{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:04:42Z","timestamp":1780524282674,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["62340"],"award-info":[{"award-number":["62340"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"publisher","award":["MYRG2015-00231-FHS"],"award-info":[{"award-number":["MYRG2015-00231-FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.cbpc.2016.10.001","type":"journal-article","created":{"date-parts":[[2016,10,9]],"date-time":"2016-10-09T00:12:26Z","timestamp":1475971946000},"page":"109-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Chronic MeHg exposure modifies the histone H3K4me3 epigenetic landscape in Caenorhabditis elegans"],"prefix":"10.1016","volume":"191","author":[{"given":"Martina","family":"Rudgalvyte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhani","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja","family":"Lakso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cbpc.2016.10.001_bb0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0022-3476(74)80291-X","article-title":"Studies of infants postnatally exposed to methylmercury","volume":"85","author":"Amin-Zaki","year":"1974","journal-title":"J. Pediatr."},{"issue":"4","key":"10.1016\/j.cbpc.2016.10.001_bb0010","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00775-013-0992-6","article-title":"Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals","volume":"18","author":"Barcia-Sanjurjo","year":"2013","journal-title":"J. Biol. Inorg. Chem."},{"issue":"2","key":"10.1016\/j.cbpc.2016.10.001_bb0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cell.2005.01.001","article-title":"Genomic maps and comparative analysis of histone modifications in human and mouse","volume":"120","author":"Bernstein","year":"2005","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.cbpc.2016.10.001_bb0020","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3233\/JAD-2011-111013","article-title":"Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease","volume":"27","author":"Bihaqi","year":"2011","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.cbpc.2016.10.001_bb0025","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/toxsci\/kfs257","article-title":"Inherited effects of low-dose exposure to methylmercury in neural stem cells","volume":"130","author":"Bose","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2016.10.001_bb0030","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"issue":"6","key":"10.1016\/j.cbpc.2016.10.001_bb0035","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/15592294.2015.1046026","article-title":"Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero","volume":"10","author":"Cardenas","year":"2015","journal-title":"Epigenetics"},{"issue":"2","key":"10.1016\/j.cbpc.2016.10.001_bb0040","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cbi.2010.04.007","article-title":"Methylmercury-induced neurotoxicity and apoptosis","volume":"188","author":"Ceccatelli","year":"2010","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.cbpc.2016.10.001_bb0045","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/joim.12045","article-title":"Long-lasting effects of exposure to methylmercury during development","volume":"273","author":"Ceccatelli","year":"2013","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.cbpc.2016.10.001_bb0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.pu.04.050183.002111","article-title":"Mercury","volume":"4","author":"Clarkson","year":"1983","journal-title":"Annu. Rev. Public Health"},{"issue":"1","key":"10.1016\/j.cbpc.2016.10.001_bb0055","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/toxsci\/kfq115","article-title":"Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver","volume":"116","author":"Cui","year":"2010","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.cbpc.2016.10.001_bb0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/em.21763","article-title":"Mercury biomarkers and the DNA methylation among Michigan dental professionals","volume":"54","author":"Goodrich","year":"2013","journal-title":"Environ. Mol. Mutagen."},{"issue":"5","key":"10.1016\/j.cbpc.2016.10.001_bb0065","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.stem.2010.03.018","article-title":"Distinct epigenomic landscapes of pluripotent and lineage-committed human cells","volume":"6","author":"Hawkins","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cbpc.2016.10.001_bb0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"issue":"3\u20134","key":"10.1016\/j.cbpc.2016.10.001_bb0075","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF03033570","article-title":"Neurobehavioral and molecular changes induced by methylmercury exposure during development","volume":"11","author":"Johansson","year":"2007","journal-title":"Neurotox. Res."},{"issue":"3","key":"10.1016\/j.cbpc.2016.10.001_bb0080","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cbi.2004.05.003","article-title":"Copper induces histone hypoacetylation through directly inhibiting histone acetyltransferase activity","volume":"148","author":"Kang","year":"2004","journal-title":"Chem. Biol. Interact."},{"issue":"5 Pt 2","key":"10.1016\/j.cbpc.2016.10.001_bb0085","first-page":"R761","article-title":"Methylmercury transport across the blood-brain barrier by an amino acid carrier","volume":"262","author":"Kerper","year":"1992","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cbpc.2016.10.001_bb0090","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"7","key":"10.1016\/j.cbpc.2016.10.001_bb0095","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1289\/ehp.1408561","article-title":"Placental DNA methylation related to both infant toenail mercury and adverse neurobehavioral outcomes","volume":"123","author":"Maccani","year":"2015","journal-title":"Environ. Health Perspect."},{"issue":"9466","key":"10.1016\/j.cbpc.2016.10.001_bb0100","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0140-6736(05)74811-X","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery","volume":"365","author":"Mishra","year":"2005","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.cbpc.2016.10.001_bb0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2008.03.008","article-title":"Chronic, low-dose prenatal exposure to methylmercury impairs motor and mnemonic function in adult C57\/B6 mice","volume":"191","author":"Montgomery","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cbpc.2016.10.001_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/0471140856.tx0109s31","article-title":"The nematode C. elegans as an animal model to explore toxicology in vivo: solid and axenic growth culture conditions and compound exposure parameters","author":"Nass","year":"2007","journal-title":"Curr. Protoc. Toxicol."},{"issue":"3","key":"10.1016\/j.cbpc.2016.10.001_bb0115","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1471-4159.2008.05484.x","article-title":"Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury","volume":"106","author":"Onishchenko","year":"2008","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.cbpc.2016.10.001_bb0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/15476910903084021","article-title":"Gestational exposure to mercury leads to persistent changes in T-cell phenotype and function in adult DBF1 mice","volume":"6","author":"Pilones","year":"2009","journal-title":"J. Immunotoxicol."},{"issue":"2","key":"10.1016\/j.cbpc.2016.10.001_bb0125","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-294X.2009.04452.x","article-title":"Mercury-associated DNA hypomethylation in polar bear brains via the LUminometric methylation assay: a sensitive method to study epigenetics in wildlife","volume":"19","author":"Pilsner","year":"2010","journal-title":"Mol. Ecol."},{"issue":"9","key":"10.1016\/j.cbpc.2016.10.001_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001091","article-title":"The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny","volume":"6","author":"Rechtsteiner","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cbpc.2016.10.001_bb0135","doi-asserted-by":"crossref","first-page":"248764","DOI":"10.1155\/2012\/248764","article-title":"Role of calcium and mitochondria in MeHg-mediated cytotoxicity","volume":"2012","author":"Roos","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.cbpc.2016.10.001_bb0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.toxlet.2013.07.014","article-title":"Methylmercury exposure increases lipocalin related (lpr) and decreases activated in blocked unfolded protein response (abu) genes and specific miRNAs in Caenorhabditis elegans","volume":"222","author":"Rudgalvyte","year":"2013","journal-title":"Toxicol. Lett."},{"issue":"2","key":"10.1016\/j.cbpc.2016.10.001_bb0145","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jbt.21768","article-title":"RNA-seq reveals acute manganese exposure increases endoplasmic reticulum related and lipocalin mRNAs in Caenorhabditis elegans","volume":"30","author":"Rudgalvyte","year":"2016","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"5","key":"10.1016\/j.cbpc.2016.10.001_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019503","article-title":"DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs","volume":"6","author":"So","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cbpc.2016.10.001_bb0155","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ydbio.2009.02.030","article-title":"Lipocalin signaling controls unicellular tube development in the Caenorhabditis elegans excretory system","volume":"329","author":"Stone","year":"2009","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.cbpc.2016.10.001_bb0160","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.taap.2007.10.010","article-title":"Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain","volume":"227","author":"Stringari","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.cbpc.2016.10.001_bb0165","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.cell.2008.10.036","article-title":"Crosstalk among histone modifications","volume":"135","author":"Suganuma","year":"2008","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.cbpc.2016.10.001_bb0175","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ydbio.2005.05.017","article-title":"Genome-wide analysis of sex-enriched gene expression during C. elegans larval development","volume":"284","author":"Thoemke","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbpc.2016.10.001_bb0180","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.cbpc.2016.10.001_bb0185","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/toxsci\/kfq285","article-title":"SKN-1\/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity","volume":"118","author":"Vanduyn","year":"2010","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.cbpc.2016.10.001_bb0190","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mrfmmm.2004.10.005","article-title":"A mutation in a cuticle collagen causes hypersensitivity to the endocrine disrupting chemical, bisphenol A, in Caenorhabditis elegans","volume":"570","author":"Watanabe","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cbpc.2016.10.001_bb0195","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinf."},{"issue":"4","key":"10.1016\/j.cbpc.2016.10.001_bb0200","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1471-4159.2008.05683.x","article-title":"The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter","volume":"107","author":"Yin","year":"2008","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.cbpc.2016.10.001_bb0205","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0378-4274(01)00365-4","article-title":"Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures of human cells identified by methylation-sensitive arbitrarily-primed PCR","volume":"122","author":"Zhong","year":"2001","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbpc.2016.10.001_bb0210","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1471-2105-11-237","article-title":"ChIPpeakAnno: a bioconductor package to annotate ChIP-seq and ChIP-chip data","volume":"11","author":"Zhu","year":"2010","journal-title":"BMC Bioinf."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045616301272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045616301272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T03:47:10Z","timestamp":1749613630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045616301272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":41,"alternative-id":["S1532045616301272"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2016.10.001","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic MeHg exposure modifies the histone H3K4me3 epigenetic landscape in Caenorhabditis elegans","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2016.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}