnolia bark extract in nanoemulsions formed by high and low energy methods improves the bioavailability of Honokiol and Magnolol","volume":"208","author":"Sampieri-Moran","year":"2025","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.cbi.2026.112305_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109741","article-title":"Honokiol improves cognitive impairment in APP\/PS1 mice through activating mitophagy and mitochondrial unfolded protein response","volume":"351","author":"Hou","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112305_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129381","article-title":"Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK\/PGC-1\u03b1\/Sirt3","volume":"437","author":"Wang","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.cbi.2026.112305_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103224","article-title":"Activation of Sirtuin3 by honokiol ameliorates alveolar epithelial cell senescence in experimental silicosis via the cGAS-STING pathway","volume":"74","author":"Zhou","year":"2024","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.cbi.2026.112305_bib36","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s12264-023-01068-z","article-title":"Compound from Magnolia officinalis ameliorates white matter injury by promoting oligodendrocyte maturation in chronic cerebral ischemia models","volume":"39","author":"Zhang","year":"2023","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.cbi.2026.112305_bib37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2147\/IJN.S214349","article-title":"Development of Nanosome-Encapsulated honokiol for intravenous therapy against experimental autoimmune encephalomyelitis","volume":"15","author":"Hsiao","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.cbi.2026.112305_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153692","article-title":"Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2\/HO-1\/NLRP3 signaling pathway","volume":"91","author":"Tao","year":"2021","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.cbi.2026.112305_bib39","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.pharep.2018.01.003","article-title":"Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of Parkinson's disease","volume":"70","author":"Chen","year":"2018","journal-title":"Pharmacol. Rep."},{"issue":"7","key":"10.1016\/j.cbi.2026.112305_bib40","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1007\/s12035-023-03830-w","article-title":"SIRT3-Mediated deacetylation of SDHA rescues mitochondrial bioenergetics contributing to neuroprotection in rotenone-induced PD models","volume":"61","author":"Shen","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.cbi.2026.112305_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111212","article-title":"A derivative of honokiol HM568 has an anti-neuroinflammatory effect in Parkinson's disease","volume":"403","author":"Zhong","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbi.2026.112305_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122158","article-title":"BDE-47 flame retardant exposure induces microglial pyroptosis and cognitive deficits by activating the mtROS-NLRP3 axis via Sirt3 downregulation and is salvaged by honokiol","volume":"334","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41419-026-08424-7","article-title":"Mitochondrial DNA drives NLRP3-IL-1beta axis activation in microglia by binding to NLRP3, leading to neurodegeneration in Parkinson's disease models","volume":"17","author":"Gan","year":"2026","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.cbi.2026.112305_bib44","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s11481-017-9746-5","article-title":"Involvement of c-Abl kinase in microglial activation of NLRP3 inflammasome and impairment in autolysosomal system","volume":"12","author":"Lawana","year":"2017","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.cbi.2026.112305_bib45","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41531-017-0032-2","article-title":"Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease","volume":"3","author":"Sarkar","year":"2017","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.cbi.2026.112305_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102714","article-title":"LPS-Induced mitochondrial dysfunction regulates innate immunity activation and \u03b1-synuclein oligomerization in Parkinson's disease","volume":"63","author":"Esteves","year":"2023","journal-title":"Redox Biol."},{"issue":"19","key":"10.1016\/j.cbi.2026.112305_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910637","article-title":"Donepezil regulates LPS and A\u03b2-Stimulated neuroinflammation through MAPK\/NLRP3 Inflammasome\/STAT3 signaling","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112305_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112299","article-title":"Protective role of cinnabar and realgar in Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity and disturbance of gut microbiota in rats","volume":"247","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.cbi.2026.112305_bib49","first-page":"6731","article-title":"Electroacupuncture alleviates the symptom of depression in mice by regulating the cGAS-STING-NLRP3 signaling","volume":"16","author":"Chen","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.cbi.2026.112305_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102945","article-title":"A novel combination therapy with Cabozantinib and Honokiol effectively inhibits c-Met-Nrf2-induced renal tumor growth through increased oxidative stress","volume":"68","author":"Rawat","year":"2023","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib51","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/22221751.2019.1617643","article-title":"Subinhibitory concentrations of Honokiol reduce \u03b1-Hemolysin (Hla) secretion by Staphylococcus aureus and the Hla-induced inflammatory response by inactivating the NLRP3 inflammasome","volume":"8","author":"Guo","year":"2019","journal-title":"Emerg. Microb. Infect."},{"issue":"7\u20139","key":"10.1016\/j.cbi.2026.112305_bib52","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1089\/ars.2021.0073","article-title":"Redox activation of mitochondrial DAMPs and the metabolic consequences for development of autoimmunity","volume":"36","author":"Koenig","year":"2022","journal-title":"Antioxidants Redox Signal."},{"issue":"2","key":"10.1016\/j.cbi.2026.112305_bib53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41580-024-00785-1","article-title":"Molecular mechanisms of mitochondrial dynamics","volume":"26","author":"T\u00e1bara","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.cbi.2026.112305_bib54","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3390\/cells12040611","article-title":"Mitochondrial lipid peroxidation is responsible for ferroptosis","volume":"12","author":"Lyamzaev","year":"2023","journal-title":"Cells"},{"issue":"13","key":"10.1016\/j.cbi.2026.112305_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22137030","article-title":"Evidence for the role of mitochondrial DNA release in the inflammatory response in neurological disorders","volume":"22","author":"Moya","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.cbi.2026.112305_bib56","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.3390\/ijms25084187","article-title":"DNA damage and Parkinson's disease","volume":"25","author":"Pfeifer","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.cbi.2026.112305_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbabio.2022.148554","article-title":"Mitochondrial DNA replication and repair defects: clinical phenotypes and therapeutic interventions","volume":"1863","author":"Roy","year":"2022","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"issue":"1","key":"10.1016\/j.cbi.2026.112305_bib58","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12964-025-02603-3","article-title":"Mitochondrial DNA release via mPTP and BAX\/BAK drives inflammatory injury in intestinal ischemia reperfusion","volume":"24","author":"Jing","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"6","key":"10.1016\/j.cbi.2026.112305_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165761","article-title":"Mechanisms of mitochondrial DNA escape and its relationship with different metabolic diseases","volume":"1866","author":"P\u00e9rez-Trevi\u00f1o","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"8","key":"10.1016\/j.cbi.2026.112305_bib60","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.cbi.2026.112305_bib61","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2020.09.020","article-title":"TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS\/STING in ALS","volume":"183","author":"Yu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cbi.2026.112305_bib62","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3389\/fphys.2020.00595","article-title":"Cyclophilin D: an integrator of mitochondrial function","volume":"11","author":"Amanakis","year":"2020","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.cbi.2026.112305_bib63","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neurobiolaging.2009.03.003","article-title":"Cyclophilin D deficiency improves mitochondrial function and learning\/memory in aging Alzheimer disease mouse model","volume":"32","author":"Du","year":"2011","journal-title":"Neurobiol. Aging"},{"issue":"9","key":"10.1016\/j.cbi.2026.112305_bib64","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1089\/ars.2010.3849","article-title":"Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease","volume":"16","author":"Thomas","year":"2012","journal-title":"Antioxid. Redox Signaling"},{"issue":"16","key":"10.1016\/j.cbi.2026.112305_bib65","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1089\/ars.2019.7734","article-title":"Parkin regulates programmed necrosis and myocardial Ischemia\/Reperfusion injury by targeting Cyclophilin-D","volume":"31","author":"Sun","year":"2019","journal-title":"Antioxidants Redox Signal."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726004138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726004138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:24:50Z","timestamp":1788495890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726004138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":65,"alternative-id":["S0009279726004138"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112305","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Honokiol targets cyclophilin D and blocks mitochondrial DNA release to inhibit microglial NLRP3 inflammasome activation and alleviate neurodegeneration in Parkinson's disease models","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112305","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112305"}}