{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T03:51:10Z","timestamp":1772941870524,"version":"3.50.1"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009997","name":"Earmarked Fund for Modern Agro-industry Technology Research System","doi-asserted-by":"publisher","award":["CARS-49"],"award-info":[{"award-number":["CARS-49"]}],"id":[{"id":"10.13039\/501100009997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.cbpb.2025.111148","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T20:59:19Z","timestamp":1755809959000},"page":"111148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Molecular expression of genes related to sex differentiation and their response to sex steroid hormones in the clam Chinese cyclina (Cyclina sinensis)"],"prefix":"10.1016","volume":"280","author":[{"given":"Mengge","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meimei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpb.2025.111148_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-13-2","article-title":"Molecular cloning and expression analysis of dmrt1 and sox9 during gonad development and male reproductive cycle in the Lambari fish, Astyanax altiparanae","volume":"13","author":"Adolfi","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"7","key":"10.1016\/j.cbpb.2025.111148_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001899","article-title":"Sex determination: Why so many ways of doing it?","volume":"12","author":"Bachtrog","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cbpb.2025.111148_bb0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cbpa.2015.12.008","article-title":"Molecular and functional characterization of the vitellogenin receptor in oriental river prawn, Macrobrachium nipponense","volume":"194","author":"Bai","year":"2016","journal-title":"Comp. Biochem. Physiol. Part A"},{"key":"10.1016\/j.cbpb.2025.111148_bib478","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.envpol.2016.08.050","article-title":"Impact of bisphenol A (BPA) on early embryo development in the marine mussel Mytilus galloprovincialis: effects on gene transcription","volume":"218","author":"Balbi","year":"2016","journal-title":"Environ. Pollut."},{"issue":"1\u20132","key":"10.1016\/j.cbpb.2025.111148_bb0025","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.gene.2007.10.005","article-title":"Characterization of reproduction-specific genes in a marine bivalve mollusc: influence of maturation stage and sex on mRNA expression","volume":"407","author":"Boutet","year":"2008","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.cbpb.2025.111148_bb0030","first-page":"259","article-title":"The relationship between sexual size dimorphism and habitat use in greater Antillean Anolis lizards","volume":"54","author":"Butler","year":"2000","journal-title":"Evolution"},{"issue":"1\u20132","key":"10.1016\/j.cbpb.2025.111148_bb0035","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mce.2007.06.002","article-title":"Bisphenol-Aalters gene expression and functional parameters in molluscan hepatopancreas","volume":"276","author":"Canesi","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"issue":"11","key":"10.1016\/j.cbpb.2025.111148_bb0040","first-page":"1385","article-title":"Molecular characterization and functional analyses of Dmrt1 in the bay scallop Argopecten irradians","volume":"28","author":"Cao","year":"2021","journal-title":"J. Fish. Sci. China"},{"key":"10.1016\/j.cbpb.2025.111148_bb0045","series-title":"Effects of exogenous hormones on early gonadal development and the growth of the tongue sole Cynoglossus semilaevis [D]","author":"Chen","year":"2023"},{"key":"10.1016\/j.cbpb.2025.111148_bb0050","series-title":"The Role of ERs in the Process of Sex Differentiation and Artificial Sex Reversal in Pelodiscus sinensis [D]","author":"Chen","year":"2023"},{"issue":"7","key":"10.1016\/j.cbpb.2025.111148_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132080","article-title":"Correction: identification of reproduction-specific genes associated with maturation and Estrogen exposure in a marine bivalve Mytilus edulis","volume":"10","author":"Ciocan","year":"2015","journal-title":"Plos.one"},{"key":"10.1016\/j.cbpb.2025.111148_bb0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jviromet.2014.10.007","article-title":"Development of an in situ hybridization assay for the detection of ostreid herpesvirus type 1 mRNAs in the Pacific oyster, Crassostrea gigas","volume":"211","author":"Corbeil","year":"2015","journal-title":"J. Virol. Methods"},{"issue":"1\u20134","key":"10.1016\/j.cbpb.2025.111148_bib479","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.aquaculture.2007.06.031","article-title":"Possible roles of sex steroids in the control of reproduction in bivalve molluscs","volume":"272","author":"Croll","year":"2007","journal-title":"Aquaculture"},{"issue":"3","key":"10.1016\/j.cbpb.2025.111148_bb0065","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1677\/jme.0.0210291","article-title":"Effects of sex steroids on gonadotropin (FSH and LH) regulation in coho salmon (Oncorhynchus kisutch)","volume":"21","author":"Dickey","year":"1998","journal-title":"J. Mol. Endocrinol."},{"issue":"12","key":"10.1016\/j.cbpb.2025.111148_bb0070","first-page":"2083","article-title":"Research progress in genetic resources assessment, culture technique and exploration utilization of Cyclina sinensis","volume":"45","author":"Dong","year":"2021","journal-title":"J. Fish. China"},{"key":"10.1016\/j.cbpb.2025.111148_bb0075","article-title":"Examination of the role of a novel transcription factor in activating Foxl2 and its potential involvement in the regulation of ovarian development in scallops","volume":"578","author":"Fan","year":"2014","journal-title":"Aquaculture"},{"issue":"1\u20132","key":"10.1016\/j.cbpb.2025.111148_bb0080","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0303-7207(96)03960-3","article-title":"Transcriptional and post-transcriptional regulation of rainbow trout estrogen receptor and vitellogenin gene expression","volume":"124","author":"Flouriot","year":"1996","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.cbpb.2025.111148_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.903575","article-title":"From dark to light\u2013an overview of over 70 years of endocrine disruption research on marine mollusks","volume":"13","author":"Fodor","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"04","key":"10.1016\/j.cbpb.2025.111148_bb0090","first-page":"523","article-title":"Distribution of sex steroids in tissues of adult yesso scallop Patinopecten yessoensis","volume":"40","author":"Guo","year":"2021","journal-title":"Fish. Sci."},{"issue":"03","key":"10.1016\/j.cbpb.2025.111148_bb0095","first-page":"14","article-title":"Research advances in genes related to sex determination and differentiation in molluscs","volume":"47","author":"Hong","year":"2023","journal-title":"J. Fish. China"},{"issue":"6","key":"10.1016\/j.cbpb.2025.111148_bb0100","doi-asserted-by":"crossref","first-page":"619","DOI":"10.4103\/1008-682X.194420","article-title":"Sex determination and maintenance: the role of DMRT1 and FOXL2","volume":"19","author":"Huang","year":"2017","journal-title":"Asian J. Androl."},{"issue":"2","key":"10.1016\/j.cbpb.2025.111148_bb0105","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cbpb.2007.05.005","article-title":"cDNA cloning and in situ hybridization of a novel lysozyme in the Pacific oyster, Crassostrea gigas","volume":"148","author":"Itoh","year":"2007","journal-title":"Comp. Biochem. Physiol. Part B Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.cbpb.2025.111148_bb0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10646-006-0110-4","article-title":"Sex steroids and potential mechanisms of non-genomic endocrine disruption in invertebrates","volume":"16","author":"Janer","year":"2007","journal-title":"Ecotoxicology"},{"issue":"01","key":"10.1016\/j.cbpb.2025.111148_bb0115","first-page":"64","article-title":"Identification of Dmrt, Sox and Wnt gene families and analysis of their expression patterns in gonadal tissues of the Cipangopaludina chinensis","volume":"44","author":"Ji","year":"2025","journal-title":"Genom. Appl. Biol."},{"issue":"2","key":"10.1016\/j.cbpb.2025.111148_bb0120","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.cbpa.2007.01.017","article-title":"Variation of steroid concentrations during the reproductive cycle of the clam Ruditapes decussatus: a one year study in the gulf of Gab\u00e8s area","volume":"147","author":"Ketata","year":"2007","journal-title":"Comp. Biochem. Physiol. Part A"},{"issue":"12","key":"10.1016\/j.cbpb.2025.111148_bb0125","article-title":"Characterization of testis-specific serine\/threonine kinase 1-like (TSSK1-like) gene and expression patterns in diploid and triploid Pacific abalone (Haliotis discus hannai; Gastropoda; Mollusca) males","volume":"14","author":"Kim","year":"2019"},{"key":"10.1016\/j.cbpb.2025.111148_bb0130","series-title":"The Expression Patterns of Two Vitellogenin Transcripts in the Chlamys Farreri during Ontogenesis [D]","author":"Li","year":"2011"},{"key":"10.1016\/j.cbpb.2025.111148_bb0135","series-title":"Cloning of Genes Wnt4, \u00df-Catenin, Dax1, and their Correlation to the Gonadal Development in Scallop Chlamys Farreri [D]","author":"Li","year":"2013"},{"key":"10.1016\/j.cbpb.2025.111148_bb0140","series-title":"Differences of Nutrition and Enzymatic Activity between Male and Female Clams (Ruditapes Philippinarum) and Preliminary Study of Sex Reversal [D]","author":"Li","year":"2016"},{"issue":"6","key":"10.1016\/j.cbpb.2025.111148_bb0145","first-page":"611","article-title":"Elucidation of key genes in sex determination in genetics teaching","volume":"36","author":"Li","year":"2014","journal-title":"Yi chuan = Hereditas"},{"issue":"03","key":"10.1016\/j.cbpb.2025.111148_bb0150","first-page":"284","article-title":"The progress in studies on vitellogenin","volume":"22","author":"Li","year":"2010","journal-title":"Chin. Bull. Life Sci."},{"issue":"02","key":"10.1016\/j.cbpb.2025.111148_bb0155","first-page":"97","article-title":"Effects of estrogen on sex proportion growth and oocyte development of sluge wom Perinereis aibuhitensis","volume":"26","author":"Li","year":"2011","journal-title":"J. Dalian Ocean Univ."},{"issue":"12","key":"10.1016\/j.cbpb.2025.111148_bb0160","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1210\/en.2013-1451","article-title":"Antagonistic roles of Dmrt1 and Foxl2 in sex differentiation via estrogen production in tilapia as demonstrated by TALENs","volume":"154","author":"Li","year":"2013","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.cbpb.2025.111148_bb0165","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/07924259.2016.1161667","article-title":"Characterization, expression, and functional analysis of testis-specific serine\/threonine kinase 1 (Tssk1) in the pen shell Atrina pectinata","volume":"60","author":"Li","year":"2016","journal-title":"Invertebr. Reprod. Dev."},{"key":"10.1016\/j.cbpb.2025.111148_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-020-07276-5","article-title":"Comparative transcriptome analysis of three gonadal development stages reveals potential genes involved in gametogenesis of the fluted giant clam (tridacna squamosa)","volume":"21","author":"Li","year":"2020","journal-title":"BMC Genomics"},{"issue":"06","key":"10.1016\/j.cbpb.2025.111148_bb0175","first-page":"1184","article-title":"Molecular cloning of sox9 cDNA and its expression characteristics in gonads at different developmental stages of Chlamys farreri","volume":"24","author":"Liang","year":"2017","journal-title":"J. Fish. Sci. China"},{"key":"10.1016\/j.cbpb.2025.111148_bb0180","series-title":"Study on the Gonadal Development and Expression of Sex Related Genes Dmrt1 and Foxl2 in Clam Cyclina Sinensis [D]","author":"Liao","year":"2022"},{"issue":"3","key":"10.1016\/j.cbpb.2025.111148_bb0185","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1139\/cjz-2013-0202","article-title":"Variations of estradiol-17\u03b2 and testosterone levels correlated with gametogenesis in the gonad of Zhikong scallop (Chlamys farreri) during annual reproductive cycle","volume":"92","author":"Liu","year":"2014","journal-title":"Can. J. Zool."},{"issue":"02","key":"10.1016\/j.cbpb.2025.111148_bb0190","first-page":"87","article-title":"The effects of 17\u03b1-methyltestosterone on growth\uff0cdevelopment and sex differentiation of Quasipaa spinosa tadpoles","volume":"41","author":"Liu","year":"2018","journal-title":"J. Zhejiang Normal Univ. (Nat. Sci.)"},{"issue":"06","key":"10.1016\/j.cbpb.2025.111148_bb0195","first-page":"801","article-title":"Cloning and expression analysis of WNT4 gene in the Hyriopsis cumingii","volume":"29","author":"Liu","year":"2020","journal-title":"J. Shanghai Ocean Univ."},{"key":"10.1016\/j.cbpb.2025.111148_bb0200","article-title":"The effect of temperature on gonadal sex differentiation of yesso scallop Patinopecten yessoensis","volume":"9","author":"Liu","year":"2022"},{"issue":"4","key":"10.1016\/j.cbpb.2025.111148_bb0205","first-page":"3571","article-title":"Effects of 17\u03b1-Methyltestosterone on the transcriptome and sex hormones in the brain of Gobiocypris rarus","volume":"24","author":"Liu","year":"2023"},{"key":"10.1016\/j.cbpb.2025.111148_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.111798","article-title":"Tissue-specific vitellogenesis and 17\u03b2-estradiol facilitate ovarian maturation of the swimming crab Portunus trituberculatus","volume":"301","author":"Liu","year":"2025","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"issue":"4","key":"10.1016\/j.cbpb.2025.111148_bb0215","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"3","key":"10.1016\/j.cbpb.2025.111148_bb0220","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1016\/j.ygeno.2020.01.022","article-title":"Transcriptome of tambaqui Colossoma macropomum during gonad differentiation: different molecular signals leading to sex identity","volume":"112","author":"Lobo","year":"2020","journal-title":"Genomics"},{"issue":"5","key":"10.1016\/j.cbpb.2025.111148_bb0225","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2109.1993.tb00635.x","article-title":"Sex reversal and growth of Oreochromis spilurus (G\u00fcnther) in brackish and sea water by feeding 17\u03b1-methyltestosterone","volume":"24","author":"Lone","year":"1993","journal-title":"Aquac. Res."},{"key":"10.1016\/j.cbpb.2025.111148_bb0230","series-title":"Effects of Exogenous Methylestosterone on Growth and Gonadal Development of Whitmania Pigra Whitman at Different Development Stages [D]","author":"Lu","year":"2019"},{"issue":"06","key":"10.1016\/j.cbpb.2025.111148_bb0235","first-page":"1487","article-title":"Steroid hormones (E2and MT) displayed difference in sex for nile tilapia oreochromis niloticus","volume":"46","author":"Ma","year":"2015","journal-title":"Oceanologia et Limnologia Sinica"},{"issue":"9","key":"10.1016\/j.cbpb.2025.111148_bb0240","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.marpolbul.2004.02.037","article-title":"Vitellogenin induction as a biomarker of exposure to estrogenic compounds in aquatic environments","volume":"48","author":"Marin","year":"2004","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpb.2025.111148_bb0245","first-page":"340","article-title":"Genetic architecture of sex determination in fish: applications to sex ratio control in aquaculture","volume":"5","author":"Mart\u00ednez","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.cbpb.2025.111148_bb0250","series-title":"Endocrine Disrupters: Hazard Testing and Assessment Methods","first-page":"143","article-title":"Endocrine disruption in molluscs: processes and testing","author":"McClellan-Green","year":"2013"},{"issue":"3","key":"10.1016\/j.cbpb.2025.111148_bb0255","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1152\/physrev.00044.2019","article-title":"Sex determination, gonadal sex differentiation, and plasticity in vertebrate species","volume":"101","author":"Nagahama","year":"2021","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.cbpb.2025.111148_bb0260","first-page":"134","article-title":"Molecular cloning and gene expression of Cg-Foxl2 during the development and the adult gametogenetic cycle in the oyster Crassostrea gigas","volume":"154","author":"Naimi","year":"2009"},{"issue":"5\u20136","key":"10.1016\/j.cbpb.2025.111148_bb0265","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000519217","article-title":"Transcriptional regulation of the Y-linked mammalian testis-determining gene SRY","volume":"15","author":"Okashita","year":"2021","journal-title":"Sex. Dev."},{"key":"10.1016\/j.cbpb.2025.111148_bb0270","series-title":"Sreening of Sex Differentiation Genes of Chlamys Farreri and Expression Analysis of Two Sex-Related Genes [D]","author":"Qin","year":"2011"},{"issue":"5","key":"10.1016\/j.cbpb.2025.111148_bb0280","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/hep.32120","article-title":"Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis","volume":"75","author":"Ren","year":"2022","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.cbpb.2025.111148_bb0285","first-page":"1116","article-title":"Foxl2l is a germ cell-intrinsic gatekeeper of oogenesis in zebrafish","volume":"45","author":"Ren","year":"2024"},{"issue":"3","key":"10.1016\/j.cbpb.2025.111148_bb0290","first-page":"3862","article-title":"Cytogenetic toxicity and gonadal effects of 17 \u03b1-methyltestosterone in Astyanax bimaculatus (Characidae) and Oreochromis niloticus (Cichlidae)","volume":"12","author":"Rivero-Wendt","year":"2013"},{"issue":"2","key":"10.1016\/j.cbpb.2025.111148_bb0295","first-page":"141","article-title":"Sexual dimorphism in hepatic gene expression and the response to dietary carbohydrate manipulation in the zebrafish (Danio rerio)","volume":"3","author":"Robison","year":"2008","journal-title":"Comp. Biochem. Physiol. Part D Genom. Proteom."},{"issue":"1","key":"10.1016\/j.cbpb.2025.111148_bb0300","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/toxsci\/kfl051","article-title":"The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals","volume":"94","author":"Sanderson","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"13","key":"10.1016\/j.cbpb.2025.111148_bb0305","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.steroids.2012.08.009","article-title":"Do mollusks use vertebrate sex steroids as reproductive hormones? Part I: critical appraisal of the evidence for the presence, biosynthesis and uptake of steroids","volume":"77","author":"Scott","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.cbpb.2025.111148_bb0310","series-title":"Molecular Identification and Functional Study of Sex Steroid Hormone Synthesis Related Genes in Hyriopsis cumingii [D]","author":"Shangguan","year":"2022"},{"issue":"03","key":"10.1016\/j.cbpb.2025.111148_bb0315","first-page":"289","article-title":"The effects of exogenous 17\u03b2-estrad iol on ovary developm ent and on the level of endogenous 17\u03b2-estradiol in E riocheir sinensis","volume":"19","author":"Shen","year":"2010","journal-title":"J. Shanghai Ocean Univ."},{"key":"10.1016\/j.cbpb.2025.111148_bb0320","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.5240","article-title":"Sex change in scallop Patinopecten yessoensis: response to population composition?","volume":"6","author":"Silina","year":"2018","journal-title":"PeerJ"},{"issue":"5","key":"10.1016\/j.cbpb.2025.111148_bib476","first-page":"712","article-title":"Effects of 17\u03b2-estradiol on early spermatogenesis and its mechanism in muller, Mugil cephalus","volume":"16","author":"Song","year":"2009","journal-title":"J. Fish. Sci. China"},{"issue":"2","key":"10.1016\/j.cbpb.2025.111148_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.113.110874","article-title":"Gonad differentiation in zebrafish is regulated by the canonical Wnt signaling pathway","volume":"90","author":"Sreenivasan","year":"2014","journal-title":"Biol. Reprod."},{"issue":"Suppl. 7","key":"10.1016\/j.cbpb.2025.111148_bb0330","first-page":"173","article-title":"Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment","volume":"103","author":"Sumpter","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbpb.2025.111148_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737732","article-title":"Examination of the roles of Foxl2 and Dmrt1 in sex differentiation and gonadal development of oysters by using RNA interference","volume":"548","author":"Sun","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2025.111148_bb0340","series-title":"Development of Genetic Sex Markers and Sex Reversal Study of Mastacembelus armatus [D]","author":"Tan","year":"2023"},{"issue":"1","key":"10.1016\/j.cbpb.2025.111148_bb0345","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1095\/biolreprod.116.143941","article-title":"Dose-dependent functions of fibroblast growth factor 9 regulate the fate of murine XY primordial germ cells","volume":"96","author":"Ulu","year":"2017","journal-title":"Biol. Reprod."},{"issue":"6718","key":"10.1016\/j.cbpb.2025.111148_bb0350","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/17068","article-title":"Female development in mammals is regulated by Wnt-4 signalling","volume":"397","author":"Vainio","year":"1999","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cbpb.2025.111148_bb0355","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/bies.200900193","article-title":"FOXL2 versus SOX9: a lifelong \u201cbattle of the sexes\u201d","volume":"32","author":"Veitia","year":"2010","journal-title":"Bioessays"},{"key":"10.1016\/j.cbpb.2025.111148_bb0365","series-title":"Cloning of cdk1 and Cyclin B3 Genes from Crassostrea Gigas and a Preliminary Study of their Role in Gonadal Development [D]","author":"Wang","year":"2011"},{"issue":"1\u20134","key":"10.1016\/j.cbpb.2025.111148_bb0370","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.aquaculture.2004.05.024","article-title":"Effects of sex steroids on gonadal development and gender determination in the sea scallop, Placopecten magellanicus","volume":"238","author":"Wang","year":"2004","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.cbpb.2025.111148_bb0375","doi-asserted-by":"crossref","first-page":"14908","DOI":"10.4238\/2015.October.18.56","article-title":"Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family","volume":"14","author":"Wang","year":"2015","journal-title":"Genet. Mol. Res."},{"issue":"05","key":"10.1016\/j.cbpb.2025.111148_bb0380","first-page":"1041","article-title":"Molecular cloning and expression analysis of wnt4 from Atrina pectinata and effects of estradiol-17\u03b2 on its expression","volume":"23","author":"Wang","year":"2016","journal-title":"J. Fish. Sci. China"},{"issue":"03","key":"10.1016\/j.cbpb.2025.111148_bb0385","first-page":"25","article-title":"Study on 17\u03b2-estradiol induced feminization of Pelteobagrus fulvidraco","volume":"16","author":"Wang","year":"2020","journal-title":"South China Fish. Sci."},{"key":"10.1016\/j.cbpb.2025.111148_bb0390","series-title":"Molecular Cloning, Gene Expression of Foxl2 and its Possible Roles in Gonadal Sex Differentiation in Southern Catfish, Silurus Meridionnalis Chen [D]","author":"Wu","year":"2007"},{"issue":"6","key":"10.1016\/j.cbpb.2025.111148_bb0395","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1095\/biolreprod.109.077362","article-title":"Wnt4 is associated with the development of ovarian tissue in the protandrous black porgy, Acanthopagrus schlegeli","volume":"81","author":"Wu","year":"2009","journal-title":"Biol. Reprod."},{"issue":"03","key":"10.1016\/j.cbpb.2025.111148_bb0400","first-page":"362","article-title":"Effects of Estradiol stimulation on Dmrt gene expression in the Manila Clam (Ruditapes philippinarum)","volume":"34","author":"Wu","year":"2019","journal-title":"J. Dalian Ocean Univ."},{"issue":"07","key":"10.1016\/j.cbpb.2025.111148_bb0405","first-page":"20","article-title":"Distribution of sex steroids in the gonad of Patinopecten yessoensis during the reproductive cycle","volume":"49","author":"Xie","year":"2019","journal-title":"Period. Ocean Univ. China"},{"key":"10.1016\/j.cbpb.2025.111148_bb0410","series-title":"Effection of Temperature and 17\u03b2- Estradiol on Sexual Differentiation of Ictalurus punctatus [D]","author":"Xu","year":"2022"},{"issue":"02","key":"10.1016\/j.cbpb.2025.111148_bb0415","first-page":"15","article-title":"Molecular cloning and expression analysis of Sox9 gene from Pteria penguin","volume":"38","author":"Xu","year":"2018","journal-title":"J. Guangdong Ocean Univ."},{"key":"10.1016\/j.cbpb.2025.111148_bb0420","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.aquaculture.2018.02.015","article-title":"Production of neo-males from gynogenetic yellow drum through 17\u03b1-methyltestosterone immersion and subsequent application for the establishment of all-female populations","volume":"489","author":"Xu","year":"2018","journal-title":"Aquaculture"},{"issue":"09","key":"10.1016\/j.cbpb.2025.111148_bb0425","first-page":"3960","article-title":"Molecular identification and expression analysis of SOX2 gene from Hyriopsis cumingii","volume":"38","author":"Xu","year":"2019","journal-title":"Genom. Appl. Biol."},{"key":"10.1016\/j.cbpb.2025.111148_bb0430","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.657559","article-title":"Expression of the testis-specific serine\/threonine kinases suggests their role in spermiogenesis of bay scallop Argopecten irradians","volume":"12","author":"Xue","year":"2021","journal-title":"Front. Physiol."},{"issue":"01","key":"10.1016\/j.cbpb.2025.111148_bb0435","first-page":"160","article-title":"Molecular cloning and gene expression of Foxl2 and sox14 gene from hyriopsis cumingii","volume":"49","author":"Ye","year":"2018","journal-title":"Oceanologia et Limnologia Sinica"},{"issue":"01","key":"10.1016\/j.cbpb.2025.111148_bb0440","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3724\/issn1000-3207-1994-1-71-3","article-title":"Molecular cloning and expression patterns of Sox11 gene in pinctada martensii","volume":"40","author":"Yu","year":"2016","journal-title":"Acta Hydrobiol. Sin."},{"issue":"02","key":"10.1016\/j.cbpb.2025.111148_bb0445","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3724\/SP.J.1035.2012.00205","article-title":"Expression of the Sox2 gene in different tissues and different months on testis of hyriopsis schlegelii","volume":"36","author":"Zeng","year":"2012","journal-title":"Acta Hydrobiol. Sin."},{"issue":"13","key":"10.1016\/j.cbpb.2025.111148_bb0450","article-title":"Full-length transcriptome sequences provide insight into hermaphroditism of freshwater pearl mussel Hyriopsis schlegelii","volume":"2022","author":"Zeng","year":"2022","journal-title":"Front. Genet."},{"issue":"12","key":"10.1016\/j.cbpb.2025.111148_bb0455","first-page":"118","article-title":"Effect of temperature and estradiol-17\u03b2 on gonad development and serum sex steroid in Amur sturgeon (Acipenser schrenckii)","volume":"42","author":"Zhang","year":"2011","journal-title":"J. Northeast. Agric. Univ."},{"issue":"7","key":"10.1016\/j.cbpb.2025.111148_bib477","first-page":"490","article-title":"Effects of estradiol benzoate on testicular development in rats","volume":"11","author":"Zhang","year":"2005","journal-title":"Natl. J. Androl."},{"issue":"08","key":"10.1016\/j.cbpb.2025.111148_bb0460","first-page":"1691","article-title":"Cloning and expression of sox9a\/b gene in the large yellow croaker (Larimichthys crocea)","volume":"43","author":"Zhang","year":"2019","journal-title":"J. Fish. China"},{"key":"10.1016\/j.cbpb.2025.111148_bb0465","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jsbmb.2014.03.002","article-title":"Evidence for the presence of sex steroid hormones in Zhikong scallop, Chlamys farreri","volume":"143","author":"Zheng","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpb.2025.111148_bb0470","article-title":"Development and gene expression analysis of gonad during 17\u03b1-methyltestosterone-induced sex reversal in mandarin fish (Siniperca chuatsi)","volume":"23","author":"Zhu","year":"2022","journal-title":"Aquac. Rep."},{"issue":"02","key":"10.1016\/j.cbpb.2025.111148_bb0475","first-page":"107","article-title":"Distribution of sex steroid hormones in the gonad of Crassostrea ariakensi during the reproductive cycle","volume":"39","author":"Zhu","year":"2023","journal-title":"J. Ludong Univ. (Nat. Sci. Ed.)"}],"container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109649592500079X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109649592500079X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:21:55Z","timestamp":1772882515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109649592500079X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":96,"alternative-id":["S109649592500079X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpb.2025.111148","relation":{},"ISSN":["1096-4959"],"issn-type":[{"value":"1096-4959","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular expression of genes related to sex differentiation and their response to sex steroid hormones in the clam Chinese cyclina (Cyclina sinensis)","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpb.2025.111148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111148"}}