{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:53:04Z","timestamp":1778755984656,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.cbpc.2010.10.008","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T04:37:48Z","timestamp":1288327068000},"page":"168-173","source":"Crossref","is-referenced-by-count":16,"title":["Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor \u03b1 and \u03b2"],"prefix":"10.1016","volume":"153","author":[{"given":"Louise","family":"Colliar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Leaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2010.10.008_bb0005","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0045-6535(02)00769-5","article-title":"Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment","volume":"50","author":"Andreozzi","year":"2003","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2010.10.008_bb0010","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.envint.2007.09.005","article-title":"Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review","volume":"34","author":"Antizar-Ladislao","year":"2008","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0015","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/toxsci\/kfh253","article-title":"Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters","volume":"82","author":"Bility","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0020","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1021\/es9705811","article-title":"Occurrence of the pharmaceutical drug clofibric acid and the herbicide mecoprop in various Swiss lakes and in the North sea","volume":"32","author":"Buser","year":"1998","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0025","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1126\/science.290.5499.2140","article-title":"Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain","volume":"290","author":"de Urquiza","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2010.10.008_bb0030","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/physrev.00025.2005","article-title":"Transcriptional regulation of metabolism","volume":"86","author":"Desvergne","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2009.02.017","article-title":"PPAR-mediated activity of phthalates: a link to the obesity epidemic?","volume":"304","author":"Desvergne","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/abio.2000.4605","article-title":"A noncommercial dual luciferase enzyme assay system for reporter gene analysis","volume":"282","author":"Dyer","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0215","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1210\/en.142.10.4195","article-title":"Rat PPARs; quantitative analysis in adult rat tissues and regulation in fasting and refeeding","volume":"142","author":"Escher","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbpc.2010.10.008_bb0045","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.plipres.2005.12.002","article-title":"From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions","volume":"45","author":"Feige","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0050","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","article-title":"Ecotoxicology of human pharmaceuticals","volume":"76","author":"Fent","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0055","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11883-009-0043-5","article-title":"Efficacy of peroxisome proliferator-activated receptor agonists in diabetes and coronary artery disease","volume":"11","author":"Fievet","year":"2009","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0060","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1073\/pnas.89.10.4653","article-title":"Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor","volume":"89","author":"G\u00f6ttlicher","year":"1992","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.cbpc.2010.10.008_bb0065","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1210\/me.2008-0485","article-title":"Minireview: the case for oobesogens","volume":"23","author":"Gr\u00fcn","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0070","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1210\/me.2005-0367","article-title":"Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates","volume":"20","author":"Gr\u00fcn","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0075","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s00018-002-8467-x","article-title":"PPARs: transcriptional effectors of fatty acids and their derivatives","volume":"59","author":"Hihi","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0080","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.cbi.2009.03.006","article-title":"Structure-dependent activation of peroxisome proliferator-activated receptor (PPAR) \u03b3 by organotin compounds","volume":"180","author":"Hiromori","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0085","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0883-2927(00)00067-6","article-title":"Organotin compounds in the environment \u2014 an overview","volume":"16","author":"Hoch","year":"2001","journal-title":"Appl. Geochem."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1677\/jme.0.0110037","article-title":"The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs","volume":"11","author":"Issemann","year":"1993","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0200","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI6223","article-title":"Peroxisome proliferator-activated receptor \u03b1 mediates the adaptive response to fasting","volume":"103","author":"Kersten","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0205","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1073\/pnas.96.13.7473","article-title":"A critical role for the peroxisome proliferators-activated receptor \u03b1 (PPAR\u03b1) in the cellular fasting response: The PPAR\u03b1-null mouse as a model of fatty acid oxidation disorders","volume":"96","author":"Leone","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cbpc.2010.10.008_bb0095","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1210\/me.2009-0261","article-title":"Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes","volume":"24","author":"Kirchner","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0100","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/es011055j","article-title":"Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999\u20132000: a national reconnaissance","volume":"36","author":"Kolpin","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0105","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1210\/me.11.6.779","article-title":"Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay","volume":"11","author":"Krey","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0110","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0041-008X(03)00014-0","article-title":"Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells","volume":"188","author":"Lampen","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0115","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1210\/en.2004-1638","article-title":"Three peroxisome proliferator-activated receptor isotypes from each of two species of marine fish","volume":"146","author":"Leaver","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbpc.2010.10.008_bb0120","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1677\/JME-06-0043","article-title":"Multiple peroxisome proliferator-activated receptor \u03b2 subtypes from Atlantic salmon (Salmo salar)","volume":"38","author":"Leaver","year":"2007","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0125","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1093\/nar\/gkg444","article-title":"The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily","volume":"31","author":"Maglich","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0130","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1161\/01.ATV.18.2.272","article-title":"RXR agonists activate PPAR\u03b1-inducible genes, lower triglycerides, and raise HDL levels in vivo","volume":"18","author":"Mukherjee","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0135","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0960-0760(02)00066-3","article-title":"Ligand and coactivator recruitment preferences of peroxisome proliferator activated receptor alpha","volume":"81","author":"Mukherjee","year":"2002","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0140","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1021\/es049593u","article-title":"Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods","volume":"38","author":"Nishikawa","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0145","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1098\/rstb.2008.0242","article-title":"A critical analysis of the biological impacts of plasticizers on wildlife","volume":"364","author":"Oehlmann","year":"2009","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0150","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1073\/pnas.091021198","article-title":"A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport","volume":"98","author":"Oliver","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.cbpc.2010.10.008_bb0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11356-009-0137-1","article-title":"Ecotoxicity assessment of lipid regulators in water and biologically treated wastewater using three aquatic organisms","volume":"17","author":"Rosal","year":"2010","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0160","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0192623308318208","article-title":"Gene profiling in the livers of wild-type and PPAR alpha-null mice exposed to perfluorooctanoic acid","volume":"36","author":"Rosen","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0210","doi-asserted-by":"crossref","first-page":"37731","DOI":"10.1074\/jbc.R100034200","article-title":"PPAR\u03b3: a nuclear regulator of metabolism, differentiation, and growth","volume":"276","author":"Rosen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0165","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0378-4274(03)00257-1","article-title":"Probablistic hazard assessment of enviornmentally occurring pharmaceuticals toxicity to fish, daphnids and algae by ECOSAR screening","volume":"144","author":"Sanderson","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0170","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cmet.2008.08.005","article-title":"The lipid messenger OEA links dietary fat intake to satiety","volume":"8","author":"Schwartz","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0175","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0048-9697(98)00339-8","article-title":"Polar drug residues in sewage and natural waters in the state of Rio de Janeiro, Brazil","volume":"225","author":"Stumpf","year":"1999","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0180","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfl135","article-title":"Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta\/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate","volume":"95","author":"Takacs","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0185","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/S0043-1354(98)00099-2","article-title":"Occurrence of drugs in German sewage treatment plants and rivers","volume":"32","author":"Ternes","year":"1998","journal-title":"Water Res."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0190","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.pharmthera.2009.12.001","article-title":"Peroxisome proliferator-activated receptor beta\/delta (PPAR\u03b2\/\u03b4) acts as regulator of metabolism linked to multiple cellular functions","volume":"25","author":"Wagner","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbpc.2010.10.008_bb0195","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1021\/jm990554g","article-title":"The PPARs: from orphan receptors to drug discovery","volume":"43","author":"Willson","year":"2000","journal-title":"J. Med. Chem."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045610001791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045610001791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:21:27Z","timestamp":1544142087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045610001791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1532045610001791"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2010.10.008","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}