{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:34:01Z","timestamp":1777566841367,"version":"3.51.4"},"reference-count":97,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Chemical Biology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.cbpa.2012.03.007","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T20:16:31Z","timestamp":1333052191000},"page":"150-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology"],"prefix":"10.1016","volume":"16","author":[{"given":"Madan K","family":"Kharel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Rohr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2012.03.007_bib0005_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1039\/C1NP00068C","article-title":"Angucyclines: biosynthesis, mode-of-action, new natural products, and synthesis","volume":"29","author":"Kharel","year":"2012","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0010","doi-asserted-by":"crossref","first-page":"492","DOI":"10.7164\/antibiotics.43.492","article-title":"Landomycins, new angucycline antibiotics from Streptomyces sp. I. Structural studies on landomycins A\u2013D","volume":"43","author":"Henkel","year":"1990","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0015","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1021\/jo00094a037","article-title":"Investigations of the biosynthesis and structural revision of landomycin A","volume":"59","author":"Weber","year":"1994","journal-title":"J Org Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0020","doi-asserted-by":"crossref","first-page":"383","DOI":"10.7164\/antibiotics.57.383","article-title":"Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and its initial characterization","volume":"57","author":"Gromyko","year":"2004","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0025","first-page":"22","article-title":"The isolation and characteristics of mutant Streptomyces globisporus 1912 defective for landomycin E biosynthesis","volume":"61","author":"Matseliukh","year":"1999","journal-title":"Mikrobiol Z"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/np100469y","article-title":"Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136","volume":"74","author":"Shaaban","year":"2011","journal-title":"J Nat Prod"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0035","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ja.2010.121","article-title":"11-Deoxylandomycinone and landomycins X\u2013Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain","volume":"64","author":"Shaaban","year":"2011","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0040","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1021\/ja973348b","article-title":"Synthesis of the hexasaccharide fragment of landomycin A: application of glycosyl tetrazoles and phosphites in the synthesis of a deoxyoligosaccharide","volume":"120","author":"Guo","year":"1998","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0045","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0968-0896(00)00166-8","article-title":"Syntheses and biological evaluation of new glyco-modified angucyclin-antibiotics","volume":"8","author":"Kirschning","year":"2000","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0050","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1021\/ja000743k","article-title":"A highly stereoselective synthesis of the landomycin A hexasaccharide unit","volume":"122","author":"Roush","year":"2000","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0055","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.1021\/jo015756a","article-title":"Studies on the synthesis of landomycin A: synthesis and glycosidation reactions of l-rhodinosyl acetate derivatives","volume":"66","author":"Roush","year":"2001","journal-title":"J Org Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0060","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1021\/jo049426c","article-title":"Studies on the synthesis of landomycin A. Synthesis of the originally assigned structure of the aglycone, landomycinone, and revision of the structure","volume":"69","author":"Roush","year":"2004","journal-title":"J Org Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0065","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1021\/ol0259286","article-title":"Efficient synthesis of the hexasaccharide fragment of landomycin A: using phenyl 2,3-O-thionocarbonyl-1-thioglycosides as 2-deoxy-beta-glycoside precursors","volume":"4","author":"Yu","year":"2002","journal-title":"Org Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0070","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1021\/ol800697k","article-title":"De novo synthesis of the trisaccharide subunit of landomycins A and E","volume":"10","author":"Zhou","year":"2008","journal-title":"Org Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0075_1","doi-asserted-by":"crossref","first-page":"12433","DOI":"10.1021\/ja205339p","article-title":"Total synthesis of landomycin A, a potent antitumor angucycline antibiotic","volume":"133","author":"Yang","year":"2011","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0080","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0960-894X(99)00261-9","article-title":"Landomycin A inhibits DNA synthesis and G1\/S cell cycle progression","volume":"9","author":"Crow","year":"1999","journal-title":"Bioorg Med Chem Lett"},{"issue":"Suppl. II","key":"10.1016\/j.cbpa.2012.03.007_bib0085","first-page":"A80\/316","article-title":"Assessment of antitumor activity of landomycin A (NSC 6399187-A)","volume":"73","author":"Depenbrock","year":"1996","journal-title":"Ann Hematol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0090","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.bcp.2007.08.026","article-title":"Mechanisms underlying the anticancer activities of the angucycline landomycin E","volume":"74","author":"Korynevska","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0095","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.2174\/138955709788922593","article-title":"Chemistry and biology of landomycins, an expanding family of polyketide natural products","volume":"9","author":"Ostash","year":"2009","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0100","first-page":"54","article-title":"Study of the mechanism of landomycin E action on mammalian cells","volume":"35","author":"Panchuk","year":"2004","journal-title":"Visn L\u2019viv Univ Ser Biol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0105","first-page":"330","article-title":"Effect of landomycin E on expression of mRNA coding for transforming growth factor beta ligands and specific receptors in MCF-7 cells","volume":"27","author":"Panchuk","year":"2005","journal-title":"Exp Oncol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1128\/jb.69.3.280-283.1955","article-title":"Chrysomycin: a new antibiotic substance for bacterial viruses","volume":"69","author":"Strelitz","year":"1955","journal-title":"J Bacteriol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0115","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1246\/bcsj.54.1338","article-title":"Crystal and molecular structure of antibiotic gilvocarcin M","volume":"54","author":"Hirayama","year":"1981","journal-title":"Bull Chem Soc Jpn"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0120","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.7164\/antibiotics.34.1544","article-title":"Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E","volume":"34","author":"Balitz","year":"1981","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0125","doi-asserted-by":"crossref","first-page":"701","DOI":"10.7164\/antibiotics.34.701","article-title":"Gilvocarcins, new antitumor antibiotics. 3. Antitumor activity","volume":"34","author":"Morimoto","year":"1981","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0130","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1139\/v81-438","article-title":"The structure of ravidomycin","volume":"59","author":"Findlay","year":"1981","journal-title":"Can J Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0135","first-page":"1157","article-title":"Toromycin: a new antibiotic produced by Streptomyces collinas subsp. albescens subsp. nov","volume":"44","author":"Hatano","year":"1980","journal-title":"Agric Biol Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0140","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0040-4020(01)91834-4","article-title":"Structure and stereochemistry of toromycin: studies of its acid-catalyzed rearrangement","volume":"39","author":"Jain","year":"1983","journal-title":"Tetrahedron"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0145","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1021\/ja00162a046","article-title":"Gilvocarcin photobiology. isolation and characterization of the DNA photoadduct","volume":"112","author":"McGee","year":"1990","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0150","doi-asserted-by":"crossref","first-page":"7818","DOI":"10.1021\/ja034781q","article-title":"The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins","volume":"125","author":"Fischer","year":"2003","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7164\/antibiotics.34.271","article-title":"Gilvocarcins, new antitumor antibiotics. 2. Structural elucidation","volume":"34","author":"Takahashi","year":"1981","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0160","doi-asserted-by":"crossref","first-page":"355","DOI":"10.7164\/antibiotics.36.355","article-title":"Ravidomycin (AY-25,545), a new antitumor antibiotic","volume":"36","author":"Sehgal","year":"1983","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0165","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.7164\/antibiotics.35.1194","article-title":"The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A","volume":"35","author":"Weiss","year":"1982","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0170","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1039\/b808633h","article-title":"Plasticity in gilvocarcin-type C-glycoside pathways: discovery and antitumoral evaluation of polycarcin V from Streptomyces polyformus","volume":"6","author":"Li","year":"2008","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0175","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.7164\/antibiotics.44.1061","article-title":"New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. II. Structure determination","volume":"44","author":"Nakajima","year":"1991","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0180","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.7164\/antibiotics.51.1105","article-title":"New ravidomycin analogues, FE35A and FE35B, apoptosis inducers produced by Streptomyces rochei","volume":"51","author":"Yamashita","year":"1998","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0185","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1751-1097.1994.tb05095.x","article-title":"Photoactivated gilvocarcin V induces DNA-protein crosslinking in genes for human ribosomal RNA and dihydrofolate reductase","volume":"60","author":"Matsumoto","year":"1994","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0190","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.6229029","article-title":"Activation of antitumor agent gilvocarcins by visible light","volume":"223","author":"Elespuru","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0195","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0006-291X(87)90320-2","article-title":"Light-induced modifications of DNA by gilvocarcin V and its aglycone","volume":"143","author":"Tse-Dinh","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0200_1","first-page":"3921","article-title":"Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts","volume":"60","author":"Matsumoto","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0205","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1751-1097.1993.tb04976.x","article-title":"Antiviral activity of gilvocarcin V plus UVA radiation","volume":"58","author":"Lytle","year":"1993","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0210","first-page":"341","article-title":"Gilvocarcins","volume":"114","author":"Hua","year":"1995","journal-title":"J R Netherl Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0215","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1021\/ja00082a023","article-title":"Total synthesis of the gilvocarcins","volume":"116","author":"Hosoya","year":"1994","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0220","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0040-4039(99)02235-2","article-title":"Total synthesis of ravidomycin: revision of absolute and relative stereochemistry","volume":"41","author":"Futagami","year":"2000","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0225","series-title":"Bioorganic Chemistry","first-page":"305","article-title":"Investigations on the biosynthesis of landomycin A","author":"Wohlert","year":"1999"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0230","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.7164\/antibiotics.36.1531","article-title":"Gilvocarcins, new antitumor antibiotics. 5. Biosynthesis of gilvocarcins: incorporation of 13C-labeled compounds into gilvocarcin aglycones","volume":"36","author":"Takahashi","year":"1983","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0235","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0040-4039(00)99854-X","article-title":"Biosynthesis of ravidomycin. Use of 13C\u201313C double quantum NMR to follow precursor incorporation","volume":"25","author":"Carter","year":"1984","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0240","doi-asserted-by":"crossref","first-page":"242","DOI":"10.7164\/antibiotics.38.242","article-title":"Biosynthesis of chrysomycins A and B. Origin of the chromophore","volume":"38","author":"Carter","year":"1985","journal-title":"J Antibiot"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0245","doi-asserted-by":"crossref","first-page":"12262","DOI":"10.1021\/ja0467521","article-title":"Oxidative rearrangement processes in the biosynthesis of gilvocarcin V","volume":"126","author":"Liu","year":"2004","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0250","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.1021\/jo00287a031","article-title":"Stereochemistry of hydrogen loss on formation of the vinyl group in the biosynthesis of ravidomycin","volume":"54","author":"Keyes","year":"1989","journal-title":"J Org Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0255","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1574-6968.1999.tb13398.x","article-title":"Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis","volume":"170","author":"Westrich","year":"1999","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0260","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-1097(03)00861-9","article-title":"Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene","volume":"230","author":"Von Mulert","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0265","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/BF02931329","article-title":"Targeted disruption of Streptomyces globisporus lndF and lndL cyclase genes involved in landomycin E biosynthesis","volume":"48","author":"Ostash","year":"2003","journal-title":"Folia Microbiol (Praha)"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0270","first-page":"97","article-title":"Cloning and sequencing of a putative positive transcription regulator gene of landomycin E biosynthetic gene cluster of Streptomyces globisporus 1912","volume":"27","author":"Pankevych","year":"2001","journal-title":"Visn L\u2019viv Univ Ser Biol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0275","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0378-1097(03)00258-1","article-title":"Production of landomycins in Streptomyces globisporus 1912 and Streptomyces cyanogenus S136 is regulated by genes encoding putative transcriptional activators","volume":"222","author":"Rebets","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0280_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1099\/mic.0.27244-0","article-title":"DNA-binding activity of LndI protein and temporal expression of the gene that upregulates landomycin E production in Streptomyces globisporus 1912","volume":"151","author":"Rebets","year":"2005","journal-title":"Microbiology"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0285_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1574-6968.2005.00087.x","article-title":"Expression of the regulatory protein LndI for landomycin E production in Streptomyces globisporus 1912 is controlled by the availability of tRNA for the rare UUA codon","volume":"256","author":"Rebets","year":"2006","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0290_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chembiol.2005.05.008","article-title":"Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A","volume":"12","author":"Luzhetskyy","year":"2005","journal-title":"Chem Biol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0295","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/cbic.200400123","article-title":"Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis","volume":"5","author":"Luzhetskyy","year":"2004","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0300","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/cbic.200500018","article-title":"LanGT2 catalyzes the first glycosylation step during landomycin A biosynthesis","volume":"6","author":"Luzhetskyy","year":"2005","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0305","first-page":"117","article-title":"Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides","volume":"1","author":"Luzhetskyy","year":"2005","journal-title":"Mol Biol Syst"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0310","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1134\/S1022795410050030","article-title":"Properties of lanK-based regulatory circuit involved in landomycin biosynthesis in Streptomyces cyanognes S136","volume":"46","author":"Ostash","year":"2010","journal-title":"Russ J Genet"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0315","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1574-6968.2008.01225.x","article-title":"Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136","volume":"285","author":"Ostash","year":"2008","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0320","first-page":"1032","article-title":"Proton-dependent transporter gene lndJ confers resistance to landomycin E in Streptomyces globisporus","volume":"43","author":"Ostash","year":"2007","journal-title":"Genetika"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0325","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00203-008-0367-5","article-title":"An ABC transporter encoding gene lndW confers resistance to landomycin E","volume":"190","author":"Ostash","year":"2008","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0330","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00203-007-0299-5","article-title":"Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes","volume":"189","author":"Rebets","year":"2008","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0335","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S1074-5521(01)00091-6","article-title":"Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics","volume":"8","author":"Trefzer","year":"2001","journal-title":"Chem Biol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0340","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/cbic.200400316","article-title":"Generation of novel landomycins M and O through targeted gene disruption","volume":"6","author":"Luzhetskyy","year":"2005","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0345","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.chembiol.2004.03.011","article-title":"Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus","volume":"11","author":"Ostash","year":"2004","journal-title":"Chem Biol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0350","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cbic.200600360","article-title":"Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136","volume":"8","author":"Zhu","year":"2007","journal-title":"ChemBiochem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0355","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/cbic.200300793","article-title":"Rational saccharide extension by using the natural product glycosyltransferase LanGT4","volume":"5","author":"Hoffmeister","year":"2004","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0360","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1021\/jo0483623","article-title":"Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone","volume":"70","author":"Zhu","year":"2005","journal-title":"J Org Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0365","doi-asserted-by":"crossref","first-page":"7842","DOI":"10.1002\/anie.200603176","article-title":"On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-glycosides from an engineered mutant of Streptomyces globisporus 1912 Delta lndE(urdGT2)","volume":"45","author":"Baig","year":"2006","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0370_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/cbic.200900673","article-title":"Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters","volume":"11","author":"Kharel","year":"2010","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0375_1","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1021\/ol1009009","article-title":"Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic","volume":"12","author":"Kharel","year":"2010","journal-title":"Org Lett"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0380","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1021\/ja982707f","article-title":"Functional characterization of the jadI gene as a cyclase forming angucyclinones","volume":"121","author":"Kulowski","year":"1999","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0385_1","series-title":"Comprehensive Natural Products II\u2014Chemistry and Biology","first-page":"227","article-title":"Structural diversity. I: type II PKS","author":"Rohr","year":"2010"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0390_1","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1039\/c0ob00036a","article-title":"Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity","volume":"8","author":"Shepherd","year":"2010","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0395","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/cbic.200800348","article-title":"Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity","volume":"10","author":"Liu","year":"2009","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0400","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1021\/ja0680515","article-title":"Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses","volume":"129","author":"Kharel","year":"2007","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0405","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/cbic.200900130","article-title":"GilR, an unusual lactone-forming enzyme involved in gilvocarcin biosynthesis","volume":"10","author":"Kharel","year":"2009","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0410","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/cbic.200600031","article-title":"Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated","volume":"7","author":"Liu","year":"2006","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0415_1","doi-asserted-by":"crossref","first-page":"23533","DOI":"10.1074\/jbc.M111.247833","article-title":"The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis","volume":"286","author":"Noinaj","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0490","doi-asserted-by":"crossref","DOI":"10.1039\/c2ob07171a","article-title":"Elucidation of post-PKS tailoring steps involved in landomycin biosynthesis","author":"Kharel","year":"2012","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0425","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/cbic.200400395","article-title":"The oxidative ring cleavage in jadomycin biosynthesis: a multistep oxygenation cascade in a biosynthetic black box","volume":"6","author":"Rix","year":"2005","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0430","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1002\/cbic.200500205","article-title":"LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis","volume":"6","author":"Mayer","year":"2005","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0435","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.chembiol.2007.12.011","article-title":"Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C","volume":"15","author":"Kallio","year":"2008","journal-title":"Chem Biol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0440_1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/anie.201105882","article-title":"Enzymatic total synthesis of defucogilvocarcin M and its implications on gilvocarcin biosynthesis","volume":"51","author":"Pahari","year":"2012","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0445","doi-asserted-by":"crossref","first-page":"12432","DOI":"10.1021\/ja072311g","article-title":"Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027","volume":"129","author":"Lin","year":"2007","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0450","doi-asserted-by":"crossref","first-page":"22508","DOI":"10.1074\/jbc.M414229200","article-title":"Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase\/dehydrase","volume":"280","author":"Chen","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0455","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/cbic.201000178","article-title":"Characterization of JadH as an FAD- and NAD(P)H-dependent bifunctional hydroxylase\/dehydrase in jadomycin biosynthesis","volume":"11","author":"Chen","year":"2010","journal-title":"ChemBioChem"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0460","doi-asserted-by":"crossref","first-page":"14901","DOI":"10.1073\/pnas.221582098","article-title":"Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine","volume":"98","author":"Chen","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0465","doi-asserted-by":"crossref","first-page":"13994","DOI":"10.1021\/bi701148b","article-title":"Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC","volume":"46","author":"Fielding","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0470_1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nature05702","article-title":"Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis","volume":"447","author":"Widboom","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0475_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1074-5521(96)90114-3","article-title":"Achieving natural product synthesis and diversity via catalytic networking ex vivo","volume":"3","author":"Roessner","year":"1996","journal-title":"Chem Biol"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0480_1","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1126\/science.8248801","article-title":"Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A","volume":"262","author":"Shen","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2012.03.007_bib0485","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nchembio.2007.22","article-title":"Enzymatic total synthesis of enterocin polyketides","volume":"3","author":"Cheng","year":"2007","journal-title":"Nat Chem Biol"}],"container-title":["Current Opinion in Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367593112000270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367593112000270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T02:28:02Z","timestamp":1761272882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1367593112000270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":97,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1367593112000270"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2012.03.007","relation":{},"ISSN":["1367-5931"],"issn-type":[{"value":"1367-5931","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2012.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}