{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:26:39Z","timestamp":1793931999563,"version":"4.8.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2024AH040196"],"award-info":[{"award-number":["2024AH040196"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21806002"],"award-info":[{"award-number":["21806002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cbi.2026.112358","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:08:01Z","timestamp":1790809681000},"page":"112358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The emerging contaminant HFPO-TA impairs hepatic glucose metabolism and induces ppar\u03b3-associated lipid metabolic disorders in zebrafish"],"prefix":"10.1016","volume":"440","author":[{"given":"Mengjiao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-9162","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"No.11","key":"10.1016\/j.cbi.2026.112358_bib1","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1039\/C9EM90047K","article-title":"Themed issues on per- and polyfluoroalkyl substances","volume":"21","author":"Ahrens","year":"2019","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.cbi.2026.112358_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118202","article-title":"Exposure to GenX and its novel analogs disrupts fatty acid metabolism in male mice","volume":"291","author":"Guo","year":"2021","journal-title":"Environ. Pollut."},{"issue":"No.14","key":"10.1016\/j.cbi.2026.112358_bib3","doi-asserted-by":"crossref","first-page":"8386","DOI":"10.1021\/acs.est.5b01648","article-title":"Alternative and legacy Perfluoroalkyl substances: differences between European and Chinese River\/Estuary systems","volume":"49","author":"Heydebreck","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"Pt 1","key":"10.1016\/j.cbi.2026.112358_bib4","article-title":"Impact of a hexafluoropropylene oxide trimer acid (HFPO-TA) exposure on impairing the gut microbiota in mice","volume":"303","author":"Hu","year":"2022","journal-title":"Chemosphere"},{"issue":"No.14","key":"10.1016\/j.cbi.2026.112358_bib5","doi-asserted-by":"crossref","first-page":"8005","DOI":"10.1021\/acs.est.8b01714","article-title":"Hepatotoxic effects of hexafluoropropylene oxide trimer acid (HFPO-TA), A novel perfluorooctanoic acid (PFOA) alternative, on mice","volume":"52","author":"Sheng","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbi.2026.112358_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jes.2021.08.012","article-title":"Profiling biotoxicities of hexafluoropropylene oxide trimer acid with human embryonic stem cell-based assays","volume":"116","author":"Liang","year":"2022","journal-title":"J. Environ. Sci. (China)"},{"issue":"No.6","key":"10.1016\/j.cbi.2026.112358_bib7","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1021\/acs.est.8b06978","article-title":"Adipogenic activity of oligomeric hexafluoropropylene oxide (perfluorooctanoic acid alternative) through Peroxisome proliferator-activated receptor gamma pathway","volume":"53","author":"Li","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"No.1","key":"10.1016\/j.cbi.2026.112358_bib8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s10020-023-00740-4","article-title":"Swimming exercise ameliorates insulin resistance and nonalcoholic fatty liver by negatively regulating PPARgamma transcriptional network in mice fed high fat diet","volume":"29","author":"Zhang","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.cbi.2026.112358_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114632","article-title":"Transcriptome and Metabolome analysis reveal HFPO-TA induced disorders of hepatic glucose and lipid metabolism in rat by interfering with PPAR signaling pathway","volume":"188","author":"Zhang","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbi.2026.112358_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.metabol.2019.03.003","article-title":"Systemic PPAR\u03b3 deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility","volume":"95","author":"Gilardi","year":"2019","journal-title":"Metab., Clin. Exp."},{"issue":"No.8","key":"10.1016\/j.cbi.2026.112358_bib11","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1128\/MCB.22.8.2607-2619.2002","article-title":"Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux","volume":"22","author":"Akiyama","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.cbi.2026.112358_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124705","article-title":"Tamoxifen-induced hepatotoxicity via lipid accumulation and inflammation in zebrafish","volume":"239","author":"Yu","year":"2020","journal-title":"Chemosphere"},{"issue":"No.5","key":"10.1016\/j.cbi.2026.112358_bib13","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1242\/dmm.011346","article-title":"The emerging use of zebrafish to model metabolic disease","volume":"6","author":"Seth","year":"2013","journal-title":"Dis. Model. Mech."},{"issue":"No.16","key":"10.1016\/j.cbi.2026.112358_bib14","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cbi.2026.112358_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142462","article-title":"Thyroid disrupting effects and the developmental toxicity of hexafluoropropylene oxide oligomer acids in zebrafish during early development","volume":"361","author":"Zhao","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbi.2026.112358_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-immunol-051116-052415","article-title":"Immune responses in the liver","volume":"36","author":"Kubes","year":"2018","journal-title":"Annu. Rev. Immunol."},{"issue":"No.1","key":"10.1016\/j.cbi.2026.112358_bib17","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1186\/s12889-024-20908-9","article-title":"Correlations between frailty index and inflammatory markers derived from blood cell count in the United States","volume":"24","author":"Han","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.cbi.2026.112358_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115020","article-title":"Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish","volume":"259","author":"Sun","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"No.1","key":"10.1016\/j.cbi.2026.112358_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-024-06463-6","article-title":"The implications of FASN in immune cell biology and related diseases","volume":"15","author":"Xiao","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbi.2026.112358_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150494","article-title":"FASN promotes anoikis resistance in colorectal liver metastases through the ERK1\/2 pathway","volume":"736","author":"Wu","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"No.8","key":"10.1016\/j.cbi.2026.112358_bib21","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1039\/C5FO00481K","article-title":"Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish","volume":"6","author":"Lee","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.cbi.2026.112358_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.nutr.24.121803.063211","article-title":"Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases","volume":"24","author":"Nakamura","year":"2004","journal-title":"Annu. Rev. Nutr."},{"issue":"No.9","key":"10.1016\/j.cbi.2026.112358_bib23","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0022-2275(20)33401-5","article-title":"Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol","volume":"40","author":"Ntambi","year":"1999","journal-title":"J. Lipid Res."},{"issue":"No.18","key":"10.1016\/j.cbi.2026.112358_bib24","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.1128\/MCB.00077-06","article-title":"Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation","volume":"26","author":"Chu","year":"2006","journal-title":"Mol. Cell Biol."},{"issue":"No.2","key":"10.1016\/j.cbi.2026.112358_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020206","article-title":"Assessment of Fatty Acid desaturase (Fads2) structure-function properties in fish in the context of environmental adaptations and as a target for genetic engineering","volume":"10","author":"Blahova","year":"2020","journal-title":"Biomolecules"},{"issue":"No.1","key":"10.1016\/j.cbi.2026.112358_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100730","article-title":"Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids","volume":"66","author":"Barnhart","year":"2025","journal-title":"J. Lipid Res."},{"issue":"No.7","key":"10.1016\/j.cbi.2026.112358_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/nu16071003","article-title":"The role of Acyl-CoA synthetase 1 in bioactive lipid accumulation and the development of hepatic insulin resistance","volume":"16","author":"Zabielski","year":"2024","journal-title":"Nutrients"},{"issue":"No.Pt 2","key":"10.1016\/j.cbi.2026.112358_bib28","article-title":"CD36 deficiency protects lipopolysaccharide-induced sepsis via inhibiting CerS6-mediated endoplasmic reticulum stress","volume":"143","author":"Kim","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"No.3","key":"10.1016\/j.cbi.2026.112358_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/0960327116646615","article-title":"Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish","volume":"36","author":"Cui","year":"2017","journal-title":"Hum. Exp. Toxicol."},{"issue":"No.2","key":"10.1016\/j.cbi.2026.112358_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/biology10020092","article-title":"A model construction of starvation induces hepatic steatosis and transcriptome analysis in zebrafish Larvae","volume":"10","author":"Xu","year":"2021","journal-title":"Biology"},{"issue":"No.3","key":"10.1016\/j.cbi.2026.112358_bib31","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/hep.25740","article-title":"Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"issue":"No.3","key":"10.1016\/j.cbi.2026.112358_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10030390","article-title":"The role of hepatic fat accumulation in glucose and insulin homeostasis-dysregulation by the liver","volume":"10","author":"London","year":"2021","journal-title":"J. Clin. Med."},{"issue":"No.9","key":"10.1016\/j.cbi.2026.112358_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0274297","article-title":"Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice","volume":"17","author":"Shimizu","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.cbi.2026.112358_bib34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbrc.2021.04.059","article-title":"Glucose metabolism is required for oocyte maturation of zebrafish","volume":"559","author":"Kang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"No.9","key":"10.1016\/j.cbi.2026.112358_bib35","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.62347\/QMGJ2157","article-title":"DNA methylation-regulated HK1 overexpression contributes to irradiation-resistance by promoting glycolysis in non-small cell lung cancer","volume":"14","author":"Hu","year":"2024","journal-title":"Am. J. Cancer Res."},{"issue":"No.6865","key":"10.1016\/j.cbi.2026.112358_bib36","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cbi.2026.112358_bib37","first-page":"83","article-title":"Pediatric patient with hyperketotic hypoglycemia diagnosed with glycogen synthase deficiency due to the novel homozygous mutation in GYS2","volume":"4","author":"Szymanska","year":"2015","journal-title":"Mol. Genet. Metab. Rep."},{"issue":"No.1","key":"10.1016\/j.cbi.2026.112358_bib38","doi-asserted-by":"crossref","first-page":"9729","DOI":"10.1038\/s41467-024-54108-1","article-title":"Base-editing corrects metabolic abnormalities in a humanized mouse model for glycogen storage disease type-Ia","volume":"15","author":"Arnaoutova","year":"2024","journal-title":"Nat. Commun."},{"issue":"No.1","key":"10.1016\/j.cbi.2026.112358_bib39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.trecan.2018.11.003","article-title":"Gluconeogenesis in cancer: function and regulation of PEPCK, FBPase, and G6Pase","volume":"5","author":"Wang","year":"2019","journal-title":"Trends Cancer"},{"issue":"No.4","key":"10.1016\/j.cbi.2026.112358_bib40","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.bbrc.2018.03.083","article-title":"Hepatic glucose-6-phosphatase-alpha deficiency leads to metabolic reprogramming in glycogen storage disease type Ia","volume":"498","author":"Cho","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"No.2","key":"10.1016\/j.cbi.2026.112358_bib41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s42000-020-00184-z","article-title":"The metabolic implications of aquaporin 7 (AQP7) promoter variants in lean children and children with obesity","volume":"19","author":"Oikonomou","year":"2020","journal-title":"Hormones (Athens)"},{"issue":"No.4","key":"10.1016\/j.cbi.2026.112358_bib42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","article-title":"PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro","volume":"4","author":"Rosen","year":"1999","journal-title":"Mol. Cell"},{"issue":"No.12","key":"10.1016\/j.cbi.2026.112358_bib43","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.7150\/ijbs.62556","article-title":"Berberine modulates deacetylation of PPARgamma to promote adipose tissue remodeling and thermogenesis via AMPK\/SIRT1 pathway","volume":"17","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cbi.2026.112358_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134337","article-title":"Persistent metabolic toxicities following developmental exposure to hexafluoropropylene oxide trimer acid (HFPO-TA): roles of peroxisome proliferator activated receptor gamma","volume":"471","author":"Zhong","year":"2024","journal-title":"J. Hazard Mater."},{"issue":"No.19","key":"10.1016\/j.cbi.2026.112358_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910431","article-title":"PPARgamma and TGFbeta-Major regulators of metabolism, inflammation, and fibrosis in the lungs and kidneys","volume":"22","author":"Kokeny","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"No.3","key":"10.1016\/j.cbi.2026.112358_bib46","first-page":"160","article-title":"New approach in the treatment of T2DM and metabolic syndrome (focus on a novel insulin sensitizer)","volume":"38","author":"Tjokroprawiro","year":"2006","journal-title":"Acta Med. Indones."},{"key":"10.1016\/j.cbi.2026.112358_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173252","article-title":"Oleanolic acid induces a dual agonist action on PPARgamma\/alpha and GLUT4 translocation: a pentacyclic triterpene for dyslipidemia and type 2 diabetes","volume":"883","author":"Loza-Rodriguez","year":"2020","journal-title":"Eur. J. Pharmacol."}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726004667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726004667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:35:34Z","timestamp":1793928934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726004667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":47,"alternative-id":["S0009279726004667"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112358","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The emerging contaminant HFPO-TA impairs hepatic glucose metabolism and induces ppar\u03b3-associated lipid metabolic disorders in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112358"}}