{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:32:41Z","timestamp":1790371961955,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.cbpb.2021.110672","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T11:50:07Z","timestamp":1629978607000},"page":"110672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Characterization, expression and CpG methylation analysis of Dmrt1 and its response to steroid hormone in blotched snakehead (Channa maculata)"],"prefix":"10.1016","volume":"257","author":[{"given":"Mi","family":"Ou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunci","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanduo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpb.2021.110672_bb0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1477-7827-13-2","article-title":"Molecular cloning and expression analysis of dmrt1 and sox9 during gonad development and male reproductive cycle in the Lambari fish, Astyanax altiparanae","volume":"13","author":"Adolfi","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000452362","article-title":"The reversible sex of gonochoristic fish: insights and consequences","volume":"10","author":"Baroiller","year":"2016","journal-title":"Sex. Dev."},{"key":"10.1016\/j.cbpb.2021.110672_bb0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ygcen.2005.04.004","article-title":"Molecular cloning of cDNAs and structural model analysis of two gonadotropin \u03b2-subunits of snakehead fish (Channa maculata)","volume":"143","author":"Chatterjee","year":"2005","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.cbpb.2021.110672_bb0020","first-page":"204","article-title":"Preliminary study on artificial propagation of Ophiocephalus maculatus lacepede","volume":"6","author":"Chen","year":"2001","journal-title":"J. Jimei Univ."},{"key":"10.1016\/j.cbpb.2021.110672_bb0025","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0044-8486(02)00057-1","article-title":"Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences","volume":"208","author":"Devlin","year":"2002","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2021.110672_bb0030","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10695-006-9005-9","article-title":"Dmrt1 expression analysis during spermatogenesis in pejerrey, Odontesthes bonariensis","volume":"32","author":"Fernandino","year":"2006","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpb.2021.110672_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dci.2013.11.007","article-title":"Molecular characterization, phylogeny and expression of a hepcidin gene in the blotched snakehead Channa maculata","volume":"44","author":"Gong","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0040","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1006\/bbrc.2000.2840","article-title":"Sexually dimorphic expression of two types of DM (Doublesex\/Mab-3)-domain genes in a teleost fish, the tilapia (Oreochromis niloticus)","volume":"272","author":"Guan","year":"2000","journal-title":"Biochem. Bioph. Res. Co."},{"key":"10.1016\/j.cbpb.2021.110672_bb0045","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.bbrc.2005.03.066","article-title":"Gene structure, multiple alternative splicing, and expression in gonads of zebrafish Dmrt1","volume":"330","author":"Guo","year":"2005","journal-title":"Biochem. Biophy. Res. Co."},{"key":"10.1016\/j.cbpb.2021.110672_bb0050","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2108\/zs190054","article-title":"Expression profiles of dmrt1 in Schizothorax kozlovi, and their relation to CpG methylation of its promoter and temperature","volume":"37","author":"He","year":"2020","journal-title":"Zool. Sci."},{"key":"10.1016\/j.cbpb.2021.110672_bb0055","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1742-4658.2011.08030.x","article-title":"Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish","volume":"278","author":"Herpin","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.cbpb.2021.110672_bb0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10695-018-0558-1","article-title":"Molecular identification of dmrt1 and its promoter CpG methylation in correlation with gene expression during gonad development in Culter alburnus","volume":"45","author":"Jia","year":"2018","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpb.2021.110672_bb0065","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cbpb.2010.03.009","article-title":"Sexually dimorphic expression of dmrt1 in immature and mature Atlantic cod (Gadus morhua L.)","volume":"156","author":"Johnsen","year":"2010","journal-title":"Comp. Biochem. Phys. B."},{"key":"10.1016\/j.cbpb.2021.110672_bb0070","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/(SICI)1526-968X(200003)26:3<174::AID-GENE2>3.0.CO;2-J","article-title":"Temperature-dependent expression of turtle Dmrt1 prior to sexual differentiation","volume":"26","author":"Kettlewell","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.cbpb.2021.110672_bb0075","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/dvdy.21409","article-title":"Sexual dimorphic expression of DMRT1 and Sox9a during gonadal differentiation and hormone-induced sex reversal in the teleost fish Nile tilapia (Oreochromis niloticus)","volume":"237","author":"Kobayashi","year":"2008","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.cbpb.2021.110672_bb0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ygcen.2018.11.015","article-title":"Roles of estrogens in fish sexual plasticity and sex differentiation","volume":"277","author":"Li","year":"2019","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.cbpb.2021.110672_bb0085","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/jfd.12911","article-title":"Detection and quantification of Aeromonas schubertii in Channa maculata by TaqMan MGB probe fluorescence real-time quantitative PCR","volume":"42","author":"Liu","year":"2019","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.cbpb.2021.110672_bb0090","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/jfb.13308","article-title":"Identification of suitable reference genes for quantitative real-time PCR normalization in blotched snakehead Channa maculata","volume":"90","author":"Mao","year":"2017","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0095","first-page":"180","article-title":"DMRT1 expression during gonadal differentiation and spermatogenesis in the rainbow trout, Oncorhynchus mykiss","volume":"1493","author":"Marchand","year":"2000","journal-title":"B.B."},{"key":"10.1016\/j.cbpb.2021.110672_bb0100","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature751","article-title":"DMY is a Y-specific DM-domain gene required for male development in the medaka fish","volume":"417","author":"Matsuda","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cbpb.2021.110672_bb0105","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s11427-014-4797-9","article-title":"Genetic basis and biotechnological manipulation of sexual dimorphism and sex determination in fish","volume":"58","author":"Mei","year":"2015","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.cbpb.2021.110672_bb0110","doi-asserted-by":"crossref","first-page":"11778","DOI":"10.1073\/pnas.182314699","article-title":"A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes","volume":"99","author":"Nanda","year":"2002","journal-title":"P. Natl. Acad. Sci. U.S."},{"key":"10.1016\/j.cbpb.2021.110672_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002447","article-title":"DNA methylation of the gonadal aromatase (cyp19a) promoter is involved in temperature-dependent sex ratio shifts in the European sea bass","volume":"7","author":"Navarro-Mart\u00edn","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cbpb.2021.110672_bb0120","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.fsi.2019.04.031","article-title":"Characterisation of scavenger receptor class b type 1 in rare minnow (Gobiocypris rarus)","volume":"89","author":"Ou","year":"2019","journal-title":"Fish Shellfish Immun."},{"key":"10.1016\/j.cbpb.2021.110672_bb0125","first-page":"100708","article-title":"Comparative transcriptome analysis on four types of gonadal tissues of blotched snakehead (Channa maculata)","volume":"35","author":"Ou","year":"2020","journal-title":"Comp. Biochem. Phys. D."},{"key":"10.1016\/j.cbpb.2021.110672_bb0130","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1038\/srep02862","article-title":"Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists","volume":"3","author":"Paul-Prasanth","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpb.2021.110672_bb0135","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.crvi.2015.04.010","article-title":"The roles of Dmrt (double sex\/male-abnormal-3 related transcription factor) genes in sex determination and differentiation mechanisms: ubiquity and diversity across the animal kingdom","volume":"338","author":"Picard","year":"2015","journal-title":"C. R. Biol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0140","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10126-012-9445-4","article-title":"Genomic approaches to study genetic and environmental influences on fish sex determination and differentiation","volume":"14","author":"Piferrer","year":"2012","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0145","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3389\/fgene.2019.00857","article-title":"The model of the conserved epigenetic regulation of sex","volume":"10","author":"Piferrer","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.cbpb.2021.110672_bb0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1677\/JME-09-0011","article-title":"Identification of multiple dmrt1s in catfish: localization, dimorphic expression pattern, changes during testicular cycle and after methyltestosterone treatment","volume":"42","author":"Raghuveer","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0155","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/dbio.1999.9461","article-title":"Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development","volume":"215","author":"Raymond","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0160","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1101\/gr.162172.113","article-title":"Epigenetic modification and inheritance in sexual reversal of fish","volume":"24","author":"Shao","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.cbpb.2021.110672_bb0165","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1530\/JOE-16-0551","article-title":"Blockage of androgen and administration of estrogen induce transdifferentiation of testis into ovary","volume":"233","author":"Shi","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0170","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0016-6480(02)00039-4","article-title":"The Dmrt1 expression in sex-reversed gonads of amphibians","volume":"127","author":"Shibata","year":"2002","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.cbpb.2021.110672_bb0175","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature08298","article-title":"The avian Z-linked gene DMRT1 is required for male sex determination in the chicken","volume":"461","author":"Smith","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cbpb.2021.110672_bb0180","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1210\/en.2013-1959","article-title":"Transdifferentiation of differentiated ovary into functional testis by long term treatment of aromatase inhibitor in Nile tilapia","volume":"155","author":"Sun","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbpb.2021.110672_bb0185","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2152\/jmi.62.19","article-title":"Epigenetic regulation of mammalian sex determination","volume":"62","author":"Tachibana","year":"2015","journal-title":"J. Med. Investig."},{"key":"10.1016\/j.cbpb.2021.110672_bb0190","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1038\/srep03400","article-title":"Induction of female-to-male sex change in adult zebrafish by aromatase inhibitor treatment","volume":"3","author":"Takatsu","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpb.2021.110672_bb0195","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1677\/JME-08-0039","article-title":"Estrogen treatment up-regulates female genes but does not suppress all early testicular markers during rainbow trout male-to-female gonadal transdifferentiation","volume":"41","author":"Vizziano-Cantonnet","year":"2008","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0200","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10695-015-0096-z","article-title":"Molecular identification and expression of the Foxl2 gene during gonadal sex differentiation in northern snakehead Channa argus","volume":"41","author":"Wang","year":"2015","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpb.2021.110672_bb0205","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/jfb.12277","article-title":"CpG methylation of dmrt1 and cyp19a promoters in relation to their sexual dimorphic expression in the Japanese flounder Paralichthys olivaceus","volume":"84","author":"Wen","year":"2014","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1095-8649.1982.tb03890.x","article-title":"Salinity adaptation in the snakehead, Ophiocephalus maculatus Lac\u00e9p\u00e8de: changes in oxygen consumption, branchial Na+-K+-ATPase and body composition","volume":"20","author":"Woo","year":"1982","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.cbpb.2021.110672_bb0215","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1095\/biolreprod.115.137463","article-title":"The testis is a primary factor that contributes to epigenetic modifications in the ovaries of the protandrous black porgy, Acanthopagrus schlegelii","volume":"94","author":"Wu","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.cbpb.2021.110672_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/gix011","article-title":"Draft genome of the northern snakehead, Channa argus","volume":"6","author":"Xu","year":"2017","journal-title":"Gigascience"},{"key":"10.1016\/j.cbpb.2021.110672_bb0225","doi-asserted-by":"crossref","first-page":"736450","DOI":"10.1016\/j.aquaculture.2021.736450","article-title":"Breeding of YY super-male of blotched snakehead (Channa maculata) and production of all-male hybrid (Channa argus \u2640 \u00d7 C. maculata \u2642)","author":"Zhao","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2021.110672_bb0230","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1101\/gad.14.14.1750","article-title":"Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers","volume":"14","author":"Zhu","year":"2000","journal-title":"Genes Dev."}],"container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096495921001111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096495921001111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:34:30Z","timestamp":1761086070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096495921001111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":46,"alternative-id":["S1096495921001111"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpb.2021.110672","relation":{},"ISSN":["1096-4959"],"issn-type":[{"value":"1096-4959","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization, expression and CpG methylation analysis of Dmrt1 and its response to steroid hormone in blotched snakehead (Channa maculata)","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpb.2021.110672","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110672"}}