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Earth Sci."},{"key":"10.1016\/j.cbpc.2006.10.010_bib69","first-page":"955","article-title":"Molecular characteristics of four new depressant insect neurotoxins purified from venom of Buthus martensi Karsch by HPLC","volume":"37","author":"Ji","year":"1994","journal-title":"Sci. China, Ser B Chem. Life Sci. Earth Sci."},{"key":"10.1016\/j.cbpc.2006.10.010_bib70","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0041-0101(96)00065-7","article-title":"Two neurotoxins (BmK I and BmK II) from the venom of the scorpion Buthus martensi Karsch: purification, amino acid sequences and assessment of specific activity","volume":"34","author":"Ji","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2006.10.010_bib71","unstructured":"Johnson, J.H., Kral, R.M.J. 1997. Insecticidal peptides from Segestria sp. spider venom. US Patent No. 5,674,846, NPS Pharmaceuticals, USA."},{"key":"10.1016\/j.cbpc.2006.10.010_bib72","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0006-291X(80)80082-9","article-title":"Two types of scorpion neurotoxins characterized by their binding to two separate receptor sites on rat brain synaptosomes","volume":"29","author":"Jover","year":"1980","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2006.10.010_bib73","doi-asserted-by":"crossref","first-page":"31679","DOI":"10.1074\/jbc.M402048200","article-title":"Molecular basis of the high insecticidal potency of scorpion alpha-toxins","volume":"23","author":"Karbat","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2006.10.010_bib74","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2220\/biomedres.3.353","article-title":"Effect of a spider venom toxin on glutaminergic synapses in mammalian brain","volume":"3","author":"Kawai","year":"1982","journal-title":"Biomed. Res."},{"key":"10.1016\/j.cbpc.2006.10.010_bib75","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0006-8993(82)91044-7","article-title":"Spider venom contains specific receptor blockers of glutaminergic synapses","volume":"247","author":"Kawai","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.cbpc.2006.10.010_bib76","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0742-8413(91)90185-V","article-title":"Spider toxin and the glutamate receptors","volume":"98","author":"Kawai","year":"1991","journal-title":"Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol."},{"key":"10.1016\/j.cbpc.2006.10.010_bib77","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11248-006-0007-2","article-title":"Spider venom toxin protects plants from insect attack","volume":"15","author":"Khan","year":"2006","journal-title":"Transgenic Res."},{"key":"10.1016\/j.cbpc.2006.10.010_bib78","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0014-5793(90)80607-K","article-title":"Primary structure of scorpion anti-insect toxins isolated from the venom of Leiurus quinquestriatus quinquestriatus","volume":"261","author":"Kopeyan","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbpc.2006.10.010_bib79","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/nt.2620010510","article-title":"Characterization of toxin III of the scorpion Leiurus quinquestriatus quinquestriatus: a new type of alpha-toxin highly toxic both to mammals and insects","volume":"1","author":"Kopeyan","year":"1993","journal-title":"Nat. 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Biol."},{"key":"10.1016\/j.cbpc.2006.10.010_bib83","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1399-3011.2000.00750.x","article-title":"Binding characteristics of BmK I, an alpha-like scorpion neurotoxic polypeptide, on cockroach nerve cord synaptosomes","volume":"56","author":"Li","year":"2000","journal-title":"J. Pept. Res."},{"key":"10.1016\/j.cbpc.2006.10.010_bib84","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0168-0102(00)00164-4","article-title":"The binding of BmK IT2, a depressant insect-selective scorpion toxin on mammal and insect sodium channels","volume":"38","author":"Li","year":"2000","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.cbpc.2006.10.010_bib85","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0014-5793(03)01303-6","article-title":"Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana","volume":"555","author":"Li","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbpc.2006.10.010_bib86","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.toxicon.2004.02.005","article-title":"An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [= Ornithoctonus huwena (Wang)]","volume":"43","author":"Liang","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2006.10.010_bib87","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0041-0101(01)00181-7","article-title":"Novel insecticidal toxins from the venom of the spider Segestria florentina","volume":"40","author":"Lipkin","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2006.10.010_bib88","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0014-5793(98)01378-7","article-title":"Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channels","volume":"439","author":"Little","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbpc.2006.10.010_bib89","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1021\/bi00458a021","article-title":"Neurotoxins active on insects: amino acid sequences, chemical modifications, and secondary structure estimation by circular dichroism of toxins from the scorpion Androctonus australis Hector","volume":"13","author":"Loret","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbpc.2006.10.010_bib90","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/bi00217a007","article-title":"An anti-insect toxin purified from the scorpion Androctonus australis Hector also acts on the alpha- and beta-sites of the mammalian sodium channel: sequence and circular dichroism study","volume":"30","author":"Loret","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.cbpc.2006.10.010_bib91","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0042-6822(91)90451-G","article-title":"Insecticidal effects of an insect-specific neurotoxin expressed by a recombinant baculovirus","volume":"184","author":"Maeda","year":"1991","journal-title":"Virology"},{"key":"10.1016\/j.cbpc.2006.10.010_bib92","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0006-8993(99)01472-9","article-title":"PhTx4, a new class of toxins from Phoneutria nigriventer spider venom, inhibits the glutamate uptake in rat brain synaptosomes","volume":"831","author":"Mafra","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.cbpc.2006.10.010_bib93","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0041-0101(02)00154-X","article-title":"Role of the structurally disordered N- and C-terminal residues in the Janus-faced atracotoxins","volume":"40","author":"Maggio","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2006.10.010_bib94","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/nt.2620010211","article-title":"The beta-type toxin Ts II from the scorpion Tityus serrulatus: amino acid sequence determination and assessment of biological and antigenic properties","volume":"1","author":"Mansuelle","year":"1992","journal-title":"Nat. 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Pharmacol."},{"key":"10.1016\/j.cbpc.2006.10.010_bib100","first-page":"848","article-title":"Development of a recombinant baculovirus expressing an insect-selective neurotoxin: potential for pest control","volume":"9","author":"McCutchen","year":"1991","journal-title":"Biotechnology (N Y)"},{"key":"10.1016\/j.cbpc.2006.10.010_bib101","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0041-0101(02)00246-5","article-title":"BotIT6: a potent depressant insect toxin from Buthus occitanus tunetanus venom","volume":"41","author":"Mejri","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2006.10.010_bib102","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0165-6147(86)90293-2","article-title":"Mechanism of action of \u03b1-latrotoxin: the presynaptic stimulatory toxin of the black widow spider venom","volume":"7","author":"Meldolesi","year":"1986","journal-title":"Trends Pharmacol. 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Biochem."},{"key":"10.1016\/j.cbpc.2006.10.010_bib121","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0300-9084(00)01167-6","article-title":"Peptides and genes coding for scorpion toxins that affect ion-channels","volume":"82","author":"Possani","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.cbpc.2006.10.010_bib122","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/j.1476-5381.1989.tb12594.x","article-title":"Antagonism of responses to excitatory amino acids on rat cortical neurones by the spider toxin, argiotoxin 636","volume":"97","author":"Priestley","year":"1989","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2006.10.010_bib123","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/bcon.1997.0605","article-title":"Effects of simultaneous expression of two sodium channel toxin genes on the properties of baculoviruses as biopesticides","volume":"12","author":"Prikhod'Ko","year":"1998","journal-title":"Biol. 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Entomol."},{"key":"10.1016\/j.cbpc.2006.10.010_bib127","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bbagen.2005.11.008","article-title":"Functional expression of lepidopteran-selective neurotoxin in baculovirus: potential for effective pest management","volume":"1760","author":"Rajendra","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2006.10.010_bib128","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0041-0101(01)00199-4","article-title":"Pharmacology and biochemistry of spider venoms","volume":"40","author":"Rash","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2006.10.010_bib129","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cbpc.2005.09.010","article-title":"Comparison of the partial proteomes of the venoms of Brazilian spiders of the genus Phoneutria","volume":"142","author":"Richardson","year":"2006","journal-title":"Comp. Biochem. Physiol. C, Comp. Pharmacol. 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