{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:32:07Z","timestamp":1779355927063,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Choose Ohio First Scholarship for Bioinformatics"},{"name":"Norbert Thompson Undergraduate Research Fellowship"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.cbpc.2018.02.002","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T07:48:34Z","timestamp":1518680914000},"page":"11-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Vascular parameters continue to decrease post-exposure with simultaneous, but not individual exposure to BPA and hypoxia in zebrafish larvae"],"prefix":"10.1016","volume":"206-207","author":[{"given":"Alysha D.","family":"Cypher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryce","family":"Fetterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Bagatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2018.02.002_bb0005","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1086\/498185","article-title":"A three-dimensional functional assessment of heart and vessel development in the larva of the zebrafish (Danio rerio)","volume":"79","author":"Bagatto","year":"2006","journal-title":"Physiol. Biochem. Zool."},{"issue":"1","key":"10.1016\/j.cbpc.2018.02.002_bb0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.32582\/aa.58.1.8","article-title":"Assessment of the effects of bisphenol-A as a disruptor on ionic regulation in Danio rerio zebrafish through a study of their chloride and prolactin cells","volume":"58","author":"Barasona","year":"2017","journal-title":"Acta Adriat."},{"issue":"2","key":"10.1016\/j.cbpc.2018.02.002_bb0015","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1590\/S1519-69842010000200027","article-title":"Aerobic and anaerobic metabolism for the zebrafish, Danio rerio, reared under normoxic and hypoxic conditions and exposed to acute hypoxia during development","volume":"70","author":"Barrioneuvo","year":"2010","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.resp.2011.05.001","article-title":"Developmental trejectories, critical windows and phenotypic alteration during cardio-respiratory development","volume":"178","author":"Burggren","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.reprotox.2007.05.008","article-title":"An ecological assessment of bisphenol-A: evidence from comparative biology","volume":"24","author":"Crain","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0035","first-page":"39","article-title":"Bisphenol A alters the cardiovascular response to hypoxia in Danio rerio embryos","volume":"174\u2013175","author":"Cypher","year":"2015","journal-title":"Comp. Biochem. Physiol. C"},{"issue":"6","key":"10.1016\/j.cbpc.2018.02.002_bb0040","first-page":"693","article-title":"Histopathological alterations in gills of some poecilid fishes after exposure to bisphenol A","volume":"5","author":"Elshaer","year":"2013","journal-title":"World J. Fish Mar. Sci."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0045","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1242\/jeb.02781","article-title":"A tribute to P.L. Lutz: a message from the heart \u2013 why hypoxic bradycardia in fishes?","volume":"210","author":"Farrell","year":"2007","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0050","doi-asserted-by":"crossref","first-page":"8399","DOI":"10.3390\/ijerph110808399","article-title":"Impact of bisphenol A on the cardiovascular system\u2014epidemiological and experimental evidence and molecular mechanisms","volume":"11","author":"Gao","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"3","key":"10.1016\/j.cbpc.2018.02.002_bb0055","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ecoenv.2005.07.006","article-title":"Comparative embryotoxicity and proteotoxicity of three carrier solvents to zebrafish (Danio rerio) embryos","volume":"63","author":"Hallare","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0060","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/20014091111695","article-title":"A review of the effects of multiple stressors on aquatic organisms and analysis of uncertainty factors for use in risk assessment","volume":"31","author":"Heugens","year":"2001","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0065","doi-asserted-by":"crossref","first-page":"7086","DOI":"10.1073\/pnas.1019031108","article-title":"Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish","volume":"108","author":"Hickens","year":"2011","journal-title":"PNAS"},{"key":"10.1016\/j.cbpc.2018.02.002_bb0070","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1016\/j.scitotenv.2009.10.067","article-title":"Interactions between effects of environment chemicals and natural stressors: a review","volume":"408","author":"Holmstrup","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0075","first-page":"R911","article-title":"The influence of hypoxia and of hypoxemia on the development of cardiac activity in zebrafish larvae","volume":"283","author":"Jacob","year":"2002","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0080","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1242\/jeb.01564","article-title":"Development of oxygen sensing in the gills of zebrafish","volume":"208","author":"Jonz","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0085","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0090","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bbrc.2004.04.125","article-title":"Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1): structural requirement of bisphenol A for degradation of HIF-1\u03b1","volume":"318","author":"Kubo","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0095","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1016\/j.scitotenv.2010.01.043","article-title":"Interactions between toxic chemicals and natural environmental factors \u2013 a meta-analysis and case studies","volume":"408","author":"Laskowski","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0100","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.1021\/es501628k","article-title":"Acute embryonic or juvenile exposure to deepwater horizon crude oil impairs the swimming performance of mahi-mahi (Coryphaena hippurus)","volume":"48","author":"Mager","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0105","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1098\/rspb.2008.1235","article-title":"Mechanisms and evolution of hypoxia tolerance in fish","volume":"276","author":"Mandic","year":"2009","journal-title":"Proc. R. Soc. B"},{"issue":"4","key":"10.1016\/j.cbpc.2018.02.002_bb0110","first-page":"1","article-title":"Cardiovascular system in larval zebrafish response to developmental hypoxia in a family specific manner","volume":"3","author":"Moore","year":"2006","journal-title":"Front. Zool."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0115","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jat.1647","article-title":"Bisphenol A decreases atrial contractility involving NO-dependent G-cyclase signaling pathway","volume":"31","author":"Pant","year":"2011","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0120","series-title":"Development of Cardiovascular Systems","first-page":"227","article-title":"Oxygen, temperature, and pH influences on the development of nonmammalian embryos and larvae","author":"Pelster","year":"1997"},{"key":"10.1016\/j.cbpc.2018.02.002_bb0125","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1161\/01.RES.79.2.358","article-title":"Disruption of hemoglobin oxygen transport does not impact oxygen-dependent physiological processes in developing embryos of zebrafish (Danio rerio)","volume":"79","author":"Pelster","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0130","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1242\/jeb.100.1.275","article-title":"The control of respiration and circulation in fish during exercise and hypoxia","volume":"100","author":"Randall","year":"1982","journal-title":"J. Exp. Biol."},{"issue":"4","key":"10.1016\/j.cbpc.2018.02.002_bb0135","first-page":"266","article-title":"Acclimation to hypoxia increases survival time of zebrafish, Danio rerio, during lethal hypoxia","volume":"289","author":"Rees","year":"2001","journal-title":"J. Exp. Zool. A Ecol. Genet. Physiol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0140","series-title":"Fish Physiology","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1546-5098(08)00010-1","article-title":"Metabolic and molecular responses of fish to hypoxia","author":"Richards","year":"2009"},{"key":"10.1016\/j.cbpc.2018.02.002_bb0145","first-page":"262","article-title":"Endocrine disruptors in the Leca River and nearby Porto Coast (NW Portugal): presence of estrogenic compounds and hypoxic conditions","volume":"94","author":"Rocha","year":"2012","journal-title":"Environ. Chem."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0150","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1242\/jeb.026575","article-title":"Hemoglobin enhances oxygen uptake in larval zebrafish (Danio rerio) but only under conditions of extreme hypoxia","volume":"212","author":"Rombough","year":"2009","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0155","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1242\/jeb.203.11.1659","article-title":"Digital motion analysis as a tool for analyzing the shape and performance of the circulatory system in transparent animals","volume":"203","author":"Schwerte","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0160","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1242\/jeb.02117","article-title":"Development of the sympatho-vagal balance in the cardiovascular system in zebrafish (Danio rerio) characterized by power spectrum and classical signal analysis","volume":"209","author":"Schwerte","year":"2006","journal-title":"J. Exp. Biol."},{"issue":"4","key":"10.1016\/j.cbpc.2018.02.002_bb0165","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1152\/jappl.2000.88.4.1474","article-title":"HIF-1: mediator of physiological and pathophysiological response to hypoxia","volume":"88","author":"Semenza","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0170","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/S0045-6535(97)10133-3","article-title":"A review of environmental fate, effects, and exposure of bisphenol A","volume":"36","author":"Staples","year":"1998","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.cbpc.2018.02.002_bb0175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1210\/er.2008-0021","article-title":"Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption","volume":"30","author":"Vandenberg","year":"2009","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.cbpc.2018.02.002_bb0180","doi-asserted-by":"crossref","DOI":"10.4161\/endo.26490","article-title":"Low dose effects of bisphenol A","volume":"1","author":"Vandenberg","year":"2013","journal-title":"Endocr. Disruptors"},{"issue":"4","key":"10.1016\/j.cbpc.2018.02.002_bb0185","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/icb\/ict080","article-title":"Interactions between oil-spill pollutants and natural stressors can compound ecotoxicological effects","volume":"53","author":"Whitehead","year":"2013","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.cbpc.2018.02.002_bb0190","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1111\/j.1095-8649.2006.01242.x","article-title":"The effects of chronic developmental hypoxia on swimming performance in zebrafish","volume":"69","author":"Widmer","year":"2006","journal-title":"J. Fish Biol."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045618300127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045618300127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T11:03:57Z","timestamp":1660475037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045618300127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":37,"alternative-id":["S1532045618300127"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2018.02.002","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular parameters continue to decrease post-exposure with simultaneous, but not individual exposure to BPA and hypoxia in zebrafish larvae","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2018.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}