{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:08:37Z","timestamp":1761167317947,"version":"build-2065373602"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"am","delay-in-days":290,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.cbpa.2023.111533","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T02:49:57Z","timestamp":1697251797000},"page":"111533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Reaction thermodynamics as a constraint on piscine steroidogenesis flux distributions"],"prefix":"10.1016","volume":"287","author":[{"given":"E.","family":"Kelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.H.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Huggett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2023.111533_bb0005","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1210\/jc.2005-2230","article-title":"Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of Corpus callosum","volume":"91","author":"Al Kandari","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cbpa.2023.111533_bb0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0301-4622(92)85002-L","article-title":"Equilibrium calculations on systems of biochemical reactions at specified pH and pMg","volume":"42","author":"Alberty","year":"1992","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.cbpa.2023.111533_bb0015","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1609\/icwsm.v3i1.13937","article-title":"Gephi: an open source software for exploring and manipulating networks","volume":"3","author":"Bastian","year":"2009","journal-title":"Proc. Int. AAAI Conf. Web Soc. Media"},{"key":"10.1016\/j.cbpa.2023.111533_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000144","article-title":"Relationship between thermodynamic driving force and one-way fluxes in reversible processes","volume":"2","author":"Beard","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpa.2023.111533_bb0025","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jtbi.2004.01.008","article-title":"Thermodynamic constraints for biochemical networks","volume":"228","author":"Beard","year":"2004","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0030","doi-asserted-by":"crossref","first-page":"11408","DOI":"10.1073\/pnas.1118704109","article-title":"Gonads directly regulate growth in teleosts","volume":"109","author":"Bhatta","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpa.2023.111533_bb0035","article-title":"The compositional and evolutionary logic of metabolism","volume":"10","author":"Braakman","year":"2013","journal-title":"Phys. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0040","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s10439-007-9309-7","article-title":"Mechanistic computational model of ovarian steroidogenesis to predict biochemical responses to endocrine active compounds","volume":"35","author":"Breen","year":"2007","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cbpa.2023.111533_bb0045","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.228031","article-title":"Shifts in the relative fitness contributions of fecundity and survival in variable and changing environments","volume":"224","author":"Buckley","year":"2021","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00004670","article-title":"Pubertal development of male African catfish,Clarias gariepinus. In vitro steroidogenesis by testis and interrenal tissue and plasma levels of sexual steroids","volume":"16","author":"Cavaco","year":"1997","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpa.2023.111533_bb0055","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1095\/biolreprod56.4.789","article-title":"The role of cytochrome P450 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase in the integration of gonadal and adrenal steroidogenesis via the delta 5 and delta 4 pathways of steroidogenesis in mammals","volume":"56","author":"Conley","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.cbpa.2023.111533_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136681","article-title":"Six decades of research on human fetal gonadal steroids","volume":"22","author":"Connan-Perrot","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpa.2023.111533_bb0065","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0960-0760(92)90083-U","article-title":"Control of steroidogenesis in Leydig cells","volume":"43","author":"Cooke","year":"1992","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0070","doi-asserted-by":"crossref","first-page":"19725","DOI":"10.1074\/jbc.RA118.004372","article-title":"Thermodynamic constraints on the regulation of metabolic fluxes","volume":"293","author":"Dai","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpa.2023.111533_bb0075","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ymben.2019.06.006","article-title":"Thermodynamic analysis of the pathway for ethanol production from cellobiose in clostridium thermocellum","volume":"55","author":"Dash","year":"2019","journal-title":"Metab. Eng."},{"key":"10.1016\/j.cbpa.2023.111533_bb0080","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF01386390","article-title":"A note on two problems in connexion with graphs","volume":"1","author":"Dijkstra","year":"1959","journal-title":"Numer. Math."},{"key":"10.1016\/j.cbpa.2023.111533_bb0085","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0016-6480(70)90059-6","article-title":"Metabolic pathways of steroid biosynthesis in ovarian tissue of a teleost, Tilapia aurea","volume":"14","author":"Eckstein","year":"1970","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0090","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1210\/mend-3-6-968","article-title":"Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions","volume":"3","author":"Fevold","year":"1989","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0095","doi-asserted-by":"crossref","first-page":"D770","DOI":"10.1093\/nar\/gkr874","article-title":"eQuilibrator--the biochemical thermodynamics calculator","volume":"40","author":"Flamholz","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbpa.2023.111533_bb0100","doi-asserted-by":"crossref","first-page":"10039","DOI":"10.1073\/pnas.1215283110","article-title":"Glycolytic strategy as a tradeoff between energy yield and protein cost","volume":"110","author":"Flamholz","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpa.2023.111533_bb0105","first-page":"4049","article-title":"Influence of reproductive mode on metabolic costs of reproduction: insight from the bimodal lizard Zootoca vivipara","volume":"217","author":"Foucart","year":"2014","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0110","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/mms.12487","article-title":"The metabolic cost of swimming and reproduction in harbor porpoises (Phocoena phocoena) as predicted by a bioenergetic model","volume":"34","author":"Gallagher","year":"2018","journal-title":"Mar. Mamm. Sci."},{"key":"10.1016\/j.cbpa.2023.111533_bb0115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1756-0500-3-125","article-title":"Thermodynamic analysis of regulation in metabolic networks using constraint-based modeling","volume":"3","author":"Garg","year":"2010","journal-title":"BMC. Res. Notes"},{"key":"10.1016\/j.cbpa.2023.111533_bb0120","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbapap.2010.06.021","article-title":"At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17","volume":"1814","author":"Gilep","year":"2011","journal-title":"Biochim. Biophys. Acta (BBA) - Proteins Proteom."},{"key":"10.1016\/j.cbpa.2023.111533_bb0125","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/en.2015-1480","article-title":"Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish","volume":"157","author":"Griffin","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbpa.2023.111533_bb0130","doi-asserted-by":"crossref","first-page":"10964","DOI":"10.1021\/acscatal.8b03401","article-title":"Mechanisms of cytochrome P450-catalyzed oxidations","volume":"8","author":"Guengerich","year":"2018","journal-title":"ACS Catal."},{"key":"10.1016\/j.cbpa.2023.111533_bb0135","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1242\/jeb.066027","article-title":"Constraints-based stoichiometric analysis of hypoxic stress on steroidogenesis in fathead minnows, Pimephales promelas","volume":"215","author":"Hala","year":"2012","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0140","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3109\/19396368.2015.1035817","article-title":"In silico analysis of perturbed steroidogenesis and gonad growth in fathead minnows (P. promelas) exposed to 17\u03b1-ethynylestradiol","volume":"61","author":"Hala","year":"2015","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.cbpa.2023.111533_bb0145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jtbi.2018.07.020","article-title":"In silico predicted transcriptional regulatory control of steroidogenesis in spawning female fathead minnows (Pimephales promelas)","volume":"455","author":"Hala","year":"2018","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0150","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1529\/biophysj.105.071720","article-title":"Genome-scale thermodynamic analysis of Escherichia coli metabolism","volume":"90","author":"Henry","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.cbpa.2023.111533_bb0155","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aquatox.2005.09.008","article-title":"Acute and chronic effects of carrier solvents in aquatic organisms: a critical review","volume":"76","author":"Hutchinson","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4310","article-title":"Innovation and tinkering in the evolution of oxidases","volume":"31","author":"Jab\u0142o\u0144ska","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.cbpa.2023.111533_bb0165","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1529\/biophysj.107.124784","article-title":"Group contribution method for thermodynamic analysis of complex metabolic networks","volume":"95","author":"Jankowski","year":"2008","journal-title":"Biophys. J."},{"key":"10.1016\/j.cbpa.2023.111533_bb0170","first-page":"127","article-title":"Aspects of basic reproductive biology and endocrinology in the fathead minnow (Pimephales promelas)","volume":"128","author":"Jensen","year":"2001","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0175","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbpa.2023.111533_bb0180","series-title":"Fundamentals of Comparative Vertebrate Endocrinology","first-page":"3","article-title":"The steroids","author":"Kime","year":"1987"},{"key":"10.1016\/j.cbpa.2023.111533_bb0185","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/BF00045230","article-title":"\u2018Classical\u2019 and \u2018non-classical\u2019 reproductive steroids in fish","volume":"3","author":"Kime","year":"1993","journal-title":"Rev. Fish Biol. Fish."},{"key":"10.1016\/j.cbpa.2023.111533_bb0190","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1677\/joe.1.06684","article-title":"Changes in mRNAs encoding steroidogenic acute regulatory protein, steroidogenic enzymes and receptors for gonadotropins during spermatogenesis in rainbow trout testes","volume":"189","author":"Kusakabe","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0195","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/bies.200900131","article-title":"How did LUCA make a living? Chemiosmosis in the origin of life","volume":"32","author":"Lane","year":"2010","journal-title":"Bioessays"},{"key":"10.1016\/j.cbpa.2023.111533_bb0200","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/mrd.22827","article-title":"Transcriptional control of genes mediating ovarian follicular growth, differentiation, and steroidogenesis in pigs","volume":"84","author":"LaVoie","year":"2017","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.cbpa.2023.111533_bb0205","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3181\/0903-MR-97","article-title":"Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3B","volume":"234","author":"LaVoie","year":"2009","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.cbpa.2023.111533_bb0210","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1021\/jacs.1c00581","article-title":"Substrate-specific allosteric effects on the enhancement of CYP17A1 Lyase efficiency by cytochrome b5","volume":"143","author":"Liu","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.cbpa.2023.111533_bb0215","doi-asserted-by":"crossref","first-page":"11913","DOI":"10.1073\/pnas.0812138106","article-title":"Independent elaboration of steroid hormone signaling pathways in metazoans","volume":"106","author":"Markov","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpa.2023.111533_bb0220","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1016\/S0021-9258(18)98705-3","article-title":"Estimation of standard Gibbs energy changes of biotransformations","volume":"266","author":"Mavrovouniotis","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpa.2023.111533_bb0225","first-page":"275","article-title":"Identification of localized and distributed bottlenecks in metabolic pathways","volume":"1","author":"Mavrovouniotis","year":"1993","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0230","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1073\/pnas.0601080103","article-title":"The group covariance effect and fitness trade-offs during evolutionary transitions in individuality","volume":"103","author":"Michod","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbpa.2023.111533_bb0235","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cbpa.2009.02.027","article-title":"Corticosteroids: friends or foes of teleost fish reproduction?","volume":"153","author":"Milla","year":"2009","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0240","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0960-0760(95)00212-X","article-title":"Mitochondrial specificity of the early steps in steroidogenesis","volume":"55","author":"Miller","year":"1995","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0950-351X(98)80461-8","article-title":"Early steps in androgen biosynthesis: from cholesterol to DHEA","volume":"12","author":"Miller","year":"1998","journal-title":"Bailliere Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cbpa.2023.111533_bb0250","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1210\/en.2005-0096","article-title":"Minireview: regulation of steroidogenesis by electron transfer","volume":"146","author":"Miller","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbpa.2023.111533_bb0255","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.tem.2017.09.002","article-title":"Steroidogenesis: unanswered questions","volume":"28","author":"Miller","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cbpa.2023.111533_bb0260","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1194\/jlr.R016675","article-title":"Early steps in steroidogenesis: intracellular cholesterol trafficking","volume":"52","author":"Miller","year":"2011","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cbpa.2023.111533_bb0265","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1677\/jme.1.01853","article-title":"Androgen metabolism via 17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme","volume":"35","author":"Mindnich","year":"2005","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0270","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0950-351X(98)80444-8","article-title":"Gonadotropin receptors and the control of gonadal steroidogenesis: physiology and pathology","volume":"12","author":"Misrahi","year":"1998","journal-title":"Bailliere Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cbpa.2023.111533_bb0275","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000342272","article-title":"Steroid hormones and the development of reproductive organs","volume":"7","author":"Morohashi","year":"2013","journal-title":"Sex. Dev."},{"key":"10.1016\/j.cbpa.2023.111533_bb0280","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1351\/pac198961101783","article-title":"Nomenclature of steroids","volume":"61","author":"Moss","year":"1989","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.cbpa.2023.111533_bb0285","first-page":"217","article-title":"Endocrine regulation of gametogenesis in fish","volume":"38","author":"Nagahama","year":"1994","journal-title":"Int. J. Dev. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.cbpa.2023.111533_bb0290","first-page":"S195","article-title":"Regulation of oocyte maturation in fish","volume":"50","author":"Nagahama","year":"2008","journal-title":"Develop. Growth Differ."},{"key":"10.1016\/j.cbpa.2023.111533_bb0295","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ygcen.2012.01.019","article-title":"Expression of 3\u03b2-hydroxysteroid dehydrogenase (hsd3b), star and ad4bp\/sf-1 during gonadal development in medaka (Oryzias latipes)","volume":"176","author":"Nakamoto","year":"2012","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0300","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/msb4100169","article-title":"Principles of optimal metabolic network operation","volume":"3","author":"Nielsen","year":"2007","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003098","article-title":"Consistent estimation of Gibbs energy using component contributions","volume":"9","author":"Noor","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003483","article-title":"Pathway thermodynamics highlights kinetic obstacles in central metabolism","volume":"10","author":"Noor","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0315","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1126\/science.101.2618.209","article-title":"The concept of integrative levels and biology","volume":"101","author":"Novikoff","year":"1945","journal-title":"Science"},{"year":"2012","author":"OECD","series-title":"Test No. 229: Fish Short Term Reproduction Assay","key":"10.1016\/j.cbpa.2023.111533_bb0320"},{"key":"10.1016\/j.cbpa.2023.111533_bb0325","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41589-019-0364-9","article-title":"Near-equilibrium glycolysis supports metabolic homeostasis and energy yield","volume":"15","author":"Park","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0330","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1210\/er.2003-0030","article-title":"Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones","volume":"25","author":"Payne","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cbpa.2023.111533_bb0335","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1086\/physzool.62.2.30156169","article-title":"Organismal performance and Darwinian fitness: approaches and interpretations","volume":"62","author":"Pough","year":"1989","journal-title":"Physiol. Zool."},{"key":"10.1016\/j.cbpa.2023.111533_bb0340","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10695-019-00752-0","article-title":"Steroidogenesis and its regulation in teleost-a review","volume":"46","author":"Rajakumar","year":"2020","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpa.2023.111533_bb0345","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1086\/283769","article-title":"Fitness, reproductive value, age structure, and the optimization of life- history patterns","volume":"117","author":"Ricklefs","year":"1981","journal-title":"Am. Nat."},{"key":"10.1016\/j.cbpa.2023.111533_bb0350","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0006-3495(73)86004-7","article-title":"The thermodynamic description of enzyme-catalyzed reactions. The linear relation between the reaction rate and the affinity","volume":"13","author":"Rottenberg","year":"1973","journal-title":"Biophys. J."},{"key":"10.1016\/j.cbpa.2023.111533_bb0355","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/msb4100162","article-title":"Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli","volume":"3","author":"Schuetz","year":"2007","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0360","first-page":"1","article-title":"Enzyme kinetics behavior and analysis of rapid equilibrium and steady state enzyme systems, chapter 1: introduction - enzymes as biological catalysts","volume":"60","author":"Segel","year":"1975","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbpa.2023.111533_bb0365","doi-asserted-by":"crossref","first-page":"13168","DOI":"10.1073\/pnas.0404922101","article-title":"Universality in intermediary metabolism","volume":"101","author":"Smith","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpa.2023.111533_bb0370","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/ast.2015.1406","article-title":"The origin of life in alkaline hydrothermal vents","volume":"16","author":"Sojo","year":"2016","journal-title":"Astrobiology"},{"key":"10.1016\/j.cbpa.2023.111533_bb0375","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1210\/en.2018-00889","article-title":"GnRH-A key regulator of FSH","volume":"160","author":"Stamatiades","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbpa.2023.111533_bb0380","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.physiol.63.1.193","article-title":"StAR protein and the regulation of steroid hormone biosynthesis","volume":"63","author":"Stocco","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0385","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1210\/me.2004-0532","article-title":"Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought","volume":"19","author":"Stocco","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0390","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1210\/jcem.86.8.7748","article-title":"Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency","volume":"86","author":"Tajima","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cbpa.2023.111533_bb0395","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1210\/jc.2012-2828","article-title":"Varied clinical presentations of seven patients with mutations in CYP11A1 encoding the cholesterol side-chain cleavage enzyme, P450scc","volume":"98","author":"Tee","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cbpa.2023.111533_bb0400","first-page":"223","article-title":"Development and organisation of gonadal steroidogenesis in bony fishes - a review","volume":"6","author":"Tenugu","year":"2021","journal-title":"Aquacult. Fish."},{"key":"10.1016\/j.cbpa.2023.111533_bb0405","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.steroids.2015.06.011","article-title":"Steroids in teleost fishes: a functional point of view","volume":"103","author":"Tokarz","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.cbpa.2023.111533_bb0410","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0960-0760(92)90097-3","article-title":"Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates","volume":"42","author":"Tuckey","year":"1992","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0415","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1432-1033.1989.tb15203.x","article-title":"Pregnenolone synthesis from cholesterol and hydroxycholesterols by mitochondria from ovaries following the stimulation of immature rats with pregnant mare\u2019s serum gonadotropin and human choriogonadotropin","volume":"186","author":"Tuckey","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cbpa.2023.111533_bb0420","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00122584","article-title":"Oocyte growth and development in teleosts","volume":"6","author":"Tyler","year":"1996","journal-title":"Rev. Fish Biol. Fish."},{"key":"10.1016\/j.cbpa.2023.111533_bb0425","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1242\/jeb.01675","article-title":"The metabolic cost of egg production is repeatable","volume":"208","author":"V\u00e9zina","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0430","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/toxsci\/kfm124","article-title":"Transcription of key genes regulating gonadal steroidogenesis in control and ketoconazole- or vinclozolin-exposed fathead minnows","volume":"98","author":"Villeneuve","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpa.2023.111533_bb0435","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.aquatox.2010.03.006","article-title":"Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue","volume":"98","author":"Villeneuve","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0440","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.abm7649","article-title":"Metabolic scaling is the product of life-history optimization","volume":"377","author":"White","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2023.111533_bb0445","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.793664","article-title":"Energy at origins: favorable thermodynamics of biosynthetic reactions in the last universal common ancestor (LUCA)","volume":"12","author":"Wimmer","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cbpa.2023.111533_bb0450","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev.ecolsys.32.081501.114006","article-title":"The physiology of life history trade-offs in animals","volume":"32","author":"Zera","year":"2001","journal-title":"Annu. Rev. Ecol. Syst."},{"key":"10.1016\/j.cbpa.2023.111533_bb0455","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.bbrc.2007.08.044","article-title":"Characterization, expression and transcriptional regulation of P450c17-I and -II in the medaka, Oryzias latipes","volume":"362","author":"Zhou","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpa.2023.111533_bb0460","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40555-014-0041-3","article-title":"Resting metabolic rate and energetics of reproduction in lactating Eothenomys miletus from Hengduan mountain region","volume":"53","author":"Zhu","year":"2014","journal-title":"Zool. Stud."}],"container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643323001666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643323001666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:22:24Z","timestamp":1761085344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1095643323001666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":92,"alternative-id":["S1095643323001666"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2023.111533","relation":{},"ISSN":["1095-6433"],"issn-type":[{"type":"print","value":"1095-6433"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reaction thermodynamics as a constraint on piscine steroidogenesis flux distributions","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2023.111533","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111533"}}