{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:24:04Z","timestamp":1784309044672,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.cbpa.2024.111784","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T02:45:54Z","timestamp":1732329954000},"page":"111784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Short communication: Can Vitamin D be supplied from the large intestine?"],"prefix":"10.1016","volume":"300","author":[{"given":"David R.","family":"Fraser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2024.111784_bb0005","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3181\/00379727-149-38853","article-title":"25-Hydroxyvitamin D3: evidence of an enterohepatic circulation in man","volume":"149","author":"Arnaud","year":"1975","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.cbpa.2024.111784_bb0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1294\/jes.33.45","article-title":"Undetectable vitamin D3 in equine skin irradiated with ultraviolet light","volume":"33","author":"Azarpeykan","year":"2022","journal-title":"J. Equine Sci."},{"key":"10.1016\/j.cbpa.2024.111784_bb0015","first-page":"663","article-title":"Investigations on metabolites of vitamin D in rat bile. Separation and partial identification of a major metabolite","volume":"J.115","author":"Bell","year":"1969","journal-title":"Biochem"},{"key":"10.1016\/j.cbpa.2024.111784_bb0020","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/0022-4731(80)90133-8","article-title":"Comparative study of the affinity of the serum vitamin D-binding protein","volume":"13","author":"Bouillon","year":"1980","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.cbpa.2024.111784_bb0025","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3389\/fendo.2019.00910","article-title":"Vitamin D binding protein: a historic overview","volume":"10","author":"Bouillon","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.cbpa.2024.111784_bb0030","doi-asserted-by":"crossref","first-page":"111666","DOI":"10.1016\/j.cbpa.2024.111666","article-title":"Short communication: metabolic synthesis of vitamin D2 by the gut microbiome","volume":"295","author":"Chaves","year":"2024","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0035","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1638\/2023-0082","article-title":"Serum vitamin D and selected biomarkers of calcium homeostasis in Asian elephants (Ellephas maximus) managed at a low latitude","volume":"55","author":"Childs-Sanford","year":"2024","journal-title":"J. Zoo Wildl. Med."},{"key":"10.1016\/j.cbpa.2024.111784_bb0040","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0140-6736(84)91874-9","article-title":"Enterohepatic circulation of vitamin D: a reappraisal of the hypothesis","volume":"323","author":"Clements","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.cbpa.2024.111784_bb0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mce.2011.07.022","article-title":"Colonic vitamin D metabolism: implications for the pathogenesis of inflammatory bowel disease and colorectal cancer","volume":"347","author":"Cross","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0050","doi-asserted-by":"crossref","first-page":"24527","DOI":"10.1073\/pnas.1915442116","article-title":"Vitamin D binding protein is required to utilize skin-generated vitamin D","volume":"116","author":"Duchow","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpa.2024.111784_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.129836","article-title":"Vitamin D composition of Australian foods","volume":"358","author":"Dunlop","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.cbpa.2024.111784_bb0060","article-title":"Vitamins D(2) and D(3) have overlapping but different effects on the human immune system revealed through analysis of the blood transcriptome","volume":"24","author":"Durrant","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0065","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3390\/nu2050482","article-title":"The relationship between ultraviolet radiation exposure and vitamin D status","volume":"2","author":"Engelsen","year":"2010","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.cbpa.2024.111784_bb0070","article-title":"Physiological significance of vitamin D produced in skin compared with oral vitamin D","volume":"21","author":"Fraser","year":"2022","journal-title":"J. Nutr. Sci."},{"key":"10.1016\/j.cbpa.2024.111784_bb0075","first-page":"bnae009","article-title":"Consensus statement on vitamin D status assessment and supplementation: whys, whens, and hows","volume":"27","author":"Giustina","year":"2024","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cbpa.2024.111784_bb0080","doi-asserted-by":"crossref","first-page":"G460","DOI":"10.1152\/ajpgi.00156.2011","article-title":"Targeted delivery of vitamin D to the colon using \u03b2-glucuronides of vitamin D: therapeutic effects in a murine model of inflammatory bowel disease","volume":"302","author":"Goff","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0085","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0006-2952(95)00202-B","article-title":"Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats","volume":"50","author":"Groenen-van Dooren","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0090","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1172\/JCI110186","article-title":"Vitamin D plasma binding protein. Turnover and fate in the rabbit","volume":"67","author":"Haddad","year":"1981","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbpa.2024.111784_bb0095","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI116492","article-title":"Human plasma transport of vitamin D after its endogenous synthesis","volume":"91","author":"Haddad","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbpa.2024.111784_bb0100","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1126\/science.157.3791.943","article-title":"Vitamins D2 and D3 in new world primates: influence on calcium absorption","volume":"157","author":"Hunt","year":"1967","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2024.111784_bb0105","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/jn\/122.3.506","article-title":"Colonic absorption of menaquinone-4 and menaquinone-9 in rats","volume":"122","author":"Ichihashi","year":"1992","journal-title":"J. Nutr."},{"key":"10.1016\/j.cbpa.2024.111784_bb0110","doi-asserted-by":"crossref","first-page":"10907","DOI":"10.1021\/jf202503c","article-title":"Seasonal variation of provitamin D2 and vitamin D2 in perennial ryegrass (Lolium perenne L.)","volume":"59","author":"J\u00e4pelt","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbpa.2024.111784_bb0115","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3945\/ajcn.117.155424","article-title":"Fecal concentrations of bacterially derived vitamin K forms are associated with gut microbiota composition but not plasma or fecal cytokine concentrations in healthy adults","volume":"106","author":"Karl","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cbpa.2024.111784_bb0120","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.3390\/nu14183690","article-title":"Megalin and vitamin D metabolism - implications in non-renal tissues and kidney disease","volume":"14","author":"Khan","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.cbpa.2024.111784_bb0125","doi-asserted-by":"crossref","first-page":"G870","DOI":"10.1152\/ajpgi.00149.2012","article-title":"Importance of apical membrane delivery of 1,25-dihydroxyvitamin D3 to vitamin D-responsive gene expression in the colon","volume":"303","author":"Koszewski","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00026.2001","article-title":"Electrolyte transport in the mammalian colon: mechanisms and implications for disease","volume":"82","author":"Kunzelmann","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cbpa.2024.111784_bb0135","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3390\/molecules15031531","article-title":"Vitamin K2 in electron transport system: are enzymes involved in vitamin K2 biosynthesis promising drug targets?","volume":"15","author":"Kurosu","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.cbpa.2024.111784_bb0140","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jsbmb.2010.02.004","article-title":"1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines","volume":"121","author":"Lagishetty","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0145","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00041433-200306000-00003","article-title":"Vitamin A uptake from foods","volume":"14","author":"Li","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0150","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3748\/wjg.v22.i3.933","article-title":"Protective links between vitamin D, inflammatory bowel disease and colon cancer","volume":"22","author":"Meeker","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0155","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.kint.2015.11.007","article-title":"Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease","volume":"89","author":"Nielsen","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.cbpa.2024.111784_bb0160","first-page":"87","article-title":"Quantitative analysis of vitamin D2 and ergosterol in yeast-based supplements using high-performance liquid chromatography with ultraviolet detection","volume":"50","author":"Paliu","year":"2024","journal-title":"Curr. Health Sci. J."},{"key":"10.1016\/j.cbpa.2024.111784_bb0165","article-title":"Proteins involved in fat-soluble vitamin and carotenoid transport across the intestinal cells: New insights from the past decade","volume":"89","author":"Reboul","year":"2022","journal-title":"Progress Lipid Res."},{"key":"10.1016\/j.cbpa.2024.111784_bb0170","doi-asserted-by":"crossref","first-page":"G253","DOI":"10.1152\/ajpgi.00355.2019","article-title":"Role of glucuronidated 25-hydroxyvitamin D on colon gene expression in mice","volume":"319","author":"Reynolds","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cbpa.2024.111784_bb0175","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.3390\/nu12113270","article-title":"Skeletal muscle and the maintenance of vitamin D status","volume":"12","author":"Rybchyn","year":"2020","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.cbpa.2024.111784_bb0180","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1755-8794-5-38","article-title":"Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL\/6J mice","volume":"28","author":"Steegenga","year":"2012","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.cbpa.2024.111784_bb0185","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3390\/cells11071129","article-title":"Vitamin D receptor influences intestinal barriers in health and disease","volume":"11","author":"Sun","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cbpa.2024.111784_bb0190","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0003-2697(91)90104-2","article-title":"Determination of the affinity of vitamin D metabolites to serum vitamin D binding protein using assay employing lipid-coated polystyrene beads","volume":"199","author":"Teegarden","year":"1991","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpa.2024.111784_bb0195","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1080\/01635581.2013.805422","article-title":"Vitamin D transport proteins megalin and disabled-2 are expressed in prostate and colon epithelial cells and are induced and activated by all-trans-retinoic acid","volume":"65","author":"Ternes","year":"2013","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.cbpa.2024.111784_bb0200","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3945\/ajcn.111.031070","article-title":"Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis","volume":"95","author":"Tripkovic","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cbpa.2024.111784_bb0205","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jcb.20910","article-title":"UVB-induced 1,25(OH)2D3 production and vitamin D activity in intestinal CaCo-2 cells and in THP-1 macrophages pretreated with a sterol Delta7-reductase inhibitor","volume":"99","author":"Vantieghem","year":"2006","journal-title":"J. Cell. Biochem."},{"issue":"9","key":"10.1016\/j.cbpa.2024.111784_bb0210","doi-asserted-by":"crossref","first-page":"1005195","DOI":"10.3389\/fnut.2022.1005195","article-title":"Porcine bile acids promote the utilization of fat and vitamin a under low-fat diets","volume":"28","author":"Yang","year":"2022","journal-title":"Front. Nutr."}],"container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643324002113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643324002113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T22:01:36Z","timestamp":1736287296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1095643324002113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":42,"alternative-id":["S1095643324002113"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2024.111784","relation":{},"ISSN":["1095-6433"],"issn-type":[{"value":"1095-6433","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short communication: Can Vitamin D be supplied from the large intestine?","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2024.111784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111784"}}