{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:56:40Z","timestamp":1790506600385,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.cbpc.2010.01.001","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T05:36:20Z","timestamp":1262928980000},"page":"379-385","source":"Crossref","is-referenced-by-count":26,"title":["In vitro and whole animal evidence that methylmercury disrupts GABAergic systems in discrete brain regions in captive mink"],"prefix":"10.1016","volume":"151","author":[{"given":"Niladri","family":"Basu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton M.","family":"Scheuhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsti","family":"Rouvinen-Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Douglas","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance L.","family":"Trudeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie H.M.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2010.01.001_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0006-8993(91)90913-G","article-title":"Mercury modulation of GABA-activated chloride channels and non-specific cation channels in rat dorsal root ganglion neurons","volume":"551","author":"Arakawa","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.cbpc.2010.01.001_bib2","series-title":"Agency for Toxic Substances and Disease Registry","article-title":"Toxicological profile for mercury","author":"ATSDR","year":"1999"},{"key":"10.1016\/j.cbpc.2010.01.001_bib3","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1139\/Y07-083","article-title":"Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system","volume":"85","author":"Awad","year":"2007","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.cbpc.2010.01.001_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0074-7742(08)60663-7","article-title":"Use-dependent regulation of GABAA receptors","volume":"39","author":"Barnes","year":"1996","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.cbpc.2010.01.001_bib5","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1897\/04-048R.1","article-title":"Effects of mercury on neurochemical receptor binding characteristics in wild mink","volume":"24","author":"Basu","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.cbpc.2010.01.001_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.taap.2004.09.009","article-title":"An inter-species comparison of mercury inhibition on muscarinic acetylcholine receptor binding in the cerebral cortex and cerebellum","volume":"205","author":"Basu","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2010.01.001_bib7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/toxsci\/kfj121","article-title":"Methylmercury impairs components of the cholinergic system in captive mink (Mustela vison)","volume":"91","author":"Basu","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2010.01.001_bib8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.envres.2006.04.005","article-title":"Mink as a sentinel species in environmental health","volume":"103","author":"Basu","year":"2007","journal-title":"Environ. Res."},{"key":"10.1016\/j.cbpc.2010.01.001_bib9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.neuro.2006.12.007","article-title":"Decreased N-methyl-d-aspartic acid (NMDA) receptor levels are associated with mercury exposure in wild and captive mink","volume":"28","author":"Basu","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbpc.2010.01.001_bib10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1897\/08-251.1","article-title":"Is dietary mercury of neurotoxicological concern to wild polar bears (Ursus maritimus)?","volume":"28","author":"Basu","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.cbpc.2010.01.001_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0013-9351(79)90038-0","article-title":"The effects of organic and inorganic lead and mercury on neurotransmitter high-affinity transport and release mechanisms","volume":"19","author":"Bondy","year":"1979","journal-title":"Environ. Res."},{"key":"10.1016\/j.cbpc.2010.01.001_bib12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/10408369708998098","article-title":"The toxicology of mercury","volume":"34","author":"Clarkson","year":"1997","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.cbpc.2010.01.001_bib13","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/10408440600845619","article-title":"The toxicology of mercury and its chemical compounds","volume":"36","author":"Clarkson","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.cbpc.2010.01.001_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-4274(83)90066-8","article-title":"Biochemical changes in the rat cerebellar cortex elicited by chronic treatment with methyl mercury","volume":"18","author":"Concas","year":"1983","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbpc.2010.01.001_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0006-8993(81)90769-1","article-title":"Methyl mercury enhances [3H]diazepam binding in different areas of the rat brain","volume":"229","author":"Corda","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/j.cbpc.2010.01.001_bib16","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0028-3908(01)00130-7","article-title":"Mercury interaction with the GABAA receptor modulates the benzodiazepine binding site in primary cultures of mouse cerebellar granule cells","volume":"41","author":"Fonfr\u00eda","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cbpc.2010.01.001_bib17","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1523\/JNEUROSCI.07-05-01503.1987","article-title":"Numbers and proportions of GABA-immunoreactive neurons in different areas of monkey cerebral cortex","volume":"7","author":"Hendry","year":"1987","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbpc.2010.01.001_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1289\/ehp.8464","article-title":"Blood mercury reporting in NHANES: identifying Asian, Pacific Islander, Native American, and multiracial groups","volume":"114","author":"Hightower","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbpc.2010.01.001_bib19","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1006\/taap.1996.0247","article-title":"Mercury chloride modulation of the GABAA receptor-channel complex in rat dorsal root ganglion neurons","volume":"140","author":"Huang","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2010.01.001_bib20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/BF01705532","article-title":"Methylmercury modulates GABAA receptor complex differentially in rat cortical and cerebellar membranes in vitro","volume":"20","author":"Komulainen","year":"1995","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cbpc.2010.01.001_bib21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000116020","article-title":"Experimental neuropathy induced by methyl mercury compounds: autoradiographic study of GABA uptake by dorsal root ganglia","volume":"25","author":"Kumamoto","year":"1986","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.cbpc.2010.01.001_bib22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jat.2550070208","article-title":"Studies of the in vitro effect of methylmercury chloride on rat brain neurotransmitter enzymes","volume":"7","author":"Kung","year":"1987","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.cbpc.2010.01.001_bib23","first-page":"41","article-title":"Cell specific enzyme markers as indicators of neurotoxicity: effects of acute exposure to methylmercury","volume":"10","author":"Kung","year":"1989","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbpc.2010.01.001_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2826.2005.01311.x","article-title":"GABAergic modulation of the expression of genes involved in GABA synaptic transmission and stress in the hypothalamus and telencephalon of the female goldfish (Carassius auratus)","volume":"17","author":"Martyniuk","year":"2005","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.cbpc.2010.01.001_bib25","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/BF02088671","article-title":"GABA receptor-channel complex as a target site of mercury, copper, zinc, and lanthanides","volume":"14","author":"Narahashi","year":"1994","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.cbpc.2010.01.001_bib26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0165-3806(85)90219-6","article-title":"Methylmercury poisoning of the developing nervous system in the rat: decreased activity of glutamic acid decarboxylase in cerebral cortex and neostriatum","volume":"353","author":"O'Kusky","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.cbpc.2010.01.001_bib27","doi-asserted-by":"crossref","first-page":"9323","DOI":"10.1523\/JNEUROSCI.2610-06.2006","article-title":"Deletion of the GABA(A) receptor alpha1 subunit increases tonic GABA(A) receptor current: a role for GABA uptake transporters","volume":"26","author":"Ortinski","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbpc.2010.01.001_bib28","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1523\/JNEUROSCI.0860-06.2006","article-title":"Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors","volume":"26","author":"Ponomarev","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cbpc.2010.01.001_bib29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pbb.2008.03.015","article-title":"The value of genetic and pharmacological approaches to understanding the complexities of GABA(A) receptor subtype functions: the anxiolytic effects of benzodiazepines","volume":"90","author":"Reynolds","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.cbpc.2010.01.001_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1579\/0044-7447(2007)36[12:EOEMOT]2.0.CO;2","article-title":"Effects of environmental methylmercury on the health of wild birds, mammals, and fish","volume":"36","author":"Scheuhammer","year":"2007","journal-title":"Ambio"},{"key":"10.1016\/j.cbpc.2010.01.001_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10646-007-0170-0","article-title":"Relationships among mercury, selenium, and neurochemical parameters in common loons (Gavia immer) and bald eagles (Haliaeetus leucocephalus)","volume":"17","author":"Scheuhammer","year":"2008","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.cbpc.2010.01.001_bib32","series-title":"Basic Neurochemistry. Molecular, Cellular and Medical Aspects","year":"2006"},{"key":"10.1016\/j.cbpc.2010.01.001_bib33","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.neuint.2006.01.005","article-title":"Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools","volume":"48","author":"Sonnewald","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbpc.2010.01.001_bib34","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.tiv.2008.03.009","article-title":"Studies with neuronal cells: from basic studies of mechanisms of neurotoxicity to the prediction of chemical toxicity","volume":"22","author":"Su\u00f1ol","year":"2008","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.cbpc.2010.01.001_bib35","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1289\/ehp.7743","article-title":"Public health and economic consequences of methyl mercury toxicity to the developing brain","volume":"113","author":"Trasande","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbpc.2010.01.001_bib36","series-title":"Wildlife criteria portions of the proposed water quality guidance for the Great Lakes system. U.S. EPA\/822\/R-93\/006. Washington, DC","author":"U.S. EPA","year":"1993"},{"key":"10.1016\/j.cbpc.2010.01.001_bib37","series-title":"Vol. VII: Characterization of Human Health and Wildlife Risks from Mercury Exposure in the United States","first-page":"152","article-title":"Mercury study report to Congress","author":"U.S. EPA","year":"1997"},{"key":"10.1016\/j.cbpc.2010.01.001_bib38","series-title":"Water Quality Criteria for the Protection of Human Health: Methylmercury. U. S. EPA-823-R-01-001. Washington, D.C","author":"U.S. EPA","year":"2001"},{"key":"10.1016\/j.cbpc.2010.01.001_bib39","series-title":"Global Mercury Assessment Report","year":"2003"},{"key":"10.1016\/j.cbpc.2010.01.001_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pharmthera.2004.06.001","article-title":"Genetic manipulations of GABAA receptor in mice make inhibition exciting","volume":"103","author":"Vicini","year":"2004","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbpc.2010.01.001_bib41","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1471-4159.1979.tb04553.x","article-title":"Characterization of the binding of [3H]muscimol, a potent gamma-aminobutyric acid agonist, to rat brain synaptosomal membranes using a filtration assay","volume":"32","author":"Williams","year":"1979","journal-title":"J. Neurochem."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045610000037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045610000037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T21:14:06Z","timestamp":1558732446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045610000037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S1532045610000037"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2010.01.001","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}