{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:14:29Z","timestamp":1783782869374,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130109"],"award-info":[{"award-number":["32130109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part A: Molecular &amp; Integrative Physiology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cbpa.2026.112007","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:09:10Z","timestamp":1778108950000},"page":"112007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Combined effects of warming and hypoxia on aquatic ectotherms: A multilevel meta-analysis of physiological and fitness responses"],"prefix":"10.1016","volume":"317","author":[{"given":"Guixian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpa.2026.112007_bb0005","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1038\/s41467-024-47064-3","article-title":"Hidden impacts of ocean warming and acidification on biological responses of marine animals revealed through meta-analysis","volume":"15","author":"Alter","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbpa.2026.112007_bb0020","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41593-017-0005-0","article-title":"Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception","volume":"20","author":"Arenas","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cbpa.2026.112007_bb0075","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1461-0248.2008.01253.x","article-title":"Interactive and cumulative effects of multiple human stressors in marine systems","volume":"11","author":"Crain","year":"2008","journal-title":"Ecol. Lett."},{"key":"10.1016\/j.cbpa.2026.112007_bb0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41586-020-2721-y","article-title":"Metabolic trait diversity shapes marine biogeography","volume":"585","author":"Deutsch","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cbpa.2026.112007_bb0110","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.physiol.61.1.243","article-title":"Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology","volume":"61","author":"Feder","year":"1999","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0125","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-marine-122414-033953","article-title":"Multiple stressors in a changing world: the need for an improved perspective on physiological responses to the dynamic marine environment","volume":"8","author":"Gunderson","year":"2016","journal-title":"Ann. Rev. Mar. Sci."},{"key":"10.1016\/j.cbpa.2026.112007_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-185X.1999.tb00180.x","article-title":"Metabolic depression in animals: physiological perspectives and biochemical generalizations","volume":"74","author":"Guppy","year":"1999","journal-title":"Biol. Rev."},{"key":"10.1016\/j.cbpa.2026.112007_bb0140","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-ento-020117-043145","article-title":"Functional hypoxia in insects: definition, assessment, and consequences for physiology, ecology, and evolution","volume":"63","author":"Harrison","year":"2018","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0150","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1890\/0012-9658(1999)080[1150:TMAORR]2.0.CO;2","article-title":"The meta-analysis of response ratios in experimental ecology","volume":"80","author":"Hedges","year":"1999","journal-title":"Ecology"},{"key":"10.1016\/j.cbpa.2026.112007_bb0175","doi-asserted-by":"crossref","first-page":"20122370","DOI":"10.1098\/rspb.2012.2370","article-title":"Experimental demonstration of the growth rate\u2013lifespan trade-off","volume":"280","author":"Lee","year":"2013","journal-title":"Proc. R. Soc. B"},{"key":"10.1016\/j.cbpa.2026.112007_bb0200","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/icb\/ict066","article-title":"Responses to temperature and hypoxia as interacting stressors in fish: implications for adaptation to environmental change","volume":"53","author":"McBryan","year":"2013","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0210","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/2041-210X.12593","article-title":"Rotl: an R package to interact with the open tree of life data","volume":"7","author":"Michonneau","year":"2016","journal-title":"Methods Ecol. Evol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0230","article-title":"PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.cbpa.2026.112007_bb0235","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/bioinformatics\/bty633","article-title":"Ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R","volume":"35","author":"Paradis","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cbpa.2026.112007_bb0245","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/ece3.1465","article-title":"Reconceptualizing synergism and antagonism among multiple stressors","volume":"5","author":"Piggott","year":"2015","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0255","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S1095-6433(02)00045-4","article-title":"Climate variations and the physiological basis of temperature dependent biogeography: systemic to molecular hierarchy of thermal tolerance in animals","volume":"132","author":"P\u00f6rtner","year":"2002","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0260","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1242\/jeb.134585","article-title":"Oxygen- and capacity-limited thermal tolerance: bridging ecology and physiology","volume":"220","author":"P\u00f6rtner","year":"2017","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0265","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2025"},{"key":"10.1016\/j.cbpa.2026.112007_bb0270","doi-asserted-by":"crossref","first-page":"31963","DOI":"10.1073\/pnas.2003292117","article-title":"Oxygen limitation may affect the temperature and size dependence of metabolism in aquatic ectotherms","volume":"117","author":"Rubalcaba","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpa.2026.112007_bb0275","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/23328940.2017.1315478","article-title":"Evolutionary tuning of TRPA1 and TRPV1 thermal and chemical sensitivity in vertebrates","volume":"4","author":"Saito","year":"2017","journal-title":"Temperature"},{"key":"10.1016\/j.cbpa.2026.112007_bb0285","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/icb\/ict028","article-title":"Energy-limited tolerance to stress as a conceptual framework to integrate the effects of multiple stressors","volume":"53","author":"Sokolova","year":"2013","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0290","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00360-007-0183-2","article-title":"Is cold the new hot? Elevated ubiquitin-conjugated protein levels in tissues of Antarctic fish as evidence for cold-denaturation of proteins in vivo","volume":"177","author":"Todgham","year":"2007","journal-title":"J. Comp. Physiol. B"},{"key":"10.1016\/j.cbpa.2026.112007_bb0300","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1890\/10-2369.1","article-title":"Oxygen supply in aquatic ectotherms: partial pressure and solubility together explain biodiversity and size patterns","volume":"92","author":"Verberk","year":"2011","journal-title":"Ecology"},{"key":"10.1016\/j.cbpa.2026.112007_bb0305","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.1111\/gcb.16319","article-title":"Body mass and cell size shape the tolerance of fishes to low oxygen in a temperature-dependent manner","volume":"28","author":"Verberk","year":"2022","journal-title":"Glob. Chang. Biol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0310","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1111\/gcb.16834","article-title":"Long-term forecast of thermal mortality with climate warming in riverine amphipods","volume":"29","author":"Verberk","year":"2023","journal-title":"Glob. Chang. Biol."},{"key":"10.1016\/j.cbpa.2026.112007_bb0315","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Soft."},{"key":"10.1016\/j.cbpa.2026.112007_bb0325","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1086\/722899","article-title":"Integrative approaches to understanding organismal responses to aquatic deoxygenation","volume":"243","author":"Woods","year":"2022","journal-title":"Biol. Bull."}],"container-title":["Comparative Biochemistry and Physiology Part A: Molecular &amp; Integrative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643326000425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643326000425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:53:03Z","timestamp":1783781583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1095643326000425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":27,"alternative-id":["S1095643326000425"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2026.112007","relation":{},"ISSN":["1095-6433"],"issn-type":[{"value":"1095-6433","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined effects of warming and hypoxia on aquatic ectotherms: A multilevel meta-analysis of physiological and fitness responses","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2026.112007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112007"}}