{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:08:45Z","timestamp":1789099725871,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["F.18-1\/2011(BSR ) 26 June 2018"],"award-info":[{"award-number":["F.18-1\/2011(BSR ) 26 June 2018"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002742","name":"Banaras Hindu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/013 (0771)\/2018-EMR-I"],"award-info":[{"award-number":["09\/013 (0771)\/2018-EMR-I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.cbpc.2022.109442","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T02:49:57Z","timestamp":1660790997000},"page":"109442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Antifilarial efficacy of andrographolide: Ex vivo studies on bovine filarial parasite Setaria cervi"],"prefix":"10.1016","volume":"261","author":[{"given":"Smita","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiyaz","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Rathaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2022.109442_bb0005","article-title":"Identification of a HSP14-3-3 in Setaria cervi and its cross-reactivity with W bancrofti-infected human sera","volume":"00","author":"Ahmad","year":"2020","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.cbpc.2022.109442_bb0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00894-011-1035-2","article-title":"Virtual screening and in vitro assay of potential drug like inhibitors from spices against glutathione-S-transferase of filarial nematodes","volume":"18","author":"Azeez","year":"2012","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.cbpc.2022.109442_bb0015","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/abbi.2001.2642","article-title":"The neutrophil NADPH oxidase","volume":"397","author":"Babior","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cbpc.2022.109442_bb0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12929-016-0257-0","article-title":"Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA- MB- 231 breast cancer line","volume":"23","author":"Banerjee","year":"2016","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.cbpc.2022.109442_bb0025","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.actatropica.2017.07.023","article-title":"Andrographolide induces oxidative stress-dependent cell death in unicellular protozoan parasite Trypanosoma brucei","volume":"176","author":"Banerjee","year":"2017","journal-title":"Acta Trop."},{"key":"10.1016\/j.cbpc.2022.109442_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182005008899","article-title":"Genetic polymorphism of the beta tubulin gene of onchocerca volvulus in ivermectin na\u00efve patients from Cameroon and its relationship with fertility of the worms","volume":"132","author":"Bourguinat","year":"2006","journal-title":"Parasitol"},{"issue":"5","key":"10.1016\/j.cbpc.2022.109442_bb0035","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1161\/STROKEAHA.108.531632","article-title":"Apoptotic mechanisms after cerebral ischemia","volume":"40","author":"Broughton","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.cbpc.2022.109442_bb0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1749-8546-5-17","article-title":"Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)","volume":"5","author":"Chao","year":"2010","journal-title":"Chin. Med."},{"key":"10.1016\/j.cbpc.2022.109442_bb0045","first-page":"48749","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","author":"Circu","year":"2010","journal-title":"FreeRadicBiol. Med"},{"key":"10.1016\/j.cbpc.2022.109442_bb0050","first-page":"167","article-title":"Anti- dengue efficacy of bioactive andrographolide from Andrographis paniculata (Lamiales: Acanthacea) against the primary dengue vector Aedes aegypti (Diptera: culicidae)","volume":"163","author":"Edwin","year":"2016","journal-title":"Actatropica"},{"key":"10.1016\/j.cbpc.2022.109442_bb0055","article-title":"The human protein disulphide isomerase family: substrate interactions and functional properties","volume":"628\u201332","author":"Ellgard","year":"2005","journal-title":"EMBO Rep."},{"issue":"6","key":"10.1016\/j.cbpc.2022.109442_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002689","article-title":"Decreased mitochondrial DNA mutagenesis in 768 human colorectal cancer","volume":"8","author":"Ericson","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cbpc.2022.109442_bb0065","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1248\/cpb.32.4161","article-title":"Determination of proteins by using the color reaction with pyrocatechol violet-molybdenum (VI) complex","volume":"32","author":"Fujita","year":"1984","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.cbpc.2022.109442_bb0070","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/ijms17030327","article-title":"Endoplasmic reticulum stress and associated ROS","volume":"17","author":"Hafiz","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2022.109442_bb0075","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/ajcn\/57.5.715S","article-title":"Lipid peroxidation: its mechanism, measurement and significance","volume":"57","author":"Halliwell","year":"1993","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cbpc.2022.109442_bb0080","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1242\/jcs.115.10.2053","article-title":"Sperm plasma-membrane-associated glutathione S-transferases as gamete ecognition molecules","volume":"115","author":"Hemachand","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cbpc.2022.109442_bb0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0166-6851(01)00252-3","article-title":"Antioxidant enzyme families in parasitic nematodes","volume":"114","author":"Henkle Duhrsen","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"issue":"3","key":"10.1016\/j.cbpc.2022.109442_bb0090","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1440-1681.2011.05633.x","article-title":"Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer","volume":"39","author":"Lim","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cbpc.2022.109442_bb0095","doi-asserted-by":"crossref","first-page":"9114","DOI":"10.1016\/S0021-9258(19)38819-2","article-title":"Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity","volume":"265","author":"Lundstrom","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2022.109442_bb0100","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.4049\/jimmunol.158.10.4612","article-title":"Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis","volume":"158","author":"Macho","year":"1997","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cbpc.2022.109442_bb0105","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004317","article-title":"Endoplasmic-reticulum calcium depletion and disease","volume":"3","author":"Mekahli","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.cbpc.2022.109442_bb0110","article-title":"Andrographolide: a novel antimalarial diterpene lactone compound from Andrographis paniculata and its interaction with curcumin and artesunate","volume":"1\u20136","author":"Mishra","year":"2011","journal-title":"J. Trop. Med."},{"issue":"7","key":"10.1016\/j.cbpc.2022.109442_bb0115","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1089\/ars.2012.4577","article-title":"Protein disulphide isomerase modification and inhibition contribute to ER stress and apoptosis induced by oxidized low density lipoproteins","volume":"18","author":"Muller","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.cbpc.2022.109442_bb0120","first-page":"281","article-title":"Herbal medicine: current status and the future","volume":"4","author":"Pal","year":"2003","journal-title":"Asian. Pacific. J. Cancer. Prev"},{"issue":"3","key":"10.1016\/j.cbpc.2022.109442_bb0125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/14786410410001709197","article-title":"A newbis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity","volume":"19","author":"Reddy","year":"2005","journal-title":"Nat. Product Res."},{"key":"10.1016\/j.cbpc.2022.109442_bb0130","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bbamcr.2010.11.012","article-title":"Integrating stress signals at the endoplasmic reticulum: the BCL-2 protein family rheostat","volume":"1813","author":"Rodriguez","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2022.109442_bb0135","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1124\/mol.108.050161","article-title":"Mitochondria-dependent reactive oxygen species-mediated programmed cell deathinduced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani","volume":"74","author":"Roy","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cbpc.2022.109442_bb0140","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.parint.2012.04.002","article-title":"Effect of ferulic acid from Hibiscus mutabilis on filarial parasite Setaria cervi: molecular and biochemical approaches","volume":"61","author":"Saini","year":"2012","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.cbpc.2022.109442_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2021.109357","article-title":"Role of anti-filarial drugs in inducing ER stress mediated signaling in bovine filarial parasitosis Setaria cervi","volume":"290","author":"Sharma","year":"2021","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.cbpc.2022.109442_bb0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/08923970701282726","article-title":"Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide","volume":"29","author":"Sheeja","year":"2007","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.cbpc.2022.109442_bb0155","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.actatropica.2016.03.004","article-title":"Inhibition of Setaria cervi protein tyrosine phosphatases by phenylarsine oxide: a proteomic and biochemical study","volume":"159","author":"Singh","year":"2016","journal-title":"Acta Trop."},{"key":"10.1016\/j.cbpc.2022.109442_bb0160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/107175400455137","article-title":"Targeting of liposomal andrographolide to L. donovani- infected macrophages in vivo","volume":"7","author":"Sinha","year":"2000","journal-title":"Drug Deliv."},{"key":"10.1016\/j.cbpc.2022.109442_bb0165","doi-asserted-by":"crossref","first-page":"10388","DOI":"10.1074\/jbc.275.14.10388","article-title":"Up-regulation of protein disulphide isomerase in response to hypoxia\/brain ischemia and its protective effect against apoptotic cell death","volume":"275","author":"Tanaka","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2022.109442_bb0170","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jprot.2014.10.007","article-title":"Effect of CDNB on filarial thioredoxin reductase: a proteomic and biochemical approach","volume":"113","author":"Tiwari","year":"2015","journal-title":"J. Proteome"},{"issue":"3","key":"10.1016\/j.cbpc.2022.109442_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093161","article-title":"Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite","volume":"9","author":"Wadhawan","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cbpc.2022.109442_bb0180","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1074\/mcp.M113.029793","article-title":"A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis","volume":"13","author":"Wang","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cbpc.2022.109442_bb0185","first-page":"767","article-title":"Antioxidant and gastroprotective activities of Andrographis paniculata (HempeduBumi) in Sprague Dawley rats","volume":"49","author":"Wasman","year":"2011","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2022.109442_bb0190","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jnr.10607","article-title":"Early induction of secondary injury factors causing activation of calpain and mitochondria-mediated neuronal apoptosis following spinal cord injury in rats","volume":"73","author":"Wingrave","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.cbpc.2022.109442_bb0195","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12974-016-0498-6","article-title":"Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes","volume":"13","author":"Wong","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cbpc.2022.109442_bb0200","series-title":"Fact Sheet of Lymphatic Filariasis","year":"2019"},{"key":"10.1016\/j.cbpc.2022.109442_bb0205","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1016\/j.vaccine.2008.03.099","article-title":"Filarial glutathione-S-transferase: a potential vaccine candidate against enzymatic filariasis","volume":"26","author":"Yadav","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.cbpc.2022.109442_bb0210","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jmgm.2009.10.003","article-title":"Structural modeling and simulation studies of brugia malayi glutathione-S-transferase with compounds exhibiting antifilarial activity: implications in drug targeting and designing","volume":"28","author":"Yadav","year":"2010","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.cbpc.2022.109442_bb0215","article-title":"Antifilarial efficacy of green silver nanoparticles synthesized using Andrographis paniculata","volume":"56","author":"Yadav","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"2","key":"10.1016\/j.cbpc.2022.109442_bb0220","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.parint.2012.12.008","article-title":"Identification of GR and TrxR systems in Setaria cervi: purification and characterization of glutathione","volume":"62","author":"Yadav","year":"2013","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.cbpc.2022.109442_bb0225","first-page":"503","article-title":"Cardiovascular effects of 14-deoxy-11,12-didehydroandrographolide and Andrographis paniculata extracts","volume":"73","author":"Yoopan","year":"2007","journal-title":"Plantamedica"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045622001776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045622001776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:52:51Z","timestamp":1778521971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045622001776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":45,"alternative-id":["S1532045622001776"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2022.109442","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antifilarial efficacy of andrographolide: Ex vivo studies on bovine filarial parasite Setaria cervi","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2022.109442","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109442"}}