{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:16:54Z","timestamp":1775539014687,"version":"3.50.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":256,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["152753\/2017-6"],"award-info":[{"award-number":["152753\/2017-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005639","name":"Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/16320-7"],"award-info":[{"award-number":["2014\/16320-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/11530-1"],"award-info":[{"award-number":["2017\/11530-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.cbpc.2020.108910","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T01:31:34Z","timestamp":1602293494000},"page":"108910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Diclofenac and caffeine inhibit hepatic antioxidant enzymes in the freshwater fish Astyanax altiparanae (Teleostei: Characiformes)"],"prefix":"10.1016","volume":"240","author":[{"given":"Marcela","family":"Mu\u00f1oz-Pe\u00f1uela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Laura","family":"Lo Nostro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Dal'Olio Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Eduardo","family":"Tolussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovana Souza","family":"Branco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo Silva","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe Guilherme Andrade de","family":"Godoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Guimar\u00e3es","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2020.108910_bb0005","first-page":"33","article-title":"Exposure to aluminum, aluminum + manganese and acid pH triggers different antioxidant responses in gills and liver of Astyanax altiparanae (Teleostei: Characiformes: Characidae) males","volume":"215","author":"Abdalla","year":"2019","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology"},{"key":"10.1016\/j.cbpc.2020.108910_bb0010","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.envint.2015.09.023","article-title":"Balancing the health benefits and environmental risks of pharmaceuticals: diclofenac as an example","volume":"85","author":"Acu\u00f1a","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbpc.2020.108910_bb0015","first-page":"7","article-title":"F\u00e1rmacos na represa Billings","volume":"6","author":"Almeida","year":"2005","journal-title":"Revista Sa\u00fade e Ambiente"},{"key":"10.1016\/j.cbpc.2020.108910_bb0020","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-1218(95)90078-0","article-title":"Fish micronuclei for assessing genotoxicity in water","volume":"343","author":"Al-Sabti","year":"1995","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cbpc.2020.108910_bb0025","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ecoenv.2006.03.013","article-title":"Enzymatic inhibition and morphological changes in Hoplias malabaricus from dietary exposure to lead (II) or methylmercury","volume":"67","author":"Alves-Costa","year":"2007","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2020.108910_bb0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ecoenv.2015.12.012","article-title":"Characterization of antioxidant system parameters in four freshwater fish species","volume":"126","author":"Atli","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1\u20132","key":"10.1016\/j.cbpc.2020.108910_bb0035","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.lfs.2013.12.002","article-title":"Caffeine supplementation modulates oxidative stress markers in the liver of trained rats","volume":"96","author":"Barcelos","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.cbpc.2020.108910_bb0040","unstructured":"Beutler, E. 1975. Catalase. In E. Beutler (Ed.), Red Cell Metabolism. A manual of biochemical methods. New York: Grune and Straton. P. 89\u201390."},{"key":"10.1016\/j.cbpc.2020.108910_bb0045","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.chemosphere.2017.04.084","article-title":"Eco-pharmacovigilance of non-steroidal anti-inflammatory drugs: necessity and opportunities","volume":"181","author":"Bing-Shu","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2020.108910_bb0050","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/em.22123","article-title":"Micronuclei and other erythrocyte nuclear abnormalities in fishes from the Great Lakes Basin, USA","volume":"58","author":"Braham","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.cbpc.2020.108910_bb0055","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.scitotenv.2016.04.125","article-title":"Use of an integrated biomarker-based strategy to evaluate physiological stress responses induced by environmental concentrations of caffeine in the Mediterranean mussel Mytilus galloprovincialis","volume":"563-564","author":"Capolupo","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2020.108910_bb0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1570159X13666141210215655","article-title":"Caffeine: cognitive and physical performance enhancer or psychoactive drug?","volume":"13","author":"Cappelletti","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0065","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1139\/f90-237","article-title":"Assessment of the piscine micronucleus test as an in situ biological indicator of chemical contaminant effects","volume":"47","author":"Carrasco","year":"1990","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.cbpc.2020.108910_bb0070","first-page":"116","article-title":"Occurrence, ecotoxicology, removal of diclofenac by adsorption on activated carbon and biodegradation and its effect on bacterial community: a review","volume":"10","author":"Cherik","year":"2015","journal-title":"World Scientific News"},{"key":"10.1016\/j.cbpc.2020.108910_bb0075","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.scitotenv.2015.06.099","article-title":"Ecological relevance of biomarkers in monitoring studies of macro-invertebrates and fish in Mediterranean rivers","volume":"540","author":"Colin","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.cbpc.2020.108910_bb0080","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/etc.599","article-title":"Diclofenac in fish: blood plasma levels similar to human therapeutic levels affect global hepatic gene expression","volume":"30","author":"Cuklev","year":"2011","journal-title":"Environ. Toxicol. Chem."},{"issue":"3","key":"10.1016\/j.cbpc.2020.108910_bb0085","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2165\/00003088-199733030-00003","article-title":"Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls","volume":"33","author":"Davies","year":"1997","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.cbpc.2020.108910_bb0090","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0095","author":"European Commission"},{"issue":"2","key":"10.1016\/j.cbpc.2020.108910_bb0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/13547500903315598","article-title":"Responses of the European flounder Platichthys flesus to the chemical stress in estuaries: load of contaminants, gene expression, cellular impact and growth rate","volume":"15","author":"Evrard","year":"2010","journal-title":"Biomarkers"},{"issue":"1","key":"10.1016\/j.cbpc.2020.108910_bb0105","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/mutage\/geq052","article-title":"Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells: review","volume":"26","author":"Fenech","year":"2011","journal-title":"Mutagenesis"},{"key":"10.1016\/j.cbpc.2020.108910_bb0110","first-page":"65","article-title":"Descri\u00e7\u00e3o de uma esp\u00e9cie nova de Astyanax (Teleostei: Characidae) da bacia do alto rio Paran\u00e1 e considera\u00e7\u00f5es sobre as demais esp\u00e9cies do g\u00eanero na bacia","volume":"13","author":"Garutti","year":"2000","journal-title":"Comunica\u00e7\u00f5es do Museu de Ci\u00eancias e Tecnologia, S\u00e9rie Zoologia Porto Alegre"},{"issue":"1","key":"10.1016\/j.cbpc.2020.108910_bb0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00128-015-1693-3","article-title":"Evaluation of biochemical, genetic and hematological biomarkers in a commercial catfish Rhamdia quelen exposed to diclofenac","volume":"96","author":"Ghelfi","year":"2016","journal-title":"Bulletin Environmental Contamination and Toxicology"},{"key":"10.1016\/j.cbpc.2020.108910_bb0120","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.ijcard.2016.08.233","article-title":"Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts","volume":"223","author":"Ghosh","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0125","first-page":"108720","article-title":"Endocrine disruptive action of diclofenac and caffeine on Astyanax altiparanae males (Teleostei: Characiformes: Characidae)","volume":"231","author":"Godoi","year":"2020","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology"},{"key":"10.1016\/j.cbpc.2020.108910_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ygcen.2014.10.008","article-title":"The role of ovarian steroids in reproductive plasticity in Hoplias malabaricus (Teleostei: Characiformes: Erythrinidae) in tropical reservoirs with different degrees of pollution","volume":"222","author":"Gomes","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"issue":"10","key":"10.1016\/j.cbpc.2020.108910_bb0135","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11745-016-4196-z","article-title":"Fatty acid composition of tropical fish depends on reservoir trophic status and fish feeding habit","volume":"51","author":"Gomes","year":"2016","journal-title":"Lipids"},{"key":"10.1016\/j.cbpc.2020.108910_bb0140","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ecoenv.2014.11.020","article-title":"Effects of trophic exposure to dexamethasone and diclofenac in freshwater fish","volume":"114","author":"Guiloski","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2020.108910_bb0145","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ecoenv.2017.01.053","article-title":"Effects of environmentally relevant concentrations of the anti-inflammatory drug diclofenac in freshwater fish Rhamdia quelen","volume":"139","author":"Guiloski","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"22","key":"10.1016\/j.cbpc.2020.108910_bb0150","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.cbpc.2020.108910_bb0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0891-5849(95)00020-X","article-title":"Quantification of lipid peroxidation in tissue extracts based on Fe (III) xylenol orange complex formation","volume":"19","author":"Hermes-Lima","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbpc.2020.108910_bb0160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.aquatox.2005.07.006","article-title":"Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario)","volume":"75","author":"Hoeger","year":"2005","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0165","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2141.1973.tb01768.x","article-title":"Glutathione peroxidase in human red cells in health and disease","volume":"25","author":"Hopkins","year":"1973","journal-title":"Journal of Haematology"},{"key":"10.1016\/j.cbpc.2020.108910_bb0170","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ecoenv.2013.01.025","article-title":"Diclofenac-induced oxidative stress in brain, liver, gill and blood of common carp (Cyprinus carpio)","volume":"92","author":"Islas-Flores","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2020.108910_bb0175","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s10695-016-0222-6","article-title":"Effects of acidic water, aluminum, and manganese on testicular steroidogenesis in Astyanax altiparanae","volume":"43","author":"Kida","year":"2016","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpc.2020.108910_bb0180","first-page":"103","article-title":"Comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis","volume":"3","author":"Kobayashi","year":"1995","journal-title":"MMS Communications"},{"key":"10.1016\/j.cbpc.2020.108910_bb0185","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/s40064-015-1284-0","article-title":"Assessing developmental toxicity of caffeine and sweeteners in medaka (Oryzias latipes)","volume":"4","author":"Lee","year":"2015","journal-title":"Springer Plus"},{"key":"10.1016\/j.cbpc.2020.108910_bb0190","doi-asserted-by":"crossref","unstructured":"Lesser, M.P. 2012. Oxidative stress in tropical marine ecosystems. In: D, Abele, J. P, Vasquez-Medina, T, Zenteno-Sav\u00edn (Eds.). Oxidative Stress in Aquatic Ecosystems. Wiley: Blackwell, pp. 9\u201319 cap 1.","DOI":"10.1002\/9781444345988.ch1"},{"key":"10.1016\/j.cbpc.2020.108910_bb0195","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.scitotenv.2016.09.210","article-title":"Nutrients, emerging pollutants and pesticides in a tropical urban reservoir: spatial distributions and risk assessment","volume":"575","author":"L\u00f3pez-Doval","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2020.108910_bb0200","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2020.108910_bb0205","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.scitotenv.2020.137182","article-title":"Influence of tropical reservoirs eutrophication on the polyunsaturated fatty acid profile in Astyanax altiparanae (Pisces: Characidae)","volume":"717","author":"Marques","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2020.108910_bb0210","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0300-483X(00)00306-1","article-title":"Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology","volume":"153","author":"Mat\u00e9s","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.cbpc.2020.108910_bb0220","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase an enzymatic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2020.108910_bb0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00244-007-9059-4","article-title":"Assessing caffeine as an emerging environmental concern using conventional approaches","volume":"54","author":"Moore","year":"2008","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0230","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.aquatox.2017.05.017","article-title":"Diclofenac affects kidney histology in the three-spined stickleback (Gasterosteus aculeatus) at low \u03bcg\/L concentrations","volume":"189","author":"N\u00e4slund","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0235","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"2011"},{"key":"10.1016\/j.cbpc.2020.108910_bb0240","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-0173(92)90012-B","article-title":"Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects","volume":"17","author":"Nehlig","year":"1992","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.cbpc.2020.108910_bb0245","first-page":"108683","article-title":"Neurotoxic and respiratory effects of human use drugs on a neotropical fish species, Phalloceros harpagos","volume":"230","author":"Oliveira dos Santos","year":"2020","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology"},{"issue":"1","key":"10.1016\/j.cbpc.2020.108910_bb0250","first-page":"178","article-title":"Caffeine oxidation in water by Fenton and Fenton-like processes: effects of inorganic anions and ecotoxicological evaluation on aquatic organisms","volume":"26","author":"Oliveira","year":"2015","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.cbpc.2020.108910_bb0255","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.aquatox.2017.03.007","article-title":"Evaluation of DNA damage and physiological responses in Nile tilapia, Oreochromis niloticus (Linnaeus, 1758) exposed to sub-lethal diclofenac (DCF)","volume":"186","author":"Pandey","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0260","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.chemosphere.2018.12.143","article-title":"Water temperature and acid pH influence the cytotoxic and genotoxic effects of aluminum in the freshwater teleost Astyanax altiparanae (Teleostei: Characidae)","volume":"220","author":"Pinheiro","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2020.108910_bb0265","doi-asserted-by":"crossref","first-page":"114252","DOI":"10.1016\/j.envpol.2020.114252","article-title":"Aluminum, at an environmental concentration, associated with acidic pH and high water temperature, causes impairment of sperm quality in the freshwater teleost Astyanax altiparanae (Teleostei: Characidae)","volume":"262","author":"Pinheiro","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2020.108910_bb0270","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1007\/s11356-016-7789-4","article-title":"Do pharmaceuticals reach and affect the aquatic ecosystems in Brazil? A critical review of current studies in a developing country","volume":"24","author":"Quadra","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpc.2020.108910_bb0275","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.ecoenv.2010.07.032","article-title":"Evaluation of zebrafish DNA integrity after exposure to pharmacological agents present in aquatic environments","volume":"73","author":"Rocco","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"10","key":"10.1016\/j.cbpc.2020.108910_bb0280","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/tox.20685","article-title":"Micronucleus test and comet assay for the evaluation of zebrafish genomic damage induced by erythromycin and lincomycin","volume":"27","author":"Rocco","year":"2012","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0285","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.etap.2018.02.002","article-title":"Evaluation of caffeine effects on biochemical and genotoxic biomarkers in the neotropical freshwater teleost Prochilodus lineatus","volume":"58","author":"Santos-Silva","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0290","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.aquatox.2004.03.014","article-title":"Toxic effects of the non-steroidal anti-inflammatory drug diclofenac part I: histopathological alterations and bioaccumulation in rainbow trout","volume":"68","author":"Schwaiger","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2020.108910_bb0295","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/app9071362","article-title":"Ecotoxicological effect of single and combined exposure of carbamazepine and cadmium on female Danio rerio: A multibiomarker study","volume":"9","author":"Shi","year":"2019","journal-title":"Applied Science"},{"key":"10.1016\/j.cbpc.2020.108910_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/gep.2017.513001","article-title":"Guarapiranga reservoir-pharmaceuticals and historical urban occupation in a water source","volume":"5","author":"Shihomatsu","year":"2017","journal-title":"Journal of Geoscience and Environmental Protection"},{"key":"10.1016\/j.cbpc.2020.108910_bb0305","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"Single technique for quantification of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cbpc.2020.108910_bb0310","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jhazmat.2018.04.043","article-title":"Occurrence, control and fate of contaminants of emerging concern in environmental compartments in Brazil","volume":"372","author":"Starling","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2020.108910_bb0315","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.etap.2012.09.011","article-title":"The effects of diclofenac on early life stages of common carp (Cyprinus carpio)","volume":"35","author":"Stepanova","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbpc.2020.108910_bb0320","first-page":"80","article-title":"Contaminantes emergentes en \u00e1guas: metabolitos de f\u00e1rmacos","volume":"10","author":"Tejada","year":"2014","journal-title":"Una revisi\u00f3n. Revista Facultad de Ciencias Basicas"},{"key":"10.1016\/j.cbpc.2020.108910_bb0325","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.ecoenv.2017.09.056","article-title":"Environmental pollution affects molecular and biochemical responses during gonadal maturation of Astyanax fasciatus (Teleostei: Characiformes: Characidae)","volume":"147","author":"Tolussi","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2020.108910_bb0335","first-page":"862","article-title":"Fish embryotoxicity of carbamazepine, diclofenac and metoprolol","volume":"73","author":"Van der Brandohf","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2020.108910_bb0340","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1007\/s00216-012-6139-8","article-title":"Analysis of selected pharmaceuticals in fish and the freshwater bodies directly affected by reclaimed water using liquid chromatography-tandem mass spectrometry","volume":"404","author":"Wang","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"10.1016\/j.cbpc.2020.108910_bb0345","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3390\/ijms18010138","article-title":"Zinc as a signal to stimulate red blood cell formation in fish","volume":"18","author":"Yen-Hua","year":"2017","journal-title":"International Journal of Molecular Science"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045620302106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045620302106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:27:33Z","timestamp":1761517653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045620302106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":67,"alternative-id":["S1532045620302106"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2020.108910","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diclofenac and caffeine inhibit hepatic antioxidant enzymes in the freshwater fish Astyanax altiparanae (Teleostei: Characiformes)","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2020.108910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108910"}}