{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:00:35Z","timestamp":1771268435418,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.cbpc.2006.01.005","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T12:34:11Z","timestamp":1141389251000},"page":"150-157","source":"Crossref","is-referenced-by-count":17,"title":["Cellular responses to environmental contaminants in amoebic cells of the slime mould Dictyostelium discoideum"],"prefix":"10.1016","volume":"143","author":[{"given":"Francesco","family":"Dondero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Rebelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Pesce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Berti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Viarengo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2006.01.005_bib1","doi-asserted-by":"crossref","first-page":"12007","DOI":"10.1073\/pnas.94.22.12007","article-title":"Origin and evolution of the slime molds (Mycetazoa)","volume":"94","author":"Baldauf","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2006.01.005_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of Ca2+ signaling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.cbpc.2006.01.005_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1054\/ceca.1998.0014","article-title":"Occurrence of Na+\u2013Ca2+ exchange in the ciliate Euplotes crassus and its role in Ca2+ homeostasis","volume":"25","author":"Burlando","year":"1999","journal-title":"Cell Calcium"},{"key":"10.1016\/j.cbpc.2006.01.005_bib4","doi-asserted-by":"crossref","first-page":"C1461","DOI":"10.1152\/ajpcell.00429.2001","article-title":"Essential role of Ca2+-dependent phospholipase A2 in estradiol-induced lysosome activation","volume":"283","author":"Burlando","year":"2002","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.cbpc.2006.01.005_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1006\/bbrc.2002.6463","article-title":"Occurrence of Cu-ATPase in Dictyostelium: possible role in resistance to copper","volume":"291","author":"Burlando","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2006.01.005_bib6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000071865","article-title":"Ligand-independent tyrosine kinase signaling in RTH 149 trout hepatoma cells: comparison among heavy metals and pro-oxidants","volume":"13","author":"Burlando","year":"2003","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.cbpc.2006.01.005_bib7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0166-445X(02)00186-8","article-title":"Effects of PCB congeners on the immune function of Mytilus hemocytes: alterations of tyrosine kinase-mediated cell signalling","volume":"63","author":"Canesi","year":"2003","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2006.01.005_bib8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ygcen.2003.12.003","article-title":"Rapid effects of 17 \u03b2-estradiol on cell signaling and function of Mytilus haemocytes","volume":"136","author":"Canesi","year":"2004","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cbpc.2006.01.005_bib9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0955-0674(94)90120-1","article-title":"Actin dependent motile forces and cell motility","volume":"6","author":"Cramer","year":"1994","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.cbpc.2006.01.005_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1078\/143446104774199565","article-title":"Biochemical characterization and quantitative gene expression analysis of the multi-stress inducible metallothionein from Tetrahymena thermophila","volume":"155","author":"Dondero","year":"2004","journal-title":"Protist"},{"key":"10.1016\/j.cbpc.2006.01.005_bib11","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0161-5890(01)00108-0","article-title":"Calcium oxidative stress: from cell signaling to cell death","volume":"38","author":"Ermak","year":"2001","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cbpc.2006.01.005_bib12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0045-6535(02)00143-1","article-title":"Cholinesterase activity and effects of its inhibition by neurotoxic drugs in Dictyostelium discoideum","volume":"48","author":"Falugi","year":"2002","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2006.01.005_bib13","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2006.01.005_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0166-2236(88)90046-X","article-title":"Paramecium: a model system for the study of excitable cells","volume":"11","author":"Hinrichsen","year":"1988","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.cbpc.2006.01.005_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1126\/science.7678470","article-title":"Tyrosine phosphorylation of actin in Dictyostelium associated with cell-shape changes","volume":"259","author":"Howard","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2006.01.005_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0014-5793(95)01165-B","article-title":"Stress induced phosphorylation of actin in Dictyostelium cells and localization of the phosphorylation site tyrosine-53 adjacent to the DNAse I binding loop","volume":"375","author":"Jungbluth","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbpc.2006.01.005_bib17","series-title":"Dictyostelium: Evolution, Cell Biology and the Development of Multicellularity","first-page":"294","author":"Kessin","year":"2001"},{"key":"10.1016\/j.cbpc.2006.01.005_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0166-445X(94)00045-X","article-title":"Contaminant induced lysosomal membrane damage in marine mussel digestive cells: an in vitro study","volume":"30","author":"Lowe","year":"1994","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2006.01.005_bib19","series-title":"Dictyostelium: A Model System for Cell and Developmental Biology","first-page":"488","author":"Maeda","year":"1997"},{"key":"10.1016\/j.cbpc.2006.01.005_bib20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.aquatox.2003.09.003","article-title":"Mercury- and copper-induced lysosomal membrane destabilisation depends on [Ca2+]i-dependent phospholipase A2 activation","volume":"66","author":"Marchi","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2006.01.005_bib21","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1006\/bbrc.1998.9200","article-title":"Mechanism of action of a new component of the Ca(2+)-dependent proteolytic system in rat brain: the calpain activator","volume":"249","author":"Melloni","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2006.01.005_bib22","series-title":"The Effects of Stress and Pollution on Marine Animals","first-page":"46","article-title":"Cytological and cytochemical measurements","author":"Moore","year":"1985"},{"key":"10.1016\/j.cbpc.2006.01.005_bib23","first-page":"241","article-title":"Pseudoplasmodium formation and organization in Dictyostelium discoideum","volume":"56","author":"Raper","year":"1940","journal-title":"J. Elisha Mitchell Sci. Soc."},{"key":"10.1016\/j.cbpc.2006.01.005_bib24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1126\/science.2876518","article-title":"Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis","volume":"234","author":"Rogers","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2006.01.005_bib25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1078\/1434-4610-00061","article-title":"Identification, cloning and characterisation of a novel copper-MT in Tetrahymena pigmentosa. Sequencing of cDNA and expression","volume":"152","author":"Santovito","year":"2001","journal-title":"Protist"},{"key":"10.1016\/j.cbpc.2006.01.005_bib26","doi-asserted-by":"crossref","first-page":"33179","DOI":"10.1074\/jbc.274.47.33179","article-title":"Gelsolin, a multifunctional actin regulatory protein","volume":"274","author":"Sun","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2006.01.005_bib27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0742-8413(93)90001-2","article-title":"Mechanisms of heavy metal cation homeostasis in marine invertebrates","volume":"104","author":"Viarengo","year":"1993","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.cbpc.2006.01.005_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0305-0491(92)90408-J","article-title":"A simple procedure for evaluating the protein degradation rate in mussel (Mytilus galloprovincialis Lam.) tissues and its application in a study of phenanthrene effects on protein catabolism","volume":"103","author":"Viarengo","year":"1992","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.cbpc.2006.01.005_bib29","first-page":"161","article-title":"Heavy metal effects on cytosolic free Ca2+ level in the marine protozoan Euplotes crassus evaluated by confocal laser scanning microscopy","volume":"113","author":"Viarengo","year":"1996","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.cbpc.2006.01.005_bib30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/bj1190171","article-title":"Growth of myxamoebae of the cellular slime mould Dictyostelium discoideum in axenic culture","volume":"119","author":"Watts","year":"1970","journal-title":"Biochem. J."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045606000251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045606000251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T14:05:13Z","timestamp":1627135513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045606000251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S1532045606000251"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2006.01.005","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}