{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:50:09Z","timestamp":1775911809990,"version":"3.50.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"am","delay-in-days":264,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS114514"],"award-info":[{"award-number":["R01NS114514"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["76129-RT-REP"],"award-info":[{"award-number":["76129-RT-REP"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part A: Molecular &amp; Integrative Physiology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.cbpa.2023.111453","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T21:10:21Z","timestamp":1684876221000},"page":"111453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Molecular profiling of CO2\/pH-sensitive neurons in the locus coeruleus of bullfrogs reveals overlapping noradrenergic and glutamatergic cell identity"],"prefix":"10.1016","volume":"283","author":[{"given":"Lara","family":"Amaral-Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Santin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2023.111453_bb0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-0173(03)00143-7","article-title":"The locus coeruleus\u2013noradrenergic system: modulation of behavioral state and state-dependent cognitive processes","volume":"42","author":"Berridge","year":"2003","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.cbpa.2023.111453_bb0010","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s00424-007-0338-8","article-title":"Locus coeruleus noradrenergic neurons and CO2 drive to breathing","volume":"455","author":"Biancardi","year":"2008","journal-title":"Pfl\u00fcg. Arc. Euro. J. Physiol"},{"key":"10.1016\/j.cbpa.2023.111453_bb0015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41593-018-0305-z","article-title":"Active control of arousal by a locus coeruleus GABAergic circuit","volume":"22","author":"Breton-Provencher","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0020","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1074\/jbc.M110.189290","article-title":"Genetic inactivation of Kcnj16 identifies Kir5. 1 as an important determinant of neuronal PCO2\/pH sensitivity","volume":"286","author":"D\u2019Adamo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpa.2023.111453_bb0025","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1113\/jphysiol.2008.168260","article-title":"Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness","volume":"587","author":"Dias","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0030","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/cne.23524","article-title":"vglut2 and gad expression reveal distinct patterns of dual GABAergic versus glutamatergic cotransmitter phenotypes of dopaminergic and noradrenergic neurons in the zebrafish brain","volume":"522","author":"Filippi","year":"2014","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.resp.2014.11.014","article-title":"Orexin in the toad Rhinella schneideri: the location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia","volume":"224","author":"Fonseca","year":"2014","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2021.103717","article-title":"5-HT neurons of the medullary raphe contribute to respiratory control in toads","volume":"293","author":"Fonseca","year":"2021","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0045","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuroscience.2008.05.044","article-title":"Role of pontine neurons in central O2 chemoreflex during development in bullfrogs (Lithobates catesbeiana)","volume":"155","author":"Fournier","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.cbpa.2023.111453_bb0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0896-6273(01)00344-0","article-title":"The expression of vesicular glutamate transporters defines two classes of excitatory synapse","volume":"31","author":"Fremeau","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.cbpa.2023.111453_bb0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nbt.3443","article-title":"Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes","volume":"34","author":"Fuzik","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0060","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.0910059107","article-title":"Task2 potassium channels set central respiratory CO2 and O2 sensitivity","volume":"107","author":"Gestreau","year":"2010","journal-title":"PNAS"},{"key":"10.1016\/j.cbpa.2023.111453_bb0065","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-neuro-092920-121538","article-title":"Ion channel degeneracy, variability, and covariation in neuron and circuit resilience","volume":"44","author":"Goaillard","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0070","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1113\/JP276104","article-title":"Bicarbonate directly modulates activity of chemosensitive neurons in the retrotrapezoid nucleus","volume":"596","author":"Gon\u00e7alves","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0075","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/cne.903310306","article-title":"Noradrenaline in the brain of the south african clawed frog Xenopus laevis: a study with antibodies against noradrenaline and dopamine-\u03b2-hydroxylase","volume":"331","author":"Gonz\u00e1lez","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/cne.903460105","article-title":"Ontogeny of catecholamine systems in the central nervous system of anuran amphibians: an immunohistochemical study with antibodies against tyrosine hydroxylase and dopamine","volume":"346","author":"Gonz\u00e1lez","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0085","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/glia.24152","article-title":"Brain H+\/CO2 sensing and control by glial cells","volume":"70","author":"Gourine","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.cbpa.2023.111453_bb0090","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.neuron.2015.08.001","article-title":"Neural control of breathing and CO 2 homeostasis","volume":"87","author":"Guyenet","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.cbpa.2023.111453_bb0095","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/s41467-017-01316-7","article-title":"The north American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA","volume":"8","author":"Hammond","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbpa.2023.111453_bb0100","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1073\/pnas.69.9.2722","article-title":"The use of dopamine \u03b2-hydroxylase as a marker for the central noradrenergic nervous system in rat brain","volume":"69","author":"Hartman","year":"1972","journal-title":"PNAS"},{"key":"10.1016\/j.cbpa.2023.111453_bb0105","doi-asserted-by":"crossref","first-page":"11006","DOI":"10.1074\/jbc.M313507200","article-title":"pH dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits","volume":"279","author":"Hesselager","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpa.2023.111453_bb0110","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1523\/JNEUROSCI.4729-07.2008","article-title":"Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons","volume":"28","author":"Hodges","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0115","first-page":"600","article-title":"Acid-base balance in cold-blooded vertebrates as a function of body temperature","volume":"218","author":"Howell","year":"1970","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cbpa.2023.111453_bb0120","doi-asserted-by":"crossref","DOI":"10.1098\/rspb.2022.1131","article-title":"Transformation to ischaemia tolerance of frog brain function corresponds to dynamic changes in mRNA co-expression across metabolic pathways","volume":"289","author":"Hu","year":"2022","journal-title":"Proc. R. Soc. B"},{"key":"10.1016\/j.cbpa.2023.111453_bb0125","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1113\/jphysiol.2012.232470","article-title":"Acid-sensing ion channels contribute to chemosensitivity of breathing-related neurons of the nucleus of the solitary tract","volume":"590","author":"Huda","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0130","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.bbadis.2014.07.027","article-title":"A HCO3\u2212-dependent mechanism involving soluble adenylyl cyclase for the activation of Ca2+ currents in locus coeruleus neurons","volume":"1842","author":"Imber","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpa.2023.111453_bb0135","doi-asserted-by":"crossref","first-page":"29725","DOI":"10.1016\/S0021-9258(18)43941-5","article-title":"Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice","volume":"269","author":"Kobayashi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpa.2023.111453_bb0140","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1523\/JNEUROSCI.1500-19.2019","article-title":"Graded coexpression of ion channel, neurofilament, and synaptic genes in fast-spiking vestibular nucleus neurons","volume":"40","author":"Kodama","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0145","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.aaa0922","article-title":"Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons","volume":"348","author":"Kumar","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2023.111453_bb0150","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s12272-019-01196-z","article-title":"The regulation of glutamic acid decarboxylases in GABA neurotransmission in the brain","volume":"42","author":"Lee","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.cbpa.2023.111453_bb0155","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-020-2770-2","article-title":"Structural basis for pH gating of the two-pore domain K+ channel TASK2","volume":"586","author":"Li","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cbpa.2023.111453_bb0160","doi-asserted-by":"crossref","first-page":"R780","DOI":"10.1152\/ajpregu.00029.2013","article-title":"Transient outwardly rectifying a currents are involved in the firing rate response to altered CO2 in chemosensitive locus coeruleus neurons from neonatal rats","volume":"305","author":"Li","year":"2013","journal-title":"Am. J. Physiol.- Comp. Int. Reg. Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1113\/jphysiol.1976.sp011356","article-title":"Cholinergic motor neurones in the stomatogastric system of the lobster","volume":"257","author":"Marder","year":"1976","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0170","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1152\/jn.00038.2019","article-title":"The differential contribution of pacemaker neurons to synaptic transmission in the pyloric network of the Jonah crab, Cancer borealis","volume":"122","author":"Martinez","year":"2019","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0175","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1002\/j.2040-4603.2022.tb00236.x","article-title":"Control of breathing in ectothermic vertebrates","volume":"12","author":"Milsom","year":"2022","journal-title":"Compreh. Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0180","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s12264-020-00625-0","article-title":"Locus coeruleus acid-sensing ion channels modulate sleep\u2013wakefulness and state transition from NREM to REM sleep in the rat","volume":"37","author":"Mir","year":"2021","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.cbpa.2023.111453_bb0185","doi-asserted-by":"crossref","first-page":"12055","DOI":"10.1523\/JNEUROSCI.2556-06.2006","article-title":"Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain","volume":"26","author":"Moechars","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0190","first-page":"155","article-title":"Glutamatergic chemical transmission: look! Here, there, and anywhere","volume":"135","author":"Moriyama","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpa.2023.111453_bb0195","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/nn1357","article-title":"Respiratory control by ventral surface chemoreceptor neurons in rats","volume":"7","author":"Mulkey","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0200","doi-asserted-by":"crossref","first-page":"R997","DOI":"10.1152\/ajpregu.00090.2006","article-title":"Locus coeruleus is a central chemoreceptive site in toads","volume":"291","author":"Noronha-de-Souza","year":"2006","journal-title":"Am. J. Physiol.-Reg., Int. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.cbpa.2023.111453_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001971","article-title":"Neuron populations use variable combinations of short-term feedback mechanisms to stabilize firing rate","volume":"21","author":"Pellizari","year":"2023","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0210","first-page":"109","article-title":"Uniqueness and redundancy in GABA production","volume":"5","author":"Pinal","year":"1998","journal-title":"Perspect. Dev. Neurobiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0215","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0306-4522(96)00485-X","article-title":"Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton-and polyamine-sensitive inward rectifier potassium current","volume":"77","author":"Pineda","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.cbpa.2023.111453_bb0220","doi-asserted-by":"crossref","first-page":"C1493","DOI":"10.1152\/ajpcell.00282.2004","article-title":"Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons","volume":"287","author":"Putnam","year":"2004","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0225","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1523\/JNEUROSCI.1945-12.2012","article-title":"Rapid homeostatic plasticity of intrinsic excitability in a central pattern generator network stabilizes functional neural network output","volume":"32","author":"Ransdell","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0230","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0034-5687(72)90030-8","article-title":"An imidazole alphastat hypothesis for vertebrate acid-base regulation: tissue carbon dioxide content and body temperature in bullfrogs","volume":"14","author":"Reeves","year":"1972","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0235","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.resp.2012.11.002","article-title":"Respiratory signaling of locus coeruleus neurons during hypercapnic acidosis in the bullfrog, Lithobates catesbeianus","volume":"185","author":"Santin","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0240","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cbpa.2017.09.015","article-title":"How important is the CO2 chemoreflex for the control of breathing? Environmental and evolutionary considerations","volume":"215","author":"Santin","year":"2018","journal-title":"Comp. Biochem. Physiol.-Part A"},{"key":"10.1016\/j.cbpa.2023.111453_bb0245","first-page":"R1045","article-title":"Activation state of the hyperpolarization-activated current modulates temperature-sensitivity of firing in locus coeruleus neurons from bullfrogs","volume":"308","author":"Santin","year":"2015","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cbpa.2023.111453_bb0250","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1113\/JP272777","article-title":"Environmentally-induced return to juvenile-like chemosensitivity in the respiratory control system of adult bullfrogs, Lithobates catesbeianus","volume":"594","author":"Santin","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0255","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.cub.2019.04.008","article-title":"Membrane voltage is a direct feedback signal that determines ion channel expression patterns in neurons","volume":"20","author":"Santin","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0260","doi-asserted-by":"crossref","first-page":"R1451","DOI":"10.1152\/ajpregu.00348.2013","article-title":"Temperature influences neuronal activity and CO2\/pH sensitivity of locus coeruleus neurons in the bullfrog, Lithobates catesbeianus","volume":"305","author":"Santin","year":"2013","journal-title":"Am. J. Physiol.-Reg, Int. Comp. Physiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0265","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nn1639","article-title":"Variable channel expression in identified single and electrically coupled neurons in different animals","volume":"9","author":"Schulz","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0270","doi-asserted-by":"crossref","first-page":"13187","DOI":"10.1073\/pnas.0705827104","article-title":"Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression","volume":"104","author":"Schulz","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0275","series-title":"Phylogeny and Development of Catecholamine Systems in the CNS of Vertebrates","author":"Smeets","year":"1994"},{"key":"10.1016\/j.cbpa.2023.111453_bb0280","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1242\/jeb.203.13.2065","article-title":"Effect of temperature on pH and electrolyte concentration in air-breathing ectotherms","volume":"203","author":"Stinner","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0285","doi-asserted-by":"crossref","first-page":"13637","DOI":"10.1038\/s41598-018-31765-z","article-title":"Neurotransmitter identity and electrophysiological phenotype are genetically coupled in midbrain dopaminergic neurons","volume":"8","author":"Tapia","year":"2018","journal-title":"Sci. Report."},{"key":"10.1016\/j.cbpa.2023.111453_bb0290","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1152\/jn.00622.2011","article-title":"Neuromodulation independently determines correlated channel expression and conductance levels in motor neurons of the stomatogastric ganglion","volume":"107","author":"Temporal","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0295","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.cub.2014.06.067","article-title":"Activity-dependent feedback regulates correlated ion channel mRNA levels in single identified motor neurons","volume":"24","author":"Temporal","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0300","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.resp.2018.10.002","article-title":"Noradrenergic modulation determines respiratory network activity during temperature changes in the in vitro brainstem of bullfrogs","volume":"258","author":"Vallejo","year":"2018","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cbpa.2023.111453_bb0305","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s42003-020-01248-x","article-title":"Connexin26 mediates CO2-dependent regulation of breathing via glial cells of the medulla oblongata","volume":"3","author":"Van de Wiel","year":"2020","journal-title":"Comm. Bil."},{"key":"10.1016\/j.cbpa.2023.111453_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-7-384","article-title":"Analysis of promoter regions of co-expressed genes identified by microarray analysis","volume":"7","author":"Veerla","year":"2006","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.cbpa.2023.111453_bb0315","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3390\/brainsci12020134","article-title":"Locus coeruleus in non-mammalian vertebrates","volume":"12","author":"Wang","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.cbpa.2023.111453_bb0320","series-title":"xPharm: The Comprehensive Pharmacology Reference","first-page":"1","article-title":"Dopamine beta-hydroxylase","author":"Weinshenker","year":"2007"},{"issue":"823\u2013838","key":"10.1016\/j.cbpa.2023.111453_bb0325","article-title":"Locus coeruleus anchors a trisynaptic circuit controlling fear-induced suppression of feeding","volume":"109","author":"Yang","year":"2021","journal-title":"Neuron"}],"container-title":["Comparative Biochemistry and Physiology Part A: Molecular &amp; Integrative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643323000867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643323000867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:21:57Z","timestamp":1761085317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1095643323000867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":65,"alternative-id":["S1095643323000867"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2023.111453","relation":{},"ISSN":["1095-6433"],"issn-type":[{"value":"1095-6433","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular profiling of CO2\/pH-sensitive neurons in the locus coeruleus of bullfrogs reveals overlapping noradrenergic and glutamatergic cell identity","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2023.111453","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111453"}}