{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:35:38Z","timestamp":1777887338331,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/14167-8"],"award-info":[{"award-number":["2020\/14167-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.cbpa.2024.111608","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T20:13:47Z","timestamp":1708200827000},"page":"111608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The pancreas does not contribute to the non-adrenergic-non-cholinergic stimulation of heart rate in digesting pythons"],"prefix":"10.1016","volume":"291","author":[{"given":"Igor Noll","family":"Guagnoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja Bundgaard","family":"Last","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil","family":"Rindom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2024.111608_bb0005","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S1095-6433(99)00137-3","article-title":"Understanding autonomic sympathovagal balance from short term heart rate variations. Are we analyzing noise?","volume":"124","author":"Altimiras","year":"1999","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0300-9629(96)00402-1","article-title":"Cholinergic and adrenergic tones in the control of heart rate in teleosts. How should they be calculated?","volume":"118A","author":"Altimiras","year":"1997","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0015","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12933-023-01859-8","article-title":"Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart","volume":"22","author":"Aranda-Domene","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jeb.197848","article-title":"Autonomic control of cardiovascular adjustments associated with orthostasis in the scansorial snake Boa constrictor","volume":"222","author":"Armelin","year":"2019","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0025","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jez.2448","article-title":"The nonpharmacological sequence method provides a reliable evaluation of baroreflex sensitivity in fish","volume":"335","author":"Armelin","year":"2021","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.cbpa.2024.111608_bb0030","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1113\/EP090584","article-title":"Acute effects of insulin and insulin-induced hypoglycaemia on carotid body chemoreceptor activity and cardiorespiratory responses in dogs","volume":"108","author":"Baby","year":"2023","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0035","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1081\/CLT-120023761","article-title":"Glucagon in beta blocker and calcium channel blocker overdoses: a systematic review","volume":"41","author":"Benoit","year":"2003","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0040","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1242\/jeb.86.1.197","article-title":"Localization of baroreceptors and gain of the baroreceptor-heart rate reflex in the lizard Trachydosaurus rugosus","volume":"89","author":"Berger","year":"1980","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0045","first-page":"S79","article-title":"A new approach to analysis of the arterial baroreflex","volume":"3","author":"Bertinieri","year":"1985","journal-title":"J. Hypertens."},{"key":"10.1016\/j.cbpa.2024.111608_bb0050","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/jez.2036","article-title":"The effects of feeding on cardiac control of the broad-nosed Caiman (Caiman latirostris): the role of the autonomic nervous system and NANC factors","volume":"325A","author":"Braga","year":"2016","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.cbpa.2024.111608_bb0055","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1242\/jeb.02278","article-title":"Evidence for a respiratory component, similar to mammalian respiratory sinus arrhythmia, in the heart rate variability signal from the rattlesnake, Crotalus durissus terrificus","volume":"209","author":"Campbell","year":"2006","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0060","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1590\/s1984-46702015000600009","article-title":"Autonomic regulation of heart rate during specific dynamic action associated with digestion in the bullfrog Lithobates catesbeianus","volume":"32","author":"Cla\u00ebsson","year":"2015","journal-title":"Zoologia."},{"key":"10.1016\/j.cbpa.2024.111608_bb0065","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1242\/jeb.00486","article-title":"Ontogeny of baroreflex control in the American alligator Alligator mississippiensis","volume":"206","author":"Crossley","year":"2003","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0070","first-page":"25","article-title":"Advancements in estimating Baroreflex function","volume":"20","author":"Di Rienzo","year":"2001","journal-title":"IEEE."},{"key":"10.1016\/j.cbpa.2024.111608_bb0075","first-page":"R744","article-title":"Baroreflex effectiveness index: an additional measure of baroreflex control of heart rate in daily life","volume":"280","author":"Di Rienzo","year":"2001","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cbpa.2024.111608_bb0080","article-title":"Heart rate variability in the tegu lizard, Salvator merianae, its neuroanatomical basis and role in the assessment of recovery from experimental manipulation","volume":"240A","author":"Duran","year":"2020","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0085","first-page":"R1176","article-title":"Humoral regulation of heart rate during digestion in pythons (Python molurus and Python regius)","volume":"302","author":"Enok","year":"2012","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cbpa.2024.111608_bb0090","first-page":"3009","article-title":"Improved cardiac filling facilitates the postprandial elevation of stroke volume in Python regius","volume":"219","author":"Enok","year":"2016","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0095","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jez.2273","article-title":"Evaluation of the sequence method as a tool to assess spontaneous baroreflex in reptiles","volume":"331","author":"Filogonio","year":"2019","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.cbpa.2024.111608_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0242346","article-title":"Baroreflex gain and time of pressure decay at different body temperatures in the tegu lizard, Salvator merianae","volume":"15","author":"Filogonio","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpa.2024.111608_bb0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00360-020-01317-x","article-title":"Postprandial cardiorespiratory responses and the regulation of digestion-associated tachycardia in Nile tilapia (Oreochromis niloticus)","volume":"191","author":"Guagnoni","year":"2021","journal-title":"J. Comp. Physiol. B."},{"key":"10.1016\/j.cbpa.2024.111608_bb0110","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.247105","article-title":"Cardiovascular responses and the role of the neurohumoral cardiac regulation during digestion in the herbivorous lizard Iguana iguana","author":"Guagnoni","year":"2024","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0031-9384(01)00633-3","article-title":"Stressful and behavioral conditions that affect reversible cardiac arrest in the Nile tilapia, Oreochromis niloticus (Teleostei)","volume":"75","author":"Ide","year":"2002","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.cbpa.2024.111608_bb0120","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cbpa.2010.03.026","article-title":"Autonomic regulation of the heart during digestion and aerobic swimming in the European sea bass (Dicentrarchus labrax)","volume":"156A","author":"Iversen","year":"2010","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cbpa.2017.02.012","article-title":"The influence of mechanical ventilation on physiological parameters in ball pythons (Python regius)","volume":"207A","author":"Jakobsen","year":"2017","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0130","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1152\/physiol.00025.2023","article-title":"The elusive hypertrophy of the python heart","volume":"39","author":"Jensen","year":"2024","journal-title":"Physiology"},{"key":"10.1016\/j.cbpa.2024.111608_bb0135","first-page":"H45","article-title":"Evidence for histamine as a neurotransmitter in the cardiac sympathetic nervous system","volume":"291","author":"Li","year":"2006","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cbpa.2024.111608_bb0140","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1210\/jc.2014-3865","article-title":"Incretin effect after oral amino acid ingestion in humans","volume":"100","author":"Lindgren","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cbpa.2024.111608_bb0145","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.autneu.2017.10.008","article-title":"The influence of midazolam on heart rate arises from cardiac autonomic tones alterations in Burmese pythons, Python molurus","volume":"208","author":"Lopes","year":"2017","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.cbpa.2024.111608_bb0150","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2337\/diab.32.2.S64","article-title":"The stages in diabetic renal disease: with emphasis on the stage of incipient diabetic nephropathy","volume":"32","author":"Mogensen","year":"1983","journal-title":"Diabetes."},{"key":"10.1016\/j.cbpa.2024.111608_bb0155","article-title":"Oxyntomodulin increases intrinsic heart rate through the glucagon receptor","volume":"1","author":"Mukharji","year":"2013","journal-title":"Phys. Rep."},{"key":"10.1016\/j.cbpa.2024.111608_bb0160","doi-asserted-by":"crossref","first-page":"12829","DOI":"10.3390\/ijms241612829","article-title":"Glucagon and its receptors in the mammalian heart","volume":"24","author":"Neumann","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpa.2024.111608_bb0165","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.2460\/javma.233.12.1883","article-title":"Effects of preoperative administration of butorphanol or meloxicam on physiologic responses to surgery in ball pythons","volume":"233","author":"Olesen","year":"2008","journal-title":"JAVMA."},{"key":"10.1016\/j.cbpa.2024.111608_bb0170","first-page":"361","article-title":"Respiratory consequences of feeding in the snake Python molorus","volume":"124A","author":"Overgaard","year":"1999","journal-title":"Comp. Biochem. Physiol. Part A."},{"key":"10.1016\/j.cbpa.2024.111608_bb0175","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016828","article-title":"High-dose glucagon has hemodynamic effects regardless of cardiac beta-adenoreceptor blockade: a randomized clinical trial","volume":"9","author":"Petersen","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.cbpa.2024.111608_bb0180","first-page":"H311","article-title":"Effects of neuropeptides on heart rate in dogs: comparison of VIP, PHI, NPY, CGRP, and NT","volume":"255","author":"Rigel","year":"1988","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cbpa.2024.111608_bb0185","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1242\/jeb.034058","article-title":"Prioritizing blood flow: cardiovascular performance in response to the competing demands of locomotion and digestion for the Burmese python, Python molurus","volume":"213","author":"Secor","year":"2010","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0190","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/jeb.203.16.2447","article-title":"Ventilatory and cardiovascular responses of a python (Python molurus) to exercise and digestion","volume":"203","author":"Secor","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0195","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00315583","article-title":"Insulin-induced increase in heart rate and its prevention by propranolol","volume":"38","author":"Siani","year":"1990","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0200","first-page":"R774","article-title":"Histamine induces postprandial tachycardia through a direct effect on cardiac H2-receptors in pythons","volume":"296","author":"Skovgaard","year":"2009","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cbpa.2024.111608_bb0205","first-page":"153","article-title":"Cardiovascular effects of histamine in three widely diverse species of reptiles","volume":"188B","author":"Skovgaard","year":"2017","journal-title":"J. Comp. Physiol. B."},{"key":"10.1016\/j.cbpa.2024.111608_bb0210","first-page":"1784","article-title":"Reduction of blood oxygen levels enhances postprandial cardiac hypertrophy in Burmese python (Python bivittatus)","volume":"217","author":"Slay","year":"2014","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0215","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1242\/jeb.01478","article-title":"Patterns of blood flow during postprandial response in ball pythons, Python regius","volume":"208","author":"Starck","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0220","first-page":"H482","article-title":"Baroreceptor reflex sensitivity estimated by the sequence technique is reliable in rats","volume":"291","author":"Stauss","year":"2006","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cbpa.2024.111608_bb0225","article-title":"The physiological response to digestion in snakes: a feast for the integrative physiologist","volume":"254A","author":"Wang","year":"2021","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0230","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1242\/jeb.204.20.3553","article-title":"Autonomic control of heart rate during forced activity and digestion in the snake Boa constrictor","volume":"204","author":"Wang","year":"2001","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2024.111608_bb0235","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.242202","article-title":"Maintained barostatic regulation of heart rate in digesting snakes (Boa constrictor)","volume":"224","author":"Wang","year":"2021","journal-title":"J. Exp. Biol."}],"container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643324000357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643324000357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:09:03Z","timestamp":1777608543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1095643324000357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":47,"alternative-id":["S1095643324000357"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2024.111608","relation":{},"ISSN":["1095-6433"],"issn-type":[{"value":"1095-6433","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pancreas does not contribute to the non-adrenergic-non-cholinergic stimulation of heart rate in digesting pythons","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2024.111608","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111608"}}