{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:08:33Z","timestamp":1761167313521,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["04229"],"award-info":[{"award-number":["04229"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.cbpa.2022.111342","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T22:27:34Z","timestamp":1668205654000},"page":"111342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Apocynin reduces dihydroethidium fluorescence in naked mole-rat cortex independently of NADPH oxidase"],"prefix":"10.1016","volume":"276","author":[{"given":"Liam","family":"Eaton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Welch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Karim","family":"Halal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bengtsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E.","family":"Pamenter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2022.111342_bb0005","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1523\/JNEUROSCI.4468-06.2007","article-title":"Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation","volume":"27","author":"Abramov","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbpa.2022.111342_bb0010","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2174\/138920008786049285","article-title":"Classical inhibitors of NOX NAD(P)H oxidases are not specific","volume":"9","author":"Aldieri","year":"2008","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.cbpa.2022.111342_bb0015","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1089\/ars.2013.5814","article-title":"Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement","volume":"23","author":"Altenhofer","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cbpa.2022.111342_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101272","article-title":"Pharmacological characterization of the seven human NOX isoforms and their inhibitors","volume":"26","author":"Augsburger","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1042\/BJ20081258","article-title":"Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation","volume":"418","author":"Aykin-Burns","year":"2009","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.cbpa.2022.111342_bb0030","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/brv.12791","article-title":"The naked truth: a comprehensive clarification and classification of current \u2018myths\u2019 in naked mole-rat biology","volume":"97","author":"Buffenstein","year":"2022","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.cbpa.2022.111342_bb0035","doi-asserted-by":"crossref","first-page":"36027","DOI":"10.1074\/jbc.M304854200","article-title":"Production of reactive oxygen species by mitochondria: central role of complex III","volume":"278","author":"Chen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpa.2022.111342_bb0040","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fcell.2018.00132","article-title":"Reactive oxygen species formation in the brain at different oxygen levels: the role of hypoxia inducible factors","volume":"6","author":"Chen","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0045","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1113\/JP281942","article-title":"Naked mole-rat brain mitochondria tolerate in vitro ischaemia","volume":"599","author":"Cheng","year":"2021","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/metabo12010056","article-title":"Metabolomic analysis of carbohydrate and amino acid changes induced by hypoxia in naked mole-rat brain and liver","volume":"12","author":"Cheng","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.cbpa.2022.111342_bb0055","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.cbpa.2022.111342_bb0060","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.3390\/ijms20102407","article-title":"Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases","volume":"20","author":"Collin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpa.2022.111342_bb0065","first-page":"3550","article-title":"Functional calcium imaging in developing cortical networks","volume":"56","author":"Dawitz","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cbpa.2022.111342_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2022.111259","article-title":"What to do with low O2: redox adaptations in vertebrates native to hypoxic environments","volume":"271","author":"Eaton","year":"2022","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"year":"2022","series-title":"Naked Mole-Rat Cortex Maintains Reactive Oxygen Species Homeostasis during In Vitro Hypoxia or Ischemia and Reperfusion","author":"Eaton","key":"10.1016\/j.cbpa.2022.111342_bb0075"},{"key":"10.1016\/j.cbpa.2022.111342_bb0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","article-title":"Identification of ROS using oxidized DCFDA and flow-cytometry","volume":"594","author":"Eruslanov","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0085","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1530\/jrf.0.0930427","article-title":"Social control of reproduction in breeding and non-breeding male naked mole-rats (Heterocephalus glaber)","volume":"93","author":"Faulkes","year":"1991","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.cbpa.2022.111342_bb0090","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuint.2013.09.012","article-title":"The effect of NADPH-oxidase inhibitor apocynin on cognitive impairment induced by moderate lateral fluid percussion injury: role of inflammatory and oxidative brain damage","volume":"63","author":"Ferreira","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbpa.2022.111342_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2022.111282","article-title":"Naked mole-rats resist the accumulation of hypoxia-induced oxidative damage","volume":"273","author":"Hadj-Moussa","year":"2022","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/HYPERTENSIONAHA.107.100214","article-title":"Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant","volume":"51","author":"Heumuller","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.cbpa.2022.111342_bb0105","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.yfrne.2009.04.010","article-title":"Neuroendocrinology and sexual differentiation in eusocial mammals","volume":"30","author":"Holmes","year":"2009","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0110","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.biopha.2017.10.123","article-title":"Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion hippocampus injury in rat brain","volume":"97","author":"Kapoor","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cbpa.2022.111342_bb0115","doi-asserted-by":"crossref","first-page":"11315","DOI":"10.1523\/JNEUROSCI.3590-07.2007","article-title":"Rapid activation of antioxidant defenses by nerve growth factor suppresses reactive oxygen species during neuronal apoptosis: evidence for a role in cytochrome c redistribution","volume":"27","author":"Kirkland","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbpa.2022.111342_bb0120","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbabio.2008.03.005","article-title":"Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport","volume":"1777","author":"Lambert","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpa.2022.111342_bb0125","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1471-4159.2007.04466.x","article-title":"Suppression of reactive oxygen species production enhances neuronal survival in vitro and in vivo in the anoxia-tolerant turtle Trachemys scripta","volume":"101","author":"Milton","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cbpa.2022.111342_bb0130","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s11064-014-1260-z","article-title":"Isoproterenol induced stressful reactions in the brain are characterized by inflammation due to activation of NADPH oxidase and ER stress: attenuated by Apocynin, Rehmannia complex and Triterpene acids","volume":"39","author":"Mo","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cbpa.2022.111342_bb0135","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.196725","article-title":"Adaptations to a hypoxic lifestyle in naked mole-rats","volume":"225","author":"Pamenter","year":"2022","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2021.111139","article-title":"Supermole-rat to the rescue: does the naked mole-rat offer a panacea for all that ails us?","volume":"266","author":"Pamenter","year":"2022","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0145","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00360-007-0145-8","article-title":"Anoxia-induced changes in reactive oxygen species and cyclic nucleotides in the painted turtle","volume":"177","author":"Pamenter","year":"2007","journal-title":"J. Comp. Physiol. B."},{"key":"10.1016\/j.cbpa.2022.111342_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101466","article-title":"A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action","volume":"32","author":"Reis","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0155","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3892\/mmr.2012.1147","article-title":"Attenuation of brain edema and spatial learning de fi cits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats","volume":"7","author":"Song","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cbpa.2022.111342_bb0160","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/ajrcmb.11.1.8018341","article-title":"Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol","volume":"11","author":"Stolk","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0165","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4161\/cbt.9.2.10583","article-title":"N-acetylcysteine, reactive oxygen species and beyond","volume":"9","author":"Sun","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.cbpa.2022.111342_bb0170","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/glia.22724","article-title":"Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases","volume":"62","author":"Wang","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.cbpa.2022.111342_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2020.110792","article-title":"Nitric oxide homeostasis is maintained during acute in vitro hypoxia and following reoxygenation in naked mole-rat but not mouse cortical neurons","volume":"250","author":"Wang","year":"2020","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0180","doi-asserted-by":"crossref","first-page":"9264","DOI":"10.1073\/pnas.1720530115","article-title":"Responses to pup vocalizations in subordinate naked mole-rats are induced by estradiol ingested through coprophagy of queen\u2019s feces","volume":"115","author":"Watarai","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpa.2022.111342_bb0185","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1476-5381.2010.00920.x","article-title":"Comparative pharmacology of chemically distinct NADPH oxidase inhibitors","volume":"161","author":"Wind","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbpa.2022.111342_bb0190","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.abb.2006.11.010","article-title":"The oxidation of apocynin catalyzed by myeloperoxidase: proposal for NADPH oxidase inhibition","volume":"457","author":"Ximenes","year":"2007","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643322002008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643322002008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:21:33Z","timestamp":1761085293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1095643322002008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":38,"alternative-id":["S1095643322002008"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2022.111342","relation":{},"ISSN":["1095-6433"],"issn-type":[{"type":"print","value":"1095-6433"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apocynin reduces dihydroethidium fluorescence in naked mole-rat cortex independently of NADPH oxidase","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2022.111342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111342"}}