{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:46:03Z","timestamp":1786653963590,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008682","name":"Shanghai Ocean University","doi-asserted-by":"publisher","award":["2025ZD0408100"],"award-info":[{"award-number":["2025ZD0408100"]}],"id":[{"id":"10.13039\/501100008682","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cbpa.2026.112044","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:31:14Z","timestamp":1782851474000},"page":"112044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Disruption of Pik3r1 promotes muscle hyperplasia and lipolysis in grass carp (Ctenopharyngodon idella)"],"prefix":"10.1016","volume":"319","author":[{"given":"Wenyao","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaozhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruitao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruicong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"31","key":"10.1016\/j.cbpa.2026.112044_bb0005","doi-asserted-by":"crossref","first-page":"9668","DOI":"10.1073\/pnas.1510802112","article-title":"Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditions","volume":"112","author":"Aspiras","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"45","key":"10.1016\/j.cbpa.2026.112044_bb0010","doi-asserted-by":"crossref","first-page":"37489","DOI":"10.1074\/jbc.M506967200","article-title":"Increased P85\u03b1 is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess","volume":"280","author":"Barbour","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cbpa.2026.112044_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2023.101039","article-title":"Effects of CRISPR\/Cas9-mediated dnd1 knockout impairs gonadal development in striped catfish","volume":"18","author":"Booncherd","year":"2024","journal-title":"Animal"},{"key":"10.1016\/j.cbpa.2026.112044_bib316","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tibs.2014.12.003","article-title":"Synergy in activating class I PI3Ks","volume":"40","author":"Burke","year":"2015","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.cbpa.2026.112044_bb0020","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2497112","article-title":"PPAR-mediated reduction of lipid accumulation in hepatocytes involves the autophagy-lysosome-mitochondrion axis","volume":"57","author":"Cetti","year":"2025","journal-title":"Ann. Med."},{"issue":"5","key":"10.1016\/j.cbpa.2026.112044_bb0025","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3390\/nu15051071","article-title":"Signals for muscular protein turnover and insulin resistance in critically ill patients: a narrative review","volume":"15","author":"Chapela","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.cbpa.2026.112044_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/crispr.2021.0113","article-title":"Inference of CRISPR edits from sanger trace data","volume":"5","author":"Conant","year":"2022","journal-title":"Crispr j"},{"key":"10.1016\/j.cbpa.2026.112044_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738290","article-title":"CRISPR\/Cas-9 induced knockout of myostatin gene improves growth and disease resistance in channel catfish (Ictalurus punctatus)","volume":"557","author":"Coogan","year":"2022","journal-title":"Aquaculture"},{"issue":"14","key":"10.1016\/j.cbpa.2026.112044_bb0040","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400370R","article-title":"Loss of bmp15 function in the seasonal spawner Atlantic salmon results in ovulatory failure","volume":"38","author":"Crespo","year":"2024","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.cbpa.2026.112044_bb0050","first-page":"61","article-title":"Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r","volume":"69","author":"Fei","year":"2017","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.cbpa.2026.112044_bb0055","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/81715","article-title":"Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85\u03b1","volume":"26","author":"Fruman","year":"2000","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.cbpa.2026.112044_bb0060","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K pathway in human disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cbpa.2026.112044_bb0065","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ygcen.2013.06.009","article-title":"Regulation of skeletal muscle growth in fish by the growth hormone--insulin-like growth factor system","volume":"192","author":"Fuentes","year":"2013","journal-title":"Gen. Comp. Endocrinol."},{"issue":"4","key":"10.1016\/j.cbpa.2026.112044_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2022.151897","article-title":"Techniques for digital histological morphometry of the pineal gland","volume":"124","author":"Gheban","year":"2022","journal-title":"Acta Histochem."},{"key":"10.1016\/j.cbpa.2026.112044_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2025.106198","article-title":"Dietary pyridoxine promoted muscle protein deposition relating to PI3K\/AKT\/TOR pathway and the ubiquitin proteasome system in grass carp (Ctenopharyngodon idella)","volume":"66","author":"Gong","year":"2025","journal-title":"Food Biosci."},{"key":"10.1016\/j.cbpa.2026.112044_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739979","article-title":"Genome-wide association study reveals growth-related SNPs and candidate genes in grass carp (Ctenopharyngodon idella)","volume":"577","author":"Hao","year":"2023","journal-title":"Aquaculture"},{"issue":"19","key":"10.1016\/j.cbpa.2026.112044_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e38323","article-title":"Targeted metabolomics of muscle amino acid profles and hepatic transcriptomics analyses in grass carp (Ctenopharyngodon idellus) fed with broad beans","volume":"10","author":"Hao","year":"2024","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.cbpa.2026.112044_bb0090","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011189","article-title":"PI3K-PKB\/Akt pathway","volume":"4","author":"Hemmings","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cbpa.2026.112044_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.739130","article-title":"Multi-locus gene editing effectively knocked out cyp19a1a and foxl2 in Monopterus albus, a hermaphroditic fish","volume":"565","author":"Hou","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpa.2026.112044_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737207","article-title":"Heterozygous depletion of pik3r1 improves growth and feed conversion efficiency in Gibel carp (Carassius gibelio)","volume":"545","author":"Huang","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpa.2026.112044_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1310000","article-title":"Cloning, distribution, and effects of growth regulation of MC3R and MC4R in red crucian carp (Carassius auratus red var.)","volume":"14","author":"Huang","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.cbpa.2026.112044_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741526","article-title":"Integrated transcriptomic and epigenomic analyses to disclose the transcriptional regulatory mechanisms of lipid and energy metabolism under cold stress in grass carp","volume":"595","author":"Huang","year":"2025","journal-title":"Aquaculture"},{"issue":"5","key":"10.1016\/j.cbpa.2026.112044_bb0120","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1242\/jcs.093773","article-title":"Classes of phosphoinositide 3-kinases at a glance","volume":"127","author":"Jean","year":"2014","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.cbpa.2026.112044_bb0125","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/ajmg.c.31531","article-title":"Somatic overgrowth disorders of the PI3K\/AKT\/mTOR pathway & therapeutic strategies","volume":"172","author":"Keppler-Noreuil","year":"2016","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"issue":"4","key":"10.1016\/j.cbpa.2026.112044_bb0135","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.bbrc.2009.07.110","article-title":"Suppression of myostatin with vector-based RNA interference causes a double-muscle effect in transgenic zebrafish","volume":"387","author":"Lee","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpa.2026.112044_bb0140","article-title":"Effects of arginine supplementation in high-carbohydrate diets on the growth, hematological parameters, and hepatic and skeletal muscle glucose metabolism of juvenile mirror carp (Cyprinus carpio) based on PI3K\/Akt signaling pathway","volume":"39","author":"Li","year":"2024","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.cbpa.2026.112044_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142428","article-title":"Impact of cadmium and diclofenac exposure on biochemical responses, transcriptome, gut microflora, and growth performance in grass carp (Ctenopharyngodon idella)","volume":"360","author":"Li","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpa.2026.112044_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2024.110183","article-title":"Transcriptomic data of BT549 triple negative breast cancer cells treated with 20 \u03bcM NU7441, a DNA-dependent kinase inhibitor","volume":"53","author":"Li","year":"2024","journal-title":"Data Brief"},{"key":"10.1016\/j.cbpa.2026.112044_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117379","article-title":"Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K\/AKT\/mTOR\/SREBP-1c pathway","volume":"287","author":"Liu","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cbpa.2026.112044_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740440","article-title":"CRISPR-Cas9\/Cas12a-based genome editing in Atlantic cod (Gadus morhua)","volume":"581","author":"L\u00f3pez-Porras","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpa.2026.112044_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739910","article-title":"Dietary inositol improved glucose and lipid metabolism mediated by the insulin-PI3K-Akt signaling pathway in Pacific white shrimp (Litopenaeus vannamei)","volume":"577","author":"Lu","year":"2023","journal-title":"Aquaculture"},{"issue":"10","key":"10.1016\/j.cbpa.2026.112044_bb0170","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.4161\/cc.4.10.2062","article-title":"The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer","volume":"4","author":"Luo","year":"2005","journal-title":"Cell Cycle"},{"issue":"3","key":"10.1016\/j.cbpa.2026.112044_bb0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1083\/jcb.200503088","article-title":"The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex","volume":"170","author":"Luo","year":"2005","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.cbpa.2026.112044_bb0180","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1172\/JCI0213305","article-title":"Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes","volume":"109","author":"Mauvais-Jarvis","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.cbpa.2026.112044_bb0185","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3390\/genes15060726","article-title":"In search of a target gene for a desirable phenotype in aquaculture: genome editing of Cyprinidae and Salmonidae species","volume":"15","author":"Orlova","year":"2024","journal-title":"Genes"},{"key":"10.1016\/j.cbpa.2026.112044_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2022.107948","article-title":"Transcriptomic data of MCF-7 breast cancer cells treated with G1, a G-protein coupled estrogen receptor (GPER) agonist","volume":"41","author":"Pal","year":"2022","journal-title":"Data Brief"},{"issue":"3","key":"10.1016\/j.cbpa.2026.112044_bb0195","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2008.07.007","article-title":"SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth","volume":"8","author":"Porstmann","year":"2008","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.cbpa.2026.112044_bb0205","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899297","article-title":"Waking up muscle stem cells: PI3K signalling is ringing","volume":"37","author":"Relaix","year":"2018","journal-title":"EMBO J."},{"issue":"45","key":"10.1016\/j.cbpa.2026.112044_bb0210","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1073\/pnas.1716173114","article-title":"Twenty-five years of mTOR: uncovering the link from nutrients to growth","volume":"114","author":"Sabatini","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.cbpa.2026.112044_bb0215","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cbpa.2026.112044_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.softx.2024.101634","article-title":"CyEnGNet\u2014app: a new Cytoscape app for the reconstruction of large co-expression networks using an ensemble approach","volume":"25","author":"Saz-Navarro","year":"2024","journal-title":"SoftwareX"},{"issue":"4","key":"10.1016\/j.cbpa.2026.112044_bb0225","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1089\/crispr.2020.0115","article-title":"Genome editing using the CRISPR-Cas9 system to generate a solid-red germline of Nile Tilapia (Oreochromis niloticus)","volume":"4","author":"Segev-Hadar","year":"2021","journal-title":"The CRISPR Journal"},{"key":"10.1016\/j.cbpa.2026.112044_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2025.111850","article-title":"Transcriptome analysis and CRISPR-Cas9-mediated mutagenesis identify gpr116 as a candidate gene for growth promotion in grass carp (Ctenopharyngodon idella)","volume":"305","author":"Sheng","year":"2025","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpa.2026.112044_bb0235","series-title":"A Refinement to Gene Editing in Atlantic Salmon Using Asymmetrical Oligonucleotide Donors","author":"Straume","year":"2021"},{"key":"10.1016\/j.cbpa.2026.112044_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735597","article-title":"Disruption of mstna and mstnb gene through CRISPR\/Cas9 leads to elevated muscle mass in blunt snout bream (Megalobrama amblycephala)","volume":"528","author":"Sun","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpa.2026.112044_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.743355","article-title":"CRISPR\/Cas9-mediated myostatin b knockout enhances growth performance and muscle hypertrophy in grass carp (Ctenopharyngodon idella)","volume":"613","author":"Sun","year":"2026","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpa.2026.112044_bb0250","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.fsi.2017.10.022","volume":"72","author":"Tan","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpa.2026.112044_bb0255","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.aquaculture.2016.07.004","article-title":"Understanding fish muscle growth regulation to optimize aquaculture production","volume":"467","author":"V\u00e9lez","year":"2017","journal-title":"Aquaculture"},{"issue":"19","key":"10.1016\/j.cbpa.2026.112044_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910766","article-title":"Zebrafish and Medaka: important animal models for human neurodegenerative diseases","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpa.2026.112044_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.domaniend.2024.106892","article-title":"Effects of rumen metabolite butyric acid on bovine skeletal muscle satellite cells proliferation, apoptosis and transcriptional states during myogenic differentiation","volume":"90","author":"Wang","year":"2025","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.cbpa.2026.112044_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.anifeedsci.2025.116471","article-title":"The individual and synergistic effects of dietary lipids and DHA on the growth performance, feed utilization, lipid metabolism, antioxidant capacity, and immune responses of grass carp (Ctenopharyngodon idellus)","volume":"329","author":"Xue","year":"2025","journal-title":"Anim. Feed Sci. Technol."},{"issue":"1","key":"10.1016\/j.cbpa.2026.112044_bb0275","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.243","article-title":"PIK3R3 regulates PPAR\u03b1 expression to stimulate fatty acid \u03b2-oxidation and decrease hepatosteatosis","volume":"50","author":"Yang","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"12","key":"10.1016\/j.cbpa.2026.112044_bb0280","first-page":"4965","article-title":"Identification and expression analysis of apple PDHB-1 gene family","volume":"39","author":"Yang","year":"2023","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"10.1016\/j.cbpa.2026.112044_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739707","article-title":"Pomc knockout increases growth in zebrafish","volume":"574","author":"Yang","year":"2023","journal-title":"Aquaculture"},{"issue":"9","key":"10.1016\/j.cbpa.2026.112044_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091970","article-title":"Mechanisms of IGF-1-mediated regulation of skeletal muscle hypertrophy and atrophy","volume":"9","author":"Yoshida","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.cbpa.2026.112044_bb0295","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1128\/MCB.18.3.1379","article-title":"Regulation of the p85\/p110 phosphatidylinositol 3\u2032-kinase: stabilization and inhibition of the p110\u03b1 catalytic subunit by the p85 regulatory subunit","volume":"18","author":"Yu","year":"1998","journal-title":"Mol. Cell. Biol."},{"issue":"21","key":"10.1016\/j.cbpa.2026.112044_bb0300","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1007\/s00018-013-1330-4","article-title":"Skeletal muscle hypertrophy and regeneration: interplay between the myogenic regulatory factors (MRFs) and insulin-like growth factors (IGFs) pathways","volume":"70","author":"Zanou","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbpa.2026.112044_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107617","article-title":"AlphaFold-based AI docking reveals AMPK\/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease","volume":"212","author":"Zhang","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbpa.2026.112044_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133799","article-title":"Dietary cinnamaldehyde improves muscle protein content by promoting muscle fiber growth via PTP1B\/IGF1\/PI3K\/AKTs-TOR\/FOXO3a signaling pathway in grass carp (Ctenopharyngodon idella)","volume":"399","author":"Zhou","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.cbpa.2026.112044_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.aqrep.2022.101060","article-title":"The growth performance, antioxidant capacity, liver fat metabolism and intestinal flora composition responsiveness to fish meal replacement by peanut cake for juvenile hybrid grouper (Epinephelus fuscoguttatus \u2640 \u00d7 Epinephelus lanceolatus \u2642)","volume":"23","author":"Zhu","year":"2022","journal-title":"Aquaculture Reports"}],"container-title":["Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643326000802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1095643326000802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:04:14Z","timestamp":1786651454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1095643326000802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":60,"alternative-id":["S1095643326000802"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpa.2026.112044","relation":{},"ISSN":["1095-6433"],"issn-type":[{"value":"1095-6433","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of Pik3r1 promotes muscle hyperplasia and lipolysis in grass carp (Ctenopharyngodon idella)","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpa.2026.112044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112044"}}