{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:46:31Z","timestamp":1790628391840,"version":"4.1.0"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.cbpc.2021.109034","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T04:22:38Z","timestamp":1616473358000},"page":"109034","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["A symphony of destruction: Dynamic differential fibrinogenolytic toxicity by rattlesnake (Crotalus and Sistrurus) venoms"],"prefix":"10.1016","volume":"245","author":[{"given":"Lorenzo","family":"Seneci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina N.","family":"Zdenek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachlan A.","family":"Bourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chip","family":"Cochran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elda E.","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Neri-Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisa","family":"B\u00e9nard-Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Alag\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan G.","family":"Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2021.109034_bb0005","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ympev.2016.07.029","article-title":"Diversification in vipers: phylogenetic relationships, time of divergence and shifts in speciation rates","volume":"105","author":"Alencar","year":"2016","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.cbpc.2021.109034_bb0010","first-page":"1","article-title":"Evolutionary history of vipers","author":"Alencar","year":"2018","journal-title":"ELS"},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1655\/HERPMONOGRAPHS-D-11-00012.1","article-title":"Phylogeography of northern populations of the black-tailed rattlesnake (Crotalus molossus Baird and Girard, 1853), with the revalidation of C. ornatus Hallowell, 1854","volume":"26","author":"Anderson","year":"2012","journal-title":"Herpetol. Monogr."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0020","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/mpev.2001.1013","article-title":"Molecular systematics of the western rattlesnake, Crotalus viridis (Viperidae), with comments on the utility of the D-loop in phylogenetic studies of snakes","volume":"21","author":"Ashton","year":"2001","journal-title":"Mol. Phylogenet. Evol."},{"issue":"1666","key":"10.1016\/j.cbpc.2021.109034_bb0025","first-page":"2443","article-title":"Coevolution of diet and prey-specific venom activity supports the role of selection in snake venom evolution","volume":"276","author":"Barlow","year":"2009","journal-title":"Proc. Biol. Sci. B: Biological Sciences"},{"key":"10.1016\/j.cbpc.2021.109034_bb0030","series-title":"The Biology of Rattlesnakes","first-page":"5","article-title":"Rattlesnakes: research trends and annotated checklist","author":"Beaman","year":"2008"},{"key":"10.1016\/j.cbpc.2021.109034_bb0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ympev.2015.12.020","article-title":"Diversity-dependent cladogenesis throughout western Mexico: evolutionary biogeography of rattlesnakes (Viperidae: Crotalinae: Crotalus and Sistrurus)","volume":"97","author":"Blair","year":"2016","journal-title":"Mol. Phylogenet. Evol."},{"issue":"3","key":"10.1016\/j.cbpc.2021.109034_bb0040","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0041-0101(73)90059-7","article-title":"L-amino acid oxidase, phosphodiesterase, total protein and other properties of juvenile timber rattlesnake (C. h. horridus) venom at different stages of growth","volume":"11","author":"Bonilla","year":"1973","journal-title":"Toxicon"},{"issue":"2\u20138","key":"10.1016\/j.cbpc.2021.109034_bb0045","article-title":"Trimeresurus albolabris snakebite treatment implications arising from ontogenetic venom comparisons of anticoagulant function, and antivenom efficacy","volume":"327","author":"Bourke","year":"2020","journal-title":"Toxicol. Lett."},{"issue":"12","key":"10.1016\/j.cbpc.2021.109034_bb0050","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1111\/j.1365-2699.2011.02565.x","article-title":"Ephemeral Pleistocene woodlands connect the dots for highland rattlesnakes of the Crotalus intermedius group","volume":"38","author":"Bryson","year":"2011","journal-title":"J. Biogeogr."},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0055","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2699.2010.02431.x","article-title":"Evolutionary drivers of phylogeographical diversity in the highlands of Mexico: A case study of the Crotalus triseriatus species group of montane rattlesnakes","volume":"38","author":"Bryson","year":"2011","journal-title":"J. Biogeogr."},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb0060","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/pr9008749","article-title":"Snake venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America","volume":"9","author":"Calvete","year":"2010","journal-title":"J. Proteome Res."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0065","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1021\/pr201021d","article-title":"Snake venomics of Crotalus tigris: the minimalist toxin arsenal of the deadliest neartic rattlesnake venom","volume":"11","author":"Calvete","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbpc.2021.109034_bb0070","series-title":"The Venomous Reptiles of the Western Hemisphere","author":"Campbell","year":"2005"},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0075","doi-asserted-by":"crossref","first-page":"451","DOI":"10.11646\/zootaxa.4729.4.1","article-title":"Accessing cryptic diversity in Neotropical rattlesnakes (Serpentes: Viperidae: Crotalus) with the description of two new species","volume":"4729","author":"Carbajal-M\u00e1rquez","year":"2020","journal-title":"Zootaxa"},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0080","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tree.2012.10.020","article-title":"Complex cocktails: the evolutionary novelty of venoms","volume":"28","author":"Casewell","year":"2013","journal-title":"Trends Ecol. Evol."},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb0085","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1365-2699.2008.01991.x","article-title":"Comparative phylogeography of pit-vipers suggests a consensus of ancient Middle American highland biogeography","volume":"36","author":"Castoe","year":"2009","journal-title":"J. Biogeogr."},{"issue":"6","key":"10.1016\/j.cbpc.2021.109034_bb1005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005662","article-title":"Incidence and mortality due to snakebite in the Americas","volume":"11","author":"Chippaux","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"11","key":"10.1016\/j.cbpc.2021.109034_bb0090","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0041-0101(91)90116-9","article-title":"Snake venom variability: methods of study","volume":"29","author":"Chippaux","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109034_bb2010","first-page":"53","article-title":"Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (Pseudonaja)","volume":"197","author":"Cipriani","year":"2017","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2021.109034_bb0095","series-title":"Rattlesnakes of Arizona","first-page":"93","article-title":"The hunting and feeding behavior of wild rattlesnakes","author":"Clark","year":"2016"},{"issue":"6565","key":"10.1016\/j.cbpc.2021.109034_bb0100","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/379537a0","article-title":"Diet and snake venom evolution","volume":"379","author":"Daltry","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2021.109034_bb0105","series-title":"Rattlesnakes of Arizona","first-page":"39","article-title":"The western rattlesnake complex: 200 years of intrigue and change","author":"Davis","year":"2016"},{"key":"10.1016\/j.cbpc.2021.109034_bb0110","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tiv.2019.03.038","article-title":"Basal but divergent: clinical implications of differential coagulotoxicity in a clade of Asian vipers","volume":"58","author":"Debono","year":"2019","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.cbpc.2021.109034_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2019.108567","article-title":"Clinical implications of coagulotoxic variations in Mamushi (Viperidae: Gloydius) snake venoms","volume":"225","author":"Debono","year":"2019","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2021.109034_bb0120","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tiv.2018.11.008","article-title":"Habu coagulotoxicity: clinical implications of the functional diversification of Protobothrops snake venoms upon blood clotting factors","volume":"55","author":"Debono","year":"2019","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.cbpc.2021.109034_bb6005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.toxlet.2019.09.003","article-title":"Clinical implications of differential antivenom efficacy in neutralising coagulotoxicity produced by venoms from species within the arboreal viperid snake genus Trimeresurus","volume":"316","author":"Debono","year":"2019","journal-title":"Toxicol. Lett."},{"issue":"6","key":"10.1016\/j.cbpc.2021.109034_bb0125","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0041-0101(72)90116-X","article-title":"Characterization of the coagulant activity of some snake venoms","volume":"10","author":"Denson","year":"1972","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109034_bb0130","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cbpc.2017.10.008","article-title":"Rattling the border wall: pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus","volume":"205","author":"Dobson","year":"2018","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2021.109034_bb3015","first-page":"62","article-title":"Rattling the border wall: pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus","volume":"205","author":"Dobson","year":"2018","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2021.109034_bb0135","series-title":"Biology of the Vipers","first-page":"11","article-title":"Phylogeography of the western rattlesnake (Crotalus viridis) complex, with emphasis on the Colorado Plateau","author":"Douglas","year":"2002"},{"issue":"11","key":"10.1016\/j.cbpc.2021.109034_bb0140","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1111\/j.1365-294X.2006.03007.x","article-title":"Evolution of rattlesnakes (Viperidae; Crotalus) in the warm deserts of western North America shaped by Neogene vicariance and Quaternary climate change","volume":"15","author":"Douglas","year":"2006","journal-title":"Mol. Ecol."},{"issue":"18","key":"10.1016\/j.cbpc.2021.109034_bb0145","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.cub.2016.07.038","article-title":"The deep origin and recent loss of venom toxin genes in rattlesnakes","volume":"26","author":"Dowell","year":"2016","journal-title":"Curr. Biol."},{"issue":"7","key":"10.1016\/j.cbpc.2021.109034_bb0150","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cub.2018.02.031","article-title":"Extremely divergent haplotypes in two toxin gene complexes encode alternative venom types within rattlesnake species","volume":"28","author":"Dowell","year":"2018","journal-title":"Curr. Biol."},{"issue":"9","key":"10.1016\/j.cbpc.2021.109034_bb0155","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1021\/acs.jproteome.7b00414","article-title":"Integrated venomics and venom gland transcriptome analysis of juvenile and adult mexican rattlesnakes Crotalus simus, C. tzabcan, and C. culminatus revealed miRNA-modulated ontogenetic shifts","volume":"16","author":"Durban","year":"2017","journal-title":"J. Proteome. Res."},{"issue":"3","key":"10.1016\/j.cbpc.2021.109034_bb0160","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1101\/gr.3228405","article-title":"From genome to \u201cvenome\u201d: molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins","volume":"15","author":"Fry","year":"2005","journal-title":"Genome Re"},{"key":"10.1016\/j.cbpc.2021.109034_bb0165","series-title":"Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery","author":"Fry","year":"2015"},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0170","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/mcp.M700094-MCP200","article-title":"Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia)","volume":"7","author":"Fry","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb0175","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.genom.9.081307.164356","article-title":"The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms","volume":"10","author":"Fry","year":"2009","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"issue":"6","key":"10.1016\/j.cbpc.2021.109034_bb0180","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.toxicon.2009.01.034","article-title":"Functional basis of a molecular adaptation: prey-specific toxic effects of venom from Sistrurus rattlesnakes","volume":"53","author":"Gibbs","year":"2009","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00239-008-9067-7","article-title":"Rapid evolution by positive selection and gene gain and loss: PLA 2 venom genes in closely related Sistrurus rattlesnakes with divergent diets","volume":"66","author":"Gibbs","year":"2008","journal-title":"J. Mol. Evol."},{"issue":"10","key":"10.1016\/j.cbpc.2021.109034_bb0190","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/j.jprot.2011.06.013","article-title":"Proteomic analysis of ontogenetic and diet-related changes in venom composition of juvenile and adult Dusky Pigmy rattlesnakes (Sistrurus miliarius barbouri)","volume":"74","author":"Gibbs","year":"2011","journal-title":"J. Proteom."},{"issue":"6","key":"10.1016\/j.cbpc.2021.109034_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067220","article-title":"Phylogeny-based comparative analysis of venom proteome variation in a clade of rattlesnakes (Sistrurus sp.)","volume":"8","author":"Gibbs","year":"2013","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.cbpc.2021.109034_bb4020","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1111\/mec.15529","article-title":"The molecular basis of venom resistance in a rattlesnake\u2010squirrel predator\u2010prey system","volume":"29","author":"Gibbs","year":"2020","journal-title":"Mol. Ecol."},{"issue":"20","key":"10.1016\/j.cbpc.2021.109034_bb0200","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1073\/pnas.1920011117","article-title":"The origin and diversification of a novel protein family in venomous snakes","volume":"117","author":"Giorgianni","year":"2020","journal-title":"P. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb0205","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0041-0101(78)90065-X","article-title":"Mojave rattlesnake Crotalus scutulatus scutulatus venom: variation in toxicity with geographical origin","volume":"16","author":"Glenn","year":"1978","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0210","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0041-0101(89)90203-1","article-title":"Intergradation of two different venom populations of the Mojave rattlesnake (Crotalus scutulatus scutulatus) in Arizona","volume":"27","author":"Glenn","year":"1989","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb5025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0041-0101(83)90055-7","article-title":"Geographical variation in Crotalus scutulatus scutulatus (Mojave rattlesnake) venom properties","volume":"21","author":"Glenn","year":"1983","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109034_bb0215","first-page":"1","article-title":"The rattlesnakes. Genera Sistrurus and Crotalus: a study in zoogeography and evolution","volume":"4","author":"Gloyd","year":"1940","journal-title":"Spec. Publ. Chicago Acad. Sci"},{"key":"10.1016\/j.cbpc.2021.109034_bb0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.toxicon.2019.09.011","article-title":"Predator-prey interactions and venom composition in a high elevation lizard specialist, Crotalus pricei (Twin-spotted Rattlesnake)","volume":"170","author":"Grabowsky","year":"2019","journal-title":"Toxicon"},{"issue":"10","key":"10.1016\/j.cbpc.2021.109034_bb0225","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0041-0101(86)90005-X","article-title":"An isoelectric focusing study of seasonal variation in rattlesnake venom proteins","volume":"24","author":"Gregory-Dwyer","year":"1986","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.cbpc.2021.109034_bb0230","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.toxicon.2005.02.029","article-title":"Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage","volume":"45","author":"Guti\u00e9rrez","year":"2005","journal-title":"Toxicon"},{"issue":"10","key":"10.1016\/j.cbpc.2021.109034_bb0235","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3390\/toxins8100304","article-title":"A comprehensive view of the structural and functional alterations of extracellular matrix by snake venom metalloproteinases (SVMPs): novel perspectives on the pathophysiology of envenoming","volume":"8","author":"Guti\u00e9rrez","year":"2016","journal-title":"Toxins"},{"issue":"7","key":"10.1016\/j.cbpc.2021.109034_bb0240","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1073\/pnas.68.7.1560","article-title":"Biological roles of the two components of crotoxin","volume":"68","author":"Hendon","year":"1971","journal-title":"P. Natl. Acad. Sci."},{"issue":"1829","key":"10.1016\/j.cbpc.2021.109034_bb0245","article-title":"Coevolution of venom function and venom resistance in a rattlesnake predator and its squirrel prey","volume":"283","author":"Holding","year":"2016","journal-title":"Proc. Biol. Sci. B: Biological Sciences"},{"issue":"10","key":"10.1016\/j.cbpc.2021.109034_bb0250","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1111\/jeb.13347","article-title":"Local prey community composition and genetic distance predict venom divergence among populations of the northern Pacific rattlesnake (Crotalus oreganus)","volume":"31","author":"Holding","year":"2018","journal-title":"J. Evol. Biol."},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0255","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1670\/0022-1511(2002)036[0589:DOCLKB]2.0.CO;2","article-title":"Diet of Crotalus lepidus klauberi (banded rock rattlesnake)","volume":"36","author":"Holycross","year":"2012","journal-title":"J. Herpetol."},{"issue":"11","key":"10.1016\/j.cbpc.2021.109034_bb0260","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/toxins8110309","article-title":"Rapid radiations and the race to redundancy: an investigation of the evolution of Australian elapid snake venoms","volume":"8","author":"Jackson","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2021.109034_bb0265","series-title":"Rattlesnakes: Their Habits, Life Histories, and Influence on Mankind","author":"Klauber","year":"1972"},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0270","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2307\/1447637","article-title":"Crotaline intergeneric relationships based on mitochondrial DNA sequence data","volume":"1996","author":"Kraus","year":"1996","journal-title":"Copeia"},{"issue":"8","key":"10.1016\/j.cbpc.2021.109034_bb0275","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1139\/z11-034","article-title":"Digestive performance in neonatal Southern Pacific rattlesnakes (Crotalus oreganus helleri)","volume":"89","author":"LaBonte","year":"2011","journal-title":"Can. J. Zool."},{"key":"10.1016\/j.cbpc.2021.109034_bb0280","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jprot.2013.10.036","article-title":"Venomics of New World pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon","volume":"96","author":"Lomonte","year":"2014","journal-title":"J. Proteome"},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0285","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/toxins12020074","article-title":"Diet breadth mediates the prey specificity of venom potency in snakes","volume":"12","author":"Lyons","year":"2020","journal-title":"Toxins"},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb0290","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2307\/1445927","article-title":"Venom ontogeny in the Pacific rattlesnakes Crotalus viridis helleri and C. v. oreganus","volume":"1988","author":"Mackessy","year":"1988","journal-title":"Copeia"},{"key":"10.1016\/j.cbpc.2021.109034_bb0295","series-title":"The Biology of Rattlesnakes","first-page":"495","article-title":"Venom composition in rattlesnakes: trends and biological significance","author":"Mackessy","year":"2008"},{"issue":"8","key":"10.1016\/j.cbpc.2021.109034_bb0300","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.toxicon.2010.02.028","article-title":"Evolutionary trends in venom composition in the Western Rattlesnakes (Crotalus viridis sensu lato): toxicity vs. tenderizers","volume":"55","author":"Mackessy","year":"2010","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0305","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1643\/HA03-037.1","article-title":"Ontogenetic variation in venom composition and diet of Crotalus oreganus concolor: a case of venom paedomorphosis?","volume":"2003","author":"Mackessy","year":"2003","journal-title":"Copeia"},{"issue":"3","key":"10.1016\/j.cbpc.2021.109034_bb0310","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1534\/genetics.117.202655","article-title":"Selection to increase expression, not sequence diversity, precedes gene family origin and expansion in rattlesnake venom","volume":"206","author":"Margres","year":"2017","journal-title":"Genetics"},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0315","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2014634118","article-title":"The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype","volume":"118","author":"Margres","year":"2021","journal-title":"Proc. Nat. Acad. Sci."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0320","first-page":"119","article-title":"Rattlesnake venom enzymes that interact with components of the hemostatic system","volume":"2","author":"Markland","year":"1983","journal-title":"Toxin Rev."},{"key":"10.1016\/j.cbpc.2021.109034_bb0325","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxicon.2013.05.006","article-title":"Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico","volume":"71","author":"Mart\u00ednez-Romero","year":"2013","journal-title":"Toxicon"},{"issue":"9","key":"10.1016\/j.cbpc.2021.109034_bb0330","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.jprot.2012.02.035","article-title":"Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from Southern Arizona","volume":"75","author":"Massey","year":"2012","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2021.109034_bb0335","series-title":"Rattlesnakes of Arizona","first-page":"277","article-title":"Structure, ontogeny, and evolutionary development of the rattlesnake rattle","author":"Meik","year":"2016"},{"issue":"10220","key":"10.1016\/j.cbpc.2021.109034_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(19)32510-3","article-title":"Focus on snake ecology to fight snakebite","volume":"395","author":"Murray","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0345","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/jbi.12873","article-title":"Asynchronous diversification of snakes in the North American warm deserts","volume":"44","author":"Myers","year":"2017","journal-title":"J. Biogeogr."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0350","doi-asserted-by":"crossref","first-page":"100007","DOI":"10.1016\/j.toxcx.2019.100007","article-title":"Detection and quantification of a \u03b2-neurotoxin (crotoxin homologs) in the venom of the rattlesnakes Crotalus simus, C. culminatus and C. tzabcan from Mexico","volume":"X","author":"Neri-Castro","year":"2019","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109034_bb6030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.22201\/fc.25942158e.2020.2.205","article-title":"Serpientes venenosas en M\u00e9xico: revisi\u00f3n al estudio de los venenos, los antivenenos y la epidemiolog\u00eda","volume":"3","author":"Neri-Castro","year":"2020","journal-title":"Revista Latinoamericana Herpetol."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins11020094","article-title":"De novo assessment and review of pan-American pit viper anticoagulant and procoagulant venom activities via kinetomic analyses","volume":"11","author":"Nielsen","year":"2019","journal-title":"Toxins"},{"issue":"3","key":"10.1016\/j.cbpc.2021.109034_bb0360","doi-asserted-by":"crossref","first-page":"576","DOI":"10.2307\/1447591","article-title":"Molecular systematics and biogeographical history of pit-vipers as determined by mitochondrial ribosomal DNA sequences","volume":"1999","author":"Parkinson","year":"1999","journal-title":"Copeia"},{"key":"10.1016\/j.cbpc.2021.109034_bb0365","series-title":"Biology of the Vipers","first-page":"93","article-title":"Multigene phylogenetic analysis of pit-vipers, with comments on their biogeography","author":"Parkinson","year":"2002"},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb0370","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1670\/103-03N","article-title":"A quantitative analysis of the ancestral area of rattlesnakes","volume":"38","author":"Place","year":"2004","journal-title":"J. Herpetol."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0375","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/mpev.1999.0756","article-title":"Historical biogeography of the Western Rattlesnake (Serpentes: Viperidae: Crotalus viridis), inferred from mitochondrial DNA sequence information","volume":"15","author":"Pook","year":"2000","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.cbpc.2021.109034_bb0380","series-title":"Rattlesnakes of Arizona","first-page":"21","article-title":"Art and rattlesnakes: introduction to rattlesnakes in art","author":"Reiserer","year":"2016"},{"key":"10.1016\/j.cbpc.2021.109034_bb0385","series-title":"Rattlesnakes of Arizona","first-page":"245","article-title":"The origin and evolution of the rattlesnake rattle: misdirection, clarification, theory, and progress","author":"Reiserer","year":"2016"},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb7035","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.2041-210X.2011.00169.x","article-title":"phytools: an R package for phylogenetic comparative biology (and other things)","volume":"3","author":"Revell","year":"2012","journal-title":"Methods Ecol. Evol."},{"issue":"5","key":"10.1016\/j.cbpc.2021.109034_bb0395","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.toxicon.2011.01.008","article-title":"A high-throughput venom-gland transcriptome for the Eastern Diamondback Rattlesnake (Crotalus adamanteus) and evidence for pervasive positive selection across toxin classes","volume":"57","author":"Rokyta","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109034_bb0400","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.toxicon.2015.02.015","article-title":"The transcriptomic and proteomic basis for the evolution of a novel venom phenotype within the Timber Rattlesnake (Crotalus horridus)","volume":"98","author":"Rokyta","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109034_bb6000","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s13181-017-0633-5","article-title":"The epidemiology, clinical course, and management of snakebites in the North American Snakebite Registry","volume":"13","author":"Ruha","year":"2017","journal-title":"J. Med. Toxicol."},{"issue":"9","key":"10.1016\/j.cbpc.2021.109034_bb0405","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1021\/pr0602500","article-title":"Venom proteomes of closely related Sistrurus rattlesnakes with divergent diets","volume":"5","author":"Sanz","year":"2006","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb8040","first-page":"337","article-title":"Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: pathophysiological and therapeutic implications","volume":"50","author":"Saravia","year":"2002","journal-title":"Rev. Biol. Trop."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0410","first-page":"249","article-title":"Diet and snake venom evolution: can local selection alone explain intraspecific venom variation?","volume":"37","author":"Sasa","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109034_bb0415","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jprot.2015.03.015","article-title":"Comparative venomics of the Prairie Rattlesnake (Crotalus viridis viridis) from Colorado: identification of a novel pattern of ontogenetic changes in venom composition and assessment of the immunoreactivity of the commercial antivenom CroFab\u00ae","volume":"121","author":"Saviola","year":"2015","journal-title":"J. Proteomics"},{"key":"10.1016\/j.cbpc.2021.109034_bb0420","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.toxicon.2017.08.016","article-title":"Venom phenotypes of the Rock Rattlesnake (Crotalus lepidus) and the Ridge-nosed Rattlesnake (Crotalus willardi) from M\u00e9xico and the United States","volume":"138","author":"Saviola","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109034_bb0425","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ympev.2014.12.006","article-title":"Incipient speciation with biased gene flow between two lineages of the Western Diamondback Rattlesnake (Crotalus atrox)","volume":"83","author":"Schield","year":"2015","journal-title":"Mol. Phylogenet. Evol."},{"issue":"11","key":"10.1016\/j.cbpc.2021.109034_bb0430","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1002\/ece3.2996","article-title":"Insight into the roles of selection in speciation from genomic patterns of divergence and introgression in secondary contact in venomous rattlesnakes","volume":"7","author":"Schield","year":"2017","journal-title":"Ecol. Evol."},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0435","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1101\/gr.240952.118","article-title":"The origins and evolution of chromosomes, dosage compensation, and mechanisms underlying venom regulation in snakes","volume":"29","author":"Schield","year":"2019","journal-title":"Genome Res."},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb0440","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/biolinnean\/blz077","article-title":"Allopatric divergence and secondary contact with gene flow: a recurring theme in rattlesnake speciation","volume":"128","author":"Schield","year":"2019","journal-title":"Biol. J. Linn. Soc."},{"key":"10.1016\/j.cbpc.2021.109034_bb0445","series-title":"Rattlesnakes of Arizona","first-page":"161","article-title":"Social behavior of rattlesnakes: a shifting paradigm","author":"Schuett","year":"2016"},{"key":"10.1016\/j.cbpc.2021.109034_bb0450","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.612846","article-title":"A clot twist: extreme variations in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms","volume":"12","author":"Seneci","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbpc.2021.109034_bb0455","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1670\/10-127.1","article-title":"Rattle button loss in juvenile Ridge-nosed Rattlesnakes (Crotalus willardi): a novel mechanism for the developmental delay of the rattle","volume":"45","author":"Setser","year":"2011","journal-title":"J. Herpetol."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0460","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1098\/rsbl.2018.0876","article-title":"High levels of functional divergence in toxicity towards prey among the venoms of individual pigmy rattlesnakes","volume":"15","author":"Smiley-Walters","year":"2019","journal-title":"Biol. Lett."},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0465","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/toxins10040135","article-title":"Phenotypic variation in Mojave rattlesnake (Crotalus scutulatus) venom is driven by four toxin families","volume":"10","author":"Strickland","year":"2018","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2021.109034_bb0470","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jprot.2014.01.013","article-title":"Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications","volume":"99","author":"Sunagar","year":"2014","journal-title":"J. Proteome"},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb0480","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.toxicon.2010.05.012","article-title":"Comparative study of anticoagulant and procoagulant properties of 28 snake venoms from families Elapidae, Viperidae, and purified Russell\u2019s viper venom-factor X activator (RVV-X)","volume":"56","author":"Suntravat","year":"2010","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.cbpc.2021.109034_bb0485","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0041-0101(79)90211-3","article-title":"The effect of rattlesnake venom on digestion of prey","volume":"17","author":"Thomas","year":"1979","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.cbpc.2021.109034_bb9050","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/molbev\/msx334","article-title":"A single mutation unlocks cascading exaptations in the origin of a potent pitviper neurotoxin","volume":"35","author":"Whittington","year":"2018","journal-title":"Mol. Biol. Evol."},{"issue":"1","key":"10.1016\/j.cbpc.2021.109034_bb0490","doi-asserted-by":"crossref","first-page":"129","DOI":"10.11646\/zootaxa.4683.1.7","article-title":"Geographic variation in morphology in the Mohave Rattlesnake (Crotalus scutulatus Kennicott 1861) (Serpentes: Viperidae): implications for species boundaries","volume":"4683","author":"Watson","year":"2019","journal-title":"Zootaxa"},{"issue":"5","key":"10.1016\/j.cbpc.2021.109034_bb0495","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0041-0101(85)90014-5","article-title":"The distribution among ophidian venoms of a toxin isolated from the venom of the Mojave rattlesnake (Crotalus scutulatus scutulatus)","volume":"23","author":"Weinstein","year":"1985","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109034_bb0500","series-title":"Rattlesnakes of Arizona","article-title":"Recent developments in rattlesnake phylogenetics, phylogeography and species delimitation models","author":"W\u00fcster","year":"2016"},{"issue":"2","key":"10.1016\/j.cbpc.2021.109034_bb0510","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ympev.2008.08.019","article-title":"A nesting of vipers: phylogeny and historical biogeography of the Viperidae (Squamata: Serpentes)","volume":"49","author":"W\u00fcster","year":"2008","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.cbpc.2021.109034_bb0515","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jprot.2014.09.009","article-title":"Structures and functions of crotoxin-like heterodimers and acidic phospholipases A2 from Gloydius intermedius venom: insights into the origin of neurotoxic-type rattlesnakes","volume":"112","author":"Yang","year":"2015","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2021.109034_bb5055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jprot.2017.05.024","article-title":"Serine protease isoforms in Gloydius intermedius venom: full sequences, molecular phylogeny and evolutionary implications","volume":"164","author":"Yang","year":"2017","journal-title":"J. Proteome"},{"issue":"7","key":"10.1016\/j.cbpc.2021.109034_bb0520","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3390\/toxins11070422","article-title":"Venomous landmines: clinical implications of extreme coagulotoxic diversification and differential neutralization by antivenom of venoms within the viperid snake genus Bitis","volume":"11","author":"Youngman","year":"2019","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.cbpc.2021.109034_bb0525","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/toxins8060188","article-title":"Is hybridization a source of adaptive venom variation in rattlesnakes? A test, using a Crotalus scutulatus \u00d7 viridis hybrid zone in Southwestern New Mexico","volume":"8","author":"Zancolli","year":"2016","journal-title":"Toxins"},{"issue":"1898","key":"10.1016\/j.cbpc.2021.109034_bb0530","first-page":"20182735","article-title":"When one phenotype is not enough: divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species","volume":"286","author":"Zancolli","year":"2019","journal-title":"Proc. Biol. Sci. B: Biological Sciences"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045621000612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045621000612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:26:53Z","timestamp":1761517613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045621000612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":115,"alternative-id":["S1532045621000612"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2021.109034","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A symphony of destruction: Dynamic differential fibrinogenolytic toxicity by rattlesnake (Crotalus and Sistrurus) venoms","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2021.109034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109034"}}