{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:08:39Z","timestamp":1780542519554,"version":"3.54.1"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institutes of Health Pathway to Independence","award":["R00ES017044"],"award-info":[{"award-number":["R00ES017044"]}]},{"name":"Grant-in-Aid of Research from Sigma Xi, The Scientific Research Society","award":["493758"],"award-info":[{"award-number":["493758"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.cbpc.2016.10.006","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T07:11:03Z","timestamp":1476861063000},"page":"138-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress"],"prefix":"10.1016","volume":"191","author":[{"given":"Andrew","family":"Holowiecki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britton","family":"O'Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Jenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2016.10.006_bb0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1124\/pr.107.07104","article-title":"Pharmacological and clinical aspects of heme oxygenase","volume":"60","author":"Abraham","year":"2008","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1179\/174329210X12650506623122","article-title":"The phosphate makes a difference: cellular functions of NADP","volume":"15","author":"Agledal","year":"2010","journal-title":"Redox Rep."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0015","doi-asserted-by":"crossref","first-page":"9226","DOI":"10.1074\/jbc.M108239200","article-title":"Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress","volume":"277","author":"Ahmad","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0020","doi-asserted-by":"crossref","first-page":"26071","DOI":"10.1074\/jbc.274.37.26071","article-title":"Nrf2, a cap \u2018n\u2019 collar transcription factor, regulates induction of the heme oxygenase-1 gene","volume":"274","author":"Alam","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0025","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1182\/blood-2008-12-189910","article-title":"The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish","volume":"114","author":"Amigo","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0030","doi-asserted-by":"crossref","first-page":"16093","DOI":"10.1073\/pnas.252626999","article-title":"Biliverdin reductase: a major physiologic cytoprotectant","volume":"99","author":"Bara\u00f1ano","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0035","doi-asserted-by":"crossref","first-page":"10996","DOI":"10.1073\/pnas.191351298","article-title":"Neural roles for heme oxygenase: contrasts to nitric oxide synthase","volume":"98","author":"Bara\u00f1ano","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0040","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1167\/iovs.10-6219","article-title":"Biliverdin rescues the HO-2 null mouse phenotype of unresolved chronic inflammation following corneal epithelial injury","volume":"52","author":"Bellner","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0045","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1182\/blood.V98.3.643","article-title":"Myelopoiesis in the zebrafish, Danio rerio","volume":"98","author":"Bennett","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0050","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1182\/blood-2009-09-244590","article-title":"Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo","volume":"115","author":"Bertrand","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0055","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1242\/dev.015297","article-title":"CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis","volume":"135","author":"Bertrand","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0060","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1242\/dev.012385","article-title":"Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo","volume":"134","author":"Bertrand","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0065","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1084\/jem.192.7.1015","article-title":"Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis","volume":"192","author":"Brouard","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0012-1606(02)00041-6","article-title":"Characterization of embryonic globin genes of the zebrafish","volume":"255","author":"Brownlie","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0075","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1038\/sj.onc.1205326","article-title":"Transcriptional regulation of erythropoiesis: an affair involving multiple partners","volume":"21","author":"Cantor","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0080","first-page":"1573","article-title":"The zebrafish embryo as a dynamic model of anoxia tolerance","volume":"237","author":"Chen","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0085","first-page":"e50644","article-title":"High resolution whole mount in situ hybridization within zebrafish embryos to study gene expression and function","author":"Chitramuthu","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0090","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.exphem.2014.06.001","article-title":"Developmental hematopoiesis: ontogeny, genetic programming and conservation","volume":"42","author":"Ciau-Uitz","year":"2014","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0095","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1182\/blood-2004-03-1089","article-title":"Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome","volume":"105","author":"Craven","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0100","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nature01973","article-title":"cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes","volume":"425","author":"Davidson","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0105","doi-asserted-by":"crossref","first-page":"10713","DOI":"10.1073\/pnas.92.23.10713","article-title":"Intraembryonic hematopoietic cell migration during vertebrate development","volume":"92","author":"Detrich","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0110","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.exphem.2008.04.008","article-title":"Montalcino, a zebrafish model for variegate porphyria","volume":"36","author":"Dooley","year":"2008","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0115","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1073\/pnas.96.5.2445","article-title":"Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury","volume":"96","author":"Dor\u00e9","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0120","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3324\/haematol.2014.116368","article-title":"Heme oxygenase-1 deficiency alters erythroblastic island formation, steady-state erythropoiesis and red blood cell lifespan in mice","volume":"100","author":"Fraser","year":"2015","journal-title":"Haematologica"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0125","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/gtc.12249","article-title":"Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1","author":"Fuse","year":"2015","journal-title":"Genes Cells"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0130","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.devcel.2004.12.001","article-title":"Loss of Gata1 but not Gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos","volume":"8","author":"Galloway","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0135","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ydbio.2012.03.021","article-title":"Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR","volume":"366","author":"Ganis","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0140","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1182\/blood-2013-04-496760","article-title":"Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme","volume":"123","author":"Garcia-Santos","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0150","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"Gorrini","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2016.09.022","article-title":"Characterization of heme oxygenase and biiverdin reductase gene expression in zebrafish (Danio rerio): basal expression and response to pro-oxidant exposures","author":"Holowiecki","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0160","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1182\/blood.V82.10.2998.2998","article-title":"Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1","volume":"82","author":"Hromas","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0165","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/0305-0491(73)90262-9","article-title":"Chemical and physiological properties of the larval and the adult hemoglobins in rainbow trout, Salmo gairdnerii Irideus","volume":"44","author":"Iuchi","year":"1973","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0170","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1432-1033.1991.tb16059.x","article-title":"A study of the control of NADP(+) -dependent isocitrate dehydrogenase activity during gonadotropin-induced development of the rat ovary","volume":"625","author":"Jennings","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0175","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1242\/dev.029637","article-title":"Definitive hematopoietic stem\/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI","volume":"136","author":"Jin","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0180","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1182\/blood-2007-01-069005","article-title":"Migratory path of definitive hematopoietic stem\/progenitor cells during zebrafish development","volume":"109","author":"Jin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0185","doi-asserted-by":"crossref","first-page":"16168","DOI":"10.1074\/jbc.M010120200","article-title":"Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase","volume":"276","author":"Jo","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.cbpc.2016.10.006_bb0190","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/gb-2007-8-s1-s7","article-title":"Tol2: a versatile gene transfer vector in vertebrates","volume":"8","author":"Kawakami","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0195","doi-asserted-by":"crossref","first-page":"11403","DOI":"10.1073\/pnas.97.21.11403","article-title":"Identification of a functional transposase of the Tol2 element, an Ac-like element from the Japanese medaka fish, and its transposition in the zebrafish germ lineage","volume":"97","author":"Kawakami","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0200","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1096\/fj.00-0823hyp","article-title":"NAD(P)H, a directly operating antioxidant?","volume":"15","author":"Kirsch","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0205","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature08761","article-title":"Blood stem cells emerge from aortic endothelium by a novel type of cell transition","volume":"464","author":"Kissa","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0210","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1182\/blood-2007-07-099499","article-title":"Live imaging of emerging hematopoietic stem cells and early thymus colonization","volume":"111","author":"Kissa","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0215","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0092-8674(90)90219-5","article-title":"The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene","volume":"61","author":"Klemsz","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0220","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1128\/MCB.13.7.4011","article-title":"DNA-binding specificities of the GATA transcription factor family","volume":"13","author":"Ko","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0225","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1046\/j.1365-2443.2002.00561.x","article-title":"Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system","volume":"7","author":"Kobayashi","year":"2002","journal-title":"Genes Cells"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0230","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0167-4781(96)00099-1","article-title":"Cloning and characterization of the cDNA encoding human biliverdin-IX alpha reductase","volume":"1309","author":"Komuro","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0235","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1016\/S0021-9258(19)69552-9","article-title":"Purification and characterization of biliverdin reductase from rat liver","volume":"256","author":"Kutty","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0240","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1002\/dvdy.21343","article-title":"The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs","volume":"236","author":"Kwan","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0245","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1182\/blood-2008-04-149898","article-title":"Zebrafish runx1 promoter-EGFP transgenics mark discrete sites of definitive blood progenitors","volume":"113","author":"Lam","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0250","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1182\/blood-2010-01-264382","article-title":"Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells","volume":"116","author":"Lam","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0255","doi-asserted-by":"crossref","first-page":"6870","DOI":"10.1073\/pnas.0800750105","article-title":"Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling","volume":"105","author":"Lerner-Marmarosh","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0260","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1073\/pnas.0502173102","article-title":"Human biliverdin reductase: a member of the insulin receptor substrate family with serine\/threonine\/tyrosine kinase activity","volume":"102","author":"Lerner-Marmarosh","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0265","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0270","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1073\/pnas.082695299","article-title":"A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes","volume":"99","author":"Lyons","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0275","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0022-3565(24)38855-X","article-title":"Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1","volume":"296","author":"Maines","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0280","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/dev.040998","article-title":"Embryonic origin of the adult hematopoietic system: advances and questions","volume":"138","author":"Medvinsky","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0285","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/dvdy.21584","article-title":"Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo","volume":"237","author":"Mendelsohn","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0290","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/dvdy.21581","article-title":"The zebrafish embryo as a dynamic model of anoxia tolerance","volume":"237","author":"Mendelsohn","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0295","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1182\/blood-2011-05-355362","article-title":"The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels","volume":"118","author":"Merchant","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0300","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/emboj.2011.34","article-title":"The gata1\/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1gamma","volume":"30","author":"Monteiro","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0305","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/toxsci\/kfs193","article-title":"Elevated hepatic iron activates NF-E2-related factor 2-regulated pathway in a dietary iron overload mouse model","volume":"129","author":"Moon","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0310","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.immuni.2006.10.015","article-title":"Tracing hematopoietic precursor migration to successive hematopoietic organs during zebrafish development","volume":"25","author":"Murayama","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026884","article-title":"Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles","volume":"6","author":"Nakajima","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0320","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/74680","article-title":"Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway","volume":"6","author":"Otterbein","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0325","doi-asserted-by":"crossref","first-page":"7331","DOI":"10.1073\/pnas.131213198","article-title":"Oxygen deprivation causes suspended animation in the zebrafish embryo","volume":"98","author":"Padilla","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0330","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.exphem.2013.04.002","article-title":"A model of glucose-6-phosphate dehydrogenase deficiency in the zebrafish","volume":"41","author":"Patrinostro","year":"2013","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0335","first-page":"L312","article-title":"Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts","volume":"278","author":"Petrache","year":"2000","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0340","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1242\/dev.121.1.163","article-title":"Development of hematopoietic cells lacking transcription factor GATA-1","volume":"121","author":"Pevny","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0345","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1074\/jbc.M602954200","article-title":"Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion","volume":"282","author":"Pongratz","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0350","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.94.20.10919","article-title":"Heme oxygenase 1 is required for mammalian iron reutilization","volume":"94","author":"Poss","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0355","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1152\/physiolgenomics.00112.2001","article-title":"Isolation and characterization of zebrafish NFE2","volume":"11","author":"Pratt","year":"2002","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0360","first-page":"97","article-title":"Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. Dev","volume":"8","author":"Rhodes","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0365","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbabio.2006.03.010","article-title":"Mitochondrial NADPH, transhydrogenase and disease","volume":"1757","author":"Rydstrom","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0370","doi-asserted-by":"crossref","first-page":"10929","DOI":"10.1074\/jbc.M010753200","article-title":"Human biliverdin reductase is Autophosphorylated, and phosphorylation is required for bilirubin formation","volume":"276","author":"Salim","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0375","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.8079170","article-title":"Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages","volume":"265","author":"Scott","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109517","article-title":"FIH-1, a novel interactor of mindbomb, functions as an essential anti-angiogenic factor during zebrafish vascular development","volume":"9","author":"So","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0385","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12864-015-1303-0","article-title":"Genome-wide comparison of PU.1 and Api-B binding sites in a mouse B lymphoma cell line","volume":"16","author":"Solomon","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0390","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1073\/pnas.84.16.5918","article-title":"Antioxidant activity of albumin-bound bilirubin","volume":"84","author":"Stocker","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0395","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0400","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1182\/blood.V96.3.910","article-title":"GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies","volume":"96","author":"Takahashi","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0405","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1016\/S0021-9258(18)63477-5","article-title":"Microsomal heme oxygenase. Characterization of the enzyme","volume":"244","author":"Tenhunen","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0410","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0091-679X(04)77027-2","article-title":"Spatial and temporal expression of the zebrafish genome by large-scale in situ hybridization screening","volume":"77","author":"Thisse","year":"2004","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0415","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0425","first-page":"89","article-title":"Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo, free Radic","volume":"65","author":"Timme-Laragy","year":"2013","journal-title":"Biol. Med."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0430","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1074\/jbc.M111.260125","article-title":"Nrf2b, novel zebrafish paralog of oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2)","volume":"287","author":"Timme-Laragy","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0435","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/ncb2699","article-title":"Nrf2 regulates haematopoietic stem cell function","volume":"15","author":"Tsai","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0440","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/BJ20080018","article-title":"Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin","volume":"413","author":"Tudor","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0445","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/sj.onc.1202237","article-title":"Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes","volume":"17","author":"Venugopal","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0450","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.placenta.2003.10.012","article-title":"Marked developmental changes in heme oxygenase-1 (HO-1) expression in the mouse placenta: correlation between HO-1 expression and placental development","volume":"25","author":"Watanabe","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.cbpc.2016.10.006_bb0455","doi-asserted-by":"crossref","first-page":"9623","DOI":"10.1073\/pnas.92.21.9623","article-title":"Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis","volume":"92","author":"Weiss","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0460","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/toxsci\/kfr183","article-title":"Beneficial role of Nrf2 in regulating NADPH generation and consumption","volume":"123","author":"Wu","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0465","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1073\/pnas.89.6.2130","article-title":"Characterization of NADPH-dependent methemoglobin reductase as a heme-binding protein present in erythrocytes and liver","volume":"89","author":"Xu","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cbpc.2016.10.006_bb0470","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1089\/ars.2012.4639","article-title":"Mitochondrial thiols in the regulation of cell death pathways","volume":"17","author":"Yin","year":"2012","journal-title":"Antioxid. Redox Signal."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045616301326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045616301326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T17:02:27Z","timestamp":1749661347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045616301326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":92,"alternative-id":["S1532045616301326"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2016.10.006","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2016.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}