{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:42:27Z","timestamp":1790401347301,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["2013-T2-2-126"],"award-info":[{"award-number":["2013-T2-2-126"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012415","name":"Biomedical Research Council","doi-asserted-by":"publisher","award":["10\/1\/21\/19\/661"],"award-info":[{"award-number":["10\/1\/21\/19\/661"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.cbpc.2015.08.007","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T02:01:10Z","timestamp":1440986470000},"page":"68-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["An adult osteopetrosis model in medaka reveals the importance of osteoclast function for bone remodeling in teleost fish"],"prefix":"10.1016","volume":"178","author":[{"given":"Thuy Thanh","family":"To","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Eckhard","family":"Witten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Huysseune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2015.08.007_bb0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1136\/jmedgenet-2011-100520","article-title":"An SNX10 mutation causes malignant osteopetrosis of infancy","volume":"49","author":"Aker","year":"2012","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/B978-0-12-381320-6.00010-2","article-title":"Not all bones are created equal\u2014using zebrafish and other teleost species in osteogenesis research","volume":"105","author":"Apschner","year":"2011","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb9000","series-title":"Cellular and molecular biology of bone","first-page":"445","article-title":"Cellular and molecular biology of the osteoclast","author":"Baron","year":"1993"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0015","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-213X-12-28","article-title":"Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation","volume":"12","author":"Bensimon-Brito","year":"2012","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0020","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/03008207.2015.1013193","article-title":"Power and challenges of using zebrafish as a model for skeletal tissue imaging","volume":"56","author":"Bruneel","year":"2015","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0030","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1359\/jbmr.090715","article-title":"Committed osteoclast precursors colonize the bone and improve the phenotype of a mouse model of autosomal recessive osteopetrosis","volume":"25","author":"Cappariello","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0035","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.molmed.2014.06.001","article-title":"Osteoclasts: more than \u2018bone eaters\u2019","volume":"20","author":"Charles","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0040","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ydbio.2011.09.013","article-title":"Osteoclasts in bone modeling, as revealed by in vivo imaging, are essential for organogenesis in fish","volume":"360","author":"Chatani","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00198-010-1272-8","article-title":"New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK\/RANKL axis","volume":"22","author":"Crockett","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2007.08.029","article-title":"Genetics, pathogenesis and complications of osteopetrosis","volume":"42","author":"Del Fattore","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0055","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0006-291X(02)00598-3","article-title":"Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat","volume":"294","author":"Dobbins","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00429-005-0061-1","article-title":"Features of the clear zone of odontoclasts in the Chinook salmon (Oncorhynchus tshawytscha)","volume":"211","author":"Domon","year":"2006","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0065","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1101\/gad.13.18.2412","article-title":"RANK is essential for osteoclast and lymph node development","volume":"13","author":"Dougall","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0070","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1242\/dev.00952","article-title":"A central role for the notochord in vertebral patterning","volume":"131","author":"Fleming","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0075","doi-asserted-by":"crossref","first-page":"18903","DOI":"10.1073\/pnas.1010335107","article-title":"Skeletal development in sloths and the evolution of mammalian vertebral patterning","volume":"107","author":"Hautier","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0080","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/jemt.10375","article-title":"Osteoclast diseases","volume":"61","author":"Helfrich","year":"2003","journal-title":"Microsc Res Techniq"},{"key":"10.1016\/j.cbpc.2015.08.007_bb9005","first-page":"33","article-title":"Observations on the development of some parts of the skeleton of fishes","volume":"7","author":"Huxley","year":"1859","journal-title":"Q. J. Microsc. Sci. (continued as Journal of Cell Science)"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ar.1092340102","article-title":"Bone and cartilage resorption in relation to tooth development in the anterior part of the mandible in cichlid fish: a light and TEM study","volume":"234","author":"Huysseune","year":"1992","journal-title":"Anat. Rec."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0090","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1210\/me.2014-1316","article-title":"Minireview: nuclear receptor regulation of osteoclast and bone remodeling","volume":"29","author":"Jin","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0095","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1210\/er.2007-0014","article-title":"Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease","volume":"29","author":"Kearns","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0100","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.devcel.2011.04.014","article-title":"Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin","volume":"20","author":"Knopf","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cbpc.2015.08.007_bb9010","first-page":"214","article-title":"On the structure of the chorda dorsalis of the plagiostomes and some other fishes, and on the relation of its proper sheath to the development of the vertebrae","volume":"10","author":"K\u00f6lliker","year":"1859","journal-title":"Proceedings of the Royal Society of London"},{"key":"10.1016\/j.cbpc.2015.08.007_bb9015","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1096-3642.1976.tb00830.x","article-title":"The development, function, and design of amphicoelous vertebrae in teleost fishes","volume":"58","author":"Laerm","year":"1976","journal-title":"Zool J Linn Soc"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0250","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1007\/s00198-012-1958-1","article-title":"A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis","volume":"23","author":"Lekamwasam","year":"2012","journal-title":"Osteoporos Int."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0110","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bbrc.2006.02.147","article-title":"Osteoclast and its roles in calcium metabolism and bone development and remodeling","volume":"343","author":"Li","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0115","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s007740200049","article-title":"Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis","volume":"20","author":"Mizuno","year":"2002","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0120","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/jbmr.559","article-title":"RANK-dependent autosomal recessive osteopetrosis: characterization of five new cases with novel mutations","volume":"27","author":"Pangrazio","year":"2012","journal-title":"J, Bone Miner, Res."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0125","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bone.2013.11.014","article-title":"Exome sequencing identifies CTSK mutations in patients originally diagnosed as intermediate osteopetrosis","volume":"59","author":"Pangrazio","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.cbpc.2015.08.007_bb9020","series-title":"Osteoporosis, etiology, diagnosis, and management","first-page":"45","article-title":"Bone remodelling: Relationship to amount and structure of bone, and the pathogenesis and prevention of fractures","author":"Parfitt","year":"1988"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0130","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S8756-3282(01)00416-1","article-title":"The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation\/function","volume":"28","author":"Rajapurohitam","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0140","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/dvdy.21836","article-title":"Osterix-mCherry transgenic medaka for in vivo imaging of bone formation","volume":"238","author":"Renn","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0135","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ydbio.2013.05.030","article-title":"A col10a1:nlGFP transgenic line displays putative osteoblast precursors at the medaka notochordal sheath prior to mineralization","volume":"381","author":"Renn","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0145","doi-asserted-by":"crossref","first-page":"13453","DOI":"10.1073\/pnas.95.23.13453","article-title":"Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice","volume":"95","author":"Saftig","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0150","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/ng2076","article-title":"Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL","volume":"39","author":"Sobacchi","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0155","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrendo.2013.137","article-title":"Osteopetrosis: genetics, treatment and new insights into osteoclast function","volume":"9","author":"Sobacchi","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0160","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1084952102000587","article-title":"Formation and function of the ruffled border in osteoclasts","volume":"13","author":"Stenbeck","year":"2002","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0165","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/211866b0","article-title":"Wavy-fused mutants in medaka Oryzias latipes","volume":"211","author":"Takeuchi","year":"1966","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0170","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1242\/dev.071035","article-title":"Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model","volume":"139","author":"To","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0175","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1073\/pnas.87.18.7260","article-title":"Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells","volume":"87","author":"Udagawa","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0180","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1083\/jcb.111.3.1305","article-title":"Evidence for the presence of a proton pump of the vacuolar H+-atpase type in the ruffled borders of osteoclasts","volume":"111","author":"Vaananen","year":"1990","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0185","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1242\/dev.123.1.153","article-title":"Mutations affecting somite formation and patterning in the zebrafish, Danio rerio","volume":"123","author":"vanEeden","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-008-9196-4","article-title":"Infantile malignant, autosomal recessive osteopetrosis: the rich and the poor","volume":"84","author":"Villa","year":"2009","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0200","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s004410050782","article-title":"Enzyme histochemical characteristics of osteoblasts and mononucleated osteoclasts in a teleost fish with acellular bone (Oreochromis niloticus, Cichlidae)","volume":"287","author":"Witten","year":"1997","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0205","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1469-7580.2003.00239.x","article-title":"Seasonal changes in the lower jaw skeleton in male Atlantic salmon (Salmo salar L.): remodelling and regression of the kype after spawning","volume":"203","author":"Witten","year":"2003","journal-title":"J. Anat."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0220","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1469-185X.2009.00077.x","article-title":"A comparative view on mechanisms and functions of skeletal remodelling in teleost fish, with special emphasis on osteoclasts and their function","volume":"84","author":"Witten","year":"2009","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0225","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1439-0426.2010.01410.x","article-title":"The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals","volume":"26","author":"Witten","year":"2010","journal-title":"J. Appl. Ichthyol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0235","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1439-0426.1997.tb00115.x","article-title":"Growth requires bone resorption at particular skeletal elements in a teleost fish with acellular bone (Oreochromis niloticus, Teleostei : Cichlidae)","volume":"13","author":"Witten","year":"1997","journal-title":"J. Appl. Ichthyol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0195","first-page":"F252","article-title":"Bone resorption by mononucleated cells during skeletal development in fish with acellular bone","volume":"12","author":"Witten","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0215","first-page":"1258","article-title":"Immunohistochemical identification of a vacuolar proton pump (V-ATPase) in bone-resorbing cells of an advanced teleost species, Oreochromis niloticus","volume":"55","author":"Witten","year":"1999","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0240","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1046\/j.1439-0426.2000.00233.x","article-title":"Bone resorption and bone remodelling in juvenile carp, Cyprinus carpio L","volume":"16","author":"Witten","year":"2000","journal-title":"J. Appl. Ichthyol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0210","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jmor.1065","article-title":"Features of mono- and multinucleated bone resorbing cells of the zebrafish Danio rerio and their contribution to skeletal development, remodeling, and growth","volume":"250","author":"Witten","year":"2001","journal-title":"J. Morphol."},{"key":"10.1016\/j.cbpc.2015.08.007_bb0230","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.aquaculture.2006.05.005","article-title":"Vertebrae fusion in Atlantic salmon (Salmo salar): development, aggravation and pathways of containment","volume":"258","author":"Witten","year":"2006","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpc.2015.08.007_bb0245","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1002\/jbmr.2269","article-title":"The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine","volume":"29","author":"Wright","year":"2014","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045615001118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045615001118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:19:59Z","timestamp":1761517199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045615001118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":54,"alternative-id":["S1532045615001118"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2015.08.007","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An adult osteopetrosis model in medaka reveals the importance of osteoclast function for bone remodeling in teleost fish","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2015.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}