{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T02:23:23Z","timestamp":1794104603648,"version":"4.8.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021183","name":"Science Fund for Distinguished Young Scholars of Jiangxi Province","doi-asserted-by":"publisher","award":["20224ACB215001"],"award-info":[{"award-number":["20224ACB215001"]}],"id":[{"id":"10.13039\/501100021183","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370896"],"award-info":[{"award-number":["32370896"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900597"],"award-info":[{"award-number":["31900597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560418"],"award-info":[{"award-number":["82560418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022957","name":"Double Thousand Plan of Jiangxi Province","doi-asserted-by":"publisher","award":["jxsq2023201122"],"award-info":[{"award-number":["jxsq2023201122"]}],"id":[{"id":"10.13039\/100022957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["S20258619"],"award-info":[{"award-number":["S20258619"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemico-Biological Interactions"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cbi.2026.112382","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:11:07Z","timestamp":1791501067000},"page":"112382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Exemestane induces a reduction in hematopoietic stem cells and immunotoxicity in zebrafish larvae by downregulating wnt signaling pathway"],"prefix":"10.1016","volume":"440","author":[{"given":"Weirong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junquan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milen I.","family":"Georgiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8463-4996","authenticated-orcid":false,"given":"Zigang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbi.2026.112382_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jchemneu.2018.10.004","article-title":"Aromatase expression and function in the brain and behavior: a comparison across communication systems in teleosts","volume":"94","author":"Shaw","year":"2018","journal-title":"J. Chem. Neuroanat."},{"issue":"6","key":"10.1016\/j.cbi.2026.112382_bib2","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1007\/s11010-021-04099-0","article-title":"Regulation of aromatase in cancer","volume":"476","author":"Molehin","year":"2021","journal-title":"Mol. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.cbi.2026.112382_bib3","doi-asserted-by":"crossref","DOI":"10.1124\/molpharm.122.000545","article-title":"Inhibition of the aromatase enzyme by exemestane cysteine conjugates","volume":"102","author":"Teslenko","year":"2022","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.cbi.2026.112382_bib4","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s12325-021-01924-2","article-title":"Role of exemestane in the treatment of estrogen-receptor-positive breast cancer: a narrative review of recent evidence","volume":"39","author":"Wang","year":"2022","journal-title":"Adv. Ther."},{"issue":"2","key":"10.1016\/j.cbi.2026.112382_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1016121822916","article-title":"Overview of the pharmacology of the aromatase inactivator exemestane","volume":"74","author":"Brueggemeier","year":"2002","journal-title":"Breast Cancer Res. Treat."},{"issue":"17","key":"10.1016\/j.cbi.2026.112382_bib6","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.2174\/1871520620666200627204105","article-title":"Aromatase inhibitors for the treatment of breast cancer: a journey from the scratch","volume":"20","author":"Ratre","year":"2020","journal-title":"Anti Cancer Agents Med. Chem."},{"issue":"3","key":"10.1016\/j.cbi.2026.112382_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1158\/1940-6207.CAPR-15-0269","article-title":"Exemestane use in postmenopausal women at high risk for invasive breast cancer: evaluating biomarkers of efficacy and safety","volume":"9","author":"Gatti-Mays","year":"2016","journal-title":"Cancer Prev. Res."},{"issue":"4","key":"10.1016\/j.cbi.2026.112382_bib8","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1177\/1078155220957726","article-title":"Exemestane induced cholestatic liver injury - a case report","volume":"27","author":"Fritzsche","year":"2021","journal-title":"J. Oncol. Pharm. Pract. : official publication of the International Society of Oncology Pharmacy Practitioners"},{"issue":"4","key":"10.1016\/j.cbi.2026.112382_bib9","article-title":"A case of exemestane induced pseudocellulitis","volume":"33","author":"Xue Ting","year":"2020"},{"key":"10.1016\/j.cbi.2026.112382_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152951","article-title":"Lenvatinib exposure induces hepatotoxicity in zebrafish via inhibiting Wnt signaling","volume":"462","author":"Huang","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.cbi.2026.112382_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.socscimed.2020.113420","article-title":"Health care, overconsumption and uneconomic growth: a conceptual framework","volume":"266","author":"Hensher","year":"2020","journal-title":"Soc. Sci. Med."},{"issue":"11","key":"10.1016\/j.cbi.2026.112382_bib12","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1039\/c000408c","article-title":"Pharmacologically active compounds in the environment and their chirality","volume":"39","author":"Kasprzyk-Hordern","year":"2010","journal-title":"Chem. Soc. Rev."},{"issue":"10","key":"10.1016\/j.cbi.2026.112382_bib13","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1111\/risa.13856","article-title":"Judging pharmaceutical environmental risk by its cover? The effects of prescription medication and disease severity on environmental risk perception","volume":"42","author":"Lu\u00eds","year":"2021","journal-title":"Risk Anal."},{"key":"10.1016\/j.cbi.2026.112382_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108898","article-title":"Sanguinarine exposure induces immunotoxicity and abnormal locomotor behavior in zebrafish","volume":"139","author":"Li","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbi.2026.112382_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108977","article-title":"Immunotoxicity and transcriptome analysis of zebrafish embryos exposure to Nitazoxanide","volume":"141","author":"Lu","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbi.2026.112382_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116902","article-title":"Benzalkonium chloride induces hematopoietic stem cell reduction and immunotoxicity in zebrafish larvae","volume":"284","author":"Zeng","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.cbi.2026.112382_bib17","article-title":"The zebrafish: a fintastic model for hematopoietic development and disease","volume":"7","author":"Gore","year":"2018","journal-title":"Wiley Interdiscip. Rev.: Dev. Biol."},{"issue":"7","key":"10.1016\/j.cbi.2026.112382_bib18","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1182\/blood-2007-10-052761","article-title":"Zebrafish in hematology: sushi or science?","volume":"111","author":"Carradice","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.cbi.2026.112382_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2024.105286","article-title":"Zebrafish use conserved CLR and TLR signaling pathways to respond to fungal PAMPs in zymosan","volume":"162","author":"Glass","year":"2025","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.cbi.2026.112382_bib20","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/cpt.2311","article-title":"Interaction between SNP genotype and efficacy of anastrozole and exemestane in early-stage breast cancer","volume":"110","author":"Cairns","year":"2021","journal-title":"Clin. Pharmacol. Therapeut."},{"issue":"2","key":"10.1016\/j.cbi.2026.112382_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13020122","article-title":"The Acute Toxicity and Cardiotoxic Effects of Levofloxacin on Zebrafish (Danio rerio)","volume":"13","author":"Wu","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.cbi.2026.112382_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuro.2022.10.016","article-title":"Propranolol hydrochloride induces neurodevelopmental toxicity and locomotor disorders in zebrafish larvae","volume":"93","author":"Li","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbi.2026.112382_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113842","article-title":"Zebrafish (Danio rerio) as a model organism for screening nephrotoxic chemicals and related mechanisms","volume":"242","author":"Lim","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbi.2026.112382_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.113926","article-title":"Exposure to diclofop-methyl induces cardiac developmental toxicity in zebrafish embryos","volume":"259","author":"Cao","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbi.2026.112382_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124423","article-title":"Immunotoxicity and transcriptome analysis of zebrafish embryos in response to glufosinate-ammonium exposure","volume":"236","author":"Xiong","year":"2019","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.cbi.2026.112382_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10695-025-01588-7","article-title":"Exemestane induces liver toxicity in zebrafish larvae by upregulating the p53 signaling pathway","volume":"51","author":"Li","year":"2025","journal-title":"Fish Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.cbi.2026.112382_bib28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.stem.2011.06.011","article-title":"Wnt to notch relay signaling induces definitive hematopoiesis","volume":"9","author":"Loeffler","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cbi.2026.112382_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108672","article-title":"Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4\/NF-\u03baB\/p53 pathway","volume":"135","author":"Jia","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.cbi.2026.112382_bib30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/wsbm.1331","article-title":"Signaling via the NF\u03baB system","volume":"8","author":"Mitchell","year":"2016","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.cbi.2026.112382_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1214095","article-title":"NF-kB's contribution to B cell fate decisions","volume":"14","author":"Guldenpfennig","year":"2023","journal-title":"Front. Immunol."},{"issue":"7\u20138","key":"10.1016\/j.cbi.2026.112382_bib32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.etp.2013.02.003","article-title":"Didecyldimethylammonium chloride induces pulmonary fibrosis in association with TGF-\u03b2 signaling in mice","volume":"65","author":"Ohnuma-Koyama","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.cbi.2026.112382_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109550","article-title":"Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish","volume":"345","author":"Umamaheswari","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"6","key":"10.1016\/j.cbi.2026.112382_bib33","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00467-018-4005-4","article-title":"Oxidative stress in chronic kidney disease","volume":"34","author":"Daenen","year":"2019","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.cbi.2026.112382_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113870","article-title":"Isoprocarb causes neurotoxicity of zebrafish embryos through oxidative stress-induced apoptosis","volume":"242","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.cbi.2026.112382_bib36","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180992","article-title":"Apoptosis and apoptotic body: disease message and therapeutic target potentials","volume":"39","author":"Xu","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.cbi.2026.112382_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152102","article-title":"Hematopoietic stem cell and immunotoxicity in zebrafish embryos induced by exposure to Metalaxyl-M","volume":"809","author":"Zeng","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.cbi.2026.112382_bib38","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12943-020-01276-5","article-title":"Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities","volume":"19","author":"Xu","year":"2020","journal-title":"Mol. Cancer"}],"container-title":["Chemico-Biological Interactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726004904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009279726004904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T01:28:35Z","timestamp":1794101315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009279726004904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":37,"alternative-id":["S0009279726004904"],"URL":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112382","relation":{},"ISSN":["0009-2797"],"issn-type":[{"value":"0009-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exemestane induces a reduction in hematopoietic stem cells and immunotoxicity in zebrafish larvae by downregulating wnt signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Chemico-Biological Interactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbi.2026.112382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112382"}}