{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:18:12Z","timestamp":1790309892421,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008787","name":"National Institute of Fisheries Science","doi-asserted-by":"publisher","award":["R2025036"],"award-info":[{"award-number":["R2025036"]}],"id":[{"id":"10.13039\/501100008787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cbpb.2025.111124","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T21:24:48Z","timestamp":1751664288000},"page":"111124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Microplastic and Vibrio harveyi co-exposure induces oxidative stress in big-belly seahorse Hippocampus abdominalis"],"prefix":"10.1016","volume":"279","author":[{"given":"Jin A","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Yoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Don","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpb.2025.111124_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115896","article-title":"Evaluation of oxidative stress, antioxidant enzymes and genotoxic potential of bisphenol a in fresh water bighead carp (Aristichthys nobils) fish at low concentrations","volume":"268","author":"Akram","year":"2021","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.cbpb.2025.111124_bb0015","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/08997659.2012.743932","article-title":"Mixed metazoan and bacterial infection of the gas bladder of the lined seahorse\u2014a case report","volume":"25","author":"Anderson","year":"2013","journal-title":"J. Aquat. Anim. Health"},{"key":"10.1016\/j.cbpb.2025.111124_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2022.851281","article-title":"Micro (nano) plastics prevalence, food web interactions, and toxicity assessment in aquatic organisms: a review","volume":"9","author":"Benson","year":"2022","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.cbpb.2025.111124_bb0025","doi-asserted-by":"crossref","first-page":"1135250","DOI":"10.3389\/fmars.2023.1135250","article-title":"Fatty acid profiles of cultured Hippocampus hippocampus trunk muscles and potential nutritional value","volume":"10","author":"Cabral","year":"2023","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.cbpb.2025.111124_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.108470","article-title":"Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills","volume":"132","author":"Cao","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpb.2025.111124_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2021.110592","article-title":"Primary, secondary, and tertiary stress responses of juvenile seahorse Hippocampus reidi exposed to acute acid stress in brackish and seawater","volume":"255","author":"Carneiro","year":"2021","journal-title":"Comp. Biochem. Physiol. B: Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpb.2025.111124_bb0040","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.marpolbul.2019.07.052","article-title":"Microplastics as vectors of contaminants","volume":"146","author":"Caruso","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpb.2025.111124_bb0045","doi-asserted-by":"crossref","first-page":"1158198","DOI":"10.3389\/fchem.2023.1158198","article-title":"Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases","volume":"11","author":"Chaudhary","year":"2023","journal-title":"Front. Chem."},{"issue":"13","key":"10.1016\/j.cbpb.2025.111124_bb0050","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.3390\/ijerph19138137","article-title":"The occurrence of microplastics and the formation of biofilms by pathogenic and opportunistic bacteria as threats in aquaculture","volume":"19","author":"Cholewi\u0144ska","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.cbpb.2025.111124_bb0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3329\/jsr.v12i1.41716","article-title":"Oxidative stress in fish: a review","volume":"12","author":"Chowdhury","year":"2020","journal-title":"J. Sci. Res."},{"issue":"2","key":"10.1016\/j.cbpb.2025.111124_bb0060","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/jfb.15284","article-title":"Crosstalk between reproductive and immune systems: the teleostean perspective","volume":"102","author":"Chuphal","year":"2023","journal-title":"J. Fish Biol."},{"issue":"1","key":"10.1016\/j.cbpb.2025.111124_bb0065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/23308249.2016.1237469","article-title":"Seahorse aquaculture, biology and conservation: knowledge gaps and research opportunities","volume":"25","author":"Cohen","year":"2017","journal-title":"Rev. Fish. Sci. Aquacul."},{"issue":"10","key":"10.1016\/j.cbpb.2025.111124_bb0070","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.3390\/microorganisms10102060","article-title":"Real-time PCR protocol for detection and quantification of three pathogenic members of the Vibrionaceae family","volume":"10","author":"Costa","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.cbpb.2025.111124_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165076","article-title":"The emerging role of microplastics in systemic toxicity: involvement of reactive oxygen species (ROS)","volume":"895","author":"Das","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpb.2025.111124_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2019.110769","article-title":"Morphological and histopathological changes in seahorse (Hippocampus reidi) gills after exposure to the water-accommodated fraction of diesel oil","volume":"150","author":"Delunardo","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpb.2025.111124_bb0085","article-title":"Exposure to metals premixed with microplastics increases toxicity through bioconcentration and impairs antioxidant defense and cholinergic response in a marine mysid","volume":"249","author":"Eom","year":"2021","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbpb.2025.111124_bb0090","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/aqc.2493","article-title":"Opportunities and challenges for analysis of wildlife trade using CITES data\u2013seahorses as a case study","volume":"26","author":"Foster","year":"2016","journal-title":"Aquat. Conserv. Mar. Freshwat. Ecosyst."},{"key":"10.1016\/j.cbpb.2025.111124_bb0095","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.fsi.2016.08.028","article-title":"Characterization of a 1-cysteine peroxiredoxin from big-belly seahorse (Hippocampus abdominalis); insights into host antioxidant defense, molecular profiling and its expressional response to septic conditions","volume":"57","author":"Godahewa","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpb.2025.111124_bb0100","doi-asserted-by":"crossref","unstructured":"Halliwell, B., Gutteridge, J. M. (2015). Free radicals in biology and medicine. Oxford university press. doi: https:\/\/doi.org\/10.1093\/acprof:oso\/9780198717478.001.0001.","DOI":"10.1093\/acprof:oso\/9780198717478.001.0001"},{"key":"10.1016\/j.cbpb.2025.111124_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116712","article-title":"A review of the neurobehavioural, physiological, and reproductive toxicity of microplastics in fishes","volume":"282","author":"Hasan","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.cbpb.2025.111124_bb0110","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/antiox13050524","article-title":"H2O2-induced oxidative stress responses in Eriocheir sinensis: antioxidant defense and immune gene expression dynamics","volume":"13","author":"He","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbpb.2025.111124_bb0115","author":"Kecheliev"},{"key":"10.1016\/j.cbpb.2025.111124_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2023.114216","article-title":"Synthetic microfiber exposure negatively affects reproductive parameters in male medaka (Oryzias latipes)","volume":"334","author":"Kim","year":"2023","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cbpb.2025.111124_bb0125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.aquaculture.2009.11.010","article-title":"A global review of seahorse aquaculture","volume":"302","author":"Koldewey","year":"2010","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.cbpb.2025.111124_bb0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2478\/cjf-2019-0005","article-title":"The problem of plastic waste and microplastics in the seas and oceans: impact on marine organisms","volume":"77","author":"Kurtela","year":"2019","journal-title":"Croatian J. Fish."},{"key":"10.1016\/j.cbpb.2025.111124_bb0135","article-title":"Concurrent impacts of polystyrene nanoplastic exposure and Aeromonas hydrophila infection on oxidative stress, immune response and intestinal microbiota of grass carp (Ctenopharyngodon idella)","volume":"912","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"10","key":"10.1016\/j.cbpb.2025.111124_bb0140","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3390\/biology13100807","article-title":"Effects of stocking density on the survival, growth, and stress levels of the juvenile lined seahorse (Hippocampus erectus) in recirculating aquaculture systems","volume":"13","author":"Lin","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.cbpb.2025.111124_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153694","article-title":"Can microplastics facilitate the emergence of infectious diseases?","volume":"823","author":"Loiseau","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpb.2025.111124_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153694","article-title":"Can microplastics facilitate the emergence of infectious diseases?","volume":"823","author":"Loiseau","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.cbpb.2025.111124_bb0160","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/microplastics3030022","article-title":"A study on the distribution of microplastics in the south coast of Korea and Gwangyang Bay","volume":"3","author":"Min","year":"2024","journal-title":"Microplastics"},{"issue":"5","key":"10.1016\/j.cbpb.2025.111124_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155063","article-title":"The effects of natural and anthropogenic microparticles on individual fitness in Daphnia magna","volume":"11","author":"Ogonowski","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpb.2025.111124_bib246","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.fsi.2016.08.052","article-title":"Copper-zinc-superoxide dismutase (CuZnSOD), an antioxidant gene from seahorse (Hippocampus abdominalis); molecular cloning, sequence characterization, antioxidant activity and potential peroxidation function of its recombinant protein","volume":"57","author":"Perera","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.cbpb.2025.111124_bb0170","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/jfd.12533","article-title":"A bacterial infection by Vibrio harveyi causing heavy reduction of cultured lined seahorse Hippocampus erectus","volume":"40","author":"Qin","year":"2017","journal-title":"J. Fish Dis."},{"issue":"1","key":"10.1016\/j.cbpb.2025.111124_bb0175","first-page":"151","article-title":"Characterization and infectivity evaluation of Vibrio harveyi causing white patch disease among captive reared seahorses, Hippocampus kuda","volume":"39","author":"Raj","year":"2010","journal-title":"Indian J. Marine Sci., 2010"},{"issue":"3","key":"10.1016\/j.cbpb.2025.111124_bb0180","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/ars.2010.3393","article-title":"Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H2O2, and protein chaperones","volume":"15","author":"Rhee","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cbpb.2025.111124_bb0185","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1590\/S1679-62252007000300020","article-title":"Population characteristics, space use and habitat associations of the seahorse Hippocampus reidi (Teleostei: Syngnathidae)","volume":"5","author":"Rosa","year":"2007","journal-title":"Neotropical Ichthyology"},{"key":"10.1016\/j.cbpb.2025.111124_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142619","article-title":"Genotoxicity and metabolic changes induced via ingestion of virgin and UV-aged polyethylene microplastics by the freshwater fish Perca fluviatilis","volume":"362","author":"Sampsonidis","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpb.2025.111124_bb0195","doi-asserted-by":"crossref","first-page":"21530","DOI":"10.1007\/s11356-017-9910-8","article-title":"Microplastic pollution, a threat to marine ecosystem and human health: a short review","volume":"24","author":"Sharma","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpb.2025.111124_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138381","article-title":"The adverse impact of microplastics and their attached pathogen on hemocyte function and antioxidative response in the mussel Mytilus galloprovincialis","volume":"325","author":"Sun","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpb.2025.111124_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149646","article-title":"Effects of chronic exposure to environmental levels of tributyltin on the lined seahorse (Hippocampus erectus) liver: analysis of bioaccumulation, antioxidant defense, and immune gene expression","volume":"801","author":"Tang","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.cbpb.2025.111124_bb0210","doi-asserted-by":"crossref","DOI":"10.1111\/jfd.12411","article-title":"A novel pathogenic bacteria (Vibrio fortis) causing enteritis in cultured seahorses, Hippocampus erectus Perry, 1810","volume":"39","author":"Wang","year":"2016","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.cbpb.2025.111124_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138801","article-title":"Toxic effects of microplastic (polyethylene) exposure: bioaccumulation, hematological parameters and antioxidant responses in crucian carp, Carassius carassius","volume":"332","author":"Yu","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpb.2025.111124_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108547","article-title":"Involvement of Nrf2 in the immune regulation of Litopenaeus vannamei against Vibrio harveyi infection","volume":"133","author":"Yuan","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"7","key":"10.1016\/j.cbpb.2025.111124_bb0225","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/ddi.12741","article-title":"Predicting distributions, habitat preferences and associated conservation implications for a genus of rare fishes, seahorses (Hippocampus spp.)","volume":"24","author":"Zhang","year":"2018","journal-title":"Divers. Distrib."},{"key":"10.1016\/j.cbpb.2025.111124_bb0230","article-title":"Current status of microplastics pollution in the aquatic environment, interaction with other pollutants, and effects on aquatic organisms","volume":"1\u201330","author":"Zhang","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpb.2025.111124_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114711","article-title":"Microbial profiles and immune responses in seahorse gut and brood pouch under chronic exposure to environmental antibiotics","volume":"253","author":"Zhao","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpb.2025.111124_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114818","article-title":"Transport of microplastics in the body and interaction with biological barriers, and controlling of microplastics pollution","volume":"255","author":"Zhu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"22","key":"10.1016\/j.cbpb.2025.111124_bb0245","doi-asserted-by":"crossref","first-page":"13397","DOI":"10.1021\/acs.est.7b03574","article-title":"Impact of microplastic beads and fibers on waterflea (Ceriodaphnia dubia) survival, growth, and reproduction: implications of single and mixture exposures","volume":"51","author":"Ziajahromi","year":"2017","journal-title":"Environ. Sci. Technol."}],"container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096495925000557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096495925000557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T19:16:39Z","timestamp":1753211799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096495925000557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":48,"alternative-id":["S1096495925000557"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpb.2025.111124","relation":{},"ISSN":["1096-4959"],"issn-type":[{"value":"1096-4959","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microplastic and Vibrio harveyi co-exposure induces oxidative stress in big-belly seahorse Hippocampus abdominalis","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpb.2025.111124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111124"}}