{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:41:52Z","timestamp":1785778912531,"version":"3.56.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/24033-3"],"award-info":[{"award-number":["2016\/24033-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2015\/17329-0"],"award-info":[{"award-number":["2015\/17329-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307390\/2017-9"],"award-info":[{"award-number":["307390\/2017-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309361\/2019-2"],"award-info":[{"award-number":["309361\/2019-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["409187\/2016-0"],"award-info":[{"award-number":["409187\/2016-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.cbpc.2021.109198","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T14:47:07Z","timestamp":1633013227000},"page":"109198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Environmentally realistic concentrations of cocaine in seawater disturbed neuroendrocrine parameters and energy status in the marine mussel Perna perna"],"prefix":"10.1016","volume":"251","author":[{"given":"Mayana Karoline","family":"Fontes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Leocadio Rosa","family":"Dourado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Galv\u00e3o de","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane Alves","family":"Maranho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Alves de","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis Moledo de Souza","family":"Abessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo Dias Seabra","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2021.109198_bb0005","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0025-326X(03)00256-X","article-title":"Effects of trace metal and exposure to air on serotonin and dopamine levels in tissues of the mussel Perna perna","volume":"46","author":"Almeida","year":"2003","journal-title":"Mar. Pollut. Bull."},{"issue":"5","key":"10.1016\/j.cbpc.2021.109198_bb0015","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.3390\/ijms21051649","article-title":"Serotonin in animal cognition and behavior","volume":"21","author":"Bacqu\u00e9-Cazenave","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.cbpc.2021.109198_bb0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.marpolbul.2013.10.050","article-title":"Physiological disturbance of the Manila clam, Ruditapes philippinarum, by altered environmental conditions in a tidal flat on the west coast Korea","volume":"78","author":"Baek","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpc.2021.109198_bb0030","series-title":"Disposition of Toxic Drugs and Chemicals in Man","author":"Baselt","year":"2004"},{"key":"10.1016\/j.cbpc.2021.109198_bb0035","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/BF00350681","article-title":"Effect of the neurotransmitters dopamine, serotonin, and norepinephrine oh the ciliary activity of mussel (Mytilus edulis) larvae","volume":"122","author":"Beiras","year":"1995","journal-title":"Mar. Biol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0040","article-title":"Integrated biomarker response: a useful tool for ecology risk assessment","volume":"1316-1322","author":"Beliaeff","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.cbpc.2021.109198_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2019.00820","article-title":"New challenges in marine pollution monitoring","author":"Bellas","year":"2020","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.cbpc.2021.109198_bb0050","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.marenvres.2017.07.024","article-title":"Blue mussels (Mytilus edulis spp.) as sentinel organisms, in coastal pollution monitoring: a review","volume":"130","author":"Beyer","year":"2017","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.cbpc.2021.109198_bb0055","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.chemosphere.2011.10.056","article-title":"Illicit drugs as new environmental pollutants: cyto-genotoxic effects of cocaine on the biological model Dreissena polymorpha","volume":"86","author":"Binelli","year":"2012","journal-title":"Chemosphere."},{"key":"10.1016\/j.cbpc.2021.109198_bb0065","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.scitotenv.2016.10.089","article-title":"Occurrence of cocaine and benzoylecgonine in drinking and source water in the S\u00e3o Paulo State region, Brazil","volume":"576","author":"Campestrini","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109198_bb0070","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s11270-011-1010-7","article-title":"Presence of cocaine in the tissues of the European eel, Anguilla anguilla, exposed to environmental cocaine concentrations","volume":"223","author":"Capaldo","year":"2012","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.cbpc.2021.109198_bb0075","doi-asserted-by":"crossref","unstructured":"Copeman, L.A., Parrish, C.C., Brown, J.A., Harelm, M. 2002. Effects of docosahexaenoic, eicosapentaenoic, and arachidonic acids on the early growth, survival, lipid composition and pigmentation of yellowtail flounder (Limanda ferruginea): a live food enrichment experiment. Aquac. 210, 285\u2013304. http:\/\/ doi:https:\/\/doi.org\/10.1016\/S0044-8486(01)00849-3.","DOI":"10.1016\/S0044-8486(01)00849-3"},{"issue":"7","key":"10.1016\/j.cbpc.2021.109198_bb0080","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3390\/md17070428","article-title":"Prostaglandins in marine organisms: a review","volume":"17","author":"Costanzo","year":"2019","journal-title":"Marine Drugs."},{"key":"10.1016\/j.cbpc.2021.109198_bb0090","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.aquatox.2010.02.007","article-title":"Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis)","volume":"98","author":"Cubero-Leon","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0095","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.lfs.2013.04.016","article-title":"Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria","volume":"92","author":"Cunha-Oliveira","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.cbpc.2021.109198_bb0100","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.toxlet.2013.03.025","article-title":"Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria","volume":"219","author":"Cunha-Oliveira","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbpc.2021.109198_bb0105","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jpba.2014.05.039","article-title":"A rapid and simple method for the determination of 3,4-dihydroxyphenylacetic acid, norepinephrine, dopamine, and serotonin inmouse brain homogenate by HPLC with fluorimetric detection","volume":"98","author":"De Benedetto","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.cbpc.2021.109198_bb0110","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1006\/dbio.1995.1298","article-title":"Serotonin-induced meiosis reinitiation from the first prophase and from the first metaphase in oocytes of the marine bivalve Hiatella flaccida: respective changes in intracellular Ca2\u00fe and pH","volume":"171","author":"Deguchi","year":"1995","journal-title":"Dev. Biol."},{"issue":"11","key":"10.1016\/j.cbpc.2021.109198_bb0115","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0024-3205(97)00013-1","article-title":"Impairment of mithocondrial respiration and electron transport chain enzymes during cocaine- induced hepatic injury","volume":"60","author":"Devi","year":"1997","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109198_bb0125","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.marpolbul.2013.06.041","article-title":"Occurrence of contaminants of emerging concern in mussels (Mytillus spp) along the California coast and the influence of land, storm water discharge, and treated wastewater effluent","volume":"81","author":"Dodder","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpc.2021.109198_bb0130","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.fsi.2017.01.043","article-title":"The modulation of serotonin in Pacific oyster Crassostrea gigas in response to air exposure","volume":"62","author":"Dong","year":"2017","journal-title":"Fish and Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0135","series-title":"NIDA- National Institute on Drug Abuse. 1988. Research Monographies Series: Mechanisms of Cocaine Abuse and Toxicity","author":"Dunwiddie","year":"1988"},{"issue":"2","key":"10.1016\/j.cbpc.2021.109198_bb0140","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbpc.2021.109198_bb0145","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer\u2019s disease: targeting the cholinergic system","volume":"14","author":"Ferreira-Vieira","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0150","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pnpbp.2016.02.012","article-title":"Drugs related to monoamine oxidase activity","volume":"69","author":"Fi\u0161ar","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.cbpc.2021.109198_bb0160","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1017\/S0025315415000326","article-title":"Lipid composition modifications in the blue mussels (Mytilus edulis L.) from the White Sea","volume":"95","author":"Fokina","year":"2015","journal-title":"J. Marine Biolog. Assoc. of the UK"},{"key":"10.1016\/j.cbpc.2021.109198_bb0165","doi-asserted-by":"crossref","first-page":"110545","DOI":"10.1016\/j.marpolbul.2019.110545","article-title":"Seasonal monitoring of cocaine and benzoylecgonine in a subtropical coastal zone (Santos Bay, Brazil)","volume":"149","author":"Fontes","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpc.2021.109198_bb0170","doi-asserted-by":"crossref","first-page":"30998","DOI":"10.1007\/s11356-020-08375-2","article-title":"Review on the occurrence and biological effects of illicit drugs in aquatic ecosystems","volume":"27","author":"Fontes","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.cbpc.2021.109198_bb0175","doi-asserted-by":"crossref","first-page":"143808","DOI":"10.1016\/j.scitotenv.2020.143808","article-title":"Mussels get higher: a study on the occurrence of cocaine and benzoylecgonine in seawater, sediment and mussels from a subtropical ecosystem (Santos Bay, Brazil)","volume":"757","author":"Fontes","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109198_bb0180","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/clinchem\/18.7.673","article-title":"Improved determination of total serum lipids by the sulfo-phospovanilin reaction reaction","volume":"18","author":"Frings","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cbpc.2021.109198_bb0185","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/S0024-3205(01)01538-7","article-title":"The endocrine disruptor nonylphenol preferencially blocks cyclooxygenase-1","volume":"70","author":"Fujimoto","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.cbpc.2021.109198_bb0190","first-page":"117","article-title":"Effects of municipal effects on serotonin and dopamine levels in the freshwater mussel Ellipio complanata","volume":"136","author":"Gagn\u00e9","year":"2003","journal-title":"Comp. Biochem. Phsysiol. Part C."},{"key":"10.1016\/j.cbpc.2021.109198_bb0195","first-page":"542","article-title":"Toxicological effects of primary-treated urban wastewaters, before and after ozone treatment, on freshwater mussels (Elliptio complanata)","volume":"145","author":"Gagn\u00e9","year":"2007","journal-title":"Comp. Biochem. Physiol. Part C"},{"key":"10.1016\/j.cbpc.2021.109198_bb0205","first-page":"207","article-title":"Neurochemical effects of benzodiazepine and morphine on freshwater mussels","volume":"152","author":"Gagn\u00e9","year":"2010","journal-title":"Comp. Biochem. Physiol, Parc C."},{"key":"10.1016\/j.cbpc.2021.109198_bb0210","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1016\/j.scitotenv.2011.04.037","article-title":"Evidence of neuroendocrine disruption in freshwater mussels exposed to municipal wastewaters","volume":"409","author":"Gagn\u00e9","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109198_bb0215","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ygcen.2006.06.008","article-title":"Immunohistochemical localization of serotonin (5- hydroxytryptamine) in the gonad and digestive gland Mya arenaria (Mollusca: bivalvia)","volume":"149","author":"Garnero","year":"2006","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0220","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1016\/j.watres.2011.07.020","article-title":"Temporal variability of pharmaceuticals and illicit drugs wastewater and the effects of a major sporting event","volume":"45","author":"Gerrity","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.cbpc.2021.109198_bb0225","first-page":"2","article-title":"Lipid droplets in health and disease","volume":"16","author":"Gizem","year":"2017","journal-title":"BMC."},{"issue":"3","key":"10.1016\/j.cbpc.2021.109198_bb0235","first-page":"259","article-title":"Administration of purified human plasma cholinesterase protects against cocaine toxicity in mice","volume":"34","author":"Hoffman","year":"2008","journal-title":"J. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0240","article-title":"Molluscan bivalve settlement and metamorphosis: neuroendocrine inducersand morphogenetic responses","volume":"64-82","author":"Joyce","year":"2018","journal-title":"Aquac."},{"issue":"6","key":"10.1016\/j.cbpc.2021.109198_bb0245","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.envpol.2009.03.017","article-title":"Illicit drugs and pharmaceuticals in the environment \u2013 forensic applications of environmental data. Part 1: estimation of the usage of drugs in local communities","volume":"157","author":"Kasprzyk-Hordern","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2021.109198_bb0250","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4319\/lo.1975.20.5.0849","article-title":"Respiration and the activity of the respiratory electron transport system in marine zooplankton","volume":"20","author":"King","year":"1975","journal-title":"Limnol. Oceanogr."},{"key":"10.1016\/j.cbpc.2021.109198_bb0255","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.envint.2013.01.009","article-title":"Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary","volume":"54","author":"Klosterhaus","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbpc.2021.109198_bb0260","doi-asserted-by":"crossref","first-page":"13715","DOI":"10.1038\/srep13715","article-title":"Monoamine content during the reproductive cycle of Perna perna depends on site of origin on the Atlantic Coast of Morocco","volume":"5","author":"Klouche","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.cbpc.2021.109198_bb0265","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0163-7258(02)00329-7","article-title":"Cardiovascular disorders associated with cocaine use: myths and truths","volume":"97","author":"Knuepfer","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cbpc.2021.109198_bb0270","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ncl.2020.07.002","article-title":"Toxin-induced coma and central nervous system depression","volume":"38","author":"Krause","year":"2020","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.cbpc.2021.109198_bb0275","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3389\/fphys.2018.01456","article-title":"The neuroendocrine- immune regulation in response to environmental stress in marine bivalves","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0280","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF03259995","article-title":"Clinical toxicology of cocaine","volume":"4","author":"Loper","year":"1989","journal-title":"Med. Toxicol. Adverse. Drug. Exp."},{"key":"10.1016\/j.cbpc.2021.109198_bb0285","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.marpolbul.2019.07.042","article-title":"Psychoactive substances in mussels: analysis and occurrence assessment","volume":"146","author":"L\u00f3pez-Garc\u00eda","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpc.2021.109198_bb0290","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ecoenv.2015.04.010","article-title":"Toxicological evaluation of sediment samples spiked with human pharmaceutical products: energy status and neuroendocrine effects in marine polychaetes Hediste diversicolor","volume":"118","author":"Maranho","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2021.109198_bb0295","series-title":"Neonatal-perinatal Medicine: Diseases of Fetus and Infant","author":"Martin","year":"2014"},{"key":"10.1016\/j.cbpc.2021.109198_bb0300","doi-asserted-by":"crossref","first-page":"100377","DOI":"10.1016\/j.aqrep.2020.100377","article-title":"Lipid content and fatty acid dynamics of female muscle, oocytes and larvae of Prochilodus argentus (Spix & Agassiz, 1829)","volume":"17","author":"Martins","year":"2020","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.cbpc.2021.109198_bb0310","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0016-6480(87)90210-3","article-title":"In vitro effects of serotonin and prostaglandins on release of eggs from the ovary of the scallop, Patinopecten yessoensis","volume":"67","author":"Matsutani","year":"1987","journal-title":"Gen. Comp. Endocrinol."},{"issue":"3","key":"10.1016\/j.cbpc.2021.109198_bb0315","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/01.ftd.0000211812.27558.6e","article-title":"Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeine","volume":"28","author":"Maurer","year":"2006","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.cbpc.2021.109198_bb0320","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cbpb.2006.11.001","article-title":"Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus","volume":"146","author":"McPhee","year":"2007","journal-title":"Comp. Biochem. Physiol. Part B."},{"key":"10.1016\/j.cbpc.2021.109198_bb0325","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/mollus\/eys014","article-title":"Sexual differences in serotonin distribution and induction of synchronous larval release by serotonin in the freshwater mussel Hyriopsis bialatus","volume":"78","author":"Meechonkit","year":"2012","journal-title":"J. Molluscan Stud."},{"issue":"1","key":"10.1016\/j.cbpc.2021.109198_bb0330","first-page":"249","article-title":"The relaxation induced by indole and nonindole 5-HT agonists in the molluscan smooth muscle","volume":"90","author":"Murakami","year":"1998","journal-title":"Comp. Biochem. Physiol. C"},{"issue":"3","key":"10.1016\/j.cbpc.2021.109198_bb0340","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF00353897","article-title":"Immunohistochemical localization and radioenzymatic measurements of serotonin (5-hydroxytryptamine) in hearts of Aplysia and several bivalve mollusks","volume":"269","author":"Ono","year":"1992","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cbpc.2021.109198_bb0345","series-title":"Detoxification, Oxidative Stress, and Cytogenotoxicity of Crack Cocaine in the Brown Mussel Perna perna","first-page":"27569","volume":"26","author":"Ortega","year":"2018"},{"key":"10.1016\/j.cbpc.2021.109198_bb0350","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0090-6980(90)90011-J","article-title":"The levels of reproductive cycle prostaglandins associated with the reproductive cycle of the scallop, Patinonpecten yessoensis","volume":"40","author":"Osada","year":"1990","journal-title":"Prostaglandins."},{"issue":"764","key":"10.1016\/j.cbpc.2021.109198_bb0355","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ejphar.2015.07.044","article-title":"Psychostimulants affect dopamine transmission through both dopamine transporter-dependent and independent mechanisms","volume":"5","author":"Pe\u00f1a","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.cbpc.2021.109198_bb0360","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.ecoenv.2011.02.019","article-title":"Integrated biomarker responses as environmental status descriptors of a coastal zone (S\u00e3o Paulo, Brazil)","volume":"74","author":"Pereira","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.cbpc.2021.109198_bb0365","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/tox.20638","article-title":"Chronic contamination assessment integrating biomarkers\u2019 responses in transplanted mussels \u2014 a seasonal monitoring","volume":"27","author":"Pereira","year":"2012","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0370","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.marenvres.2013.11.002","article-title":"Ecological relevance of sentinels\u2019 biomarker responses: a multi-level approach","volume":"96","author":"Pereira","year":"2014","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.cbpc.2021.109198_bb0375","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.scitotenv.2016.01.051","article-title":"Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone","volume":"548-549","author":"Pereira","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109198_bb0380","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ecoenv.2005.02.007","article-title":"Use of two biomarkers (CYP450 and acetylcholinesterase) in zebra mussel for the biomonitoring of Lake Maggiore (northern Italy)","volume":"63","author":"Ricciardi","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2021.109198_bb0385","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.aquatox.2003.11.004","article-title":"Can acetylcholinesterase be considered a biomarker of effect? A study of the mussel Mytilus edulis exposed to the priority pollutant Chlorfenvinphos","volume":"67","author":"Rickwood","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0390","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1194\/jlr.R800042-JLR200","article-title":"Cyclooxygenases: structural and functional insights","volume":"50","author":"Rouzer","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cbpc.2021.109198_bb0395","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.fsi.2018.05.061","article-title":"Evaluation of the immune responses of the brow mussel Perna perna as indicators of fecal pollution","volume":"80","author":"Santos","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109198_bb0400","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4155\/fmc.11.181","article-title":"Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity","volume":"4","author":"Schindler","year":"2012","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.cbpc.2021.109198_bb0405","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ecolind.2011.08.009","article-title":"Application of an integrated biomarker response index (IBR) to assess temporal variation of environmental quality in two Portuguese aquatic systems","volume":"19","author":"Serafim","year":"2012","journal-title":"Ecol. Indic."},{"issue":"4","key":"10.1016\/j.cbpc.2021.109198_bb0410","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI90678","article-title":"Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain","volume":"127","author":"Singh","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbpc.2021.109198_bb0415","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00227-003-1284-4","article-title":"Serotonergic neurotransmission in the bivalve Venus verrucose (Veneridae): a neurochemical and immunohistochemical study of the visceral ganglion and gonads","volume":"144","author":"Siniscalchi","year":"2004","journal-title":"Mar. Biol."},{"key":"10.1016\/j.cbpc.2021.109198_bb0420","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.envpol.2003.09.027","article-title":"Cellular energy allocation in zebra mussels exposed along a pollution gradient: linking cellular effects to higher levels of biological organization","volume":"129","author":"Smolders","year":"2004","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.cbpc.2021.109198_bb0425","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/jawr.12164","article-title":"Screening for selected human pharmaceuticals and cocaine in the urban streams of Manaus, Amazonas, Brazil","volume":"50","author":"Thomas","year":"2014","journal-title":"J. Am. Water Resour As."},{"key":"10.1016\/j.cbpc.2021.109198_bb0430","series-title":"Book 2: Drug Use and Health Consequences","article-title":"World drug report (United Nations publication, sales, no. E.20.XI.6)","author":"UNODC","year":"2020"},{"issue":"2","key":"10.1016\/j.cbpc.2021.109198_bb0435","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/02791072.1985.10472334","article-title":"Cocaine: pharmacology, effects and treatment of abuse","volume":"17","author":"Zentner","year":"1985","journal-title":"J. Psychoactive Drugs"},{"issue":"4\u20135","key":"10.1016\/j.cbpc.2021.109198_bb0440","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.watres.2007.09.010","article-title":"Illicit drugs, a novel group of environmental contaminants","volume":"42","author":"Zuccato","year":"2008","journal-title":"Water Res."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045621002258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045621002258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:27:46Z","timestamp":1761517666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045621002258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":78,"alternative-id":["S1532045621002258"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2021.109198","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmentally realistic concentrations of cocaine in seawater disturbed neuroendrocrine parameters and energy status in the marine mussel Perna perna","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2021.109198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109198"}}