{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:07:55Z","timestamp":1790629675436,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnolo\u00f3gico"},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.cbpc.2018.03.008","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T17:39:56Z","timestamp":1522258796000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["In vitro effects of Crotalus atrox snake venom on chick and mouse neuromuscular preparations"],"prefix":"10.1016","volume":"209","author":[{"given":"Raphael","family":"Schezaro-Ramos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo L.","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz B.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda T.","family":"Santa F\u00e9 Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noroska G.S.","family":"Mogoll\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hyslop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor C.","family":"Carregari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2018.03.008_bb0005","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1186\/s12864-015-1832-6","article-title":"Snake venoms are integrated systems, but abundant venom proteins evolve more rapidly","volume":"16","author":"Aird","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.toxicon.2016.08.007","article-title":"CoaTx-II, a new dimeric Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom with bactericidal potential: insights into its structure and biological roles","volume":"120","author":"Almeida","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2016.03.008","article-title":"Biochemical and functional studies of ColTx-I, a new myotoxic phospholipase A2 isolated from Crotalus oreganus lutosus (Great Basin rattlesnake) snake venom","volume":"117","author":"Almeida","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxicon.2017.09.016","article-title":"Neuromuscular effect of venoms from adults and juveniles of Crotalus durissus cumanensis (Humboldt, 1811) from Guajira, Colombia","volume":"139","author":"Arevalo-Paez","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2307\/3669867","article-title":"Food habits of the western diamondback rattlesnake, Crotalus atrox, in Texas (Viperidae)","volume":"20","author":"Beavers","year":"1976","journal-title":"Southwest. Nat."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0030","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.toxicon.2003.12.001","article-title":"Neurotoxic and myotoxic actions of crotoxin-like and Crotalus durissus cascavella whole venom in the chick biventer cervicis preparation","volume":"43","author":"Beghini","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0035","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.jprot.2010.06.001","article-title":"Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management","volume":"73","author":"Boldrini-Fran\u00e7a","year":"2010","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0040","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s13181-013-0373-0","article-title":"A case of neurotoxicity following envenomation by the sidewinder rattlesnake, Crotalus cerastes","volume":"10","author":"Bosak","year":"2014","journal-title":"J. Med. Toxicol."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1476-5381.1997.tb06771.x","article-title":"Observations on the isolated phrenic nerve diaphragm preparation of the rat","volume":"120","author":"B\u00fclbring","year":"1946","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0050","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1021\/pr900249q","article-title":"Exploring the venom proteome of the western diamondback rattlesnake, Crotalus atrox, via snake venomics and combinatorial peptide ligand library approaches","volume":"8","author":"Calvete","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0055","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/pr9008749","article-title":"Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America","volume":"9","author":"Calvete","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0060","first-page":"31","article-title":"Neuromuscular action of venom from the South American colubrid snake Philodryas patagoniensis","volume":"148","author":"Carreiro da Costa","year":"2008","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0065","first-page":"37","article-title":"Biological characterization of Bothrops marajoensis snake venom","volume":"2","author":"Cavalcante","year":"2011","journal-title":"J. Venom. Res."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0070","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxicon.2015.01.006","article-title":"Neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis","volume":"96","author":"Cavalcante","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0075","first-page":"126","article-title":"Neurotoxins with phospholipase A2 activity in snake venoms","volume":"9","author":"Chang","year":"1985","journal-title":"Proc. Natl. Sci. Counc. Repub. China B"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005662","article-title":"Incidence and mortality due to snakebite in the Americas","volume":"11","author":"Chippaux","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0085","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0196-0644(97)70111-2","article-title":"Successful treatment of crotalid-induced neurotoxicity with a new polyspecific crotalid Fab antivenom","volume":"30","author":"Clark","year":"1997","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0090","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0041-0101(93)90397-2","article-title":"Effect of Bothrops insularis venom on the mouse and chick nerve-muscle preparation","volume":"31","author":"Cogo","year":"1993","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0095","series-title":"Contr. Welder Wildl. Found","first-page":"45","article-title":"Notes on food of moccasins and rattlesnakes from the welder wildlife refuge, Sinton, Texa","volume":"1\u201312","author":"Cottam","year":"1959"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0100","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.toxicon.2005.04.011","article-title":"Neurotoxic and myotoxic actions from Lachesis muta muta (surucucu) whole venom on the mouse and chick nerve-muscle preparations","volume":"46","author":"Damico","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0105","first-page":"62","article-title":"Rattling the border wall: pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus","volume":"205","author":"Dobson","year":"2017","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0110","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.cub.2016.07.038","article-title":"The deep origin and recent loss of venom toxin genes in rattlesnakes","volume":"26","author":"Dowell","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0115","first-page":"6","article-title":"Neuromuscular activity of Bothrops fonsecai snake venom in vertebrate preparations","volume":"5","author":"Fernandes","year":"2014","journal-title":"J. Venom. Res."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0120","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1021\/pr901042p","article-title":"Snake venomic of Crotalus durissus terrificus\u2013correlation with pharmacological activities","volume":"9","author":"Georgieva","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0125","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1476-5381.1960.tb01264.x","article-title":"The isolated chick biventer cervicis nerve-muscle preparation","volume":"15","author":"Ginsborg","year":"1960","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0130","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1093\/gbe\/evu166","article-title":"Restriction and recruitment-gene duplication and the origin and evolution of snake venom toxins","volume":"6","author":"Hargreaves","year":"2014","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0135","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0041-0101(94)90078-7","article-title":"Screening of snake venoms for neurotoxic and myotoxic effects using simple in vitro preparations from rodents and chicks","volume":"32","author":"Harvey","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0140","first-page":"1","article-title":"The inhibitory effect of Camellia sinensis extracts against the neuromuscular blockade of Crotalus durissus terrificus venom","volume":"1","author":"de Jesus","year":"2010","journal-title":"J. Venom. Res."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0145","first-page":"1367","article-title":"Venomous snakebites in the United States: management review and update","volume":"65","author":"Juckett","year":"2002","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0150","article-title":"Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0155","series-title":"Rattlesnakes: Their Habits, Life Histories, and Influence on Mankind","author":"Klauber","year":"1972"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0160","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/sysbio\/42.3.356","article-title":"Choosing among hypotheses of rattlesnake phylogeny: a best-fit rate test for DNA sequence data","volume":"42","author":"Knight","year":"1993","journal-title":"Syst. Biol."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/1438279","article-title":"Influence of availability on the feeding habits of the common garter snake","volume":"1945","author":"Lagler","year":"1945","journal-title":"Copeia"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0170","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2307\/1445927","article-title":"Venom ontogeny in the Pacific rattlesnakes Crotalus viridis helleri and C. v. oreganus","volume":"1988","author":"Mackessy","year":"1988","journal-title":"Copeia"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0175","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/jez.411","article-title":"Prey envenomation does not improve digestive performance in western diamondback rattlesnakes (Crotalus atrox)","volume":"307","author":"McCue","year":"2007","journal-title":"J. Exp. Zool. A Ecol. Genet. Physiol."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0180","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.toxicon.2011.11.011","article-title":"Neuromuscular activity of Bothrops alcatraz snake venom in chick biventer cervicis preparations","volume":"59","author":"de Moraes","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0185","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11239-017-1549-2","article-title":"Effects of purified human fibrinogen modified with carbon monoxide and iron on coagulation in rabbits injected with Crotalus atrox venom","volume":"44","author":"Nielsen","year":"2017","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0190","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/S0041-0101(01)00107-6","article-title":"Neutralization of the pharmacological effects of bothropstoxin-I from Bothrops jararacussu (jararacu\u00e7u) venom by crotoxin antiserum and heparin","volume":"39","author":"Oshima-Franco","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0195","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0041-0101(95)00146-8","article-title":"The effects of Duvernoy's gland secretion from the xenodontine colubrid Philodryas olfersii on striated muscle and the neuromuscular junction: partial characterization of a neuromuscular fraction","volume":"34","author":"Prado-Franceschi","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002302","article-title":"Neurotoxicity in snakebite--the limits of our knowledge","volume":"7","author":"Ranawaka","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.toxicon.2017.01.002","article-title":"Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A2, AplTx-I, purified from Agkistrodon piscivorus leucostoma snake venom","volume":"127","author":"Resende","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0210","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/15563650701338187","article-title":"Rattlesnake envenomation with neurotoxicity refractory to treatment with crotaline Fab antivenom","volume":"45","author":"Richardson","year":"2007","journal-title":"Clin. Toxicol. (Phila)"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0215","series-title":"Critical Care Toxicology: Diagnosis and Management of the Critically Poisoned Patient","first-page":"2527","article-title":"South and Central American snakes","author":"Sant'Ana Malaque","year":"2017"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0220","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jprot.2015.03.015","article-title":"Comparative venomics of the prairie rattlesnake (Crotalus viridis viridis) from Colorado: identification of a novel pattern of ontogenetic changes in venom composition and assessment of the immunoreactivity of the commercial antivenom CroFab\u00ae","volume":"121","author":"Saviola","year":"2015","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0225","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/jbt.20376","article-title":"Effects of the Crotalus durissus terrificus snake venom on hepatic metabolism and oxidative stress","volume":"25","author":"da Silva","year":"2011","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0230","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/abbi.2001.2524","article-title":"Purification, sequencing, and phylogenetic analyses of novel Lys-49 phospholipases A2 from the venoms of rattlesnakes and other pit vipers","volume":"394","author":"Tsai","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbpc.2018.03.008_bb0235","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/15563650701638925","article-title":"Fasciculations after rattlesnake envenomations: a retrospective statewide poison control system study","volume":"46","author":"Vohra","year":"2008","journal-title":"Clin. Toxicol. (Phila)"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0240","series-title":"Snakes of the World: A Catalogue of Living and Extinct Species","author":"Wallach","year":"2014"},{"key":"10.1016\/j.cbpc.2018.03.008_bb0245","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/toxins8060188","article-title":"Is hybridization a source of adaptive venom variation in rattlesnakes? A test, using a Crotalus scutulatus\u202f\u00d7\u202fviridis hybrid zone in southwestern New Mexico","volume":"8","author":"Zancolli","year":"2016","journal-title":"Toxins"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045618300243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045618300243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T23:50:02Z","timestamp":1534981802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045618300243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":49,"alternative-id":["S1532045618300243"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2018.03.008","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro effects of Crotalus atrox snake venom on chick and mouse neuromuscular preparations","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2018.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}