{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:33:53Z","timestamp":1784367233532,"version":"3.55.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100023674","name":"Deanship of Scientific Research, King Khalid University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020912","name":"King Faisal University","doi-asserted-by":"publisher","award":["KFU252172"],"award-info":[{"award-number":["KFU252172"]}],"id":[{"id":"10.13039\/501100020912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.cbpb.2025.111151","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T15:08:54Z","timestamp":1756480134000},"page":"111151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Chitosan nanogel mitigates Shewanella-induced oxidative stress, brain neurotransmitter imbalance, biochemical, hepatic, and renal dysfunction, and histopathological changes in Nile tilapia"],"prefix":"10.1016","volume":"280","author":[{"given":"Rowida E.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehad E.","family":"Elshopakey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"AlSaqufi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah Tageldein","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Alkhamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham A.","family":"Hassanien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh H.","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Khamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afaf N.","family":"Abdel Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpb.2025.111151_bb0005","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s10499-019-00388-0","article-title":"Antimicrobial activities of chitosan nanoparticles against pathogenic microorganisms in Nile tilapia, Oreochromis niloticus","volume":"27","author":"Abdel-Razek","year":"2019","journal-title":"Aquac. Int."},{"key":"10.1016\/j.cbpb.2025.111151_bb0010","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.fsi.2019.02.063","article-title":"Immunostimulatory effect of dietary chitosan nanoparticles on the performance of Nile tilapia, Oreochromis niloticus (L.)","volume":"88","author":"Abdel-Tawwab","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.54660\/IJMCR.2025.4.1.08-14","article-title":"Shewanella: pathogenicity classification and its relationship with biofilm formation","volume":"4","author":"Abdulmaged","year":"2024","journal-title":"Int. J. Multidiscip. Comp. Res."},{"key":"10.1016\/j.cbpb.2025.111151_bb0020","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/toxics11040313","article-title":"Exopolysaccharides-mediated ZnO nanoparticles for the treatment of aquatic diseases in freshwater fish Oreochromis mossambicus","volume":"11","author":"Abinaya","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.cbpb.2025.111151_bb0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Oxidoreductases acting on groups other than CHOH: catalase","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0030","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/jfd.13212","article-title":"In vitro assessment of the antimicrobial efficacy of chitosan nanoparticles against major fish pathogens and their cytotoxicity to fish cell lines","volume":"43","author":"Ahmed","year":"2020","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.cbpb.2025.111151_bb0035","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.15244\/pjoes\/189369","article-title":"Evaluation of antioxidant response and histopathological alterations in Cyprinus carpio and Oreochromis niloticus infected with zoonotic bacterial, Aeromonas hydrophila","volume":"34","author":"Al-Shammari","year":"2025","journal-title":"Pol. J. Environ. Stud."},{"key":"10.1016\/j.cbpb.2025.111151_bb0040","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1163\/156853974X00534","article-title":"Observational study of behavior: sampling methods","volume":"49","author":"Altmann","year":"1974","journal-title":"Behaviour"},{"key":"10.1016\/j.cbpb.2025.111151_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108628","article-title":"The antibacterial activity and immunomodulatory effect of naturally synthesized chitosan and silver nanoparticles against Pseudomonas fluorescence infection in Nile tilapia (Oreochromis niloticus): an in vivo study","volume":"135","author":"Aly","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0050","series-title":"Standard Methods for the Examination of Water and Wastewater","first-page":"1","author":"APHA","year":"2005"},{"key":"10.1016\/j.cbpb.2025.111151_bb0055","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1080\/07388551.2016.1185389","article-title":"Chitosan magnetic nanoparticles for drug delivery systems","volume":"37","author":"Assa","year":"2017","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2016.12.016","article-title":"Melaleuca alternifolia essential oil enhances the non-specific immune system and prevents oxidative damage in Rhamdia quelen experimentally infected by Aeromonas hydrophila: effects on cholinergic and purinergic systems in liver tissue","volume":"61","author":"Baldissera","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0065","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.rbp.2012.11.003","article-title":"Pathophysiology of bacterial infection of the central nervous system and its putative role in the pathogenesis of behavioral changes","volume":"35","author":"Barichello","year":"2013","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.cbpb.2025.111151_bb0070","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s10695-019-00645-2","article-title":"Effects of methylphenidate on the aggressive behavior, serotonin and dopamine levels, and dopamine-related gene transcription in brain of male Nile tilapia (Oreochromis niloticus)","volume":"45","author":"Batalh\u00e3o","year":"2019","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpb.2025.111151_bb0075","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.micpath.2016.12.009","article-title":"Fowl typhoid in laying hens cause hepatic oxidative stress","volume":"103","author":"Biazus","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.cbpb.2025.111151_bb0080","doi-asserted-by":"crossref","first-page":"12533","DOI":"10.1021\/acs.est.5c01559","article-title":"Blood-brain and blood-gill barrier disruption in coho salmon exposed to roadway runoff and 6PPD-quinone","volume":"59","author":"Blair","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0085","series-title":"Tietz Textbook of Clinical Chemistry","author":"Burtis","year":"1994"},{"issue":"1","key":"10.1016\/j.cbpb.2025.111151_bb0090","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1097-4628(19970103)63:1<125::AID-APP13>3.0.CO;2-4","article-title":"Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers","volume":"63","author":"Calvo","year":"1997","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.cbpb.2025.111151_bb0095","series-title":"Canadian Council on Animal Care Guidelines on: The Care and Use of Fish in Research, Teaching and Testing. Ottawa","author":"CCoA, C","year":"2005"},{"key":"10.1016\/j.cbpb.2025.111151_bb0100","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/raq.12753","article-title":"Application of haematology parameters for health management in fish farms","volume":"15","author":"Chen","year":"2023","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.cbpb.2025.111151_bb0105","first-page":"524","article-title":"Feeding and territorial behaviour in juveniles of three co-existing triggerfishes","volume":"59","author":"Chen","year":"2001","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3329\/jsr.v12i1.41716","article-title":"Oxidative stress in fish: a review","volume":"12","author":"Chowdhury","year":"2020","journal-title":"J. Sci. Res."},{"key":"10.1016\/j.cbpb.2025.111151_bb0115","series-title":"Standard Methods of Clinical Chemistry","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/B978-0-12-609106-9.50021-X","article-title":"The determination of glucose by the ortho-toluidine method (filtrate and direct procedure)","author":"Cooper","year":"1970"},{"issue":"1","key":"10.1016\/j.cbpb.2025.111151_bb0120","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0009-8981(71)90365-2","article-title":"Albumin standards and the measurement of serum albumin with bromcresol green","volume":"31","author":"Doumas","year":"1971","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cbpb.2025.111151_bb0125","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/are.15632","article-title":"Antibacterial activity of silver nanoparticles against antibiotic-resistant Aeromonas veronii infections in Nile Tilapia, Oreochromis niloticus (L.), in vitro and in vivo assay","volume":"53","author":"Elgendy","year":"2022","journal-title":"Aquac. Res."},{"key":"10.1016\/j.cbpb.2025.111151_bb0130","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.aquaculture.2007.07.235","article-title":"Acute viral and bacterial infections elevate water cortisol concentrations in fish tanks","volume":"272","author":"Ellis","year":"2007","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2025.111151_bb0135","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/raq.12738","article-title":"From Africa to the world\u2014the journey of Nile tilapia","volume":"15","author":"El-Sayed","year":"2023","journal-title":"Rev. Aquac."},{"issue":"5","key":"10.1016\/j.cbpb.2025.111151_bb0140","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.actbio.2014.01.009","article-title":"Designing nanogel carriers for antibacterial applications","volume":"10","author":"Ferrer","year":"2014","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.cbpb.2025.111151_bb0145","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/clinchem\/29.8.1494","article-title":"Enzymic creatinine assay: a new colorimetric method based on hydrogen peroxide measurement","volume":"29","author":"Fossati","year":"1983","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cbpb.2025.111151_bb0150","series-title":"Pathobiology of Marine and Estuarine Organisms","first-page":"53","article-title":"Bacterial diseases of fish","author":"Fryer","year":"2021"},{"issue":"2\u20133","key":"10.1016\/j.cbpb.2025.111151_bb0155","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.colsurfb.2005.06.001","article-title":"Modulation of surface charge, particle size and morphological properties of chitosan\u2013TPP nanoparticles intended for gene delivery","volume":"44","author":"Gan","year":"2005","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"8","key":"10.1016\/j.cbpb.2025.111151_bb0160","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.4315\/0362-028X-72.8.1735","article-title":"Antimicrobial activity of chitosan against Campylobacter spp. and other microorganisms and its mechanism of action","volume":"72","author":"Ganan","year":"2009","journal-title":"J. Food Prot."},{"key":"10.1016\/j.cbpb.2025.111151_bb0170","series-title":"Colorimetric Determination of Total Protein","first-page":"181","author":"Henry","year":"1964"},{"key":"10.1016\/j.cbpb.2025.111151_bb0175","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/23308249.2020.1795616","article-title":"Oxidative stress and antioxidant defense in fish: the implications of probiotic, prebiotic, and synbiotics","volume":"29","author":"Hoseinifar","year":"2020","journal-title":"Rev. Fish. Sci. Aquac."},{"key":"10.1016\/j.cbpb.2025.111151_bb0180","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3390\/fishes9100388","article-title":"Dietary chitosan nanoparticles enhance growth, antioxidant defenses, immunity, and Aeromonas veronii biovar sobria resistance in Nile tilapia Oreochromis niloticus","volume":"9","author":"Hossam-Elden","year":"2024","journal-title":"Fishes"},{"issue":"11","key":"10.1016\/j.cbpb.2025.111151_bb0185","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3390\/pharmaceutics13111913","article-title":"Advances in the application of nanomaterials as treatments for bacterial infectious diseases","volume":"13","author":"Hung","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cbpb.2025.111151_bb0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1089\/biores.2019.0028","article-title":"Antioxidant properties and redox-modulating activity of chitosan and its derivatives: biomaterials with application in cancer therapy","volume":"9","author":"Ivanova","year":"2020","journal-title":"Bio Res. Open Access"},{"issue":"4","key":"10.1016\/j.cbpb.2025.111151_bb0195","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.clinmicnews.2014.01.006","article-title":"Shewanella: a marine pathogen as an emerging cause of human disease","volume":"36","author":"Janda","year":"2014","journal-title":"Clin. Microbiol. Newsl."},{"key":"10.1016\/j.cbpb.2025.111151_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1042977","article-title":"Identification of Shewanella putrefaciens as a novel pathogen of the largemouth bass (Micropterus salmoides) and histopathological analysis of diseased fish","volume":"12","author":"Jiang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"6","key":"10.1016\/j.cbpb.2025.111151_bb0205","first-page":"1","article-title":"The efficacy of clove oil as anesthetic in common carp (Cyprinus carpio) and its potential metabolism reducing capacity","volume":"1","author":"Kamble","year":"2014","journal-title":"Int. J. Fauna Biol. Stud."},{"key":"10.1016\/j.cbpb.2025.111151_bb0215","first-page":"532","article-title":"Isolation of Shewanella putrefaciens from cultured European sea bass,(Dicentrarchus labrax) in Turkey","volume":"160","author":"Korun","year":"2009","journal-title":"Rev. Med. Vet."},{"issue":"13","key":"10.1016\/j.cbpb.2025.111151_bb0220","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.3390\/ijerph20136237","article-title":"Cortisol as a stress indicator in fish: sampling methods, analytical techniques, and organic pollutant exposure assessments","volume":"20","author":"Lemos","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.cbpb.2025.111151_bb0225","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s10646-013-1112-7","article-title":"Antioxidant response and histopathological changes in brain tissue of pigeon exposed to avermectin","volume":"22","author":"Li","year":"2013","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.cbpb.2025.111151_bb0230","series-title":"Applications of Chitan and Chitosan","first-page":"3","article-title":"Applications and properties of chitosan","author":"Li","year":"2020"},{"key":"10.1016\/j.cbpb.2025.111151_bb0240","first-page":"159","article-title":"Shewanella in a tilapia fish farm","volume":"4","author":"Lu","year":"2010","journal-title":"J. Fish Sci."},{"key":"10.1016\/j.cbpb.2025.111151_bb0245","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1096\/fj.201700768R","article-title":"Uropathogenic Escherichia coli virulence factor hemolysin a causes programmed cell necrosis by altering mitochondrial dynamics","volume":"32","author":"Lu","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.cbpb.2025.111151_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2023.110876","article-title":"Chitosan nanogel aqueous treatment improved blood biochemicals, antioxidant capacity, immune response, immune-related gene expression and infection resistance of Nile tilapia","volume":"269","author":"Mahboub","year":"2024","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0255","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12917-025-04568-4","article-title":"Nano-chitosan hydrogel alleviates Candida albicans-induced health alterations in Nile tilapia (Oreochromis niloticus): antioxidant response, neuro-behaviors, hepato-renal functions, and histopathological investigation","volume":"21","author":"Mahboub","year":"2025","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.cbpb.2025.111151_bb0260","series-title":"Dietary Supplements for the Health and Quality of Cultured Fish","first-page":"10","article-title":"Fish health assessment","author":"Maita","year":"2007"},{"key":"10.1016\/j.cbpb.2025.111151_bb0265","series-title":"Bacterial Fish Diseases","first-page":"399","article-title":"Summary of economic losses due to bacterial pathogens in aquaculture industry","author":"Maldonado-Miranda","year":"2022"},{"issue":"1","key":"10.1016\/j.cbpb.2025.111151_bb0270","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejar.2017.01.002","article-title":"First recording of Shewanella putrefaciens in cultured Oreochromis niloticus and its identification by 16Sr RNA in Egypt","volume":"43","author":"Manal","year":"2017","journal-title":"Egypt. J. Aquat. Res."},{"key":"10.1016\/j.cbpb.2025.111151_bb0275","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1232109","article-title":"Nanogels as novel drug nanocarriers for CNS drug delivery","volume":"10","author":"Manimaran","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.cbpb.2025.111151_bb0280","series-title":"Fish Histology: From Cells to Organs","author":"Mokhtar","year":"2021"},{"issue":"2","key":"10.1016\/j.cbpb.2025.111151_bb0285","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.cbpb.2025.111151_bb0290","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J. Lab. Clin. Med."},{"issue":"4","key":"10.1016\/j.cbpb.2025.111151_bb0295","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1515\/jvetres-2016-0064","article-title":"Shewanella putrefaciens\u2013a new opportunistic pathogen of freshwater fish","volume":"60","author":"Pa\u017adzior","year":"2016","journal-title":"J. Vet. Res."},{"issue":"3","key":"10.1016\/j.cbpb.2025.111151_bb0300","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jfd.12231","article-title":"Phenotypical and genotypical characterization of Shewanella putrefaciens strains isolated from diseased freshwater fish","volume":"38","author":"P\u0119kala","year":"2015","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.cbpb.2025.111151_bb0305","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s10695-014-9928-5","article-title":"Blood chemistry profile as indicator of nutritional status in European seabass (Dicentrarchus labrax)","volume":"40","author":"Peres","year":"2014","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpb.2025.111151_bb0310","first-page":"225","article-title":"Effect of water salinity on total protein and electrophoretic pattern of serum proteins of grass carp, Ctenopharyngodon idella","volume":"5","author":"Peyghan","year":"2014","journal-title":"Vet. Res. Forum"},{"key":"10.1016\/j.cbpb.2025.111151_bb0315","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.carbpol.2015.09.054","article-title":"Colloidal chitin nanogels: a plethora of applications under one shell","volume":"136","author":"Priya","year":"2016","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.cbpb.2025.111151_bb0320","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1365-2109.2012.03260.x","article-title":"First report of Shewanella sp. and Listonella sp. infection in freshwater cultured loach, Misgurnus anguillicaudatus","volume":"45","author":"Qin","year":"2014","journal-title":"Aquac. Res."},{"issue":"12","key":"10.1016\/j.cbpb.2025.111151_bb0325","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1128\/AEM.00453-08","article-title":"Insights into the mode of action of chitosan as an antibacterial compound","volume":"74","author":"Raafat","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0330","series-title":"Antibiotic Residue and Resistance in Seafood Safety and Quality","first-page":"165","article-title":"Fighting the spread of antibiotic resistance in Bacteria: a global challenge in environment and food","author":"Rathlavath","year":"2025"},{"issue":"1","key":"10.1016\/j.cbpb.2025.111151_bb0335","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s12917-024-04175-9","article-title":"Implications of ammonia stress for the pathogenicity of Shewanella spp. in Oreochromis niloticus: effects on hematological, biochemical, immunological, and histopathological parameters","volume":"20","author":"Reda","year":"2024","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.cbpb.2025.111151_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109588","article-title":"Infection dynamics of Shewanella spp. in Nile tilapia under varied water temperatures: a hematological, biochemical, antioxidant-immune analysis, and histopathological alterations","volume":"149","author":"Reda","year":"2024","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.cbpb.2025.111151_bb0345","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0350","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.colsurfb.2013.10.015","article-title":"Dual drug encapsulated thermo-sensitive fibrinogen-graft-poly (N-isopropyl acrylamide) nanogels for breast cancer therapy","volume":"114","author":"Rejinold","year":"2014","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"7","key":"10.1016\/j.cbpb.2025.111151_bb0355","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3390\/md20070425","article-title":"Therapeutic intervention with dietary chitosan nanoparticles alleviates fish pathological and molecular systemic inflammatory responses against infections","volume":"20","author":"Saleh","year":"2022","journal-title":"Mar. Drugs"},{"issue":"1","key":"10.1016\/j.cbpb.2025.111151_bb0360","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2989\/16085914.2017.1295918","article-title":"Cortisol stress response and histopathological alteration index in Clarias gariepinus exposed to sublethal concentrations of qua Iboe crude oil and rig wash","volume":"42","author":"Saliu","year":"2017","journal-title":"Afr. J. Aquat. Sci."},{"key":"10.1016\/j.cbpb.2025.111151_bb0365","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jconrel.2016.08.029","article-title":"Functionalized nanogels carrying an anticancer microRNA for glioblastoma therapy","volume":"239","author":"Shatsberg","year":"2016","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.cbpb.2025.111151_bb0370","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/jwas.12686","article-title":"Large-scale mortality in cultured tilapia Oreochromis niloticus due to infection with Shewanella putrefaciens in India","volume":"51","author":"Sood","year":"2020","journal-title":"J. World Aquacult. Soc."},{"key":"10.1016\/j.cbpb.2025.111151_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.111707","article-title":"The effects of acute ammonia stress on liver antioxidant, immune and metabolic responses of juvenile yellowfin tuna (Thunnus albacares)","volume":"297","author":"Sun","year":"2024","journal-title":"Comp. Biochem. Physiol. -Part A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0380","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques. Elsevier Health Sciences","author":"Suvarna","year":"2018"},{"key":"10.1016\/j.cbpb.2025.111151_bb0385","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.aquaculture.2007.12.024","article-title":"Effects of oxygen concentration and body weight on maximum feed intake, growth and hematological parameters of Nile tilapia, Oreochromis niloticus","volume":"275","author":"Tran-Duy","year":"2008","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2025.111151_bb0390","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10529-015-1977-z","article-title":"Application of magnetic nanoparticles in smart enzyme immobilization","volume":"38","author":"Vaghari","year":"2016","journal-title":"Biotechnol. Lett."},{"issue":"2","key":"10.1016\/j.cbpb.2025.111151_bb0395","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/jwas.12963","article-title":"The contribution of aquaculture systems to global aquaculture production","volume":"54","author":"Verdegem","year":"2023","journal-title":"J. World Aquacult. Soc."},{"key":"10.1016\/j.cbpb.2025.111151_bb0400","first-page":"836","article-title":"Isolation and characterization of Shewanella spp. from patients of food poisoning","volume":"30","author":"Wang","year":"2009","journal-title":"Chin. J. Epidemiol."},{"issue":"34","key":"10.1016\/j.cbpb.2025.111151_bb0405","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1039\/C7TB01624G","article-title":"Recent advances in engineered chitosan-based nanogels for biomedical applications","volume":"5","author":"Wang","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.cbpb.2025.111151_bb0410","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.fsi.2019.09.055","article-title":"Effects of short-term fasting on the resistance of Nile tilapia (Oreochromis niloticus) to Streptococcus agalactiae infection","volume":"94","author":"Wang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.cbpb.2025.111151_bb0415","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3390\/ijms21031061","article-title":"Defeating antibiotic-resistant bacteria: exploring alternative therapies for a post-antibiotic era","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpb.2025.111151_bb0420","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jmst.2019.10.013","article-title":"Neuroprotective effect of chitosan nanoparticle gene delivery system grafted with acteoside (ACT) in Parkinson\u2019s disease models","volume":"43","author":"Xue","year":"2020","journal-title":"J. Mater. Sci. Techol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0425","article-title":"An investigation into the effects of Streptococcus agalactiae on the 5-HT system and the behavior of GIFT tilapia (Oreochromis niloticus)","volume":"15","author":"Yi","year":"2019","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.cbpb.2025.111151_bb0430","article-title":"Behavioral dysregulation in Nile tilapia (Oreochromis niloticus, GIFT) post-Streptococcus agalactia infection: role of the microbiota-gut-brain axis","volume":"285","author":"Yi","year":"2024","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpb.2025.111151_bb0435","article-title":"Taurine can play a positive role in growth, liver health and resistance to Aeromonas hydrophila of yellow catfish Pelteobagrus fulvidraco exposed to ammonia stress for a long time","volume":"38","author":"Zhang","year":"2024","journal-title":"Aquac. Rep."}],"container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109649592500082X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109649592500082X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T23:37:09Z","timestamp":1766619429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109649592500082X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":84,"alternative-id":["S109649592500082X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpb.2025.111151","relation":{},"ISSN":["1096-4959"],"issn-type":[{"value":"1096-4959","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chitosan nanogel mitigates Shewanella-induced oxidative stress, brain neurotransmitter imbalance, biochemical, hepatic, and renal dysfunction, and histopathological changes in Nile tilapia","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpb.2025.111151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111151"}}