{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:20:47Z","timestamp":1773199247676,"version":"3.50.1"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["300727"],"award-info":[{"award-number":["300727"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.cbpc.2021.109265","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T12:24:30Z","timestamp":1641212670000},"page":"109265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Acute exposure to environmentally relevant concentrations of phenytoin damages early development and induces oxidative stress in zebrafish embryos"],"prefix":"10.1016","volume":"253","author":[{"given":"Jes\u00fas Daniel","family":"Cardoso-Vera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leobardo Manuel","family":"G\u00f3mez-Oliv\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hariz","family":"Islas-Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Garc\u00eda-Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Orozco-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Heredia-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Axel","family":"Elizalde-Vel\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Galar-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nely","family":"SanJuan-Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2021.109265_bb0005","doi-asserted-by":"crossref","DOI":"10.1212\/CON.0000000000000289","article-title":"Antiepileptic drugs","author":"Abou-Khalil","year":"2016","journal-title":"Contin. Lifelong Learn. Neurol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0021-9673(00)01187-0","article-title":"Determination of drug residues in water by the combination of liquid chromatography or capillary electrophoresis with electrospray mass spectrometry","volume":"910","author":"Ahrer","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.cbpc.2021.109265_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2014.01.093","article-title":"The occurrence of emerging trace organic chemicals in wastewater effluents in Saudi Arabia","author":"Alidina","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109265_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2018.02.106","article-title":"Occurrence, distribution, and seasonality of emerging contaminants in urban watersheds","author":"Bai","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2021.109265_bb0025","series-title":"Environmental Toxicology and Chemistry","article-title":"Integrated biomarker response: a useful tool for ecological risk assessment","author":"Beliaeff","year":"2002"},{"key":"10.1016\/j.cbpc.2021.109265_bb0030","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpc.2021.109265_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2013.10.005","article-title":"Short-term effects of neuroactive pharmaceutical drugs on a fish species: biochemical and behavioural effects","author":"Brand\u00e3o","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/ene.13560","article-title":"A critical appraisal of randomized controlled trials on intravenous phenytoin in convulsive status epilepticus","author":"Brigo","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0045","series-title":"Biomembranes - Part C: Biological Oxidations","first-page":"302","article-title":"[30] Microsomal lipid peroxidation","author":"Buege","year":"1978"},{"key":"10.1016\/j.cbpc.2021.109265_bb0050","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.vascn.2006.02.015","article-title":"Modified protein carbonyl assay detects oxidised membrane proteins: a new tool for assessing drug- and chemically-induced oxidative cell injury","volume":"56","author":"Burcham","year":"2007","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.cbpc.2021.109265_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145487","article-title":"A review of antiepileptic drugs: part 1 occurrence, fate in aquatic environments and removal during different treatment technologies","author":"Cardoso-Vera","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109265_bb0060","series-title":"Chapter 11 - Antiepileptic Drugs: First Generation","first-page":"159","author":"Cotterman-Hart","year":"2015"},{"key":"10.1016\/j.cbpc.2021.109265_bb0065","series-title":"Therapeutic Drug Monitoring Data","article-title":"Chapter 9 - antiepileptic drugs","author":"Dasgupta","year":"2020"},{"key":"10.1016\/j.cbpc.2021.109265_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107286","article-title":"Levetiracetam vs. phenytoin as 2nd-line treatment for status epilepticus: a systematic review and meta-analysis","author":"DeMott","year":"2020","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.cbpc.2021.109265_bb0075","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/bdrc.20098","article-title":"Effects of oxidative stress on embryonic development.","volume":"81","author":"Dennery","year":"2007","journal-title":"<sb:contribution><sb:title>Birth Defects Res.<\/sb:title><\/sb:contribution><sb:host><sb:issue><sb:series><sb:title> C Embryo Today Rev.<\/sb:title><\/sb:series><\/sb:issue><\/sb:host>"},{"key":"10.1016\/j.cbpc.2021.109265_bb0080","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chemosphere.2011.02.087","article-title":"Dimethoate-induced oxidative stress and DNA damage in Oncorhynchus mykiss","volume":"84","author":"Dogan","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2021.109265_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.seizure.2018.02.002","article-title":"Epidemiological profile of epilepsy in low income populations","author":"Espinosa-Jovel","year":"2018","journal-title":"Seizure"},{"key":"10.1016\/j.cbpc.2021.109265_bb0090","series-title":"Oxygen Radicals in Biological Systems","first-page":"114","article-title":"[12] Assays of glutathione peroxidase","author":"Floh\u00e9","year":"1984"},{"key":"10.1016\/j.cbpc.2021.109265_bb0095","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ydbio.2016.05.004","article-title":"Hydrogen peroxide (H2O2) controls axon pathfinding during zebrafish development","volume":"414","author":"Gauron","year":"2016","journal-title":"Dev. Biol. 4"},{"key":"10.1016\/j.cbpc.2021.109265_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.07.042","article-title":"First nationwide investigation and environmental risk assessment of 72 pharmaceuticals and personal care products from Sri Lankan surface waterways","author":"Guruge","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109265_bb0105","article-title":"Status epilepticus: the slow and agonizing death of phenytoin","author":"Hall","year":"2020","journal-title":"J. Pediatr. Pharmacol. Ther."},{"key":"10.1016\/j.cbpc.2021.109265_bb0110","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0887-2333(95)00072-G","article-title":"Glutathione status in chemical embryotoxicity: synthesis, turnover and adduct formation","volume":"9","author":"Harris","year":"1995","journal-title":"Toxicol. InVitro"},{"key":"10.1016\/j.cbpc.2021.109265_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2011.01.005","article-title":"Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies","author":"Hermsen","year":"2011","journal-title":"Toxicol. InVitro"},{"key":"10.1016\/j.cbpc.2021.109265_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2009.04.071","article-title":"Molecularly imprinted polymers for simultaneous determination of antiepileptics in river water samples by liquid chromatography-tandem mass spectrometry","author":"Hoshina","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.cbpc.2021.109265_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2010.10.036","article-title":"Occurrence and removal of pharmaceuticals and hormones through drinking water treatment","author":"Huerta-Fontela","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.cbpc.2021.109265_bb0130","first-page":"287","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alex.J. Med."},{"key":"10.1016\/j.cbpc.2021.109265_bb0135","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ecolind.2018.05.019","article-title":"An integrated biomarker response study explains more than the sum of the parts: oxidative stress in the fish Australoheros facetus exposed to imidacloprid","volume":"93","author":"Iturburu","year":"2018","journal-title":"Ecol. Indic."},{"key":"10.1016\/j.cbpc.2021.109265_bb0140","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0003-2697(92)90122-N","article-title":"Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein","volume":"202","author":"Jiang","year":"1992","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpc.2021.109265_bb0145","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.molstruc.2018.05.030","article-title":"Crystal structure and theoretical charge density studies of dilantin molecule","volume":"1170","author":"Kalaiarasi","year":"2018","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.cbpc.2021.109265_bb0150","series-title":"The Top 300 of 2019, ClinCalc DrugStats Database, Version 19.1 [WWW Document]","author":"Kane","year":"2018"},{"key":"10.1016\/j.cbpc.2021.109265_bb0155","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-017-8465-4","article-title":"Phenytoin: a step by step insight into its multiple mechanisms of action\u201480 years of mechanistic studies in neuropharmacology","author":"Keppel Hesselink","year":"2017","journal-title":"J. Neurol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2017.09.020","article-title":"Phenytoin repositioned in wound healing: clinical experience spanning 60 years","author":"Keppel Hesselink","year":"2018","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.cbpc.2021.109265_bb0165","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-017-8391-5","article-title":"Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action","author":"Keppel Hesselink","year":"2017","journal-title":"J. Neurol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2006.06.034","article-title":"Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters","author":"Kim","year":"2007","journal-title":"Water Res."},{"key":"10.1016\/j.cbpc.2021.109265_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cbpc.2021.109265_bb0180","series-title":"Systems Biology of Free Radicals And Antioxidants","first-page":"567","article-title":"Recent developments in the mechanism of teratogenesis - electron transfer, reactive oxygen species, and antioxidants","author":"Kovacic","year":"2014"},{"key":"10.1016\/j.cbpc.2021.109265_bb0185","article-title":"Outcomes of topical phenytoin in the management of traumatic wounds","author":"Kumar","year":"2020","journal-title":"J. Clin. Orthop. Trauma"},{"key":"10.1016\/j.cbpc.2021.109265_bb5000","first-page":"1","article-title":"Oxidative stress, unfolded protein response, and apoptosis","author":"Kupsco","year":"2015","journal-title":"Dev. Tox. Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2010.11.021","article-title":"Attenuation of contaminants of emerging concern during surface-spreading aquifer recharge","author":"Laws","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109265_bb0195","series-title":"Oxygen Radicals in Biological Systems Part C","first-page":"346","article-title":"[37] Carbonyl assays for determination of oxidatively modified proteins","author":"Levine","year":"1994"},{"key":"10.1016\/j.cbpc.2021.109265_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.seizure.2020.03.002","article-title":"Levetiracetam versus phenytoin for the treatment of established status epilepticus: a systematic review and meta-analysis of randomized controlled trials","author":"Li","year":"2020","journal-title":"Seizure"},{"key":"10.1016\/j.cbpc.2021.109265_bb0205","doi-asserted-by":"crossref","DOI":"10.1006\/taap.1994.1070","article-title":"In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: potential molecular targets of chemical teratogenesis","volume":"125","author":"Liu","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/0891-5849(95)00082-9","article-title":"DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2\u2032-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues","volume":"19","author":"Liu","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbpc.2021.109265_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntt.2015.11.008","article-title":"Effects of diphenylhydantoin on locomotion and thigmotaxis of larval zebrafish","author":"Liu","year":"2016","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0220","article-title":"Occurrence and health risk assessment of pharmaceutical and personal care products (PPCPs) in tap water of Shanghai","author":"Liu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2021.109265_bb0225","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0024-3205(97)00401-3","article-title":"Decreased total antioxidant capacity and elevated lipid hydroperoxide concentrations in sera of epileptic patients receiving phenytoin","volume":"61","author":"Mahle","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.cbpc.2021.109265_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntt.2018.01.008","article-title":"In vivo study of teratogenic and anticonvulsant effects of antiepileptics drugs in zebrafish embryo and larvae","author":"Martinez","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2018.09.033","article-title":"Occurrence of emerging pollutants in estuaries of the Basque Country: analysis of sources and distribution, and assessment of the environmental risk","author":"Mijangos","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.cbpc.2021.109265_bb0240","doi-asserted-by":"crossref","DOI":"10.1007\/s13312-014-0543-4","article-title":"Consensus guidelines on management of childhood convulsive status epilepticus","author":"Mishra","year":"2014","journal-title":"Indian Pediatr."},{"key":"10.1016\/j.cbpc.2021.109265_bb0245","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2021.109265_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2004.11.001","article-title":"Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally","volume":"45","author":"Moreno","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2021.109265_bb0255","doi-asserted-by":"crossref","DOI":"10.1021\/tx9700836","article-title":"Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation","volume":"10","author":"Munns","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0260","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.chemosphere.2018.01.141","article-title":"Zearalenone induced embryo and neurotoxicity in zebrafish model (Danio rerio): role of oxidative stress revealed by a multi biomarker study","volume":"198","author":"Muthulakshmi","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2021.109265_bb0265","doi-asserted-by":"crossref","DOI":"10.1007\/s12098-020-03221-2","article-title":"Clinical effectiveness of levetiracetam compared to fosphenytoin in the treatment of benzodiazepine refractory convulsive status epilepticus","author":"Nalisetty","year":"2020","journal-title":"Indian J. Pediatr."},{"key":"10.1016\/j.cbpc.2021.109265_bb0270","series-title":"Test No. 236: Fish Embryo Acute Toxicity (FET) Test. OECD Guidel. Test. Chem. Sect. 2","author":"OECD","year":"2013"},{"key":"10.1016\/j.cbpc.2021.109265_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2015.02.104","article-title":"Characterization of pharmaceuticals and personal care products in hospital effluent and waste water influent\/effluent by direct-injection LC-MS-MS","author":"Oliveira","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109265_bb0280","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.39.25079","article-title":"Free radical intermediates of phenytoin and related teratogens: prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis","volume":"273","author":"Parman","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2021.109265_bb0285","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.etap.2004.11.002","article-title":"Protein carbonyls: novel biomarkers of exposure to oxidative stress-inducing pesticides in freshwater fish Channa punctata (Bloch)","volume":"20","author":"Parvez","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111393","article-title":"Phenytoin \u2013 an anti-seizure drug: overview of its chemistry, pharmacology and toxicology","author":"Patocka","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0295","doi-asserted-by":"crossref","DOI":"10.1111\/j.1528-1167.2005.463007.x","article-title":"An introduction to antiepileptic drugs","author":"Perucca","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.cbpc.2021.109265_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.03.034","article-title":"Embryotoxicity of ozonated diclofenac, carbamazepine, and oxazepam in zebrafish (Danio rerio)","author":"Pohl","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2021.109265_bb0305","doi-asserted-by":"crossref","DOI":"10.1007\/s10646-016-1694-y","article-title":"Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior","author":"Qiang","year":"2016","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.cbpc.2021.109265_bb0310","doi-asserted-by":"crossref","first-page":"22028","DOI":"10.1016\/S0021-9258(18)54740-2","article-title":"Detection of catalase in rat heart mitochondria","volume":"266","author":"Radi","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2021.109265_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(16)00004-1","article-title":"Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial","author":"Raftopoulos","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0320","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4939-7883-0_18","article-title":"Analysis of lethality and malformations during zebrafish (Danio rerio) development","author":"Raghunath","year":"2018"},{"key":"10.1016\/j.cbpc.2021.109265_bb0325","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-012-1359-1","article-title":"A novel \u201cIntegrated Biomarker Response\u201d calculation based on reference deviation concept","volume":"20","author":"Sanchez","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpc.2021.109265_bb0330","series-title":"Advances in Molecular Toxicology","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-444-64199-1.00007-5","article-title":"Zebrafish early life stages for toxicological screening: insights from molecular and biochemical markers","author":"Santos","year":"2018"},{"key":"10.1016\/j.cbpc.2021.109265_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2013.08.067","article-title":"Pharmaceuticals, perfluorosurfactants, and other organic wastewater compounds in public drinking water wells in a shallow sand and gravel aquifer","author":"Schaider","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109265_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2015.02.059","article-title":"Occurrence of selected pharmaceuticals at drinking water purification plants in Japan and implications for human health","author":"Simazaki","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.cbpc.2021.109265_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2020.106471","article-title":"Influenza immunization does not predominantly alter levels of phenytoin, and cytochrome P-450 enzymes in epileptic patients receiving phenytoin monotherapy","author":"Soontornpun","year":"2020","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.cbpc.2021.109265_bb0355","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.21509","article-title":"Mechanisms of trazodone-induced cytotoxicity and the protective effects of melatonin and\/or taurine toward freshly isolated rat hepatocytes","volume":"27","author":"Taziki","year":"2013","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0360","doi-asserted-by":"crossref","DOI":"10.1021\/es0613198","article-title":"Analysis of pharmaceuticals in water by isotope dilution liquid chromatography\/tandem mass spectrometry","author":"Vanderford","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2021.109265_bb5005","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2011.01.004","article-title":"Zebrafish (Danio rerio) embryos as a model for testing proteratogens","author":"Weigt","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.cbpc.2021.109265_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2005.01.061","article-title":"Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species","author":"Wells","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2021.109265_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/S0891-5849(96)00340-1","article-title":"Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis","volume":"22","author":"Winn","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbpc.2021.109265_bb0375","doi-asserted-by":"crossref","DOI":"10.1124\/jpet.103.052639","article-title":"Oxidative stress-induced homologous recombination as a novel mechanism for phenytoin-initiated toxicity","volume":"306","author":"Winn","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbpc.2021.109265_bb0380","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.chemosphere.2017.05.054","article-title":"Effects of ibuprofen, diclofenac and paracetamol on hatch and motor behavior in developing zebrafish (Danio rerio)","volume":"182","author":"Xia","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2021.109265_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2009.10.049","article-title":"Occurrence of endocrine disrupting compounds, pharmaceuticals, and personal care products in the Han River (Seoul, South Korea)","author":"Yoon","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2021.109265_bb0390","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000013689","article-title":"A systematic review of phenytoin intoxication induced by compound phenytoin sodium, ephedrine hydrochloride and theophylline tablets in China","author":"Zhang","year":"2018","journal-title":"Medicine"},{"key":"10.1016\/j.cbpc.2021.109265_bb0395","article-title":"Behavioral profile alterations in zebrafish larvae exposed to environmentally relevant concentrations of eight priority pharmaceuticals","author":"Zhou","year":"2019","journal-title":"Sci. Total Environ."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045621002921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045621002921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:28:36Z","timestamp":1761517716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045621002921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":80,"alternative-id":["S1532045621002921"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2021.109265","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute exposure to environmentally relevant concentrations of phenytoin damages early development and induces oxidative stress in zebrafish embryos","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2021.109265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109265"}}