{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:08:33Z","timestamp":1761167313926,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000154","name":"National Science Foundation Division of Integrative Organismal Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.cbpa.2023.111440","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T15:37:06Z","timestamp":1683646626000},"page":"111440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Exposure to hypoxia during embryonic development affects blood flow patterns and heart rate in juvenile American alligators during digestion"],"prefix":"10.1016","volume":"282","author":[{"given":"Brandt","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janna L.","family":"Crossley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Conner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M.","family":"Elsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Dane A.","family":"Crossley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2023.111440_bb0005","doi-asserted-by":"crossref","first-page":"8592","DOI":"10.1038\/s41598-019-45023-3","article-title":"Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics","volume":"9","author":"Alderman","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpa.2023.111440_bb0010","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00360-020-01257-6","article-title":"Growing up gator: a proteomic perspective on cardiac maturation in an oviparous reptile, the American alligator (alligator mississippiensis)","volume":"190","author":"Alderman","year":"2020","journal-title":"J. Comp. Physiol. B Biochem. Syst. Environ. Physiol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0015","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1086\/375439","article-title":"Cardiorespiratory effects of forced activity and digestion in toads","volume":"76","author":"Andersen","year":"2003","journal-title":"Physiol. Biochem. Zool."},{"key":"10.1016\/j.cbpa.2023.111440_bb0020","series-title":"Physiological and Ecological Adaptations to Feeding in Vertebrates","first-page":"306","article-title":"Specific dynamic action in ectothermic vertebrates: A review of the determinants of postprandial metabolic response in fishes, amphibians, and reptiles","author":"Andrade","year":"2005"},{"key":"10.1016\/j.cbpa.2023.111440_bb0025","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1469-445X.2001.tb00045.x","article-title":"The crocodilian heart; more controlled than we thought?","volume":"86","author":"Axelsson","year":"2001","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0030","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1242\/jeb.198.12.2509","article-title":"The role of the pericardium and the effects of adrenaline and changes in oxygen tension on the performance of an in situ perfused crocodile heart","volume":"198","author":"Axelsson","year":"1995","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0035","first-page":"R875","article-title":"Flow dynamics of the crocodilian heart","volume":"256","author":"Axelsson","year":"1989","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cbpa.2023.111440_bb0040","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1113\/jphysiol.2014.271460","article-title":"The biology of developmental plasticity and the predictive adaptive response hypothesis","volume":"592","author":"Bateson","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0034-5687(01)00206-7","article-title":"Effects of embryonic CO2 exposure on the adult ventilatory response in quail: does gender matter?","volume":"126","author":"Bavis","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0050","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1126\/science.1140273","article-title":"Oxygen and evolution","volume":"316","author":"Berner","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2023.111440_bb0055","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/jez.2036","article-title":"The effects of feeding on cardiac control of the broad-nosed Caiman (Caiman latirostris): the role of the autonomic nervous system and NANC factors","volume":"325","author":"Braga","year":"2016","journal-title":"J. Exp. Zool. A Ecol. Genet. Physiol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0060","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1242\/jeb.203.20.3117","article-title":"Effects of feeding on arterial blood gases in the American alligator alligator mississippiensis","volume":"203","author":"Busk","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0065","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1086\/515868","article-title":"The influence of feeding on oxygen consumption and nitrogen excretion in the Antarctic nemertean Parborlasia corrugatus","volume":"70","author":"Clarke","year":"1997","journal-title":"Physiol. Zool."},{"key":"10.1016\/j.cbpa.2023.111440_bb0070","first-page":"1","article-title":"Does the left aorta provide proton-rich blood to the gut when crocodilians digest a meal?","volume":"222","author":"Conner","year":"2019","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1242\/jeb.01355","article-title":"Cardiovascular development in embryos of the American alligator alligator mississippiensis: effects of chronic and acute hypoxia","volume":"208","author":"Crossley","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0080","first-page":"R1176","article-title":"Humoral regulation of heart rate during digestion in pythons (Python molurus and Python regius)","volume":"302","author":"Enok","year":"2012","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cbpa.2023.111440_bb0085","first-page":"3009","article-title":"Improved cardiac filling facilitates the postprandial elevation of stroke volume in Python regius","volume":"219","author":"Enok","year":"2016","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1086\/524150","article-title":"The right-to-left shunt of crocodilians serves digestion","volume":"81","author":"Farmer","year":"2008","journal-title":"Physiol. Biochem. Zool."},{"key":"10.1016\/j.cbpa.2023.111440_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpa.2017.09.001","article-title":"Feeding alters blood flow patterns in the American alligator (alligator mississippiensis)","volume":"215","author":"Findsen","year":"2018","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0100","first-page":"R1164","article-title":"Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis","volume":"311","author":"Galli","year":"2016","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cbpa.2023.111440_bb0105","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1242\/jeb.203.16.2437","article-title":"Patterns of cardiovascular and ventilatory response to elevated metabolic states in the lizard Varanus exanthematicus","volume":"203","author":"Hicks","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0110","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1242\/jeb.176.1.247","article-title":"The physiology of the alligator heart: left aortic flow patterns and right-to-left shunts","volume":"176","author":"Jones","year":"1993","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0115","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.215335","article-title":"What determines systemic blood flow in vertebrates?","volume":"223","author":"Joyce","year":"2020","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0120","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00360-018-1181-2","article-title":"The effects of embryonic hypoxic programming on cardiovascular function and autonomic regulation in the American alligator (Alligator mississippiensis) at rest and during swimming","volume":"188","author":"Joyce","year":"2018","journal-title":"J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol."},{"year":"1982","series-title":"The Nest Environment of the American Crocodile (Crocodylus acutus). South Florida Research Center Report T-67 38","author":"Lutz","key":"10.1016\/j.cbpa.2023.111440_bb0125"},{"key":"10.1016\/j.cbpa.2023.111440_bb0130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2307\/1445047","article-title":"The nest environment of the American crocodile (Crocodylus acutus)","volume":"1984","author":"Lutz","year":"1984","journal-title":"Copeia"},{"key":"10.1016\/j.cbpa.2023.111440_bb0135","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cbpa.2006.03.011","article-title":"Specific dynamic action: a century of investigation","volume":"144","author":"McCue","year":"2006","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0140","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/1933719107302324","article-title":"Fetal programming of cardiac function and disease","volume":"14","author":"Meyer","year":"2007","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.cbpa.2023.111440_bb0145","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1098\/rspb.2011.0971","article-title":"The role of developmental plasticity in evolutionary innovation","volume":"278","author":"Moczek","year":"2011","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.cbpa.2023.111440_bb0150","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2174\/156652410792630643","article-title":"Hypoxia and fetal heart development","volume":"10","author":"Patterson","year":"2010","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.cbpa.2023.111440_bb0155","series-title":"Physiological Adaptations in Vertebrates. Respiration, Circulation and Metabolism","article-title":"Shunting of blood flow in the caiman. Blood flow patterns in the right and left aortas and pulmonary arteries","author":"Pettersson","year":"1992"},{"key":"10.1016\/j.cbpa.2023.111440_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00360-008-0283-7","article-title":"Specific dynamic action: a review of the postprandial metabolic response","volume":"179","author":"Secor","year":"2009","journal-title":"J. Comp. Physiol. B."},{"key":"10.1016\/j.cbpa.2023.111440_bb0165","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1242\/jeb.034058","article-title":"Prioritizing blood flow: cardiovascular performance in response to the competing demands of locomotion and digestion for the Burmese python, python molurus","volume":"213","author":"Secor","year":"2010","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0170","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/jeb.203.16.2447","article-title":"Ventilatory and cardiovascular responses of a python (python molurus) to exercise and digestion","volume":"203","author":"Secor","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0175","article-title":"Embryonic developmental oxygen preconditions cardiovascular functional response to acute hypoxic exposure and maximal beta-adrenergic stimulation of anesthetized juvenile American alligators (Alligator mississippiensis)","volume":"222","author":"Smith","year":"2019","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0180","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1242\/jeb.01478","article-title":"Patterns of blood flow during the postprandial response in ball pythons, Python regius","volume":"208","author":"Starck","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0185","first-page":"R1267","article-title":"Periods of cardiovascular susceptibility to hypoxia in embryonic American alligators (Alligator mississippiensis)","volume":"310","author":"Tate","year":"2016","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cbpa.2023.111440_bb0190","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1086\/physzool.68.2.30166499","article-title":"Metabolic, ventilatory, and acid-base responses associated with specific dynamic action in the toad Bufo marinus","volume":"68","author":"Wang","year":"1995","journal-title":"Physiol. Zool."},{"key":"10.1016\/j.cbpa.2023.111440_bb0195","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1242\/jeb.204.20.3553","article-title":"Autonomic control of heart rate during forced activity and digestion in the snake boa constrictor","volume":"204","author":"Wang","year":"2001","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0200","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1095-6433(02)00250-7","article-title":"Effects of temperature on the metabolic response to feeding in Python molurus","volume":"133","author":"Wang","year":"2002","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2023.111440_bb0205","first-page":"R176","article-title":"Phenotypic plasticity in the common snapping turtle (Chelydra serpentina): long-term physiological effects of chronic hypoxia during embryonic development","volume":"310","author":"Wearing","year":"2016","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cbpa.2023.111440_bb0210","first-page":"2589","article-title":"Embryonic hypoxia programmes postprandial cardiovascular function in adult common snapping turtles (Chelydra serpentina)","volume":"220","author":"Wearing","year":"2017","journal-title":"J. Exp."},{"key":"10.1016\/j.cbpa.2023.111440_bb0215","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.109.153239","article-title":"Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: role of protein kinase C\u03f5","volume":"330","author":"Xue","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643323000739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643323000739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:21:37Z","timestamp":1761085297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1095643323000739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":43,"alternative-id":["S1095643323000739"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2023.111440","relation":{},"ISSN":["1095-6433"],"issn-type":[{"type":"print","value":"1095-6433"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to hypoxia during embryonic development affects blood flow patterns and heart rate in juvenile American alligators during digestion","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2023.111440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111440"}}