{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:45:23Z","timestamp":1760121923672,"version":"3.38.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.cbpc.2010.12.007","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T09:31:35Z","timestamp":1294133495000},"page":"350-354","source":"Crossref","is-referenced-by-count":22,"title":["Purification and properties of antimicrobial peptides from skin secretions of the Eritrea clawed frog Xenopus clivii (Pipidae)"],"prefix":"10.1016","volume":"153","author":[{"given":"J. Michael","family":"Conlon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Mechkarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Leprince","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Vaudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay D.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Takada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2010.12.007_bb0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0167-4838(01)00272-2","article-title":"Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)","volume":"1550","author":"Ali","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0010","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1432-1033.1985.tb08957.x","article-title":"Solid-phase synthesis of PYLa and isolation of its natural counterpart, PGLa [PYLa-(4-24)] from skin secretion of Xenopus laevis","volume":"149","author":"Andreu","year":"1985","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0015","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.mib.2010.09.006","article-title":"Alarming \u03b2-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae","volume":"13","author":"Bush","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0020","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1017\/S0006323197005045","article-title":"The natural history of amphibian skin secretions, their normal functioning and potential medical applications","volume":"72","author":"Clarke","year":"1997","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"year":"2008","series-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Approved Standard M07-A8","key":"10.1016\/j.cbpc.2010.12.007_bb0025"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0030","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ymeth.2007.01.004","article-title":"Strategies for transformation of naturally-occurring amphibian antimicrobial peptides into therapeutically valuable anti-infective agents","volume":"42","author":"Conlon","year":"2007","journal-title":"Methods"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0035","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.peptides.2010.06.032","article-title":"Potent and rapid bactericidal action of alyteserin-1c and its [E4K] analog against multidrug-resistant strains of Acinetobacter baumannii","volume":"31","author":"Conlon","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0040","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.peptides.2010.03.002","article-title":"Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae)","volume":"31","author":"Conlon","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0045","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0014-5793(97)00055-0","article-title":"Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical peptides","volume":"403","author":"Dathe","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.peptides.2007.10.026","article-title":"Activities of the frog skin peptide, ascaphin-8 and its lysine-substituted analogs against clinical isolates of extended-spectrum beta-lactamase (ESBL) producing bacteria","volume":"29","author":"Eley","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ympev.2004.04.018","article-title":"A mitochondrial DNA phylogeny of African clawed frogs: phylogeography and implications for polyploid evolution","volume":"33","author":"Evans","year":"2004","journal-title":"Mol. Phylogenet. Evol."},{"year":"2010","series-title":"Amphibian Species of the World: An Online Reference. Version 5.4","author":"Frost","key":"10.1016\/j.cbpc.2010.12.007_bb0060"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0065","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0022-3565(25)38195-4","article-title":"Xenopsin, neurotensin, neurotensin(8-13) and N-acetyl-neurotensin(8-13) inhibit vascular leakage in rats after tissue injury","volume":"265","author":"Gao","year":"1993","journal-title":"Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0070","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1046\/j.1432-1033.2001.02494.x","article-title":"Amphipathic \u03b1-helical peptides. A systematic study of the effects of structural and physical properties on biological activity","volume":"268","author":"Giangaspero","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0075","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1016\/S0021-9258(19)57220-9","article-title":"Novel peptide fragments originating from PGLa and the caerulein and xenopsin precursors from Xenopus laevis","volume":"261","author":"Gibson","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/bj2430113","article-title":"Biosynthesis and degradation of peptides derived from Xenopus laevis prohormones","volume":"243","author":"Giovannini","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0085","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.bbamem.2008.10.009","article-title":"Structure, membrane orientation, mechanism, and function of pexiganan \u2014 a highly potent antimicrobial peptide designed from magainin","volume":"1788","author":"Gottler","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0090","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/abio.1994.1086","article-title":"Purification of antimicrobial peptides from an extract of the skin of Xenopus laevis using heparin-affinity HPLC: characterization by ion-spray mass spectrometry","volume":"217","author":"James","year":"1994","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0095","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","article-title":"A simple method for displaying the hydropathic character of a protein","volume":"157","author":"Kyte","year":"1982","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0100","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1086\/593185","article-title":"Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream","volume":"47","author":"Lipsky","year":"2008","journal-title":"Clin. Infect. Dis."},{"issue":"Suppl 1","key":"10.1016\/j.cbpc.2010.12.007_bb0105","doi-asserted-by":"crossref","first-page":"i29","DOI":"10.1093\/jac\/dkp255","article-title":"Has the era of untreatable infections arrived?","volume":"64","author":"Livermore","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0110","series-title":"IUCN 2010. IUCN Red List of Threatened Species. Version 2010.3","article-title":"Xenopus clivii","author":"Measey","year":"2004"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0115","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cbpc.2010.07.007","article-title":"Antimicrobial peptides with therapeutic potential from skin secretions of the Marsabit clawed frog Xenopus borealis (Pipidae)","volume":"152","author":"Mechkarska","year":"2010","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0120","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nsb0694-399","article-title":"Elucidating the folding problem of helical peptides using empirical parameters","volume":"1","author":"Mu\u00f1oz","year":"1994","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1473-3099(05)01283-1","article-title":"Lack of development of new antimicrobial drugs: a potential serious threat to public health","volume":"5","author":"Norrby","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0130","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.peptides.2003.08.023","article-title":"The relationship between peptide structure and antibacterial activity","volume":"24","author":"Powers","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0135","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1016\/S0021-9258(17)35700-9","article-title":"Sequence of preprocaerulein cDNAs cloned from skin of Xenopus laevis. A small family of precursors containing one, three, or four copies of the final product","volume":"261","author":"Richter","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0140","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0006-3495(67)86579-2","article-title":"Use of helical wheels to represent the structures of proteins and to identify segments with helical potential","volume":"7","author":"Schiffer","year":"1967","journal-title":"Biophys. J."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0145","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0014-5793(88)80027-9","article-title":"Antimicrobial properties of peptides from Xenopus granular gland secretions","volume":"228","author":"Soravia","year":"1988","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0150","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1128\/AAC.46.11.3585-3590.2002","article-title":"Cationic hydrophobic peptides with antimicrobial activity","volume":"46","author":"Stark","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cbpc.2010.12.007_bb0155","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/j.1875-9114.1982.tb03189.x","article-title":"Pharmacology, clinical uses, and adverse effects of ceruletide, a cholecystokinetic agent","volume":"2","author":"Vincent","year":"1982","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.cbpc.2010.12.007_bb0160","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1073\/pnas.84.15.5449","article-title":"Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms and partial cDNA sequence of a precursor","volume":"84","author":"Zasloff","year":"1987","journal-title":"Proc. Nat. Acad. Sci. U.S.A."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045610002231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045610002231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T11:11:23Z","timestamp":1740827483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045610002231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S1532045610002231"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2010.12.007","relation":{},"ISSN":["1532-0456"],"issn-type":[{"type":"print","value":"1532-0456"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}