{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:22:32Z","timestamp":1776234152999,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NCRR\/BMRG","award":["8P40OD01960-10"],"award-info":[{"award-number":["8P40OD01960-10"]}]},{"name":"NCRR\/BMRG","award":["3P40OD010960-13"],"award-info":[{"award-number":["3P40OD010960-13"]}]},{"name":"Robert A. Welch Foundation Department","award":["AC-0006"],"award-info":[{"award-number":["AC-0006"]}]},{"name":"Science and Technology Fund (FONACIT) programs","award":["201400352"],"award-info":[{"award-number":["201400352"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.cbpc.2016.10.009","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T01:32:18Z","timestamp":1477618338000},"page":"168-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The binding effectiveness of anti-r-disintegrin polyclonal antibodies against disintegrins and PII and PIII metalloproteases: An immunological survey of type A, B and A+B venoms from Mohave rattlesnakes"],"prefix":"10.1016","volume":"191","author":[{"suffix":"Jr.","given":"Esteban","family":"Cant\u00fa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahiti","family":"Mallela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Nyguen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"B\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montamas","family":"Suntravat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Lucena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Rodr\u00edguez-Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elda E.","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2016.10.009_bb0005","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.toxicon.2007.03.012","article-title":"Individual venom variability in the South American rattlesnake Crotalus durissus cumanensis","volume":"50","author":"Aguilar","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0010","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1021\/pr800332p","article-title":"Snake venomics of the lancehead pitviper Bothrops asper: geographic, individual, and ontogenetic variations","volume":"7","author":"Alape-Gir\u00f3n","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0015","first-page":"291","article-title":"Neuromuscular action of the Crotalus terrificus terrificus poisons","volume":"1","author":"Barrio","year":"1951","journal-title":"Acta Physiol. Lat. Am."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0020","first-page":"86","article-title":"Morulustatin, a disintegrins that inhibits ADP-induced platelet aggregation, isolated from the Mexican Tamaulipan rock rattlesnake (Crotalus lepidus morulus)","volume":"26","author":"Borja","year":"2016","journal-title":"Rev Cient. FCV-LUZ."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0025","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1074\/mcp.M112.023135","article-title":"Differential evolution and neofunctionalization of snake venom metalloprotease domains","volume":"12","author":"Brust","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2174\/1381612053381783","article-title":"Structure-function correlations of snake venom disintegrins","volume":"11","author":"Calvete","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0035","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1586\/epr.11.61","article-title":"Proteomic tools against the neglected pathology of snake bite envenoming","volume":"8","author":"Calvete","year":"2011","journal-title":"Expert Rev. Proteomics."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0040","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.toxicon.2012.09.005","article-title":"The continuing saga of snake venom disintegrins","volume":"62","author":"Calvete","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0045","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0196-0644(97)70111-2","article-title":"Successful treatment of crotalid-induced neurotoxicity with a new polyspecific crotalid Fab antivenom","volume":"30","author":"Clark","year":"1997","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0050","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/379537a0","article-title":"Diet and snake venom evolution","volume":"379","author":"Daltry","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0055","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0041-0101(72)90095-5","article-title":"Comparative study of juvenile and adult prairie rattlesnake (Crotalus viridis viridis) venoms","volume":"10","author":"Fiero","year":"1972","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb9005","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0076-6879(95)48024-2","article-title":"Atrolysins: metalloproteinases from Crotalus atrox venom","volume":"248","author":"Fox","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0060","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.toxicon.2009.01.034","article-title":"Functional basis of a molecular adaptation: prey-specific toxic effects of venom from Sistrurus rattlesnakes","volume":"53","author":"Gibbs","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cbpc.2007.09.001","article-title":"Hemorrhagic, coagulant and fibrino(geno)lytic activities of crude venom and fractions from mapanare (Bothrops colombiensis) snakes","volume":"147","author":"Gir\u00f3n","year":"2008","journal-title":"Comp. Biochem. Physiol. C Toxicol Pharmacol."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0070","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0041-0101(78)90065-X","article-title":"Mojave rattlesnake Crotalus scutulatus scutulatus venom: variation in toxicity with geographical origin","volume":"16","author":"Glenn","year":"1978","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0075","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0041-0101(89)90203-1","article-title":"Intergradation of two different venom populations of the Mojave rattlesnake (Crotalus scutulatus scutulatus) in Arizona","volume":"27","author":"Glenn","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0080","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0041-0101(83)90055-7","article-title":"Geographical variation in Crotalus scutulatus scutulatus (Mojave rattlesnake) venom properties","volume":"21","author":"Glenn","year":"1983","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0085","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0041-0101(74)90241-4","article-title":"Fractionation of Vipera ammodytes venom and seasonal variation of its composition","volume":"12","author":"Gubensek","year":"1974","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0090","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0041-0101(83)90054-5","article-title":"Envenomation by the Mojave rattlesnake (Crotalus scutulatus scutulatus) in southern Arizona, U.S.A","volume":"21","author":"Hardy","year":"1983","journal-title":"Toxicon"},{"issue":"51","key":"10.1016\/j.cbpc.2016.10.009_bb0095","first-page":"54","article-title":"Toxicity of elapid venoms and an observation in relation to geographical location","volume":"8","author":"Irwin","year":"1970","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0100","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0196-0644(05)80898-4","article-title":"Mojave rattlesnake envenomation: prolonged neurotoxicity and rhabdomyolysis","volume":"21","author":"Jansen","year":"1992","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0041-0101(64)90021-2","article-title":"Intraspecific variations in composition of venom of the jumping viper, Bothrops mummifera","volume":"2","author":"Jimenez-Porras","year":"1964","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb9010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.toxicon.2012.09.004","article-title":"Snake venom metalloproteinases","volume":"62","author":"Markland","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0110","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0041-0101(74)90196-2","article-title":"Some observations on the venom of the rhinoceros horned viper, Bitis nasicornis (Shaw)","volume":"12","author":"Marsh","year":"1974","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0115","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.jprot.2012.02.035","article-title":"Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from Southern Arizona","volume":"75","author":"Massey","year":"2012","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0120","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/1568006043335880","article-title":"Disintegrins","volume":"4","author":"McLane","year":"2004","journal-title":"Curr Drug Targets Cardiovasc. Haematol. Disord."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0125","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0003-9861(02)00598-2","article-title":"Evidence for heterogeneous forms of the snake venom metalloproteinase jararhagin: a factor contributing to snake venom variability","volume":"409","author":"Moura-da-Silva","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0130","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.bbapap.2010.06.005","article-title":"Autolysis at the disintegrin domain of patagonfibrase, a metalloproteinase from Philodryas patagoniensis (Patagonia Green Racer; Dipsadidae) venom","volume":"1804","author":"Peichoto","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"46","key":"10.1016\/j.cbpc.2016.10.009_bb0135","first-page":"169","article-title":"Ecological niche and redescription of Crotalus vegrandis (Serpentes: Crotalidae) in Venezuela","volume":"45","author":"Pifano","year":"1996","journal-title":"Brenesia"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0140","first-page":"324","article-title":"Treatment of the bite of a Mojave rattlesnake","volume":"55","author":"Rhoten","year":"1968","journal-title":"J. Fla Med. Assoc."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.taap.2005.07.004","article-title":"Isolation and characterization of two disintegrins inhibiting ADP-induced human platelet aggregation from the venom of Crotalus scutulatus scutulatus (Mohave rattlesnake)","volume":"212","author":"S\u00e1nchez","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0150","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0041-0101(02)00330-6","article-title":"The efficacy of two antivenoms against the venom of North American snakes","volume":"41","author":"S\u00e1nchez","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0155","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.toxicon.2007.10.004","article-title":"Neutralization of two North American coral snake venoms with United States and Mexican antivenoms","volume":"51","author":"S\u00e1nchez","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0160","doi-asserted-by":"crossref","first-page":"e211","DOI":"10.1016\/j.thromres.2010.06.006","article-title":"Cloning, expression, and hemostatic activities of a disintegrin, r-mojastin 1, from the Mohave rattlesnake (Crotalus scutulatus scutulatus)","volume":"126","author":"S\u00e1nchez","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1016\/j.cbpc.2016.10.009_bb0165","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1590\/S0036-46652011000400007","article-title":"Neutralization of Bitis parviocula (Ethiopian mountain adder) venom by the South African Institute of Medical Research (SAIMR) antivenom","volume":"53","author":"S\u00e1nchez","year":"2011","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0170","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1126\/science.129.3359.1361","article-title":"Geographical pattern of crotamine distribution in the same rattlesnake subspecies","volume":"129","author":"Schenberg","year":"1959","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0175","series-title":"Statistical Method in Biological Assay. Charles Griffin, London","article-title":"Alternative methods of analysis for quantal responses, 2nd ed","volume":"volume II","author":"Spearman-Karber","year":"1964"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0180","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0076-6879(90)82008-P","volume":"182","author":"Stoscheck","year":"1990","journal-title":"Quantitation of protein. Methods in Enzymology."},{"key":"10.1016\/j.cbpc.2016.10.009_bb9015","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbapap.2011.04.009","article-title":"Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM\/ADAMTS family proteins","volume":"1824","author":"Takeda","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0185","first-page":"54","article-title":"Distribution and genetic variation in venom A and B populations of the Mojave rattlesnake (Crotalus scutulatus scutulatus) in Arizona","volume":"47","author":"Wilkinson","year":"1991","journal-title":"Herpetologica"},{"key":"10.1016\/j.cbpc.2016.10.009_bb0190","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.jprot.2011.05.027","article-title":"Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa","volume":"74","author":"Williams","year":"2011","journal-title":"J. Proteome"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045616301430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045616301430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T01:51:18Z","timestamp":1536285078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045616301430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":41,"alternative-id":["S1532045616301430"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2016.10.009","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The binding effectiveness of anti-r-disintegrin polyclonal antibodies against disintegrins and PII and PIII metalloproteases: An immunological survey of type A, B and A+B venoms from Mohave rattlesnakes","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2016.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}