{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:49:35Z","timestamp":1791546575038,"version":"4.3.4"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100029379","name":"Arthur N. Rupe Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100029379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["221610052028"],"award-info":[{"award-number":["221610052028"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cbi.2026.112352","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:06:20Z","timestamp":1791151580000},"page":"112352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chronic tetracycline exposure resulted in VPS13 dysregulation, lipid accumulation, and physiological impairments in Drosophila melanogaster"],"prefix":"10.1016","volume":"440","author":[{"given":"Priyatama","family":"Behera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3800-4783","authenticated-orcid":false,"given":"Monalisha","family":"Ojha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-3010","authenticated-orcid":false,"given":"Devi Prasanna","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3139-7621","authenticated-orcid":false,"given":"Suman","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2655-1196","authenticated-orcid":false,"given":"Harekrushna","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monalisa","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cbi.2026.112352_bib1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1021\/envhealth.3c00072","article-title":"Chronic exposure to environmentally relevant concentrations of tetracycline perturbs gut homeostasis in Zebrafish","volume":"1","author":"Jia","year":"2023","journal-title":"Environment & Health"},{"issue":"3","key":"10.1016\/j.cbi.2026.112352_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.15386\/mpr-1742","article-title":"Antibiotics in the environment: causes and consequences","volume":"93","author":"Polianciuc","year":"2020","journal-title":"Medicine and pharmacy reports"},{"issue":"6","key":"10.1016\/j.cbi.2026.112352_bib3","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s10311-024-01777-5","article-title":"Remediation of tetracycline pollution using microplastics, green materials, membranes and sonocatalysts: a review","volume":"22","author":"Sivanesan","year":"2024","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.cbi.2026.112352_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.136376","article-title":"A wearable gloved sensor based on fluorescent Ag nanoparticles and europium complexes for visualized assessment of tetracycline in food samples","volume":"424","author":"Xu","year":"2023","journal-title":"Food Chem."},{"issue":"21","key":"10.1016\/j.cbi.2026.112352_bib5","doi-asserted-by":"crossref","first-page":"12898","DOI":"10.1021\/acs.est.7b05050","article-title":"Multigenerational effects of the antibiotic tetracycline on transcriptional responses of Daphnia magna and its relationship to higher levels of biological organizations","volume":"51","author":"Kim","year":"2017","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.cbi.2026.112352_bib6","article-title":"Combined exposure to titanium dioxide and tetracycline induces neurotoxicity in Zebrafish","volume":"267","author":"Xu","year":"2023","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"},{"key":"10.1016\/j.cbi.2026.112352_bib7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jes.2021.11.029","article-title":"Sex-dependent obesogenic effect of tetracycline on Drosophila melanogaster deteriorated by dysrhythmia","volume":"124","author":"Guo","year":"2023","journal-title":"Journal of Environmental Sciences"},{"issue":"1","key":"10.1016\/j.cbi.2026.112352_bib8","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902017000116059","article-title":"Changes in weight and body fat after use of tetracycline and Lactobacillus gasseri in rats","volume":"53","author":"Marciano","year":"2017","journal-title":"Brazilian Journal of Pharmaceutical Sciences"},{"issue":"2","key":"10.1016\/j.cbi.2026.112352_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/toxsci\/kfv049","article-title":"Increased hepatic fatty acid uptake and esterification contribute to tetracycline-induced steatosis in mice","volume":"145","author":"Choi","year":"2015","journal-title":"Toxicol. Sci."},{"issue":"6","key":"10.1016\/j.cbi.2026.112352_bib10","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.3390\/ijms22062905","article-title":"The Vps13 family of lipid transporters and its role at membrane contact sites","volume":"22","author":"Dziurdzik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbi.2026.112352_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43561","article-title":"Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility","volume":"8","author":"Yeshaw","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.cbi.2026.112352_bib12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73812","article-title":"Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies","volume":"11","author":"Martelli","year":"2022","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.cbi.2026.112352_bib13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/toxsci\/kfae113","article-title":"The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity","volume":"202","author":"Mesmar","year":"2024","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.cbi.2026.112352_bib14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S1369-7021(11)70113-4","article-title":"Drosophila\u2013a versatile model in biology & medicine","volume":"14","author":"Jennings","year":"2011","journal-title":"Materials today"},{"key":"10.1016\/j.cbi.2026.112352_bib15","series-title":"Fundamental Approaches to Screen Abnormalities in Drosophila","first-page":"1","article-title":"Formulation of Drosophila food for various feeding studies","author":"Priyadarsini","year":"2019"},{"issue":"10","key":"10.1016\/j.cbi.2026.112352_bib16","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.celrep.2015.02.034","article-title":"Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research","volume":"10","author":"Moullan","year":"2015","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.cbi.2026.112352_bib17","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1534\/genetics.115.178897","article-title":"Energy homeostasis control in Drosophila adipokinetic hormone mutants","volume":"201","author":"G\u00e1likov\u00e1","year":"2015","journal-title":"Genetics"},{"key":"10.1016\/j.cbi.2026.112352_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.111684","article-title":"A trade-off between desiccation resistance and developmental humidity for pupation height in the North Indian seasonal population of Drosophilid-Zaprionus indianus","volume":"296","author":"Kalra","year":"2024","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."},{"issue":"7","key":"10.1016\/j.cbi.2026.112352_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104541","article-title":"Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity","volume":"25","author":"Cabrita","year":"2022","journal-title":"iScience"},{"issue":"3","key":"10.1016\/j.cbi.2026.112352_bib20","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3915","article-title":"Ecdysone quantification from whole body samples of Drosophila melanogaster larvae","volume":"11","author":"Koyama","year":"2021","journal-title":"Bio-protocol"},{"issue":"1","key":"10.1016\/j.cbi.2026.112352_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12915-021-01106-0","article-title":"Stop codon readthrough alters the activity of a POU\/Oct transcription factor during Drosophila development","volume":"19","author":"Zhao","year":"2021","journal-title":"BMC Biol."},{"issue":"2","key":"10.1016\/j.cbi.2026.112352_bib22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1534\/genetics.117.300268","article-title":"Cooperative control of ecdysone biosynthesis in Drosophila by transcription factors S\u00e9ance, Ouija board, and molting defective","volume":"208","author":"Uryu","year":"2018","journal-title":"Genetics"},{"issue":"11","key":"10.1016\/j.cbi.2026.112352_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001206","article-title":"A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability","volume":"6","author":"Reis","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cbi.2026.112352_bib24","series-title":"Fundamental Approaches to Screen Abnormalities in Drosophila","first-page":"111","article-title":"Detection of lipid depot within drosophila","author":"Nayak","year":"2019"},{"key":"10.1016\/j.cbi.2026.112352_bib25","series-title":"Fundamental Approaches to Screen Abnormalities in Drosophila","first-page":"135","article-title":"Biochemical estimation to detect the metabolic pathways of Drosophila","author":"Mukherjee","year":"2019"},{"issue":"3","key":"10.1016\/j.cbi.2026.112352_bib26","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1021\/acsabm.2c00983","article-title":"In vivo toxicological analysis of MnFe2O4@ poly (t BGE-alt-PA) composite as a hybrid nanomaterial for possible biomedical use","volume":"6","author":"Kumar","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.cbi.2026.112352_bib27","first-page":"1","article-title":"Platinum accumulation and antioxidant dysregulation drive behavioral impairments, apoptosis and neurodegeneration in Oxaliplatin exposed Drosophila Melanogaster","author":"Mishra","year":"2025","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.cbi.2026.112352_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12035-025-05593-y","article-title":"Unravelling the mechanism of N-Acetylcysteine in alleviating smoke-induced hypoxia-driven ocular defects in Drosophila melanogaster","volume":"63","author":"Naik","year":"2026","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.cbi.2026.112352_bib29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4161\/fly.21582","article-title":"A high throughput and sensitive method correlates neuronal disorder genotypes to Drosophila larvae crawling phenotypes","volume":"6","author":"Jakubowski","year":"2012","journal-title":"Fly"},{"key":"10.1016\/j.cbi.2026.112352_bib30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijbiomac.2020.09.144","article-title":"Fe3O4 coated guargum nanoparticles as non-genotoxic materials for biological application","volume":"165","author":"Bag","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"48","key":"10.1016\/j.cbi.2026.112352_bib31","doi-asserted-by":"crossref","first-page":"41647","DOI":"10.1074\/jbc.M111.274548","article-title":"Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease","volume":"286","author":"Costa","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbi.2026.112352_bib32","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.toxrep.2019.07.009","article-title":"Comparative toxicity evaluation of graphene oxide (GO) and zinc oxide (ZnO) nanoparticles on Drosophila melanogaster","volume":"6","author":"Sood","year":"2019","journal-title":"Toxicol. Rep."},{"issue":"10","key":"10.1016\/j.cbi.2026.112352_bib33","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1083\/jcb.201807019","article-title":"VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites","volume":"217","author":"Kumar","year":"2018","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.cbi.2026.112352_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.gde.2020.05.027","article-title":"Role of VPS13, a protein with similarity to ATG2, in physiology and disease","volume":"65","author":"Ugur","year":"2020","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.cbi.2026.112352_bib35","series-title":"Unraveling VPS13A Pathways: from Drosophila to Human","author":"Pinto","year":"2018"},{"key":"10.1016\/j.cbi.2026.112352_bib36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1146\/annurev-ento-120811-153608","article-title":"Ecdysone control of developmental transitions: lessons from Drosophila research","volume":"58","author":"Yamanaka","year":"2013","journal-title":"Annu. Rev. Entomol."},{"issue":"19","key":"10.1016\/j.cbi.2026.112352_bib37","doi-asserted-by":"crossref","first-page":"E3849","DOI":"10.1073\/pnas.1620760114","article-title":"Endocrine network essential for reproductive success in Drosophila melanogaster","volume":"114","author":"Meiselman","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbi.2026.112352_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154803","article-title":"Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans","volume":"121","author":"Axelrod","year":"2021","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.cbi.2026.112352_bib39","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3390\/antibiotics12030440","article-title":"The impact of tetracycline pollution on the aquatic environment and removal strategies","volume":"12","author":"Amangelsin","year":"2023","journal-title":"Antibiotics"},{"issue":"14","key":"10.1016\/j.cbi.2026.112352_bib40","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1080\/01496395.2023.2259079","article-title":"A review on current pollution and removal methods of tetracycline in soil","volume":"58","author":"Ren","year":"2023","journal-title":"Separ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.cbi.2026.112352_bib41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10311-013-0404-8","article-title":"Tetracycline antibiotics in the environment: a review","volume":"11","author":"Daghrir","year":"2013","journal-title":"Environ. Chem. Lett."},{"issue":"February","key":"10.1016\/j.cbi.2026.112352_bib42","first-page":"1","volume":"7","author":"Yun","year":"2017","journal-title":"Minocycline treatment suppresses juvenile development and growth by attenuating insulin\/TOR signaling in Drosophila animal model. Sci Rep [Internet]"},{"issue":"1","key":"10.1016\/j.cbi.2026.112352_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1534\/genetics.119.300160","article-title":"Life-history evolution and the genetics of fitness components in Drosophila melanogaster","volume":"214","author":"Flatt","year":"2020","journal-title":"Genetics"},{"key":"10.1016\/j.cbi.2026.112352_bib44","article-title":"Endoreplication in the Drosophila melanogaster prothoracic gland is dispensable for the critical weight checkpoint","volume":"2023","author":"Shimell","year":"2023","journal-title":"microPublication Biology"},{"issue":"6","key":"10.1016\/j.cbi.2026.112352_bib45","doi-asserted-by":"crossref","DOI":"10.1242\/bio.059386","article-title":"Lifespan and ROS levels in different Drosophila melanogaster strains after 24 h hypoxia exposure","volume":"11","author":"Malacrida","year":"2022","journal-title":"Biology Open"},{"issue":"9","key":"10.1016\/j.cbi.2026.112352_bib46","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ibmb.2004.06.009","article-title":"Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis","volume":"34","author":"Warren","year":"2004","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.cbi.2026.112352_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121061","article-title":"Multi-generational obesogenic effects of sulfomethoxazole on Caenorhabditis elegans through epigenetic regulation","volume":"382","author":"Li","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.cbi.2026.112352_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124542","article-title":"Toxicological effects of ciprofloxacin exposure to Drosophila melanogaster","volume":"237","author":"Liu","year":"2019","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.cbi.2026.112352_bib49","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1021\/acs.est.9b07889","article-title":"Obesogenic effect of sulfamethoxazole on Drosophila melanogaster with simultaneous disturbances on eclosion rhythm, glucolipid metabolism, and microbiota","volume":"54","author":"Yu","year":"2020","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.cbi.2026.112352_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145315","article-title":"Influences of sex, rhythm and generation on the obesogenic potential of erythromycin to Drosophila melanogaster","volume":"771","author":"Zhang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbi.2026.112352_bib51","series-title":"Obesity and Antibiotic Exposure: an Overhyped Theory","author":"Lannoy","year":"2025"},{"key":"10.1016\/j.cbi.2026.112352_bib52","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.micpath.2016.11.002","article-title":"Weight gain by gut microbiota manipulation in productive animals","volume":"106","author":"Angelakis","year":"2017","journal-title":"Microb. Pathog."},{"issue":"2","key":"10.1016\/j.cbi.2026.112352_bib53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3390\/microorganisms9020413","article-title":"Obesity, early life gut microbiota, and antibiotics","volume":"9","author":"Wilkins","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.cbi.2026.112352_bib54","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fendo.2017.00170","article-title":"Antibiotic exposure in early life increases risk of childhood obesity: a systematic review and meta-analysis","volume":"8","author":"Shao","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.cbi.2026.112352_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105705","article-title":"Long-term exposure to TET increases body weight of juvenile Zebrafish as indicated in host metabolism and gut microbiome","volume":"139","author":"Keerthisinghe","year":"2020","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.cbi.2026.112352_bib56","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1002\/hep.24290","article-title":"Induction of vesicular steatosis by amiodarone and tetracycline is associated with up\u2010regulation of lipogenic genes in heparg cells","volume":"53","author":"Anth\u00e9rieu","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.cbi.2026.112352_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117079","article-title":"Environmentally relevant concentrations of oxytetracycline and copper increased liver lipid deposition through inducing oxidative stress and mitochondria dysfunction in grass carp Ctenopharyngodon idella","volume":"283","author":"Xu","year":"2021","journal-title":"Environmental Pollution"},{"issue":"4","key":"10.1016\/j.cbi.2026.112352_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/boc.70009","article-title":"Lipid droplet in lipodystrophy and neurodegeneration","volume":"117","author":"Behera","year":"2025","journal-title":"Biol. Cell"},{"issue":"1","key":"10.1016\/j.cbi.2026.112352_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170106","article-title":"Drosophila Vps13 is required for protein homeostasis in the brain","volume":"12","author":"Vonk","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cbi.2026.112352_bib60","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ajhg.2016.01.014","article-title":"Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1\/Parkin-dependent mitophagy","volume":"98","author":"Lesage","year":"2016","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.cbi.2026.112352_bib61","first-page":"102","article-title":"Effects of lipids on mitochondrial functions","volume":"1862","author":"M\u00e5rtensson","year":"2017","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids"},{"issue":"1","key":"10.1016\/j.cbi.2026.112352_bib62","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41420-024-02224-8","article-title":"Lipids associated with autophagy: mechanisms and therapeutic targets","volume":"10","author":"Jarocki","year":"2024","journal-title":"Cell Death Discov."},{"issue":"6098","key":"10.1016\/j.cbi.2026.112352_bib63","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cbi.2026.112352_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155382","article-title":"Artesunate improves glucose and lipid metabolism in db\/db mice by regulating the metabolic profile and the MAPK\/PI3K\/Akt signalling pathway","volume":"126","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.cbi.2026.112352_bib65","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4\u2010hydroxy\u20102\u2010nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.cbi.2026.112352_bib66","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, Parkin, and mitochondrial fidelity in Parkinson's disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.cbi.2026.112352_bib67","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"The Journal of cell biology"},{"issue":"6","key":"10.1016\/j.cbi.2026.112352_bib68","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.devcel.2015.01.029","article-title":"Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics","volume":"32","author":"Rambold","year":"2015","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.cbi.2026.112352_bib69","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1080\/15548627.2017.1359451","article-title":"Lipid droplets and lipotoxicity during autophagy","volume":"13","author":"Nguyen","year":"2017","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.cbi.2026.112352_bib70","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cbi.2026.112352_bib71","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cbi.2026.112352_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117441","article-title":"Podophyllotoxin mediates hepatic toxicity via the C5a\/C5aR\/ROS\/NLRP3 and cGMP\/PKG\/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis","volume":"289","author":"Liu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"12","key":"10.1016\/j.cbi.2026.112352_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050764","article-title":"20-Hydroxyecdysone protects against oxidative stress-induced neuronal injury by scavenging free radicals and modulating NF-\u03baB and JNK pathways","volume":"7","author":"Hu","year":"2012","journal-title":"PLoS One"},{"issue":"1\u20132","key":"10.1016\/j.cbi.2026.112352_bib74","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mce.2013.04.014","article-title":"Steroid hormone synthesis in mitochondria","volume":"379","author":"Miller","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.cbi.2026.112352_bib75","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10646-015-1417-9","article-title":"Effects of tetracycline on developmental toxicity and molecular responses in Zebrafish (Danio rerio) embryos","volume":"24","author":"Zhang","year":"2015","journal-title":"Ecotoxicology"},{"issue":"4","key":"10.1016\/j.cbi.2026.112352_bib81","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41437-022-00554-w","article-title":"Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster","volume":"129","author":"Anderson","year":"2022","journal-title":"Heredity"},{"issue":"7288","key":"10.1016\/j.cbi.2026.112352_bib77","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature08980","article-title":"The genetics of ageing","volume":"464","author":"Kenyon","year":"2010","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.cbi.2026.112352_bib78","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/genes8120398","article-title":"The mitochondrial basis of aging and age-related disorders","volume":"8","author":"Srivastava","year":"2017","journal-title":"Genes"},{"issue":"8","key":"10.1016\/j.cbi.2026.112352_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109564","article-title":"The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life","volume":"36","author":"Lynn","year":"2021","journal-title":"Cell Rep."},{"issue":"50","key":"10.1016\/j.cbi.2026.112352_bib80","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.21224","article-title":"Minocycline treatment increases resistance to oxidative stress and extends lifespan in Drosophila via FOXO","volume":"8","author":"Lee","year":"2017","journal-title":"Oncotarget"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726004606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726004606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:52:19Z","timestamp":1791543139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726004606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":80,"alternative-id":["S0009279726004606"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112352","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic tetracycline exposure resulted in VPS13 dysregulation, lipid accumulation, and physiological impairments in Drosophila melanogaster","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112352","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112352"}}