{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:59:54Z","timestamp":1780325994265,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760647"],"award-info":[{"award-number":["81760647"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060381"],"award-info":[{"award-number":["82060381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.cbpb.2022.110717","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T08:05:17Z","timestamp":1641801917000},"page":"110717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Identification and function analysis of chitinase 2 gene in housefly, Musca domestica"],"prefix":"10.1016","volume":"259","author":[{"given":"Zhenlong","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longbing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangfan","family":"Xiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cbpb.2022.110717_bb0005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00018-009-0161-9","article-title":"Insect chitinase and chitinase-like proteins","volume":"67","author":"Arakane","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.cbpb.2022.110717_bb0010","doi-asserted-by":"crossref","first-page":"13377","DOI":"10.1038\/s41598-020-70185-w","article-title":"Glycosylhydrolase genes control respiratory tubes sizes and airway stability","volume":"10","author":"Behr","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpb.2022.110717_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cbpb.2017.03.002","article-title":"Identification and functional analysis of Chitinase 7 gene in white-backed Planthopper, Sogatella furcifera","volume":"208-209","author":"Chen","year":"2017","journal-title":"Comp. Biochem. Physiol. Part B Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.cbpb.2022.110717_bb0020","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0020-1790(91)90017-9","article-title":"Effects of 20-hydroxyecdysone and KK-42 on chitinase and \u03b2-N-acetylglucosaminidase during the larval-pupal transformation of Bombyx mori","volume":"21","author":"Daizo","year":"1991","journal-title":"Insect Biochem."},{"issue":"1","key":"10.1016\/j.cbpb.2022.110717_bb0025","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-2148-7-96","article-title":"Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family","volume":"7","author":"Funkhouser","year":"2007","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.cbpb.2022.110717_bb0030","series-title":"Flies and Disease","author":"Greengerg","year":"1971"},{"issue":"3","key":"10.1016\/j.cbpb.2022.110717_bb0035","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbrc.2017.06.112","article-title":"Identification and characterization of a novel antimicrobial protein from the housefly Musca domestica","volume":"490","author":"Guo","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.cbpb.2022.110717_bb0040","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0965-1748(93)90043-R","article-title":"Sequence of a cDNA and expression of the gene encoding epidermal and gut chitinases of Manduca sexta","volume":"23","author":"Kramer","year":"1993","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpb.2022.110717_bb0045","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cbpb.2015.05.007","article-title":"Molecular characterization and expression analysis of five chitinases associated with molting in the Chinese mitten crab, Eriocheir sinensis","volume":"187","author":"Li","year":"2015","journal-title":"Comp. Biochem. Physiol. B: Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpb.2022.110717_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cbd.2018.04.005","article-title":"Genome-wide identification of chitinase and chitin deacetylase gene families in the oriental fruit fly, Bactrocera dorsalis (Hendel)","volume":"27","author":"Liu","year":"2018","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"key":"10.1016\/j.cbpb.2022.110717_bb0055","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jinsphys.2019.03.006","article-title":"Biosynthesis, modifications and degradation of chitin in the formation and turnover of peritrophic matrix in insects","volume":"114","author":"Liu","year":"2019","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.cbpb.2022.110717_bb0060","series-title":"Insect-Derived Chitinases","author":"Merzendorfer","year":"2013"},{"key":"10.1016\/j.cbpb.2022.110717_bb0065","first-page":"1","article-title":"Bacterial pathogens identified from houseflies in different human and animal settings: A systematic review and meta-analysis","volume":"00","author":"Monyama","year":"2021","journal-title":"Vet. Med. Sci."},{"key":"10.1016\/j.cbpb.2022.110717_bb0070","article-title":"Future questions in insect chitin biology: a microreview","volume":"e21454","author":"Muthukrishnan","year":"2018","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.cbpb.2022.110717_bb0075","doi-asserted-by":"crossref","first-page":"18340","DOI":"10.1038\/srep18340","article-title":"Chitinases and Imaginal disc growth factors organize the extracellular matrix formation at barrier tissues in insects","volume":"6","author":"Pesch","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpb.2022.110717_bb0080","first-page":"4","article-title":"Drosophila Chitinase 2 is expressed in chitin producing organs for cuticle formation","author":"Pesch","year":"2016","journal-title":"Arthropod. Struct. Develop."},{"issue":"Pt 3","key":"10.1016\/j.cbpb.2022.110717_bb0085","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1042\/bj20011764","article-title":"A novel putative insect chitinase with multiple catalytic domains: hormonal regulation during metamorphosis","volume":"366","author":"Royer","year":"2002","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.cbpb.2022.110717_bb0090","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/imb.12227","article-title":"Genome-wide analysis of chitinase genes and their varied functions in larval moult, pupation and eclosion in the rice striped stem borer, Chilo suppressalis","volume":"25","author":"Su","year":"2016","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.cbpb.2022.110717_bb0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ibmb.2015.01.006","article-title":"Overview of chitin metabolism enzymes in Manduca sexta: identification, domain organization, phylogenetic analysis and gene expression","volume":"62","author":"Tetreau","year":"2015","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.cbpb.2022.110717_bb0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/imb.12133","article-title":"Chitinase-like gene family in the brown planthopper, Nilaparvata lugens","volume":"24","author":"Xi","year":"2015","journal-title":"Insect Mol. Biol."},{"issue":"1","key":"10.1016\/j.cbpb.2022.110717_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10493-016-0063-0","article-title":"Functional analysis of a chitinase gene during the larval-nymph transition in Panonychus citri by RNA interference","volume":"70","author":"Xia","year":"2016","journal-title":"Exp. Appl. Acarol."},{"issue":"10","key":"10.1016\/j.cbpb.2022.110717_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms141020048","article-title":"Transcriptional regulation of a Chitinase gene by 20-Hydroxyecdysone and starvation in the oriental fruit Fly, Bactrocera dorsalis","volume":"14","author":"Yang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.cbpb.2022.110717_bb0115","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/1744-7917.12839","article-title":"Characterization and functional analysis of chitinase family genes involved in nymph\u2013adult transition of Sogatella furcifera","volume":"28","author":"Yang","year":"2020","journal-title":"Insect Sci."},{"issue":"4\u20135","key":"10.1016\/j.cbpb.2022.110717_bb0120","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/arch.21018","article-title":"Functional analysis of two chitinase genes during the pupation and eclosion stages of the beet armyworm Spodoptera exigua by RNA interference","volume":"79","author":"Zhang","year":"2012","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.cbpb.2022.110717_bb0125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cbpb.2013.09.009","article-title":"Six chitinases from oriental river prawn macrobrachium Nipponense: cDNA characterization, classification and mRNA expression during post-embryonic development and moulting cycle","volume":"167","author":"Zhang","year":"2014","journal-title":"Comp. Biochem. Physiol. Part B Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/j.cbpb.2022.110717_bb0130","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/imb.12569","article-title":"Nuclear receptor hormone receptor 39 is required for locust moulting by regulating the chitinase and carboxypeptidase genes","volume":"28","author":"Zhao","year":"2019","journal-title":"Insect Mol. Biol."},{"issue":"451","key":"10.1016\/j.cbpb.2022.110717_bb0135","article-title":"Imaginal disc growth factor 6 (Idgf6) is involved in larval and adult wing development in Bactrocera correcta (Bezzi) (Diptera: Tephritidae)","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Genet."},{"issue":"4","key":"10.1016\/j.cbpb.2022.110717_bb0140","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ibmb.2007.06.011","article-title":"Characterization of recombinant chitinase-like proteins of Drosophila melanogaster and Tribolium castaneum","volume":"38","author":"Zhu","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"18","key":"10.1016\/j.cbpb.2022.110717_bb0145","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1073\/pnas.0800739105","article-title":"Functional specialization among insect chitinase family genes revealed by RNA interference","volume":"105","author":"Zhu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpb.2022.110717_bb0150","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-ento-010715-023933","article-title":"Biosynthesis, turnover, and functions of chitin in insects","volume":"61","author":"Zhu","year":"2016","journal-title":"Annu. Rev. Entomol."},{"issue":"7","key":"10.1016\/j.cbpb.2022.110717_bb0155","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/ps.5308","article-title":"Identification and RNAi-based function analysis of chitinase family genes in diamondback moth, Plutella xylostella","volume":"75","author":"Zhu","year":"2019","journal-title":"Pest Manag. Sci."},{"issue":"7","key":"10.1016\/j.cbpb.2022.110717_bb0160","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1007\/s11033-014-3288-1","article-title":"Chitin synthase a: a novel epidermal development regulation gene in the larvae of Bombyx mori","volume":"41","author":"Zhuo","year":"2014","journal-title":"Mol. Biol. Rep."}],"container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096495922000057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096495922000057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:35:16Z","timestamp":1761086116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096495922000057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":32,"alternative-id":["S1096495922000057"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpb.2022.110717","relation":{},"ISSN":["1096-4959"],"issn-type":[{"value":"1096-4959","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and function analysis of chitinase 2 gene in housefly, Musca domestica","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpb.2022.110717","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110717"}}