{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:25:43Z","timestamp":1793784343225,"version":"4.6.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["UF160152"],"award-info":[{"award-number":["UF160152"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["URF\/R\/221009"],"award-info":[{"award-number":["URF\/R\/221009"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Chemical Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cbpa.2026.102790","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:12:35Z","timestamp":1792167155000},"page":"102790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Intracellular nucleic acid nanotechnology"],"prefix":"10.1016","volume":"95","author":[{"given":"Catherine","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Dordevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Di Michele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2026.102790_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0022-5193(82)90002-9","article-title":"Nucleic acid junctions and lattices","volume":"99","author":"Seeman","year":"1982","journal-title":"J Theor Biol"},{"key":"10.1016\/j.cbpa.2026.102790_bib2","article-title":"DNA nanotechnology","volume":"3","author":"Seeman","year":"2018","journal-title":"Nat Rev Mater"},{"key":"10.1016\/j.cbpa.2026.102790_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nature04586","article-title":"Folding DNA to create nanoscale shapes and patterns","volume":"440","author":"Rothemund","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cbpa.2026.102790_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.102479","article-title":"RNA nanotechnology on the horizon: self-assembly, chemical modifications, and functional applications","volume":"81","author":"Stewart","year":"2024","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.cbpa.2026.102790_bib5","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1126\/science.1253920","article-title":"A single-stranded architecture for cotranscriptional folding of RNA nanostructures","volume":"345","author":"Geary","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2026.102790_bib6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1126\/science.1206938","article-title":"Organization of intracellular reactions with rationally designed RNA assemblies","volume":"333","author":"Delebecque","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2026.102790_bib7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nnano.2009.83","article-title":"A DNA nanomachine that maps spatial and temporal pH changes inside living cells","volume":"4","author":"Modi","year":"2009","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.cbpa.2026.102790_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nnano.2013.92","article-title":"Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell","volume":"8","author":"Modi","year":"2013","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.cbpa.2026.102790_bib9","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1021\/nn5011914","article-title":"Virus-inspired membrane encapsulation of DNA nanostructures to achieve in vivo stability","volume":"8","author":"Perrault","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.cbpa.2026.102790_bib10","article-title":"Resolving DNA origami structural integrity and pharmacokinetics in vivo","author":"Wang","year":"2026","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.cbpa.2026.102790_bib11","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1021\/acs.chemrev.3c00028","article-title":"Recent advances in DNA origami-engineered nanomaterials and applications","volume":"123","author":"Zhan","year":"2023","journal-title":"Chem Rev"},{"key":"10.1016\/j.cbpa.2026.102790_bib12","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/15476286.2023.2237719","article-title":"RNA origami: design, simulation and application","volume":"20","author":"Poppleton","year":"2023","journal-title":"RNA Biol"},{"key":"10.1016\/j.cbpa.2026.102790_bib13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41392-024-02035-4","article-title":"Nucleic acid drugs: recent progress and future perspectives","volume":"9","author":"Sun","year":"2024","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.cbpa.2026.102790_bib14","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1021\/acsnano.4c11858","article-title":"Emerging delivery systems for enabling precision nucleic acid therapeutics","volume":"19","author":"Bian","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.cbpa.2026.102790_bib15","doi-asserted-by":"crossref","first-page":"11738","DOI":"10.1021\/acs.nanolett.5c03000","article-title":"Programmable allosteric regulation of three-dimensional DNA nanostructures for targeted membrane protein degradation","volume":"25","author":"Wu","year":"2025","journal-title":"Nano Lett"},{"key":"10.1016\/j.cbpa.2026.102790_sref16","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1021\/acs.nanolett.4c00552","article-title":"Dynamic assembly of DNA nanostructures in cancer cells enables the coupling of autophagy activating and real-time tracking","volume":"24","author":"Guo","year":"2024","journal-title":"Nano Lett"},{"key":"10.1016\/j.cbpa.2026.102790_bib17","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.31635\/ccschem.023.202303271","article-title":"Light-mediated spatiotemporally dynamic assembly of DNA nanostructures in living cells regulates autophagy","volume":"6","author":"Zhang","year":"2024","journal-title":"CCS Chem"},{"key":"10.1016\/j.cbpa.2026.102790_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102224","article-title":"Sequential assembly of DNA nanoparticles inside cells enables lysosome interference and cell behavior regulation","volume":"56","author":"Yang","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.cbpa.2026.102790_bib19","article-title":"Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells","volume":"497","author":"Elblov\u00e1","year":"2024","journal-title":"Chem Eng J"},{"key":"10.1016\/j.cbpa.2026.102790_bib20","doi-asserted-by":"crossref","first-page":"eads8651","DOI":"10.1126\/sciadv.ads8651","article-title":"DNA-programmed responsive microorganism assembly with controlled patterns and behaviors","volume":"11","author":"Kong","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.cbpa.2026.102790_sref21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41467-025-67817-y","article-title":"Designer RNA nanostructures co-transcribed and self-assembled inside human cell nuclei","volume":"17","author":"Chang","year":"2026","journal-title":"Nat Commun"},{"key":"10.1016\/j.cbpa.2026.102790_sref22","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1038\/s41467-026-69336-w","article-title":"Expression of nano-engineered RNA organelles in bacteria","volume":"17","author":"Ng","year":"2026","journal-title":"Nat Commun"},{"key":"10.1016\/j.cbpa.2026.102790_bib23","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/s41565-026-02164-7","article-title":"Programmable artificial RNA condensates in mammalian cells","volume":"21","author":"Li","year":"2026","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.cbpa.2026.102790_bib24","article-title":"Programmable and switchable RNA scaffolds for synthetic condensate engineering in mammalian cells","author":"Xue","year":"2026","journal-title":"bioRxiv"},{"key":"10.1016\/j.cbpa.2026.102790_bib25","doi-asserted-by":"crossref","first-page":"8337","DOI":"10.1093\/nar\/gkad621","article-title":"Targeted RNA condensation in living cells via genetically encodable triplet repeat tags","volume":"51","author":"Xue","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cbpa.2026.102790_bib26","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/s41565-024-01726-x","article-title":"Co-transcriptional production of programmable RNA condensates and synthetic organelles","volume":"19","author":"Fabrini","year":"2024","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.cbpa.2026.102790_bib27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s44331-026-00020-y","article-title":"Revolutionizing biosensing with nucleic acids: cutting-edge advances","volume":"2","author":"Yolcu","year":"2026","journal-title":"Biosci Nanotech"},{"key":"10.1016\/j.cbpa.2026.102790_bib28","article-title":"Recent advances in nucleic acid-based biosensors for bacterial pathogen detection","volume":"228","author":"Singh","year":"2025","journal-title":"Microchem J"},{"key":"10.1016\/j.cbpa.2026.102790_bib29","doi-asserted-by":"crossref","first-page":"7030","DOI":"10.1021\/acs.analchem.4c00211","article-title":"Endogenous AND logic DNA nanomachine for highly specific cancer cell imaging","volume":"96","author":"Zhang","year":"2024","journal-title":"Anal Chem"},{"key":"10.1016\/j.cbpa.2026.102790_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.102127","article-title":"Tetrahedral DNA frameworks for biosensing and imaging analysis in living cells","volume":"54","author":"Qi","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.cbpa.2026.102790_bib31","first-page":"279","article-title":"DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules","volume":"33","author":"Wang","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.cbpa.2026.102790_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116409","article-title":"Construction of an exogenously and endogenously co-activated DNA logic amplifier for highly reliable intracellular MicroRNA imaging","volume":"259","author":"Zheng","year":"2024","journal-title":"Biosens Bioelectron"},{"key":"10.1016\/j.cbpa.2026.102790_sref33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-0716-4248-1_6","article-title":"3D walking nanomachine for monitoring of miRNA in living cells","author":"Meng","year":"2025","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.cbpa.2026.102790_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.125952","article-title":"A dual-core 3D DNA nanomachine based on DNAzyme positive feedback loop for highly sensitive microRNA imaging in living cells","volume":"273","author":"Li","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.cbpa.2026.102790_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.125757","article-title":"Self-driven and self-catalytic tripedal DNA nanomachine for rapid and sensitive detection of miR-21 in colorectal cancer","volume":"330","author":"Ma","year":"2025","journal-title":"Spectrochim Acta Mol Biomol Spectrosc"},{"key":"10.1016\/j.cbpa.2026.102790_bib36","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3390\/bios14080376","article-title":"Fluorogenic RNA-based biosensors of small molecules: current developments, uses, and perspectives","volume":"14","author":"Kehrli","year":"2024","journal-title":"Biosensors"},{"key":"10.1016\/j.cbpa.2026.102790_bib37","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/nar\/gkae551","article-title":"Multiplexed sequential imaging in living cells with orthogonal fluorogenic RNA aptamer\/dye pairs","volume":"52","author":"Zheng","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cbpa.2026.102790_sref38","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf839","article-title":"Visualizing intracellular glycine with two-dye and single-dye ratiometric RNA-based sensors","volume":"53","author":"Bodin","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cbpa.2026.102790_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2025.118559","article-title":"Structural DNA nanoprobe for intracellular fluorescence biosensing","volume":"195","author":"Xu","year":"2026","journal-title":"TrAC, Trends Anal Chem"},{"key":"10.1016\/j.cbpa.2026.102790_bib40","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1021\/acsabm.5c02525","article-title":"Alpha-tocopherol-conjugated DNA tetrahedron with enhanced cellular uptake and cytotoxicity for cancer therapeutics","volume":"9","author":"Chithra","year":"2026","journal-title":"ACS Appl Bio Mater"},{"key":"10.1016\/j.cbpa.2026.102790_bib41","article-title":"Transmembrane capability of DNA origami sheet enhanced by 3D configurational changes","volume":"26","author":"Liu","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.cbpa.2026.102790_bib42","article-title":"DNA origami-templated aptamer chiral structures realize cellular enantioselectivity","volume":"38","author":"Song","year":"2026","journal-title":"Adv Mater"},{"key":"10.1016\/j.cbpa.2026.102790_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242316715","article-title":"Wireframe DNA origami for the cellular delivery of platinum(ii)-based drugs","volume":"24","author":"De Luca","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cbpa.2026.102790_bib44","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1021\/acs.nanolett.8b00660","article-title":"Modulation of the cellular uptake of DNA origami through control over mass and shape","volume":"18","author":"Bastings","year":"2018","journal-title":"Nano Lett"},{"key":"10.1016\/j.cbpa.2026.102790_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202400091","article-title":"Effect of DNA origami nanostructures on bacterial growth","volume":"25","author":"Garcia-Diosa","year":"2024","journal-title":"Chembiochem"},{"key":"10.1016\/j.cbpa.2026.102790_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202502490","article-title":"Effects of DNA origami-based nanoagent design on apoptosis induction in a large 3D cancer spheroid model","volume":"21","author":"Weck","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.cbpa.2026.102790_sref47","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2025.102694","article-title":"Tetrahedral DNA nanostructure based siRNA delivery vehicle for braf gene silencing and MEK-ERK pathway inhibition in the treatment of refractory thyroid cancer","volume":"62","author":"Zhang","year":"2025","journal-title":"Nano Today"},{"key":"10.1016\/j.cbpa.2026.102790_bib48","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1021\/jacs.5c19678","article-title":"A spatially controllable DNA origami-based T-cell cluster engager for precise tumor elimination","volume":"148","author":"Li","year":"2026","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2026.102790_bib49","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1002\/cjoc.70094","article-title":"DNA nanotechnology-endowed synthetic immunology","volume":"43","author":"Chen","year":"2025","journal-title":"Chin J Chem"},{"key":"10.1016\/j.cbpa.2026.102790_sref50","doi-asserted-by":"crossref","first-page":"25836","DOI":"10.1021\/acsami.4c03700","article-title":"Hepatitis B virus neutralization with DNA origami nanoshells","volume":"16","author":"Willner","year":"2024","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.cbpa.2026.102790_bib51","doi-asserted-by":"crossref","first-page":"9581","DOI":"10.1038\/s41467-024-53937-4","article-title":"Rationally designed multimeric nanovaccines using icosahedral DNA origami for display of SARS-CoV-2 receptor binding domain","volume":"15","author":"Feng","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.cbpa.2026.102790_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/science.adx6291","article-title":"DNA origami vaccines program antigen-focused germinal centers","volume":"391","author":"Romanov","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.cbpa.2026.102790_sref53","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-026-01614-w","article-title":"DNA origami vaccine nanoparticles improve humoral and cellular immune responses to infectious diseases","author":"Zeng","year":"2026","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.cbpa.2026.102790_sref54","doi-asserted-by":"crossref","first-page":"11573","DOI":"10.1021\/acs.nanolett.4c03102","article-title":"Programming DNA nanoassemblies into polyvalent lysosomal degraders for potent degradation of pathogenic membrane proteins","volume":"24","author":"Yu","year":"2024","journal-title":"Nano Lett"},{"key":"10.1016\/j.cbpa.2026.102790_bib55","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41565-023-01507-y","article-title":"Multivalent insulin receptor activation using insulin\u2013DNA origami nanostructures","volume":"19","author":"Spratt","year":"2024","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.cbpa.2026.102790_bib56","doi-asserted-by":"crossref","first-page":"15853","DOI":"10.1021\/acsnano.5c00745","article-title":"DNA framework-based lysosome-targeting chimeras: intracellular ATP-facilitated extracellular protein degradation","volume":"19","author":"Ning","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.cbpa.2026.102790_bib57","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/s41467-024-44869-0","article-title":"Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds","volume":"15","author":"Wamhoff","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.cbpa.2026.102790_bib58","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1021\/jacs.3c10704","article-title":"Tunable multivalent aptamer-based DNA nanostructures to regulate multiheteroreceptor-mediated tumor recognition","volume":"146","author":"Hu","year":"2024","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.cbpa.2026.102790_sref59","doi-asserted-by":"crossref","first-page":"10320","DOI":"10.1021\/acsnano.5c17463","article-title":"Spatially defined DNA origami cell engagers for T and natural killer cell-mediated immune modulation","volume":"20","author":"Sun","year":"2026","journal-title":"ACS Nano"},{"key":"10.1016\/j.cbpa.2026.102790_bib60","first-page":"12159","article-title":"Interfacing biology with nucleic acid nanotechnology","volume":"117","author":"Jasinski","year":"2017","journal-title":"Chem Rev"},{"key":"10.1016\/j.cbpa.2026.102790_bib61","doi-asserted-by":"crossref","first-page":"28807","DOI":"10.1039\/D4RA03823A","article-title":"Therapeutic applications of RNA nanostructures","volume":"14","author":"Yip","year":"2024","journal-title":"RSC Adv"},{"key":"10.1016\/j.cbpa.2026.102790_bib62","doi-asserted-by":"crossref","first-page":"9221","DOI":"10.1021\/acsnano.0c04753","article-title":"Opportunities, barriers, and a strategy for overcoming translational challenges to therapeutic nucleic acid nanotechnology","volume":"14","author":"Afonin","year":"2020","journal-title":"ACS Nano"}],"container-title":["Current Opinion in Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367593126001390?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1367593126001390?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:28:23Z","timestamp":1793780903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1367593126001390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":62,"alternative-id":["S1367593126001390"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2026.102790","relation":{},"ISSN":["1367-5931"],"issn-type":[{"value":"1367-5931","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracellular nucleic acid nanotechnology","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2026.102790","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102790"}}