{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:09:48Z","timestamp":1759774188893},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26450440"],"award-info":[{"award-number":["26450440"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.cbpc.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T22:02:12Z","timestamp":1463176932000},"page":"43-49","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Hydrogen sulfide activates TRPA1 and releases 5-HT from epithelioid cells of the chicken thoracic aorta"],"prefix":"10.1016","volume":"187","author":[{"given":"Dugar","family":"Delgermurun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ichii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Otsuguro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2016.05.004_bb0005","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1292\/jvms.57.1067","article-title":"Muscarinic receptor subtypes mediating catecholamine secretion and increase in intracellular Ca2+ concentration in adrenal chromaffin cells of the guinea pig","volume":"57","author":"Asano","year":"1995","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0010","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/jid.2009.58","article-title":"Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin","volume":"129","author":"Atoyan","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0015","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.cbpc.2016.05.004_bb0020","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cbpc.2016.05.004_bb0025","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1172\/JCI34192","article-title":"TRPA1 is a major oxidant sensor in murine airway sensory neurons","volume":"118","author":"Bessac","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0030","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00424-012-1089-8","article-title":"Effects of exogenous hydrogen sulphide on calcium signaling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells","volume":"463","author":"Buckler","year":"2012","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00441-013-1780-x","article-title":"Identification of enteroendocrine cells that express TRPA1 channels in the mouse intestine","volume":"356","author":"Cho","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1292\/jvms.15-0146","article-title":"Endogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives","volume":"78","author":"Delgermurun","year":"2016","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0045","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1242\/jeb.061473","article-title":"Hydrogen sulfide (H2S) and hypoxia inhibit salmonid gastrointestinal motility: evidence for H2S as an oxygen sensor","volume":"214","author":"Dombkowski","year":"2011","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0050","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.urology.2007.06.1110","article-title":"Transient receptor potential channel A1 involved in sensory transduction or rat urinary bladder through C-fiber pathway","volume":"70","author":"Du","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.cbpc.2016.05.004_bb0055","first-page":"a003962","article-title":"The role of transient receptor potential cation channels in Ca2+ signaling","volume":"2","author":"Gees","year":"2010","journal-title":"Cold Spring Harb. Respect. Biol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0060","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12990-015-0023-4","article-title":"Polysulfide evokes acute pain through the activation of nociceptive TRPA in mouse sensory neurons","volume":"11","author":"Hatakeyama","year":"2015","journal-title":"Mol. Pain"},{"key":"10.1016\/j.cbpc.2016.05.004_bb0065","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/sj.bjp.0701489","article-title":"Release of 5-hydroxytryptamine by hypoxia from epithelioid cells of chicken thoracic aorta","volume":"122","author":"Ito","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0070","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1469-7793.1999.049ad.x","article-title":"Characteristics of 5-HT containing chemoreceptor cells of the aortic body","volume":"515","author":"Ito","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0075","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1038\/sj.bjp.0703978","article-title":"Heterogeneity of neuronal nicotinic acetylcholine receptors in 5-HT-contaning chemoreceptor cells of the chicken aorta","volume":"132","author":"Ito","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0080","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1271\/bbb.80289","article-title":"TRPA1 agonists-allyl isothiocyanate and cinnamaldehyde-induce adrenalin secretion","volume":"72","author":"Iwasaki","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.resp.2015.01.002","article-title":"Hydrogen sulfide activates the carotid chemoreceptors in cat, rabbit and rat ex vivo preparations","volume":"208","author":"Jiao","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0090","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00726-004-0072-x","article-title":"Endogenous production of hydrogen sulfide in mammals","volume":"26","author":"Kamoun","year":"2004","journal-title":"Amino Acids"},{"key":"10.1016\/j.cbpc.2016.05.004_bb0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00726-010-0510-x","article-title":"Hydrogen sulfide: its production, release and functions","volume":"41","author":"Kimura","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.cbpc.2016.05.004_bb0100","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1096\/fj.12-226415","article-title":"Polysulfides are possible H2S-derived signaling molecules in rat brain","volume":"27","author":"Kimura","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0105","doi-asserted-by":"crossref","first-page":"14744","DOI":"10.1038\/srep14774","article-title":"Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain","volume":"5","author":"Kimura","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jchemneu.2012.07.003","article-title":"An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus","volume":"45","author":"Lee","year":"2012","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0120","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1089\/ars.2009.2926","article-title":"A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels","volume":"12","author":"Li","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0125","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature05544","article-title":"Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines","author":"Macpherson","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2016.05.004_bb0130","doi-asserted-by":"crossref","first-page":"C916","DOI":"10.1152\/ajpcell.00100.2012","article-title":"Endogenous H2S is required for hypoxic sensing by carotid body glomus cells","volume":"303","author":"Makarenko","year":"2012","journal-title":"Am. J. Phys. Cell Physiol."},{"issue":"16","key":"10.1016\/j.cbpc.2016.05.004_bb0135","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.3748\/wjg.v21.i16.4840","article-title":"Hydrogen sulfide-induced enhancement of gastric fundus smooth muscle tone is mediated by voltage-dependent potassium and calcium channels in mice","volume":"21","author":"Meng","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0140","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/BJ20110841","article-title":"Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide","volume":"439","author":"Mikami","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0145","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neulet.2011.05.057","article-title":"Time- and concentration-dependent activation of TRPA1 by hydrogen sulfide in rat DRG neurons","volume":"499","author":"Miyamoto","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0150","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/ar.1092420303","article-title":"Distribution of epithelioid cells in the wall of the chicken aorta and their functional role as chemoreceptors","volume":"242","author":"Miyoshi","year":"1995","journal-title":"Anat. Rec."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00424-015-1716-2","article-title":"Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation","volume":"468","author":"Mori","year":"2016","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0160","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1096\/fj.03-1052fje","article-title":"Hydrogen sulfide induces calcium waves in astrocytes","volume":"18","author":"Nagai","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0165","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/j.1476-5381.2012.01886.x","article-title":"Hydrogen sulfide-induced mechanical hyperalgesia and allodyna require activation of both Cav3.2 and TRPA1 channels in mice","volume":"166","author":"Okubo","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0170","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/ars.2014.5930","article-title":"Hydrogen sulfide as an oxygen sensor","volume":"22","author":"Olson","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0175","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1089\/ars.2009.2921","article-title":"Hydrogen sulfide and oxygen sensing in the cardiovascular system","volume":"12","author":"Olson","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0180","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1242\/jeb.02480","article-title":"Hydrogen sulfide as an oxygen sensor\/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation","volume":"209","author":"Olson","year":"2006","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0185","first-page":"R669","article-title":"Hydrogen sulfide as an oxygen sensor in trout gill chemoreceptors","volume":"295","author":"Olson","year":"2008","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0190","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.resp.2012.05.022","article-title":"Carbon monoxide (CO) and hydrogen sulfide (H2S) in hypoxic sensing by the carotid body","volume":"184","author":"Parabhakar","year":"2012","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0195","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2005.01.005","article-title":"Pharmacological ingestigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle","volume":"509","author":"Patacchini","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0200","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1073\/pnas.1005866107","article-title":"H2S mediates O2 sensing in the carotid body","volume":"23","author":"Peng","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0205","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1152\/ajpregu.00185.2008","article-title":"Hydrogen sulfide stimulates catecholamine secretion in rainbow trout","volume":"296","author":"Perry","year":"2009","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0210","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/apha.12202","article-title":"The hypoxic ventilator response and TRPA1 antagonism in conscious mice","volume":"210","author":"Pokorski","year":"2014","journal-title":"Acta Physiol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0215","doi-asserted-by":"crossref","first-page":"C587","DOI":"10.1152\/ajpcell.00465.2010","article-title":"Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception","volume":"301","author":"Raisinghani","year":"2011","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0220","doi-asserted-by":"crossref","first-page":"C911","DOI":"10.1152\/ajpcell.00307.2012","article-title":"H2S, a gasotransmitter for oxygen sensing in carotid body. Focus on \u201cEndogenous H2S required for hypoxic sensing by carotid body glomus cells\u201d","volume":"303","author":"Smith","year":"2012","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0225","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/01.wnr.0000126559.35631.54","article-title":"Cold-sensitive, methanol-insensitive neurons in the murine sympathetic nervous system","volume":"15","author":"Smith","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.cbpc.2016.05.004_bb0230","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.eururo.2007.10.024","article-title":"Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder","volume":"53","author":"Streng","year":"2008","journal-title":"Eur. Urol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0235","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nchembio.640","article-title":"TRPA1 underlies a sensing mechanism for O2","volume":"7","author":"Takahashi","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0240","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1440-1681.2010.05351.x","article-title":"The pathophysiological significance of sulphur-containing gases interaction of hydrogen sulfide with ion channels","volume":"37","author":"Tang","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0245","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jnr.23490","article-title":"Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis","volume":"93","author":"Terada","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0250","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/sj.bjp.0706277","article-title":"Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways","volume":"145","author":"Trevisani","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0255","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejphar.2015.07.029","article-title":"Bidirectional effects of hydrogen sulfide via ATP-sensitive K+ channels and transient receptor potential A1 channels in RIN14B cells","volume":"764","author":"Ujike","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0260","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","article-title":"TRP channels","volume":"76","author":"Venkatachalam","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0265","first-page":"137","article-title":"Immunohistochemical demonstration of tyrosine hydroxylase, serotonin and neuropeptide tyrosine in the epithelioid cells within arterial walls and carotid bodies of chicks","volume":"167","author":"Yamamoto","year":"1989","journal-title":"J. Anat."},{"key":"10.1016\/j.cbpc.2016.05.004_bb0270","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tox.2012.07.008","article-title":"H2S induces catecholamine secretion in rat adrenal chromaffin cells","volume":"302","author":"Zhu","year":"2012","journal-title":"Toxicology"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045616300539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045616300539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T17:07:45Z","timestamp":1567876065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045616300539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":53,"alternative-id":["S1532045616300539"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2016.05.004","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide activates TRPA1 and releases 5-HT from epithelioid cells of the chicken thoracic aorta","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}