{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:39Z","timestamp":1791528579047,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Chemical Biology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.cbpa.2016.01.010","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T10:49:08Z","timestamp":1454582948000},"page":"50-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Microbial transformations in phosphonate biosynthesis and catabolism, and their importance in nutrient cycling"],"prefix":"10.1016","volume":"31","author":[{"given":"Jason P","family":"Chin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2016.01.010_bib0250","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrmicro3011","article-title":"Organophosphonates revealed: new insights into the microbial metabolism of ancient molecules","volume":"11","author":"McGrath","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0255","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-marine-010213-135046","article-title":"Microbially mediated transformations of phosphorus in the sea: new views of an old cycle","volume":"6","author":"Karl","year":"2014","journal-title":"Annu Rev Mar Sci"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0260","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/30881","article-title":"Marine phosphorus is selectively remineralized","volume":"393","author":"Clark","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0265","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4319\/lo.2001.46.2.0309","article-title":"Composition and cycling of marine organic phosphorus","volume":"46","author":"Kolowith","year":"2001","journal-title":"Limnol Oceanogr"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0270","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10498-009-9087-y","article-title":"Marine dissolved organic phosphorus composition: insights from samples recovered using combined electrodialysis\/reverse osmosis","volume":"16","author":"Young","year":"2010","journal-title":"Aquat Geochem"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0275","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fmicb.2012.00019","article-title":"The genes and enzymes of phosphonate metabolism by bacteria, and their distribution in the marine environment","volume":"3","author":"Villarreal-Chiu","year":"2012","journal-title":"Front Microbiol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0280","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1126\/science.1219875","article-title":"Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean","volume":"337","author":"Metcalf","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0285","doi-asserted-by":"crossref","first-page":"20759","DOI":"10.1073\/pnas.1315107110","article-title":"Diversity and abundance of phosphonate biosynthetic genes in nature","volume":"110","author":"Yu","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0290","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1462-2920.2009.02062.x","article-title":"Widespread known and novel phosphonate utilization pathways in marine bacteria revealed by functional screening and metagenomic analyses","volume":"12","author":"Martinez","year":"2010","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0295","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/j.1462-2920.2011.02612.x","article-title":"Phosphite utilization by the marine picocyanobacterium Prochlorococcus MIT9301","volume":"14","author":"Mart\u00ednez","year":"2012","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0300","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00203-011-0775-9","article-title":"Most probable number quantification of hypophosphite and phosphite oxidizing bacteria in natural aquatic and terrestrial environments","volume":"194","author":"Stone","year":"2012","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0305","first-page":"12308","article-title":"Phosphite utilization by the globally important marine diazotroph Trichodesmium","author":"Polyviou","year":"2015","journal-title":"Environ Microbiol Rep"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0310","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ismej.2011.149","article-title":"Potential for phosphite and phosphonate utilization by Prochlorococcus","volume":"6","author":"Feingersch","year":"2011","journal-title":"ISME J"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0315","doi-asserted-by":"crossref","first-page":"15468","DOI":"10.1073\/pnas.1408134111","article-title":"Redox chemistry in the phosphorus biogeochemical cycle","volume":"111","author":"Pasek","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0320","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1126\/science.aaa8181","article-title":"Major role of planktonic phosphate reduction in the marine phosphorus redox cycle","volume":"348","author":"Van Mooy","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0325","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cbpa.2013.06.018","article-title":"Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology","volume":"17","author":"Peck","year":"2013","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0330","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.cbpa.2013.06.006","article-title":"The enzymatic conversion of phosphonates to phosphate by bacteria","volume":"17","author":"Kamat","year":"2013","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0335","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.biochem.78.091707.100215","article-title":"Biosynthesis of phosphonic and phosphinic acid natural products","volume":"78","author":"Metcalf","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0340","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10295-013-1375-2","article-title":"Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways","volume":"41","author":"Ju","year":"2014","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0345","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1021\/cb400102t","article-title":"Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection","volume":"8","author":"Evans","year":"2013","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0350","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1002\/anie.201308363","article-title":"Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster","volume":"53","author":"Gao","year":"2014","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0355","doi-asserted-by":"crossref","DOI":"10.1038\/ja.2015.62","article-title":"Evaporative light scattering quantification of natural products possessing a carbon\u2013phosphorus bond","author":"Chi","year":"2015","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0360","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1021\/np400722m","article-title":"Cyanohydrin phosphonate natural product from Streptomyces regensis","volume":"77","author":"Cioni","year":"2014","journal-title":"J Nat Prod"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0365","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1128\/JB.00036-14","article-title":"Purification and characterization of phosphonoglycans from Glycomyces sp. strain NRRL B-16210 and Stackebrandtia nassauensis NRRL B-16338","volume":"196","author":"Yu","year":"2014","journal-title":"J Bacteriol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0370","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ja.2014.149","article-title":"Identification of the biosynthetic gene cluster for the herbicide phosphonothrixin in Saccharothrix sp., ST-888","volume":"68","author":"Lin","year":"2015","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0375","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1039\/C4SC03095H","article-title":"Biosynthesis of fosfazinomycin is a convergent process","volume":"6","author":"Huang","year":"2015","journal-title":"Chem Sci"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0380","doi-asserted-by":"crossref","first-page":"12157","DOI":"10.1073\/pnas.1500873112","article-title":"Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes","volume":"112","author":"Ju","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0385","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1126\/science.1240373","article-title":"Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase","volume":"342","author":"Wang","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0390","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature11998","article-title":"Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction","volume":"496","author":"Chang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0395","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1021\/ja403441x","article-title":"Reaction of HppE with substrate analogues: evidence for carbon\u2013phosphorus bond cleavage by a carbocation rearrangement","volume":"135","author":"Chang","year":"2013","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0400","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.1073\/pnas.1303568110","article-title":"Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway","volume":"110","author":"Bougioukou","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0405","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.bbapap.2014.09.009","article-title":"Spectroscopic characterization and mechanistic investigation of P-methyl transfer by a radical SAM enzyme from the marine bacterium Shewanella denitrificans OS217","volume":"1844","author":"Allen","year":"2014","journal-title":"Biochim Biophys Acta BBA\u2014Proteins Proteom"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0410","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.chembiol.2013.11.006","article-title":"Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation","volume":"21","author":"Agarwal","year":"2014","journal-title":"Chem Biol"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0415","doi-asserted-by":"crossref","first-page":"15660","DOI":"10.1021\/ja306777w","article-title":"Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase","volume":"134","author":"Cooke","year":"2012","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0420","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1021\/jacs.5b00282","article-title":"A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase","volume":"137","author":"Peck","year":"2015","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0425","doi-asserted-by":"crossref","first-page":"20702","DOI":"10.1074\/jbc.R115.648691","article-title":"Catalytic mechanisms of Fe(II)- and 2-oxoglutarate-dependent oxygenases","volume":"290","author":"Martinez","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0430","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1111\/j.1462-2920.2007.01397.x","article-title":"New ways to break an old bond: the bacterial carbon\u2013phosphorus hydrolases and their role in biogeochemical phosphorus cycling","volume":"9","author":"Quinn","year":"2007","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0435","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1128\/aem.58.4.1364-1366.1992","article-title":"Metabolism of phosphonoacetate as the sole carbon and phosphorus source by an environmental bacterial isolate","volume":"58","author":"McMullan","year":"1992","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0440","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0005-2744(70)90214-7","article-title":"The enzymic cleavage of the carbon\u2013phosphorus bond: purification and properties of phosphonatase","volume":"212","author":"La Nauze","year":"1970","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0445","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1023\/A:1008848401799","article-title":"Organophosphonates: occurrence, synthesis and biodegradation by microorganisms","volume":"14","author":"Ternan","year":"1998","journal-title":"World J Microbiol Biotechnol"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0450","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3389\/fmicb.2013.00340","article-title":"Metatranscriptomic and functional metagenomic analysis of methylphosphonate utilization by marine bacteria","volume":"4","author":"Mart\u00ednez","year":"2013","journal-title":"Front Microbiol"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0455","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1038\/ncomms5346","article-title":"Methane production by phosphate-starved SAR11 chemoheterotrophic marine bacteria","volume":"5","author":"Carini","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0460","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/MMBR.00040-13","article-title":"Utilization of glyphosate as phosphate source: biochemistry and genetics of bacterial carbon\u2013phosphorus lyase","volume":"78","author":"Hove-Jensen","year":"2014","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0465","doi-asserted-by":"crossref","first-page":"7366","DOI":"10.1021\/bi4013287","article-title":"Potent inhibition of the C\u2013P lyase nucleosidase PhnI by immucillin-A triphosphate","volume":"52","author":"Kamat","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0470","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1021\/acs.biochem.5b00194","article-title":"Subunit interactions within the carbon\u2013phosphorus lyase complex from Escherichia coli","volume":"54","author":"Ren","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0475","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature14683","article-title":"Structural insights into the bacterial carbon\u2013phosphorus lyase machinery","volume":"525","author":"Seweryn","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0480","doi-asserted-by":"crossref","first-page":"8364","DOI":"10.1021\/ja302072f","article-title":"PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon\u2013phosphorus bond","volume":"134","author":"McSorley","year":"2012","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2016.01.010_sbref0485","doi-asserted-by":"crossref","first-page":"18874","DOI":"10.1073\/pnas.1315927110","article-title":"Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases","volume":"110","author":"W\u00f6rsd\u00f6rfer","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cbpa.2016.01.010_bib0490","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1073\/pnas.1320039111","article-title":"Crystal structure of PhnZ in complex with substrate reveals a di-iron oxygenase mechanism for catabolism of organophosphonates","volume":"111","author":"van Staalduinen","year":"2014","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Current Opinion in Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367593116000065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367593116000065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T02:35:48Z","timestamp":1761273348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1367593116000065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":49,"alternative-id":["S1367593116000065"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2016.01.010","relation":{},"ISSN":["1367-5931"],"issn-type":[{"value":"1367-5931","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbial transformations in phosphonate biosynthesis and catabolism, and their importance in nutrient cycling","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2016.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}