{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:12:27Z","timestamp":1780611147238,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006469","name":"FDCT","doi-asserted-by":"publisher","award":["019\/2017\/A1"],"award-info":[{"award-number":["019\/2017\/A1"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.cbpc.2018.05.003","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T09:43:09Z","timestamp":1526895789000},"page":"7-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Does size matter? Venom proteomic and functional comparison between night adder species (Viperidae: Causus ) with short and long venom glands"],"prefix":"10.1016","volume":"211","author":[{"given":"Francisco C.P.","family":"Coimbra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Dobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina N.","family":"Zdenek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"op den Brouw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Debono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Masci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang Fai","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan G.","family":"Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cbpc.2018.05.003_bb0005","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/03946975.2001.10531151","article-title":"The ecological distribution of Causus Wagler 1830 (Viperidae) in Nigeria, with special reference to C. resimus (Peters 1862) and C. lichtensteini (Jan 1859), two species rarely recorded from this country","volume":"14","author":"Akani","year":"2012","journal-title":"Trop. Zool."},{"key":"10.1016\/j.cbpc.2018.05.003_bb0010","series-title":"Molecular Phylogenetics and Evolution Diversification in Vipers: Phylogenetic Relationships, Time of Divergence and Shifts in Speciation Rates, Molecular Phylogenetics and Evolution","first-page":"50","volume":"105","author":"Alencar","year":"2016"},{"issue":"16","key":"10.1016\/j.cbpc.2018.05.003_bb0025","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1002\/pmic.200402024","article-title":"Snake venomics: comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina","volume":"5","author":"Bazaa","year":"2005","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.cbpc.2018.05.003_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)00058-4","article-title":"Bioregulation of kinins: Kallikreins, kininogens, and kininases","volume":"44","author":"Bhoola","year":"1992","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cbpc.2018.05.003_bb0035","series-title":"FitzSimons' Snakes of Southern Africa","author":"Broadley","year":"1990"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0040","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1186\/1471-2164-10-564","article-title":"Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts","volume":"10","author":"Casewell","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0045","series-title":"Venomous Reptiles and Their Toxins: Evolutionary, Pathophysiological and Biodiscovery Implications","first-page":"347","article-title":"Snake Venom Metalloprotease Enzymes","author":"Casewell","year":"2015"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0050","series-title":"Amphibians of Central and Southern Africa","author":"Channing","year":"2001"},{"issue":"2","key":"10.1016\/j.cbpc.2018.05.003_bb0055","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.biochi.2011.07.022","article-title":"Cloning, characterization and mutagenesis of Russell's viper venom l-amino acid oxidase: insights into its catalytic mechanism","volume":"94","author":"Chen","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.cbpc.2018.05.003_bb9010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cbpc.2017.04.007","article-title":"Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (Pseudonaja)","volume":"197","author":"Cipriani","year":"2017","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2018.05.003_bb0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000205234","article-title":"Rapid physiological coagulation method in determination of fibrinogen","volume":"17","author":"Clauss","year":"1957","journal-title":"Acta Haematol."},{"key":"10.1016\/j.cbpc.2018.05.003_bb9000","author":"Clinical Toxinology Resources"},{"issue":"3","key":"10.1016\/j.cbpc.2018.05.003_bb0065","first-page":"s120","article-title":"Effects of snake venom proteases on human fibrinogen chains","volume":"8","author":"Cortelazzo","year":"2010","journal-title":"Blood Transfus."},{"issue":"1","key":"10.1016\/j.cbpc.2018.05.003_bb0070","doi-asserted-by":"crossref","DOI":"10.4102\/jsava.v83i1.205","article-title":"Morbidity and mortality following envenomation by the common night adder (Causus rhombeatus) in three dogs","volume":"83","author":"De Cramer","year":"2012","journal-title":"J. S. Afr. Vet. Assoc."},{"issue":"17","key":"10.1016\/j.cbpc.2018.05.003_bb0075","first-page":"30192","article-title":"Rattling the border wall: Pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus","author":"Dobson","year":"2017","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.cbpc.2018.05.003_bb0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/mcp.M700094-MCP200","article-title":"Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia)","volume":"7","author":"Fry","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0085","series-title":"Venomous Reptiles and Their Toxins: Evolutionary, Pathophysiological and Biodiscovery Implications","first-page":"1","article-title":"The origin and evolution of the toxicofera reptile venom system","author":"Fry","year":"2015"},{"issue":"11","key":"10.1016\/j.cbpc.2018.05.003_bb0090","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/0041-0101(95)00085-Z","article-title":"Phospholipase A2 myotoxins from Bothrops snake venoms","volume":"33","author":"Guti\u00e9rrez","year":"1995","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.cbpc.2018.05.003_bb0095","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.toxicon.2005.02.029","article-title":"Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage","volume":"45","author":"Guti\u00e9rrez","year":"2005","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.cbpc.2018.05.003_bb0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mvr.2005.10.007","article-title":"Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase","volume":"71","author":"Guti\u00e9rrez","year":"2006","journal-title":"Microvasc. Res."},{"issue":"10","key":"10.1016\/j.cbpc.2018.05.003_bb0105","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1021\/pr8003826","article-title":"Snake venomics of the lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom","volume":"7","author":"Guti\u00e9rrez","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbpc.2018.05.003_bb0110","series-title":"Handbook of Venoms and Toxins of Reptiles","first-page":"116","article-title":"Snake venom metalloproteinases: Biological roles and participation in the pathophysiolgy of envenomation","author":"Guti\u00e9rrez","year":"2009"},{"issue":"12","key":"10.1016\/j.cbpc.2018.05.003_bb0115","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1021\/bi00515a033","article-title":"Biochemical characterization of the lizard toxin gilatoxin","volume":"20","author":"Hendon","year":"1981","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.cbpc.2018.05.003_bb0120","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1006\/bbrc.2001.4452","article-title":"Fibrinogenolytic proteases isolated from the snake venom of Taiwan habu: serine proteases with kallikrein-like and angiotensin-degrading activities","volume":"281","author":"Hung","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2018.05.003_bb0125","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1095-8312.2006.00690.x","article-title":"What, if anything, is a \u201ctypical\u201d viper? Biological attributes of basal viperid snakes (genus Causus Wagler, 1830)","volume":"89","author":"Ineich","year":"2006","journal-title":"Biol. J. Linn. Soc."},{"issue":"11","key":"10.1016\/j.cbpc.2018.05.003_bb9015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/toxins8110309","article-title":"Rapid radiations and the race to redundancy: An investigation of the evolution of Australian elapid snake venoms","volume":"8","author":"Jackson","year":"2016","journal-title":"Toxins (Basel)"},{"issue":"8","key":"10.1016\/j.cbpc.2018.05.003_bb0130","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0041-0101(90)90026-4","article-title":"Antigenic relationship between the venom of the night adder Causus maculatus and venoms of other viperids","volume":"28","author":"Janssen","year":"1990","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0135","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0041-0101(92)90043-5","article-title":"Purification and characterization of an venom of the african night adder (Causus rhombeatus)","volume":"9","author":"Janssen","year":"1992","journal-title":"Toxicon"},{"issue":"1\u20132","key":"10.1016\/j.cbpc.2018.05.003_bb0140","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-1119(02)01080-6","article-title":"A survey of gene expression and diversity in the venom glands of the pitviper snake Bothrops insularis through the generation of expressed sequence tags (ESTs)","volume":"299","author":"Junqueira de Azevedo","year":"2002","journal-title":"Gene"},{"issue":"242","key":"10.1016\/j.cbpc.2018.05.003_bb0145","first-page":"1","article-title":"Enter the dragon: the dynamic and multifunctional evolution of Anguimorpha lizard venoms","volume":"9","author":"Koludarov","year":"2017","journal-title":"Toxins"},{"issue":"1","key":"10.1016\/j.cbpc.2018.05.003_bb0150","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.toxicon.2011.11.001","article-title":"Angiotensin-degrading serine peptidase: a new chymotrypsin-like activity in the venom of Bothrops jararaca partially blocked by the commercial antivenom","volume":"59","author":"Kuniyoshi","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0155","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1163\/156853804322992878","article-title":"Short notes aspects of the ecology of a population of Causus maculatus (Reptilia: Viperidae) from southern Nigeria","volume":"25","author":"Luiselli","year":"2001","journal-title":"Amphibia-Reptilia"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0160","series-title":"True Vipers: Natural History and Toxinology of Old World Vipers. Original Edition","first-page":"19","author":"Mallow","year":"2003"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0165","article-title":"Atlas and Red Data Book of the Frogs of South Africa, Lesotho and Swaziland","author":"Minter","year":"2004"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0170","series-title":"Venom Diseases","first-page":"386","author":"Minton","year":"1974"},{"issue":"3","key":"10.1016\/j.cbpc.2018.05.003_bb9005","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9030103","article-title":"How the cobra got its flesh-eating venom: Cytotoxicity as a defensive innovation and its co-evolution with hooding, aposematic marking, and spitting","volume":"9","author":"Panagides","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0180","series-title":"Snakes: A Natural History","author":"Parker","year":"1977"},{"issue":"3","key":"10.1016\/j.cbpc.2018.05.003_bb0185","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.ympev.2009.08.002","article-title":"When continents collide: phylogeny, historical biogeography and systematics of the medically important viper genus Echis (Squamata: Serpentes: Viperidae)","volume":"53","author":"Pook","year":"2009","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.cbpc.2018.05.003_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2148-13-93","article-title":"A phylogeny and revised classification of Squamata, including 4161 species of lizards and snakes","volume":"13","author":"Pyron","year":"2013","journal-title":"BMC Evol. Biol."},{"issue":"3","key":"10.1016\/j.cbpc.2018.05.003_bb0195","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/exmp.1995.1042","article-title":"Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom","volume":"63","author":"Rucavado","year":"1995","journal-title":"Exp. Mol. Pathol."},{"issue":"2","key":"10.1016\/j.cbpc.2018.05.003_bb0200","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.biochi.2010.10.004","article-title":"A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom","volume":"93","author":"Siigur","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0205","series-title":"The Dangerous Snakes of Africa. London: Ralph Curtis Books","first-page":"192","author":"Spawls","year":"1995"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0215","series-title":"Venomous Reptiles and Their Toxins: Evolutionary, Pathophysiological and Biodiscovery Implications","first-page":"291","article-title":"l-Amino acid oxidase enzymes","author":"Tan","year":"2015"},{"issue":"3","key":"10.1016\/j.cbpc.2018.05.003_bb0220","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1006\/bbrc.2000.4175","article-title":"Bothrops moojeni venom kills Leishmania spp. with hydrogen peroxide generated by its l-amino acid oxidase","volume":"280","author":"Tempone","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2018.05.003_bb0225","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1469-7998.2006.00195.x","article-title":"Anurans as prey: an exploratory analysis and size relationships between predators and their prey","volume":"271","author":"Toledo","year":"2007","journal-title":"J. Zool."},{"key":"10.1016\/j.cbpc.2018.05.003_bb0230","series-title":"A Contribution to the Classification of Snakes","first-page":"135","author":"Underwood","year":"1967"},{"issue":"16","key":"10.1016\/j.cbpc.2018.05.003_bb0235","doi-asserted-by":"crossref","first-page":"763","DOI":"10.6026\/97320630008563","article-title":"Sequence and phylogenetic analysis of viper venom serine proteases","volume":"8","author":"Vaiyapuri","year":"2012","journal-title":"Bioinformation"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0240","series-title":"Venomous Reptiles and Their Toxins: Evolutionary, Pathophysiological and Biodiscovery Implications","first-page":"267","article-title":"Kallikrein Enzymes","author":"Vaiyapuri","year":"2015"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0245","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.gene.2006.03.008","article-title":"Venom gland EST analysis of the saw-scaled viper, Echis ocellatus, reveals novel alpha(9)beta(1) integrin-binding motifs in venom metalloproteinases and a new group of putative toxins, renin-like aspartic proteases","volume":"377","author":"Wagstaff","year":"2006","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.cbpc.2018.05.003_bb0250","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jprot.2008.10.003","article-title":"Combined snake venomics and venom gland transcriptomic analysis of the ocellated carpet viper, Echis ocellatus","volume":"71","author":"Wagstaff","year":"2009","journal-title":"J. Proteome"},{"issue":"3","key":"10.1016\/j.cbpc.2018.05.003_bb0255","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4269\/ajtmh.1976.25.517","article-title":"Bites by the night adder and burrowing vipers in Nigeria","volume":"25","author":"Warrell","year":"1976","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.cbpc.2018.05.003_bb0265","series-title":"Guidelines for the Prevention and Clinical Management of Snakebite in Africa","author":"World Health Organization","year":"2010"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0270","series-title":"A Nesting of Vipers: Phylogeny and Historical Biogeography of the Viperidae (Squamata: Serpentes). Molecular Phylogenetics and Evolution","first-page":"445","volume":"49","author":"W\u00fcster","year":"2008"},{"key":"10.1016\/j.cbpc.2018.05.003_bb0275","series-title":"The Snake With the Scorpion's Sting: Novel Three-finger Toxin Sodium Channel Activators From the Venom of the Long-glanded Blue Coral Snake","first-page":"1","author":"Yang","year":"2016"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045618300590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045618300590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T17:10:01Z","timestamp":1751649001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045618300590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":54,"alternative-id":["S1532045618300590"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2018.05.003","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does size matter? Venom proteomic and functional comparison between night adder species (Viperidae: Causus) with short and long venom glands","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2018.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}