{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:12:59Z","timestamp":1783739579609,"version":"3.55.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["JQ2023C007"],"award-info":[{"award-number":["JQ2023C007"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023T160720"],"award-info":[{"award-number":["2023T160720"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012428","name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.cbpb.2026.111208","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:00:13Z","timestamp":1771952413000},"page":"111208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["\u03b1-Ketoglutarate restores redox and energy homeostasis to ameliorate splenic immune dysfunction induced by carbonate-alkaline stress in crucian carp (Carassius auratus)"],"prefix":"10.1016","volume":"284","author":[{"given":"Qianwen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanyu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpb.2026.111208_bb0005","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1101\/gr.271205.120","article-title":"A graph neural network model to estimate cell-wise metabolic flux using single-cell RNA-seq data","volume":"31","author":"Alghamdi","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.cbpb.2026.111208_bb0010","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1111\/raq.12792","article-title":"Microalgae with immunomodulatory effects on fish","volume":"15","author":"Bahi","year":"2023","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.cbpb.2026.111208_bb0015","first-page":"561","article-title":"Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine","volume":"12","author":"Belfield","year":"1971","journal-title":"Enzyme"},{"key":"10.1016\/j.cbpb.2026.111208_bb0020","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpb.2026.111208_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1105156","article-title":"Chronic stress boosts systemic inflammation and compromises antiviral innate immunity in Carassius gibel","volume":"14","author":"Dai","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/biology11050757","article-title":"Cancer-associated microbiota: from mechanisms of disease causation to microbiota-centric anti-cancer approaches","volume":"11","author":"Dey","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.cbpb.2026.111208_bb0035","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3390\/metabo13020159","article-title":"Effects of saline-alkaline stress on metabolome, biochemical parameters, and histopathology in the kidney of crucian carp (Carassius auratus)","volume":"13","author":"Ding","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.cbpb.2026.111208_bb0040","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41575-021-00431-7","article-title":"Harnessing metabolic dependencies in pancreatic cancers","volume":"18","author":"Encarnacion-Rosado","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0045","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/are.14554","article-title":"Effects of \u03b1-ketoglutarate on growth performance, antioxidant capacity and ammonia metabolization against chronic carbonate alkalinity stress in Songpu mirror carp (Cyprinus carpio Songpu)","volume":"51","author":"Fan","year":"2020","journal-title":"Aquac. Res."},{"key":"10.1016\/j.cbpb.2026.111208_bb0050","article-title":"Phosphorus nutrition in Songpu mirror carp (Cyprinus carpio Songpu) during chronic carbonate alkalinity stress: effects on growth, intestinal immunity, physical barrier function, and intestinal microflora","volume":"13","author":"Fan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0055","article-title":"Effects of \u03b1-lipoic acid supplementation in a high-fat diet on growth, lipid metabolism and mitochondrial function in spotted seabass (Lateolabrax maculatus)","volume":"39","author":"Gan","year":"2024","journal-title":"Aquacult. Rep."},{"key":"10.1016\/j.cbpb.2026.111208_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/biology13070488","article-title":"Physiological adaptation of Fenneropenaeus chinensis in response to saline-alkaline stress revealed by a combined proteomics and metabolomics method","volume":"13","author":"Gao","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.cbpb.2026.111208_bb0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0009-8981(91)90067-M","article-title":"A simple method for determination of serum catalase activity and revision of reference range","volume":"196","author":"Goth","year":"1991","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cbpb.2026.111208_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/metabo15010005","article-title":"Exploring disparities in gill physiological responses to NaHCO3-induced habitat stress in triploid and diploid crucian carp (Carassius auratus): a comprehensive investigation through multi-omics and biochemical analyses","volume":"15","author":"Han","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.cbpb.2026.111208_bb0075","series-title":"Fish Nutrition","first-page":"505","article-title":"Diet formulation and manufacture","author":"Hardy","year":"2003"},{"key":"10.1016\/j.cbpb.2026.111208_bb0080","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01274-22","article-title":"Glutamine is required for M1-like polarization of macrophages in response to Mycobacterium tuberculosis infection","volume":"13","author":"Jiang","year":"2022","journal-title":"MBio"},{"key":"10.1016\/j.cbpb.2026.111208_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107906","article-title":"Glycolysis: a multifaceted metabolic pathway and signaling hub","volume":"300","author":"Kierans","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpb.2026.111208_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.742601","article-title":"Acute alkalinity stress triggers kidney histopathology, oxidative-immune dysregulation, and MAPK\/TGF-\u03b2 signaling pathways activation in Scatophagus argus","author":"Kong","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2026.111208_bb0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1746-1448-1-10","article-title":"Saline systems of the Great Plains of western Canada: an overview of the limnogeology and paleolimnology","volume":"1","author":"Last","year":"2005","journal-title":"Saline Syst."},{"key":"10.1016\/j.cbpb.2026.111208_bb0105","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/tx00026a012","article-title":"Evaluation of the probe 2\u2032, 7\u2032-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress","volume":"5","author":"LeBel","year":"1992","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.fsi.2017.09.050","article-title":"Nutrient sensing signaling integrates nutrient metabolism and intestinal immunity in grass carp, Ctenopharyngodon idellus after prolonged starvation","volume":"71","author":"Li","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0115","article-title":"Epimedium koreanum Nakai\u2013induced liver injury\u2014a mechanistic study using untargeted metabolomics","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0120","article-title":"Effectiveness of astaxanthin as a feed supplement to improve growth performance and feed utilization in aquaculture animals: a meta-analysis","volume":"14","author":"Li","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbpb.2026.111208_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40104-025-01261-2","article-title":"Mechanisms of high-glucose-induced mitochondrial damage and glycolipid accumulation in largemouth bass","volume":"16","author":"Liao","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0130","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.fsi.2018.06.050","article-title":"Long-term crowding stress causes compromised nonspecific immunity and increases apoptosis of spleen in grass carp (Ctenopharyngodon idella)","volume":"80","author":"Lin","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0135","article-title":"Comprehensive analyses of annexins in naked carp (Gymnocypris przewalskii) unveil their roles in saline-alkaline stress","volume":"579","author":"Linlin","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2026.111208_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135814","article-title":"Multi-omics profiling and biochemical assays reveal the acute toxicity of environmental related concentrations of Di-(2-ethylhexyl) phthalate (DEHP) on the gill of crucian carp (Carassius auratus)","volume":"307","author":"Liu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpb.2026.111208_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153622","article-title":"Integrated application of multi-omics approach and biochemical assays provides insights into physiological responses to saline-alkaline stress in the gills of crucian carp (Carassius auratus)","volume":"822","author":"Liu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpb.2026.111208_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171447","article-title":"Hepatotoxic effects of chronic exposure to environmentally relevant concentrations of Di-(2-ethylhexyl) phthalate (DEHP) on crucian carp: insights from multi-omics analyses","volume":"923","author":"Liu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpb.2026.111208_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbd.2025.101466","article-title":"\u03b1-Ketoglutarate modulates the mechanisms of toxicity in crucian carp kidneys chronically exposed to NaHCO3: metabolomics insights","volume":"55","author":"Liu","year":"2025","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"key":"10.1016\/j.cbpb.2026.111208_bb0160","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2174\/1871530319666181128160411","article-title":"Development and organization of the secondary and tertiary lymphoid organs: influence of microbial and food antigens","volume":"19","author":"Magrone","year":"2019","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"10.1016\/j.cbpb.2026.111208_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020238","article-title":"HIF-1-dependent reprogramming of glucose metabolic pathway of cancer cells and its therapeutic significance","volume":"20","author":"Nagao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpb.2026.111208_bb0170","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpb.2026.111208_bb0175","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0009-8981(99)00246-6","article-title":"A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1)","volume":"293","author":"Peskin","year":"2000","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cbpb.2026.111208_bb0180","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3390\/metabo14120649","article-title":"Effects of ammonia stress on liver tissue structure, enzyme activities, and metabolome of juvenile largemouth bass Micropterus salmoides","volume":"14","author":"Pu","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.cbpb.2026.111208_bb0185","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/nprot.2006.378","article-title":"Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method","volume":"1","author":"Rahman","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cbpb.2026.111208_bb0190","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0006-3002(52)90045-0","article-title":"The measurement of lysozyme activity and the ultra-violet inactivation of lysozyme","volume":"8","author":"Shugar","year":"1952","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpb.2026.111208_bb0195","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6660616","article-title":"Qiangji Jianli decoction alleviates hydrogen peroxide-induced mitochondrial dysfunction via regulating mitochondrial dynamics and biogenesis in L6 myoblasts","volume":"2021","author":"Song","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.cbpb.2026.111208_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164734","article-title":"Effects of different saline-alkaline conditions on the characteristics of phytoplankton communities in the lakes of Songnen Plain, China","volume":"11","author":"Sui","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpb.2026.111208_bb0205","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1039\/C9RA08090B","article-title":"Exploring the metabolic biomarkers and pathway changes in crucian under carbonate alkalinity exposure using high-throughput metabolomics analysis based on UPLC-ESI-QTOF-MS","volume":"10","author":"Sun","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.cbpb.2026.111208_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739888","article-title":"Effects of salinity stress on the growth performance, health status, and intestinal microbiota of juvenile Micropterus salmoides","volume":"576","author":"Sun","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2026.111208_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13020170","article-title":"Investigating the impact of disrupting the glutamine metabolism pathway on ammonia excretion in crucian carp (Carassius auratus) under carbonate alkaline stress using metabolomics techniques","volume":"13","author":"Sun","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.cbpb.2026.111208_bb0220","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/are.14469","article-title":"Dietary \u03b1-ketoglutarate supplementation alleviates harmful effects of high environmental ammonia on grass carp, Ctenopharyngodon idella","volume":"51","author":"Tang","year":"2020","journal-title":"Aquac. Res."},{"key":"10.1016\/j.cbpb.2026.111208_bb0225","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.3390\/cells11121870","article-title":"Prostaglandin 2\u03b1 promotes autophagy and mitochondrial energy production in fish hepatocytes","volume":"11","author":"Tian","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cbpb.2026.111208_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739736","article-title":"Effects of dietary \u03b1-ketoglutarate on the growth performance, digestive enzymes, tor signaling pathway and intestinal microbiota of juvenile mirror carp (Cyprinus carpio) fed low phosphorus diets","volume":"574","author":"Wang","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2026.111208_bb0235","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0076-6879(81)77046-0","article-title":"Glutathione peroxidase","volume":"77","author":"Wendel","year":"1981"},{"key":"10.1016\/j.cbpb.2026.111208_bb0240","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fimmu.2020.00152","article-title":"Fish macrophages show distinct metabolic signatures upon polarization","volume":"11","author":"Wentzel","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0250","article-title":"Adaptability assessment of intermuscular bone-free crucian carp (Carassius auratus) to carbonate alkalinity: insights into morphological, biochemical, and histological parameters","volume":"43","author":"Wu","year":"2025","journal-title":"Aquacult. Rep."},{"key":"10.1016\/j.cbpb.2026.111208_bb0255","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41392-022-01243-0","article-title":"Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology","volume":"7","author":"Yang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cbpb.2026.111208_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.742186","article-title":"Acute alkalinity stress induces functional damage and alters immune metabolic pathways in the gill tissue of spotted scat (Scatophagus argus)","volume":"599","author":"Yang","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2026.111208_bb0265","article-title":"Mitochondrial remodeling and metabolic reprogramming drive long-term salinity adaptation in Tetrahymena thermophila","author":"Yuan","year":"2025","journal-title":"mSystems"},{"key":"10.1016\/j.cbpb.2026.111208_bb0270","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fsi.2004.09.005","article-title":"Ontogeny of the immune system of fish","volume":"20","author":"Zapata","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpb.2026.111208_bb0275","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1016\/j.watres.2012.02.033","article-title":"Hydrochemical characteristics and water quality assessment of surface water and groundwater in Songnen plain, Northeast China","volume":"46","author":"Zhang","year":"2012","journal-title":"Water Res."},{"key":"10.1016\/j.cbpb.2026.111208_bb0280","article-title":"A complex metabolic network and its biomarkers regulate laccase production in white-rot fungus Cerrena unicolor 87613","volume":"23","author":"Zhang","year":"2024","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.cbpb.2026.111208_bb0285","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s40364-024-00677-8","article-title":"Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy","volume":"12","author":"Zhang","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.cbpb.2026.111208_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.742492","article-title":"Lysine deacetylase inhibitors (KDACi) enhance the adaptability of tilapia (Oreochromis niloticus) to carbonate alkalinity stress","volume":"604","author":"Zhang","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2026.111208_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738599","article-title":"Effects of chronic alkalinity stress on immune response in Nile tilapia (Oreochromis niloticus) infected with Aeromonas hydrophila","volume":"561","author":"Zhao","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpb.2026.111208_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13061431","article-title":"Analysis of energy metabolism and lipid spatial distribution in hypoxic-ischemic encephalopathy revealed by MALDI-MSI","volume":"13","author":"Zhao","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.cbpb.2026.111208_bb0305","first-page":"513","article-title":"Toxicity of salinity and alkalinity to c. auratus gibelio fingerlings","volume":"31","author":"Zheng","year":"2001","journal-title":"J. Ocean Univ. Qingdao"},{"key":"10.1016\/j.cbpb.2026.111208_bb0310","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.fsi.2020.11.010","article-title":"Liver and spleen transcriptome reveals that Oreochromis aureus under long-term salinity stress may cause excessive energy consumption and immune response","volume":"107","author":"Zhou","year":"2020","journal-title":"Fish Shellfish Immunol."}],"container-title":["Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096495926000163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096495926000163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:27:51Z","timestamp":1783736871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096495926000163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":60,"alternative-id":["S1096495926000163"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpb.2026.111208","relation":{},"ISSN":["1096-4959"],"issn-type":[{"value":"1096-4959","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b1-Ketoglutarate restores redox and energy homeostasis to ameliorate splenic immune dysfunction induced by carbonate-alkaline stress in crucian carp (Carassius auratus)","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpb.2026.111208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111208"}}