{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:43:11Z","timestamp":1777509791383,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["201701070002E00037"],"award-info":[{"award-number":["201701070002E00037"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.cbpc.2021.109130","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T13:47:49Z","timestamp":1625752069000},"page":"109130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Avermectin induces toxic effects in insect nontarget cells involves DNA damage and its associated programmed cell death"],"prefix":"10.1016","volume":"249","author":[{"given":"Meng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2021.109130_bb0005","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0962-8924(00)88932-1","article-title":"The role of DNA fragmentation in apoptosis","volume":"5","author":"Bortner","year":"1995","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cbpc.2021.109130_bb0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41392-018-0018-5","article-title":"The independence of and associations among apoptosis, autophagy, and necrosis","volume":"3","author":"Chen","year":"2018","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cbpc.2021.109130_bb0015","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/his.12002","article-title":"Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer","volume":"62","author":"Choi","year":"2013","journal-title":"Histopathology"},{"key":"10.1016\/j.cbpc.2021.109130_bb0020","doi-asserted-by":"crossref","first-page":"41394","DOI":"10.1074\/jbc.M106417200","article-title":"Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells","volume":"276","author":"Christiane","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2021.109130_bb0025","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41418-018-0252-y","article-title":"Autophagy-dependent cell death","volume":"26","author":"Denton","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cbpc.2021.109130_bb0035","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.fct.2012.12.020","article-title":"Carbamate insecticide methomyl confers cytotoxicity through DNA damage induction","volume":"53","author":"Guanggang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109130_bb0040","doi-asserted-by":"crossref","first-page":"11364","DOI":"10.1021\/acs.jafc.9b04679","article-title":"Roundup-induced AMPK\/mTOR-mediated autophagy in human A549 cells","volume":"67","author":"Hao","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbpc.2021.109130_bb0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0027-5107(01)00111-7","article-title":"Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death","volume":"477","author":"Herceg","year":"2001","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"10.1016\/j.cbpc.2021.109130_bb0050","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1080\/15548627.2015.1038016","article-title":"Identifying an essential role of nuclear LC3 for autophagy","volume":"11","author":"Huang","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.cbpc.2021.109130_bb0055","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mito.2006.11.026","article-title":"Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage","volume":"7","author":"Indo","year":"2006","journal-title":"Mitochondrion"},{"key":"10.1016\/j.cbpc.2021.109130_bb0060","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/02656736.2019.1600052","article-title":"Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma","volume":"36","author":"Jiang","year":"2019","journal-title":"Int. J. Hyperth."},{"key":"10.1016\/j.cbpc.2021.109130_bb0065","article-title":"Investigating mitochondrial autophagy by routine transmission electron microscopy: seeing is believing?","volume":"160","author":"Joy","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cbpc.2021.109130_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cbpc.2021.109130_bb0075","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0092-8674(00)80849-1","article-title":"Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis","volume":"101","author":"Li","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.cbpc.2021.109130_bb0080","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.chemosphere.2015.05.024","article-title":"The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis","volume":"135","author":"Li","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2021.109130_bb0085","series-title":"DNA, Genomes and Genetic Variation","author":"Linacre","year":"2013"},{"key":"10.1016\/j.cbpc.2021.109130_bb0090","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2021.109130_bb0095","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.aquatox.2017.02.001","article-title":"Toxicity of abamectin and difenoconazole mixtures to a Neotropical cladoceran after simulated run-off and spray drift exposure","volume":"185","author":"Moreira","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109130_bb0100","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4161\/cbt.22954","article-title":"Prognostic impact of beclin 1, p62\/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy","volume":"14","author":"Myung Park","year":"2013","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.cbpc.2021.109130_bb0105","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/jfd.12980","article-title":"Avermectins, praziquantel and levamisole have in vitro efficacy against Neoechinorhynchus buttnerae (Neoechinorhynchidae) in Colossoma macropomum : a serrasalmidae from the Amazon","volume":"42","author":"Oliveira","year":"2019","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.cbpc.2021.109130_bb0110","article-title":"Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage","volume":"7","author":"P","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.cbpc.2021.109130_bb0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pestbp.2019.03.025","article-title":"Neochamaejasmin a extracted from stellera chamaejasme L. induces apoptosis involving mitochondrial dysfunction and oxidative stress in Sf9 cells","volume":"157","author":"Ren","year":"2019","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.cbpc.2021.109130_bb0120","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.freeradbiomed.2008.07.018","article-title":"DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae","volume":"45","author":"Rowe","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbpc.2021.109130_bb0125","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1007\/s10753-019-01027-9","article-title":"Alpha7 nicotinic acetylcholine receptor alleviates inflammatory bowel disease through induction of AMPK-mTOR-p70S6K-mediated autophagy","volume":"42","author":"Shao","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.cbpc.2021.109130_bb0130","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nature04869","article-title":"Ras, PI(3)K and mTOR signalling controls tumour cell growth","volume":"441","author":"Shaw","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2021.109130_bb0135","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pestbp.2011.08.011","article-title":"Genotoxicity evaluation of low doses of avermectin to hemocytes of silkworm ( Bombyx mori ) and response of gene expression to DNA damage","volume":"101","author":"Shen","year":"2011","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.cbpc.2021.109130_bb0140","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41392-020-00281-w","article-title":"Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK\/mTOR signaling","volume":"5","author":"Sun","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cbpc.2021.109130_bb0145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.cbpc.2021.109130_bb0150","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrm2312","article-title":"Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9: 231\u2013241","volume":"9","author":"Taylor","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cbpc.2021.109130_bb0155","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cropro.2011.12.007","article-title":"Susceptibility of adult trichogramma nubilale (Hymenoptera: Trichogrammatidae) to selected insecticides with different modes of action","volume":"34","author":"Wang","year":"2012","journal-title":"Crop Prot."},{"key":"10.1016\/j.cbpc.2021.109130_bb0160","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1080\/15548627.2017.1287657","article-title":"Autophagosome formation: where the secretory and autophagy pathways meet","volume":"13","author":"Wang","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.cbpc.2021.109130_bb0165","first-page":"52","article-title":"Spinosad induces autophagy of Spodoptera frugiperda Sf9 cells and the activation of AMPK\/mTOR signaling pathway","volume":"195","author":"Yang","year":"2017","journal-title":"Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2021.109130_bb0170","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15548627.2019.1606647","article-title":"MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint","volume":"16","author":"Yang","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.cbpc.2021.109130_bb0175","article-title":"iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer","volume":"8","author":"Yijun","year":"2017","journal-title":"Cell Death Dis."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045621001575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045621001575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:28:40Z","timestamp":1761517720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045621001575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":34,"alternative-id":["S1532045621001575"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2021.109130","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Avermectin induces toxic effects in insect nontarget cells involves DNA damage and its associated programmed cell death","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2021.109130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109130"}}