{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:51:21Z","timestamp":1793505081238,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007943","name":"Graduate School, Kasetsart University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.cbpc.2020.108784","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T12:26:58Z","timestamp":1588681618000},"page":"108784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Comparative liver metabolic enzyme activity of cytochrome P450 and glutathione-S-transferase in crocodile (Crocodylus siamensis) and livestock"],"prefix":"10.1016","volume":"235","author":[{"given":"Piriyaporn","family":"Thiendedsakul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapassorn","family":"Boonsoongnern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakorn","family":"Jara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phitsanu","family":"Tulayakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.cbpc.2020.108784_bb0005","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1124\/dmd.111.040618","article-title":"Cytochrome P450 Pig liver pie: determination of individual cytochrome P450 isoform contents in microsomes from two pig livers using liquid chromatography in conjunction with mass spectrometry [corrected]","volume":"39","author":"Achour","year":"2011","journal-title":"Drug Metab. Dispos."},{"issue":"6","key":"10.1016\/j.cbpc.2020.108784_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130002","article-title":"Biotransformaion and oxidative stress responses in Captive Nile Crocodile (Crocodylus niloticus) exposed to organic contaminants from the natural environment in South Africa","volume":"10","author":"Arukwe","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cbpc.2020.108784_bb0015","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/toxsci\/54.1.30","article-title":"Effects of dietary oltipraz and ethoxyquin on aflatoxin B1 biotransformation in non-human primates","volume":"54","author":"Bammler","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2020.108784_bb0020","author":"BBC NEWS THAI"},{"issue":"10","key":"10.1016\/j.cbpc.2020.108784_bb0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4236\/health.2013.510A1003","article-title":"Aflatoxins metabolism, effects on epigenetic mechanisms and their role in carcinogenesis","volume":"5","author":"Bbosa","year":"2013","journal-title":"Health"},{"issue":"1","key":"10.1016\/j.cbpc.2020.108784_bb0030","first-page":"36","article-title":"Biochemical genetics of glutathione-S-transferase in man","volume":"33","author":"Board","year":"1981","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.cbpc.2020.108784_bb0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"issue":"11","key":"10.1016\/j.cbpc.2020.108784_bb0040","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1071\/FP05158","article-title":"Glutathione S-transferase and aluminum toxicity in maize","volume":"32","author":"Can\u00e7ado","year":"2005","journal-title":"Funct. Plant Biol."},{"key":"10.1016\/j.cbpc.2020.108784_bb0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0076-6879(05)01002-5","article-title":"Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease","volume":"401","author":"Coles","year":"2005","journal-title":"Methods Enzymol."},{"issue":"7","key":"10.1016\/j.cbpc.2020.108784_bb0050","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/0006-2952(89)90247-5","article-title":"Electrophoretic and immunological analysis of glutathione transferase isoenzymes of human kidney carcinoma","volume":"38","author":"Di Ilio","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbpc.2020.108784_bb0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4081\/xeno.2011.e4","article-title":"Enzymatic activity in Turkey, duck, quail and chicken liver microsomes against four human cytochrome P450 prototype substrates and aflatoxin B1","volume":"1","author":"D\u00edaz","year":"2011","journal-title":"J. Xenobiotics"},{"key":"10.1016\/j.cbpc.2020.108784_bb0060","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1007\/s00204-014-1312-9","article-title":"Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences","volume":"88","author":"Dohnal","year":"2014","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.cbpc.2020.108784_bb0065","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/02772240701550182","article-title":"The effects of subcutaneous administration of T-2 toxin on liver drug metabolizing enzymes in piglets","volume":"90","author":"Dong","year":"2008","journal-title":"Toxicol. Environ. Chem."},{"issue":"7","key":"10.1016\/j.cbpc.2020.108784_bb0070","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0041-0101(02)00090-9","article-title":"Glutathione-S-transferase activity toward aflatoxin epoxide in livers of mastomys and other rodents","volume":"40","author":"Esaki","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2020.108784_bb0075","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.chemosphere.2016.04.018","article-title":"Variations in hepatic biomarkers in American alligators (Alligator mississippiensis) from three sites in Florida, USA","volume":"155","author":"Gunderson","year":"2016","journal-title":"Chemosphere"},{"issue":"22","key":"10.1016\/j.cbpc.2020.108784_bb0080","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2020.108784_bb0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/978-94-007-5881-0_8","article-title":"The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system","volume":"67","author":"Heit","year":"2013","journal-title":"Subcell. Biochem."},{"issue":"2","key":"10.1016\/j.cbpc.2020.108784_bb0090","first-page":"225","article-title":"Effect of steroidal sex hormones on the sex-related differences in the hepatic activities of gamma-glutamyltranspeptidase, glutathione S-transferase and glutathione peroxidase in rats","volume":"45","author":"Igarashi","year":"1984","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"issue":"3","key":"10.1016\/j.cbpc.2020.108784_bb0100","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0022-3565(25)20433-5","article-title":"Identification and induction of cytochrome P450 2E1 in rat Kupffer cells","volume":"258","author":"Koop","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"20","key":"10.1016\/j.cbpc.2020.108784_bb0105","doi-asserted-by":"crossref","first-page":"12063","DOI":"10.1074\/jbc.271.20.12063","article-title":"Role of CYP2E1 in the hepatotoxicity of acetaminophen","volume":"271","author":"Lee","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2020.108784_bb0110","first-page":"187","article-title":"The detoxification enzyme system","volume":"3","author":"Liska","year":"1998","journal-title":"Alternative Med. Rev."},{"issue":"5","key":"10.1016\/j.cbpc.2020.108784_bb0115","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.freeradbiomed.2007.11.004","article-title":"CYP2E1 and oxidative liver injury by alcohol","volume":"44","author":"Lu","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.cbpc.2020.108784_bb0120","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.dci.2010.12.011","article-title":"Characterization of the novel antibacterial peptide Leucrocin from crocodile (Crocodylus siamensis) white blood cell extracts","volume":"35","author":"Pata","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.cbpc.2020.108784_bb2000","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0015-6264(73)80496-1","article-title":"Metabolism as a factor in determining the toxic action of the aflatoxins in different animal species","volume":"11","author":"Patterson","year":"1973","journal-title":"Food Cosmet. Toxicol."},{"issue":"5","key":"10.1016\/j.cbpc.2020.108784_bb0125","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s10930-014-9581-y","article-title":"An investigation of antioxidant and anti-inflammatory activities from blood components of Crocodile (Crocodylus siamensis)","volume":"33","author":"Phosri","year":"2014","journal-title":"Protein J."},{"key":"10.1016\/j.cbpc.2020.108784_bb0130","article-title":"The distribution of glutathione and glutathione S-transferase activity in the organs of Dhub (the agamid lizard; Uromastyx aegyptius)","volume":"7","author":"Sarhan","year":"2007","journal-title":"J. Biol. Sci."},{"issue":"5","key":"10.1016\/j.cbpc.2020.108784_bb0135","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/carcin\/7.5.751","article-title":"A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer","volume":"7","author":"Seidegard","year":"1986","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cbpc.2020.108784_bb0140","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.exppara.2017.09.008","article-title":"Crocodiles and alligators: Antiamoebic and antitumor compounds of crocodiles","volume":"183","author":"Siddiqui","year":"2017","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.cbpc.2020.108784_bb0145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1469-1809.1984.tb00829.x","article-title":"The human glutathione S-transferases: studies on the tissue distribution and genetic variation of the GST1, GST2 and GST3 isozymes","volume":"48","author":"Strange","year":"1984","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.cbpc.2020.108784_bb0150","series-title":"Principles of Biochemical Toxicology","author":"Timbrell","year":"2008"},{"issue":"2","key":"10.1016\/j.cbpc.2020.108784_bb0155","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.toxicon.2005.03.023","article-title":"Comparative activities of glutathione-S-transferase and dialdehyde reductase toward aflatoxin B1 in livers of experimental and farm animals","volume":"46","author":"Tulayakul","year":"2005","journal-title":"Toxicon"},{"issue":"15","key":"10.1016\/j.cbpc.2020.108784_bb0160","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1021\/bi00284a011","article-title":"Molecular and catalytic properties of glutathione transferase .mu. from human liver: an enzyme efficiently conjugating epoxides","volume":"22","author":"Warholm","year":"1983","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.cbpc.2020.108784_bb0165","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1055\/s-2007-1007169","article-title":"Human glutathione S-transferases","volume":"18","author":"Whalen","year":"1998","journal-title":"Semin. Liver Dis."},{"issue":"3","key":"10.1016\/j.cbpc.2020.108784_bb0170","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1042\/bst0190746","article-title":"Microsomal activation of benzo[a]pyrene by Alligator mississippiensis: mechanisms, mutagenicity and induction","volume":"19","author":"Winston","year":"1991","journal-title":"Biochem. Soc. Trans."},{"issue":"1","key":"10.1016\/j.cbpc.2020.108784_bb0175","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbpc.2020.108784_bb0180","series-title":"Aflatoxins - Recent Advances and Future Prospects","article-title":"The significance of glutathione conjugation in Aflatoxin metabolism","author":"Ziglari","year":"2013"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045620300843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045620300843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:24:47Z","timestamp":1761517487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045620300843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":36,"alternative-id":["S1532045620300843"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2020.108784","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative liver metabolic enzyme activity of cytochrome P450 and glutathione-S-transferase in crocodile (Crocodylus siamensis) and livestock","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2020.108784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108784"}}